GREMLIN Database
IOLC - 5-dehydro-2-deoxygluconokinase
UniProt: P42414 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (286)
Sequences: 22447 (16532)
Seq/√Len: 977.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_L279_Y3.1271.00
12_D139_K2.7391.00
76_E91_V2.6921.00
61_G85_D2.5311.00
239_H245_Y2.5131.00
142_L172_V2.4731.00
14_V138_A2.4041.00
246_A291_L2.3631.00
280_G285_K2.3561.00
12_D59_K2.1991.00
162_Q198_Q2.1361.00
244_S273_Y2.1281.00
286_D289_T2.1261.00
68_D93_Q2.0841.00
73_R91_V2.0351.00
206_R239_H2.0111.00
254_F288_E1.9961.00
65_K92_D1.9241.00
228_F247_Y1.9191.00
280_G293_Y1.9161.00
15_A50_A1.9141.00
164_A169_V1.8981.00
80_R86_T1.8961.00
172_V278_I1.8821.00
65_K129_E1.8701.00
51_I82_T1.8691.00
170_K200_D1.8501.00
313_T316_E1.8491.00
161_V171_V1.8281.00
221_E253_V1.8081.00
140_M170_K1.8021.00
55_K82_T1.7841.00
158_L194_L1.7641.00
224_V247_Y1.7531.00
272_S297_S1.7501.00
245_Y255_R1.7491.00
203_I274_A1.7461.00
285_K289_T1.7441.00
53_S58_L1.7371.00
246_A254_F1.7241.00
52_G275_S1.7021.00
132_E163_Y1.6991.00
78_Y81_K1.6641.00
283_S314_A1.6431.00
140_M172_V1.6261.00
244_S295_S1.6231.00
200_D233_D1.6191.00
201_I234_L1.6091.00
76_E80_R1.6081.00
13_I53_S1.5881.00
276_A297_S1.5761.00
234_L248_S1.5751.00
288_E292_K1.5751.00
163_Y167_H1.5731.00
298_A302_V1.5691.00
277_F290_A1.5661.00
236_V277_F1.5601.00
269_A302_V1.5581.00
239_H255_R1.5411.00
239_H242_E1.5321.00
226_H230_H1.5171.00
304_K316_E1.5071.00
40_K74_F1.5031.00
158_L162_Q1.4831.00
259_Y296_A1.4781.00
159_K163_Y1.4741.00
77_S81_K1.4601.00
12_D61_G1.4601.00
159_K162_Q1.4571.00
140_M278_I1.4481.00
19_A64_G1.4481.00
226_H229_G1.4421.00
246_A287_I1.4351.00
68_D91_V1.4331.00
53_S279_Y1.4271.00
26_V37_T1.4241.00
256_A291_L1.3771.00
276_A293_Y1.3711.00
42_V75_I1.3691.00
68_D73_R1.3631.00
256_A295_S1.3581.00
170_K201_I1.3561.00
279_Y283_S1.3551.00
136_A167_H1.3451.00
73_R77_S1.3361.00
210_D216_T1.3321.00
21_I74_F1.3211.00
259_Y292_K1.3211.00
59_K85_D1.3181.00
265_K306_S1.3151.00
47_A79_M1.2991.00
219_S222_E1.2931.00
78_Y82_T1.2891.00
163_Y166_K1.2891.00
221_E225_N1.2801.00
126_E129_E1.2741.00
174_E238_K1.2621.00
247_Y253_V1.2451.00
165_K198_Q1.2431.00
228_F249_K1.2381.00
175_L204_G1.2381.00
42_V78_Y1.2371.00
193_S230_H1.2321.00
127_P159_K1.2221.00
165_K200_D1.2211.00
74_F77_S1.2101.00
199_S202_V1.2081.00
23_L38_F1.2071.00
248_S252_E1.2031.00
215_R226_H1.1991.00
234_L287_I1.1971.00
261_T303_S1.1861.00
280_G290_A1.1851.00
244_S291_L1.1771.00
76_E89_M1.1751.00
170_K233_D1.1681.00
234_L281_L1.1681.00
225_N229_G1.1581.00
280_G283_S1.1571.00
209_F237_I1.1571.00
225_N247_Y1.1561.00
72_G98_A1.1521.00
23_L40_K1.1451.00
73_R76_E1.1411.00
26_V39_S1.1321.00
141_L164_A1.1241.00
276_A294_G1.1221.00
263_V302_V1.1191.00
277_F294_G1.1181.00
58_L282_V1.1151.00
234_L277_F1.1111.00
215_R222_E1.0991.00
259_Y299_S1.0891.00
142_L278_I1.0861.00
259_Y295_S1.0851.00
58_L283_S1.0851.00
300_I303_S1.0811.00
50_A60_A1.0771.00
277_F281_L1.0741.00
289_T292_K1.0691.00
261_T302_V1.0651.00
49_I142_L1.0641.00
300_I304_K1.0621.00
203_I238_K1.0601.00
56_L276_A1.0581.00
239_H243_G1.0561.00
70_Q73_R1.0561.00
225_N253_V1.0561.00
263_V266_T1.0531.00
19_A75_I1.0461.00
201_I281_L1.0451.00
54_A84_V1.0451.00
143_V171_V1.0441.00
61_G138_A1.0421.00
74_F78_Y1.0381.00
201_I277_F1.0351.00
173_F199_S1.0311.00
113_I116_Y1.0301.00
238_K273_Y1.0261.00
23_L100_L1.0241.00
112_S115_M1.0171.00
54_A83_G1.0141.00
234_L246_A1.0131.00
53_S60_A1.0121.00
209_F223_S1.0101.00
51_I55_K1.0051.00
132_E167_H1.0031.00
206_R242_E1.0021.00
162_Q166_K1.0021.00
112_S116_Y0.9991.00
92_D124_Y0.9981.00
25_A102_F0.9951.00
222_E225_N0.9941.00
77_S80_R0.9851.00
42_V74_F0.9821.00
277_F287_I0.9781.00
272_S301_V0.9781.00
76_E86_T0.9711.00
53_S275_S0.9661.00
295_S298_A0.9591.00
19_A47_A0.9571.00
224_V237_I0.9561.00
138_A169_V0.9531.00
142_L274_A0.9491.00
141_L169_V0.9481.00
292_K296_A0.9481.00
233_D249_K0.9461.00
189_A193_S0.9421.00
258_A295_S0.9401.00
61_G88_Q0.9391.00
131_S159_K0.9361.00
19_A62_F0.9351.00
197_E231_S0.9341.00
155_E159_K0.9301.00
52_G272_S0.9241.00
203_I277_F0.9211.00
61_G134_Y0.9171.00
256_A292_K0.9081.00
15_A46_P0.9031.00
23_L71_H0.9031.00
290_A294_G0.8961.00
135_I138_A0.8911.00
285_K293_Y0.8901.00
122_D125_L0.8891.00
14_V63_I0.8891.00
111_C115_M0.8891.00
143_V161_V0.8881.00
281_L290_A0.8881.00
279_Y314_A0.8861.00
56_L297_S0.8861.00
262_K303_S0.8851.00
65_K90_I0.8831.00
86_T89_M0.8811.00
66_I76_E0.8811.00
16_I141_L0.8791.00
66_I89_M0.8761.00
245_Y253_V0.8711.00
133_D136_A0.8701.00
66_I72_G0.8661.00
279_Y293_Y0.8661.00
206_R210_D0.8651.00
194_L197_E0.8581.00
264_L305_H0.8581.00
54_A59_K0.8571.00
24_N41_Y0.8561.00
252_E288_E0.8561.00
13_I140_M0.8471.00
104_E112_S0.8471.00
67_P98_A0.8461.00
21_I40_K0.8451.00
263_V303_S0.8431.00
158_L198_Q0.8431.00
66_I91_V0.8361.00
276_A280_G0.8301.00
152_P155_E0.8291.00
222_E226_H0.8281.00
20_C99_G0.8241.00
286_D290_A0.8201.00
213_E223_S0.8191.00
256_A288_E0.8171.00
16_I160_A0.8151.00
69_D98_A0.8111.00
135_I169_V0.8091.00
12_D137_N0.8081.00
75_I98_A0.8021.00
261_T299_S0.8021.00
61_G87_T0.8021.00
196_A199_S0.8011.00
273_Y295_S0.7991.00
40_K71_H0.7981.00
204_G209_F0.7961.00
54_A60_A0.7931.00
162_Q194_L0.7861.00
143_V157_V0.7851.00
248_S287_I0.7851.00
190_V193_S0.7831.00
174_E203_I0.7811.00
13_I282_V0.7781.00
205_T208_E0.7771.00
47_A308_S0.7731.00
49_I274_A0.7731.00
243_G258_A0.7721.00
242_E255_R0.7661.00
154_R191_Y0.7611.00
35_T114_L0.7581.00
151_S155_E0.7581.00
197_E230_H0.7531.00
225_N228_F0.7521.00
56_L293_Y0.7471.00
156_A160_A0.7421.00
50_A62_F0.7391.00
295_S299_S0.7381.00
14_V61_G0.7361.00
99_G104_E0.7361.00
189_A192_Y0.7351.00
224_V235_V0.7341.00
119_D122_D0.7341.00
21_I71_H0.7321.00
140_M282_V0.7311.00
272_S298_A0.7301.00
90_I129_E0.7271.00
70_Q74_F0.7181.00
174_E204_G0.7171.00
76_E90_I0.7171.00
236_V246_A0.7161.00
39_S305_H0.7141.00
296_A300_I0.7131.00
272_S276_A0.7111.00
221_E247_Y0.7081.00
220_N239_H0.7051.00
154_R158_L0.7041.00
78_Y308_S0.7011.00
293_Y314_A0.7001.00
254_F291_L0.6991.00
221_E224_V0.6971.00
14_V134_Y0.6951.00
51_I308_S0.6941.00
172_V274_A0.6891.00
298_A301_V0.6871.00
172_V203_I0.6861.00
88_Q134_Y0.6831.00
188_T191_Y0.6811.00
172_V201_I0.6781.00
132_E136_A0.6761.00
273_Y298_A0.6751.00
221_E245_Y0.6711.00
56_L317_I0.6701.00
220_N223_S0.6701.00
71_H100_L0.6691.00
223_S227_L0.6651.00
161_V198_Q0.6641.00
132_E166_K0.6641.00
155_E158_L0.6621.00
224_V228_F0.6571.00
150_K153_S0.6561.00
273_Y294_G0.6551.00
221_E255_R0.6541.00
68_D94_D0.6521.00
101_A104_E0.6511.00
243_G255_R0.6511.00
103_T113_I0.6481.00
26_V305_H0.6471.00
248_S254_F0.6461.00
127_P155_E0.6431.00
193_S197_E0.6411.00
82_T313_T0.6401.00
111_C114_L0.6391.00
209_F227_L0.6371.00
164_A171_V0.6371.00
141_L160_A0.6361.00
22_D43_G0.6361.00
293_Y317_I0.6321.00
28_Y31_P0.6321.00
285_K290_A0.6321.00
109_E112_S0.6301.00
104_E114_L0.6291.00
56_L279_Y0.6281.00
134_Y138_A0.6271.00
110_E113_I0.6271.00
50_A84_V0.6271.00
87_T134_Y0.6261.00
224_V253_V0.6251.00
69_D72_G0.6241.00
94_D124_Y0.6161.00
88_Q91_V0.6131.00
103_T267_F0.6091.00
64_G89_M0.6041.00
300_I316_E0.6021.00
236_V273_Y0.5951.00
273_Y291_L0.5941.00
134_Y137_N0.5931.00
191_Y194_L0.5921.00
29_N110_E0.5911.00
200_D234_L0.5891.00
215_R219_S0.5891.00
291_L295_S0.5881.00
25_A38_F0.5871.00
244_S256_A0.5851.00
13_I58_L0.5851.00
173_F195_V0.5841.00
161_V195_V0.5811.00
94_D97_K0.5811.00
29_N106_L0.5791.00
119_D123_L0.5771.00
109_E114_L0.5761.00
220_N224_V0.5751.00
203_I236_V0.5731.00
99_G103_T0.5701.00
110_E115_M0.5701.00
207_D211_V0.5701.00
289_T293_Y0.5691.00
228_F248_S0.5661.00
284_G290_A0.5651.00
190_V194_L0.5631.00
300_I317_I0.5621.00
101_A115_M0.5621.00
125_L129_E0.5611.00
287_I290_A0.5601.00
215_R223_S0.5591.00
56_L275_S0.5561.00
42_V308_S0.5561.00
241_V260_K0.5561.00
110_E114_L0.5481.00
125_L130_V0.5441.00
202_V235_V0.5441.00
174_E271_D0.5431.00
15_A60_A0.5431.00
127_P156_A0.5431.00
139_K169_V0.5411.00
15_A53_S0.5411.00
127_P131_S0.5411.00
110_E116_Y0.5411.00
54_A82_T0.5401.00
140_M281_L0.5401.00
59_K282_V0.5391.00
236_V291_L0.5381.00
206_R240_G0.5371.00
47_A62_F0.5361.00
43_G48_N0.5351.00
280_G314_A0.5331.00
73_R80_R0.5311.00
70_Q77_S0.5301.00
158_L161_V0.5291.00
45_S176_D0.5271.00
128_S131_S0.5271.00
106_L112_S0.5271.00
25_A35_T0.5241.00
209_F220_N0.5231.00
79_M86_T0.5221.00
171_V199_S0.5201.00
228_F235_V0.5201.00
275_S279_Y0.5201.00
140_M201_I0.5191.00
287_I291_L0.5181.00
280_G284_G0.5161.00
228_F232_A0.5151.00
121_A124_Y0.5141.00
79_M84_V0.5141.00
19_A79_M0.5121.00
109_E116_Y0.5091.00
41_Y309_E0.5081.00
41_Y308_S0.5071.00
241_V263_V0.5071.00
26_V107_S0.5061.00
133_D137_N0.5051.00
199_S232_A0.5041.00
48_N271_D0.5021.00
164_A167_H0.5011.00
249_K252_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qcvA 3 0.9785 100 0.189 Contact Map
3ljsA 2 0.9508 100 0.195 Contact Map
1tyyA 2 0.9046 100 0.197 Contact Map
3pl2A 2 0.9508 100 0.202 Contact Map
3iq0A 2 0.9508 100 0.205 Contact Map
3hj6A 2 0.8554 100 0.207 Contact Map
2v78A 5 0.9415 100 0.217 Contact Map
4du5A 2 0.9015 100 0.218 Contact Map
2rbcA 2 0.9138 100 0.22 Contact Map
2dcnA 5 0.9323 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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