GREMLIN Database
IOLB - 5-deoxy-glucuronate isomerase
UniProt: P42413 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (250)
Sequences: 947 (549)
Seq/√Len: 34.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_V244_S3.9951.00
209_Y262_D3.6691.00
242_Y265_H3.2161.00
93_I99_F3.0981.00
47_T100_E2.9741.00
145_H164_Y2.8701.00
90_S130_N2.8661.00
81_S84_E2.6971.00
149_P161_V2.6801.00
183_L187_S2.5181.00
34_E113_Y2.4251.00
134_H141_K2.4101.00
198_D243_T2.4031.00
197_L244_S2.3560.99
182_N185_E2.3440.99
50_L55_I2.2780.99
108_R196_E2.2600.99
47_T98_A2.2530.99
41_A44_S2.2320.99
94_S122_T2.2130.99
126_K129_D2.2050.99
60_V82_V2.1740.99
57_I101_I2.1540.99
41_A106_D2.1270.99
116_S156_N2.1150.99
95_N119_Q2.0880.99
261_N269_L2.0840.99
201_Q265_H2.0390.98
155_A255_R2.0260.98
65_T104_V1.9900.98
149_P159_L1.9590.98
57_I109_V1.9480.98
103_A106_D1.9240.98
261_N266_E1.8980.97
45_S102_T1.8670.97
87_P145_H1.8660.97
67_T100_E1.8500.97
76_I124_L1.8420.97
89_D127_A1.8280.97
59_A64_I1.7660.96
71_S121_P1.7620.96
95_N156_N1.7520.96
66_V91_V1.7440.96
19_L22_E1.7260.95
65_T74_E1.7150.95
53_Q113_Y1.6850.95
38_L111_L1.6760.95
97_R122_T1.6750.95
55_I111_L1.6740.95
133_E146_N1.6530.94
42_S106_D1.6460.94
64_I107_A1.6360.94
170_W239_P1.6320.94
55_I113_Y1.6080.93
177_K186_E1.5570.92
49_E98_A1.5550.92
38_L46_Y1.5180.91
42_S105_S1.5000.91
139_S240_D1.4990.91
210_T231_A1.4850.90
147_I160_V1.4710.90
24_T28_S1.4700.90
238_V244_S1.4490.89
65_T102_T1.4470.89
20_V224_E1.4410.89
250_M257_W1.4260.88
25_T28_S1.4150.88
201_Q242_Y1.4050.88
63_K78_T1.4040.88
56_C148_L1.3970.87
140_N268_I1.3960.87
22_E36_K1.3960.87
95_N116_S1.3900.87
68_D97_R1.3660.86
48_E99_F1.3640.86
73_F122_T1.3540.86
45_S100_E1.3530.86
187_S256_K1.3450.85
205_F237_G1.3100.84
67_T72_T1.3100.84
80_E105_S1.3050.83
200_G223_N1.3030.83
161_V248_N1.2830.82
194_Y224_E1.2680.82
187_S258_K1.2600.81
202_G241_G1.2570.81
24_T27_N1.2310.80
165_T246_Y1.2300.80
18_K44_S1.2290.79
203_F239_P1.2260.79
90_S125_I1.2230.79
132_I145_H1.2180.79
196_E223_N1.2130.79
87_P132_I1.2100.78
68_D93_I1.2030.78
25_T30_L1.2020.78
167_S243_T1.2000.78
211_D214_S1.1970.78
57_I111_L1.1950.78
242_Y267_W1.1820.77
119_Q156_N1.1700.76
180_Q188_F1.1500.75
130_N145_H1.1420.74
91_V126_K1.1260.73
205_F222_G1.1140.72
139_S169_N1.1070.72
66_V76_I1.1050.72
57_I107_A1.1040.72
181_D254_T1.1040.72
182_N260_Y1.0870.70
173_Y241_G1.0780.70
266_E269_L1.0700.69
140_N240_D1.0700.69
170_W238_V1.0600.68
89_D124_L1.0590.68
163_V248_N1.0590.68
208_V227_V1.0520.68
181_D184_P1.0520.68
187_S254_T1.0520.68
236_V244_S1.0460.67
181_D187_S1.0440.67
163_V257_W1.0420.67
67_T102_T1.0400.67
207_R220_T1.0240.66
206_Q227_V1.0200.65
39_D108_R1.0130.65
67_T70_E1.0130.65
20_V39_D1.0040.64
214_S231_A1.0030.64
58_V112_C0.9890.63
96_D119_Q0.9850.63
96_D111_L0.9810.62
65_T72_T0.9790.62
133_E161_V0.9770.62
73_F91_V0.9730.62
42_S103_A0.9720.62
91_V122_T0.9630.61
261_N265_H0.9510.60
71_S81_S0.9480.60
175_P261_N0.9470.60
171_S246_Y0.9380.59
21_H226_V0.9350.59
196_E224_E0.9190.57
147_I159_L0.9110.57
172_S246_Y0.9040.56
28_S33_V0.8990.56
56_C158_L0.8970.55
209_Y233_Y0.8930.55
90_S148_L0.8930.55
35_F110_A0.8890.55
59_A89_D0.8870.55
165_T248_N0.8830.54
141_K169_N0.8810.54
173_Y242_Y0.8770.54
203_F237_G0.8730.53
116_S119_Q0.8730.53
148_L161_V0.8640.53
167_S238_V0.8640.53
209_Y264_A0.8640.53
175_P265_H0.8500.51
61_T108_R0.8490.51
170_W237_G0.8450.51
125_I153_P0.8410.51
129_D152_D0.8320.50
23_V98_A0.8290.50
210_T214_S0.8260.49
88_T147_I0.8250.49
78_T86_K0.8240.49
68_D122_T0.8220.49
76_I89_D0.8220.49
79_R162_E0.8160.49
189_L257_W0.8150.48
134_H143_T0.7990.47
82_V170_W0.7980.47
184_P187_S0.7980.47
70_E97_R0.7930.47
175_P208_V0.7920.46
101_I111_L0.7890.46
101_I109_V0.7820.46
63_K105_S0.7820.46
112_C158_L0.7730.45
106_D128_E0.7720.45
56_C112_C0.7720.45
39_D224_E0.7690.45
69_H97_R0.7650.44
56_C160_V0.7640.44
141_K166_D0.7640.44
98_A105_S0.7640.44
42_S47_T0.7640.44
51_K96_D0.7630.44
76_I104_V0.7610.44
25_T34_E0.7610.44
59_A63_K0.7540.43
57_I99_F0.7500.43
51_K98_A0.7490.43
163_V189_L0.7480.43
135_R246_Y0.7440.42
56_C147_I0.7430.42
203_F233_Y0.7430.42
34_E211_D0.7390.42
138_F249_V0.7380.42
61_T144_V0.7360.42
59_A91_V0.7360.42
177_K233_Y0.7330.42
116_S157_S0.7320.41
242_Y261_N0.7240.41
131_G146_N0.7220.41
105_S237_G0.7210.41
194_Y257_W0.7200.40
115_P160_V0.7180.40
205_F218_T0.7170.40
24_T30_L0.7170.40
202_G242_Y0.7170.40
82_V245_Y0.7130.40
164_Y243_T0.7130.40
35_F88_T0.7040.39
210_T215_I0.7020.39
33_V236_V0.7020.39
208_V236_V0.7000.39
125_I158_L0.6990.39
82_V262_D0.6980.39
60_V110_A0.6960.38
110_A255_R0.6930.38
197_L204_V0.6930.38
120_L156_N0.6920.38
237_G240_D0.6900.38
24_T29_D0.6850.38
170_W240_D0.6810.37
211_D229_V0.6800.37
73_F124_L0.6780.37
135_R165_T0.6770.37
90_S147_I0.6770.37
162_E245_Y0.6740.37
19_L36_K0.6700.36
110_A247_L0.6680.36
43_G106_D0.6680.36
165_T245_Y0.6670.36
101_I122_T0.6660.36
250_M253_P0.6630.36
204_V239_P0.6610.36
44_S65_T0.6600.36
101_I157_S0.6580.35
42_S98_A0.6510.35
95_N120_L0.6480.35
47_T106_D0.6460.35
213_R222_G0.6460.35
135_R189_L0.6440.34
132_I143_T0.6420.34
42_S69_H0.6410.34
211_D231_A0.6410.34
108_R223_N0.6410.34
102_T121_P0.6380.34
112_C249_V0.6350.34
112_C157_S0.6350.34
140_N195_H0.6340.34
137_Q225_N0.6320.33
19_L204_V0.6270.33
238_V262_D0.6260.33
137_Q240_D0.6260.33
135_R144_V0.6220.33
33_V192_T0.6210.33
114_S251_A0.6200.33
166_D169_N0.6200.33
21_H44_S0.6170.32
211_D262_D0.6170.32
143_T169_N0.6160.32
45_S69_H0.6150.32
41_A45_S0.6140.32
59_A76_I0.6130.32
175_P239_P0.6120.32
137_Q141_K0.6110.32
149_P157_S0.6110.32
185_E260_Y0.6100.32
80_E84_E0.6090.32
204_V240_D0.6080.32
78_T128_E0.6070.32
195_H222_G0.6060.32
135_R249_V0.6060.32
135_R248_N0.6010.31
68_D73_F0.6010.31
72_T128_E0.5980.31
173_Y202_G0.5980.31
179_D245_Y0.5980.31
125_I155_A0.5960.31
170_W224_E0.5940.31
163_V250_M0.5940.31
135_R225_N0.5940.31
103_A181_D0.5930.31
44_S108_R0.5930.31
103_A107_A0.5920.30
42_S104_V0.5910.30
65_T76_I0.5910.30
23_V27_N0.5890.30
255_R259_F0.5880.30
91_V125_I0.5870.30
222_G240_D0.5820.30
166_D263_P0.5810.30
167_S268_I0.5790.30
237_G268_I0.5790.30
215_I231_A0.5780.29
67_T129_D0.5780.29
63_K104_V0.5760.29
182_N186_E0.5750.29
137_Q140_N0.5750.29
33_V249_V0.5740.29
131_G152_D0.5740.29
31_T99_F0.5720.29
227_V235_P0.5700.29
245_Y252_G0.5700.29
135_R172_S0.5700.29
117_E157_S0.5690.29
56_C159_L0.5680.29
177_K252_G0.5660.29
96_D100_E0.5650.29
135_R163_V0.5650.29
179_D235_P0.5640.29
86_K164_Y0.5640.29
132_I169_N0.5620.28
165_T171_S0.5620.28
18_K46_Y0.5620.28
162_E171_S0.5620.28
207_R218_T0.5600.28
131_G151_S0.5590.28
148_L244_S0.5580.28
227_V257_W0.5580.28
84_E203_F0.5570.28
186_E233_Y0.5550.28
84_E164_Y0.5540.28
233_Y259_F0.5540.28
58_V158_L0.5540.28
84_E221_V0.5500.28
206_Q229_V0.5490.27
260_Y269_L0.5470.27
122_T268_I0.5450.27
82_V238_V0.5450.27
74_E102_T0.5440.27
164_Y221_V0.5430.27
137_Q195_H0.5420.27
89_D126_K0.5410.27
194_Y230_P0.5400.27
117_E120_L0.5360.27
183_L258_K0.5360.27
23_V226_V0.5360.27
30_L138_F0.5360.27
104_V121_P0.5330.26
93_I235_P0.5330.26
183_L188_F0.5310.26
117_E156_N0.5310.26
187_S250_M0.5290.26
153_P229_V0.5290.26
70_E96_D0.5290.26
68_D71_S0.5290.26
66_V124_L0.5250.26
189_L250_M0.5240.26
90_S153_P0.5210.26
82_V235_P0.5200.26
47_T67_T0.5180.25
209_Y251_A0.5170.25
45_S103_A0.5170.25
57_I94_S0.5160.25
167_S240_D0.5150.25
137_Q263_P0.5140.25
35_F60_V0.5140.25
20_V37_V0.5140.25
74_E104_V0.5120.25
150_D161_V0.5100.25
23_V41_A0.5100.25
41_A47_T0.5100.25
194_Y226_V0.5090.25
42_S97_R0.5090.25
69_H121_P0.5080.25
40_L122_T0.5040.25
179_D252_G0.5030.24
201_Q267_W0.5010.24
35_F112_C0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjvA 4 0.9373 100 0.178 Contact Map
1ywkA 1 0.8118 100 0.445 Contact Map
1xruA 3 0.9041 100 0.477 Contact Map
4e2qA 6 0.8081 99.2 0.876 Contact Map
1sq4A 5 0.8339 99 0.883 Contact Map
1rc6A 4 0.7712 99 0.885 Contact Map
1sefA 5 0.797 99 0.886 Contact Map
3rnsA 1 0.7343 98.9 0.889 Contact Map
1sfnA 5 0.8118 98.8 0.894 Contact Map
1y3tA 2 0.8376 98.7 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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