IOLB - BACSU - GREMLIN Contacts

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IOLB - 5-deoxy-glucuronate isomerase

UniProt:	P42413	Sequences: MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGSSYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEITAVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLVVEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDETMTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	271 (250)
Sequences:	947 (549)
Seq/√Len:	34.7

BACSU - IOLB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
204_V	244_S	3.995	1.00
209_Y	262_D	3.669	1.00
242_Y	265_H	3.216	1.00
93_I	99_F	3.098	1.00
47_T	100_E	2.974	1.00
145_H	164_Y	2.870	1.00
90_S	130_N	2.866	1.00
81_S	84_E	2.697	1.00
149_P	161_V	2.680	1.00
183_L	187_S	2.518	1.00
34_E	113_Y	2.425	1.00
134_H	141_K	2.410	1.00
198_D	243_T	2.403	1.00
197_L	244_S	2.356	0.99
182_N	185_E	2.344	0.99
50_L	55_I	2.278	0.99
108_R	196_E	2.260	0.99
47_T	98_A	2.253	0.99
41_A	44_S	2.232	0.99
94_S	122_T	2.213	0.99
126_K	129_D	2.205	0.99
60_V	82_V	2.174	0.99
57_I	101_I	2.154	0.99
41_A	106_D	2.127	0.99
116_S	156_N	2.115	0.99
95_N	119_Q	2.088	0.99
261_N	269_L	2.084	0.99
201_Q	265_H	2.039	0.98
155_A	255_R	2.026	0.98
65_T	104_V	1.990	0.98
149_P	159_L	1.959	0.98
57_I	109_V	1.948	0.98
103_A	106_D	1.924	0.98
261_N	266_E	1.898	0.97
45_S	102_T	1.867	0.97
87_P	145_H	1.866	0.97
67_T	100_E	1.850	0.97
76_I	124_L	1.842	0.97
89_D	127_A	1.828	0.97
59_A	64_I	1.766	0.96
71_S	121_P	1.762	0.96
95_N	156_N	1.752	0.96
66_V	91_V	1.744	0.96
19_L	22_E	1.726	0.95
65_T	74_E	1.715	0.95
53_Q	113_Y	1.685	0.95
38_L	111_L	1.676	0.95
97_R	122_T	1.675	0.95
55_I	111_L	1.674	0.95
133_E	146_N	1.653	0.94
42_S	106_D	1.646	0.94
64_I	107_A	1.636	0.94
170_W	239_P	1.632	0.94
55_I	113_Y	1.608	0.93
177_K	186_E	1.557	0.92
49_E	98_A	1.555	0.92
38_L	46_Y	1.518	0.91
42_S	105_S	1.500	0.91
139_S	240_D	1.499	0.91
210_T	231_A	1.485	0.90
147_I	160_V	1.471	0.90
24_T	28_S	1.470	0.90
238_V	244_S	1.449	0.89
65_T	102_T	1.447	0.89
20_V	224_E	1.441	0.89
250_M	257_W	1.426	0.88
25_T	28_S	1.415	0.88
201_Q	242_Y	1.405	0.88
63_K	78_T	1.404	0.88
56_C	148_L	1.397	0.87
140_N	268_I	1.396	0.87
22_E	36_K	1.396	0.87
95_N	116_S	1.390	0.87
68_D	97_R	1.366	0.86
48_E	99_F	1.364	0.86
73_F	122_T	1.354	0.86
45_S	100_E	1.353	0.86
187_S	256_K	1.345	0.85
205_F	237_G	1.310	0.84
67_T	72_T	1.310	0.84
80_E	105_S	1.305	0.83
200_G	223_N	1.303	0.83
161_V	248_N	1.283	0.82
194_Y	224_E	1.268	0.82
187_S	258_K	1.260	0.81
202_G	241_G	1.257	0.81
24_T	27_N	1.231	0.80
165_T	246_Y	1.230	0.80
18_K	44_S	1.229	0.79
203_F	239_P	1.226	0.79
90_S	125_I	1.223	0.79
132_I	145_H	1.218	0.79
196_E	223_N	1.213	0.79
87_P	132_I	1.210	0.78
68_D	93_I	1.203	0.78
25_T	30_L	1.202	0.78
167_S	243_T	1.200	0.78
211_D	214_S	1.197	0.78
57_I	111_L	1.195	0.78
242_Y	267_W	1.182	0.77
119_Q	156_N	1.170	0.76
180_Q	188_F	1.150	0.75
130_N	145_H	1.142	0.74
91_V	126_K	1.126	0.73
205_F	222_G	1.114	0.72
139_S	169_N	1.107	0.72
66_V	76_I	1.105	0.72
57_I	107_A	1.104	0.72
181_D	254_T	1.104	0.72
182_N	260_Y	1.087	0.70
173_Y	241_G	1.078	0.70
266_E	269_L	1.070	0.69
140_N	240_D	1.070	0.69
170_W	238_V	1.060	0.68
89_D	124_L	1.059	0.68
163_V	248_N	1.059	0.68
208_V	227_V	1.052	0.68
181_D	184_P	1.052	0.68
187_S	254_T	1.052	0.68
236_V	244_S	1.046	0.67
181_D	187_S	1.044	0.67
163_V	257_W	1.042	0.67
67_T	102_T	1.040	0.67
207_R	220_T	1.024	0.66
206_Q	227_V	1.020	0.65
39_D	108_R	1.013	0.65
67_T	70_E	1.013	0.65
20_V	39_D	1.004	0.64
214_S	231_A	1.003	0.64
58_V	112_C	0.989	0.63
96_D	119_Q	0.985	0.63
96_D	111_L	0.981	0.62
65_T	72_T	0.979	0.62
133_E	161_V	0.977	0.62
73_F	91_V	0.973	0.62
42_S	103_A	0.972	0.62
91_V	122_T	0.963	0.61
261_N	265_H	0.951	0.60
71_S	81_S	0.948	0.60
175_P	261_N	0.947	0.60
171_S	246_Y	0.938	0.59
21_H	226_V	0.935	0.59
196_E	224_E	0.919	0.57
147_I	159_L	0.911	0.57
172_S	246_Y	0.904	0.56
28_S	33_V	0.899	0.56
56_C	158_L	0.897	0.55
209_Y	233_Y	0.893	0.55
90_S	148_L	0.893	0.55
35_F	110_A	0.889	0.55
59_A	89_D	0.887	0.55
165_T	248_N	0.883	0.54
141_K	169_N	0.881	0.54
173_Y	242_Y	0.877	0.54
203_F	237_G	0.873	0.53
116_S	119_Q	0.873	0.53
148_L	161_V	0.864	0.53
167_S	238_V	0.864	0.53
209_Y	264_A	0.864	0.53
175_P	265_H	0.850	0.51
61_T	108_R	0.849	0.51
170_W	237_G	0.845	0.51
125_I	153_P	0.841	0.51
129_D	152_D	0.832	0.50
23_V	98_A	0.829	0.50
210_T	214_S	0.826	0.49
88_T	147_I	0.825	0.49
78_T	86_K	0.824	0.49
68_D	122_T	0.822	0.49
76_I	89_D	0.822	0.49
79_R	162_E	0.816	0.49
189_L	257_W	0.815	0.48
134_H	143_T	0.799	0.47
82_V	170_W	0.798	0.47
184_P	187_S	0.798	0.47
70_E	97_R	0.793	0.47
175_P	208_V	0.792	0.46
101_I	111_L	0.789	0.46
101_I	109_V	0.782	0.46
63_K	105_S	0.782	0.46
112_C	158_L	0.773	0.45
106_D	128_E	0.772	0.45
56_C	112_C	0.772	0.45
39_D	224_E	0.769	0.45
69_H	97_R	0.765	0.44
56_C	160_V	0.764	0.44
141_K	166_D	0.764	0.44
98_A	105_S	0.764	0.44
42_S	47_T	0.764	0.44
51_K	96_D	0.763	0.44
76_I	104_V	0.761	0.44
25_T	34_E	0.761	0.44
59_A	63_K	0.754	0.43
57_I	99_F	0.750	0.43
51_K	98_A	0.749	0.43
163_V	189_L	0.748	0.43
135_R	246_Y	0.744	0.42
56_C	147_I	0.743	0.42
203_F	233_Y	0.743	0.42
34_E	211_D	0.739	0.42
138_F	249_V	0.738	0.42
61_T	144_V	0.736	0.42
59_A	91_V	0.736	0.42
177_K	233_Y	0.733	0.42
116_S	157_S	0.732	0.41
242_Y	261_N	0.724	0.41
131_G	146_N	0.722	0.41
105_S	237_G	0.721	0.41
194_Y	257_W	0.720	0.40
115_P	160_V	0.718	0.40
205_F	218_T	0.717	0.40
24_T	30_L	0.717	0.40
202_G	242_Y	0.717	0.40
82_V	245_Y	0.713	0.40
164_Y	243_T	0.713	0.40
35_F	88_T	0.704	0.39
210_T	215_I	0.702	0.39
33_V	236_V	0.702	0.39
208_V	236_V	0.700	0.39
125_I	158_L	0.699	0.39
82_V	262_D	0.698	0.39
60_V	110_A	0.696	0.38
110_A	255_R	0.693	0.38
197_L	204_V	0.693	0.38
120_L	156_N	0.692	0.38
237_G	240_D	0.690	0.38
24_T	29_D	0.685	0.38
170_W	240_D	0.681	0.37
211_D	229_V	0.680	0.37
73_F	124_L	0.678	0.37
135_R	165_T	0.677	0.37
90_S	147_I	0.677	0.37
162_E	245_Y	0.674	0.37
19_L	36_K	0.670	0.36
110_A	247_L	0.668	0.36
43_G	106_D	0.668	0.36
165_T	245_Y	0.667	0.36
101_I	122_T	0.666	0.36
250_M	253_P	0.663	0.36
204_V	239_P	0.661	0.36
44_S	65_T	0.660	0.36
101_I	157_S	0.658	0.35
42_S	98_A	0.651	0.35
95_N	120_L	0.648	0.35
47_T	106_D	0.646	0.35
213_R	222_G	0.646	0.35
135_R	189_L	0.644	0.34
132_I	143_T	0.642	0.34
42_S	69_H	0.641	0.34
211_D	231_A	0.641	0.34
108_R	223_N	0.641	0.34
102_T	121_P	0.638	0.34
112_C	249_V	0.635	0.34
112_C	157_S	0.635	0.34
140_N	195_H	0.634	0.34
137_Q	225_N	0.632	0.33
19_L	204_V	0.627	0.33
238_V	262_D	0.626	0.33
137_Q	240_D	0.626	0.33
135_R	144_V	0.622	0.33
33_V	192_T	0.621	0.33
114_S	251_A	0.620	0.33
166_D	169_N	0.620	0.33
21_H	44_S	0.617	0.32
211_D	262_D	0.617	0.32
143_T	169_N	0.616	0.32
45_S	69_H	0.615	0.32
41_A	45_S	0.614	0.32
59_A	76_I	0.613	0.32
175_P	239_P	0.612	0.32
137_Q	141_K	0.611	0.32
149_P	157_S	0.611	0.32
185_E	260_Y	0.610	0.32
80_E	84_E	0.609	0.32
204_V	240_D	0.608	0.32
78_T	128_E	0.607	0.32
195_H	222_G	0.606	0.32
135_R	249_V	0.606	0.32
135_R	248_N	0.601	0.31
68_D	73_F	0.601	0.31
72_T	128_E	0.598	0.31
173_Y	202_G	0.598	0.31
179_D	245_Y	0.598	0.31
125_I	155_A	0.596	0.31
170_W	224_E	0.594	0.31
163_V	250_M	0.594	0.31
135_R	225_N	0.594	0.31
103_A	181_D	0.593	0.31
44_S	108_R	0.593	0.31
103_A	107_A	0.592	0.30
42_S	104_V	0.591	0.30
65_T	76_I	0.591	0.30
23_V	27_N	0.589	0.30
255_R	259_F	0.588	0.30
91_V	125_I	0.587	0.30
222_G	240_D	0.582	0.30
166_D	263_P	0.581	0.30
167_S	268_I	0.579	0.30
237_G	268_I	0.579	0.30
215_I	231_A	0.578	0.29
67_T	129_D	0.578	0.29
63_K	104_V	0.576	0.29
182_N	186_E	0.575	0.29
137_Q	140_N	0.575	0.29
33_V	249_V	0.574	0.29
131_G	152_D	0.574	0.29
31_T	99_F	0.572	0.29
227_V	235_P	0.570	0.29
245_Y	252_G	0.570	0.29
135_R	172_S	0.570	0.29
117_E	157_S	0.569	0.29
56_C	159_L	0.568	0.29
177_K	252_G	0.566	0.29
96_D	100_E	0.565	0.29
135_R	163_V	0.565	0.29
179_D	235_P	0.564	0.29
86_K	164_Y	0.564	0.29
132_I	169_N	0.562	0.28
165_T	171_S	0.562	0.28
18_K	46_Y	0.562	0.28
162_E	171_S	0.562	0.28
207_R	218_T	0.560	0.28
131_G	151_S	0.559	0.28
148_L	244_S	0.558	0.28
227_V	257_W	0.558	0.28
84_E	203_F	0.557	0.28
186_E	233_Y	0.555	0.28
84_E	164_Y	0.554	0.28
233_Y	259_F	0.554	0.28
58_V	158_L	0.554	0.28
84_E	221_V	0.550	0.28
206_Q	229_V	0.549	0.27
260_Y	269_L	0.547	0.27
122_T	268_I	0.545	0.27
82_V	238_V	0.545	0.27
74_E	102_T	0.544	0.27
164_Y	221_V	0.543	0.27
137_Q	195_H	0.542	0.27
89_D	126_K	0.541	0.27
194_Y	230_P	0.540	0.27
117_E	120_L	0.536	0.27
183_L	258_K	0.536	0.27
23_V	226_V	0.536	0.27
30_L	138_F	0.536	0.27
104_V	121_P	0.533	0.26
93_I	235_P	0.533	0.26
183_L	188_F	0.531	0.26
117_E	156_N	0.531	0.26
187_S	250_M	0.529	0.26
153_P	229_V	0.529	0.26
70_E	96_D	0.529	0.26
68_D	71_S	0.529	0.26
66_V	124_L	0.525	0.26
189_L	250_M	0.524	0.26
90_S	153_P	0.521	0.26
82_V	235_P	0.520	0.26
47_T	67_T	0.518	0.25
209_Y	251_A	0.517	0.25
45_S	103_A	0.517	0.25
57_I	94_S	0.516	0.25
167_S	240_D	0.515	0.25
137_Q	263_P	0.514	0.25
35_F	60_V	0.514	0.25
20_V	37_V	0.514	0.25
74_E	104_V	0.512	0.25
150_D	161_V	0.510	0.25
23_V	41_A	0.510	0.25
41_A	47_T	0.510	0.25
194_Y	226_V	0.509	0.25
42_S	97_R	0.509	0.25
69_H	121_P	0.508	0.25
40_L	122_T	0.504	0.25
179_D	252_G	0.503	0.24
201_Q	267_W	0.501	0.24
35_F	112_C	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qjvA	4	0.9373	100	0.178	Contact Map
1ywkA	1	0.8118	100	0.445	Contact Map
1xruA	3	0.9041	100	0.477	Contact Map
4e2qA	6	0.8081	99.2	0.876	Contact Map
1sq4A	5	0.8339	99	0.883	Contact Map
1rc6A	4	0.7712	99	0.885	Contact Map
1sefA	5	0.797	99	0.886	Contact Map
3rnsA	1	0.7343	98.9	0.889	Contact Map
1sfnA	5	0.8118	98.8	0.894	Contact Map
1y3tA	2	0.8376	98.7	0.897	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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