IOLA - BACSU - GREMLIN Contacts

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IOLA - Methylmalonate semialdehyde dehydrogenase [acylating]

UniProt:	P42412	Sequences: MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	487 (452)
Sequences:	36374 (21622)
Seq/√Len:	1017.0

ECOLI - BETB GABD PUUC ALDB FEAB ALDA ABDH ASTD SAD EUTE PUTA PAAZ PROA
BACSU - IOLA ALDH1 ALDH4 ALDH5 ROCA2 ROCA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
294_E	394_K	5.045	1.00
238_K	242_E	3.515	1.00
294_E	392_R	3.184	1.00
266_E	303_K	3.118	1.00
297_A	392_R	2.965	1.00
25_D	37_Q	2.809	1.00
354_R	365_G	2.793	1.00
54_A	220_E	2.784	1.00
261_N	293_E	2.736	1.00
373_T	376_M	2.708	1.00
329_E	333_K	2.626	1.00
270_T	307_K	2.593	1.00
341_K	377_T	2.591	1.00
187_K	190_E	2.560	1.00
340_E	344_E	2.513	1.00
301_M	390_V	2.497	1.00
261_N	295_G	2.451	1.00
80_S	113_E	2.419	1.00
82_H	85_E	2.400	1.00
416_T	422_I	2.348	1.00
25_D	34_V	2.313	1.00
339_I	364_V	2.245	1.00
54_A	222_K	2.239	1.00
193_E	199_K	2.200	1.00
42_T	45_D	2.194	1.00
83_K	106_G	2.138	1.00
336_L	340_E	2.134	1.00
75_F	192_F	2.133	1.00
78_L	194_K	2.086	1.00
396_L	421_A	2.074	1.00
407_E	454_S	2.035	1.00
348_R	371_N	2.022	1.00
217_E	239_K	2.015	1.00
141_Y	475_K	2.014	1.00
213_N	217_E	2.001	1.00
180_R	328_R	1.993	1.00
336_L	355_E	1.981	1.00
341_K	345_E	1.973	1.00
257_T	272_I	1.937	1.00
305_Q	309_A	1.936	1.00
326_V	335_T	1.934	1.00
140_R	469_D	1.930	1.00
424_Y	428_N	1.922	1.00
336_L	364_V	1.908	1.00
85_E	187_K	1.906	1.00
299_E	303_K	1.900	1.00
71_I	197_L	1.868	1.00
350_V	370_D	1.862	1.00
47_D	214_G	1.855	1.00
235_Y	238_K	1.828	1.00
343_L	349_L	1.805	1.00
262_D	421_A	1.800	1.00
51_Q	220_E	1.795	1.00
291_T	402_I	1.794	1.00
234_E	454_S	1.793	1.00
82_H	194_K	1.765	1.00
78_L	81_Q	1.745	1.00
140_R	472_T	1.743	1.00
430_D	453_K	1.740	1.00
379_W	391_I	1.738	1.00
84_E	102_L	1.737	1.00
396_L	424_Y	1.712	1.00
369_F	378_I	1.708	1.00
78_L	195_A	1.698	1.00
47_D	51_Q	1.679	1.00
293_E	393_V	1.673	1.00
34_V	37_Q	1.654	1.00
291_T	399_A	1.650	1.00
374_T	402_I	1.650	1.00
348_R	370_D	1.635	1.00
308_V	368_I	1.635	1.00
78_L	191_L	1.624	1.00
73_F	113_E	1.611	1.00
89_L	187_K	1.605	1.00
398_E	401_E	1.597	1.00
189_V	204_V	1.595	1.00
305_Q	350_V	1.594	1.00
297_A	301_M	1.581	1.00
112_V	164_P	1.576	1.00
394_K	398_E	1.574	1.00
272_I	300_F	1.574	1.00
277_F	308_V	1.561	1.00
377_T	381_D	1.557	1.00
64_A	67_R	1.556	1.00
302_A	306_E	1.554	1.00
57_F	61_S	1.553	1.00
80_S	109_I	1.542	1.00
47_D	218_H	1.538	1.00
172_T	201_V	1.534	1.00
337_S	377_T	1.523	1.00
77_Q	81_Q	1.515	1.00
303_K	306_E	1.515	1.00
329_E	362_Y	1.513	1.00
265_L	303_K	1.513	1.00
290_V	388_L	1.499	1.00
74_N	77_Q	1.482	1.00
269_V	303_K	1.474	1.00
298_D	392_R	1.474	1.00
23_Y	37_Q	1.463	1.00
67_R	70_R	1.454	1.00
260_L	421_A	1.446	1.00
190_E	194_K	1.441	1.00
291_T	393_V	1.438	1.00
73_F	120_S	1.433	1.00
297_A	370_D	1.430	1.00
32_K	360_D	1.425	1.00
349_L	369_F	1.424	1.00
397_K	428_N	1.422	1.00
271_N	415_F	1.422	1.00
62_K	428_N	1.419	1.00
88_H	92_I	1.413	1.00
272_I	290_V	1.405	1.00
412_A	431_A	1.405	1.00
299_E	302_A	1.404	1.00
307_K	310_D	1.400	1.00
63_V	67_R	1.397	1.00
398_E	402_I	1.396	1.00
292_V	300_F	1.395	1.00
118_A	121_L	1.394	1.00
261_N	421_A	1.394	1.00
76_Q	113_E	1.389	1.00
84_E	88_H	1.389	1.00
312_K	320_G	1.382	1.00
77_Q	113_E	1.381	1.00
139_Y	427_E	1.380	1.00
112_V	160_C	1.375	1.00
27_V	34_V	1.370	1.00
148_G	173_F	1.366	1.00
340_E	343_L	1.361	1.00
82_H	187_K	1.346	1.00
45_D	48_Y	1.345	1.00
338_Y	383_I	1.338	1.00
213_N	239_K	1.327	1.00
88_H	317_L	1.326	1.00
335_T	385_A	1.325	1.00
237_Y	457_F	1.323	1.00
33_E	360_D	1.320	1.00
223_A	248_Q	1.317	1.00
22_Q	40_I	1.315	1.00
260_L	393_V	1.314	1.00
91_T	101_A	1.309	1.00
332_K	336_L	1.308	1.00
393_V	402_I	1.285	1.00
345_E	377_T	1.284	1.00
28_N	31_T	1.284	1.00
332_K	355_E	1.277	1.00
332_K	364_V	1.273	1.00
333_K	337_S	1.266	1.00
159_P	175_L	1.264	1.00
298_D	302_A	1.263	1.00
57_F	172_T	1.260	1.00
189_V	202_F	1.253	1.00
260_L	425_F	1.251	1.00
306_E	309_A	1.249	1.00
98_T	102_L	1.246	1.00
301_M	305_Q	1.244	1.00
50_A	218_H	1.226	1.00
400_I	425_F	1.224	1.00
329_E	332_K	1.221	1.00
258_I	399_A	1.220	1.00
76_Q	80_S	1.220	1.00
312_K	322_F	1.212	1.00
293_E	395_N	1.210	1.00
309_A	351_C	1.210	1.00
46_I	211_V	1.207	1.00
43_K	214_G	1.207	1.00
192_F	202_F	1.204	1.00
466_D	469_D	1.203	1.00
293_E	296_I	1.191	1.00
395_N	398_E	1.190	1.00
213_N	235_Y	1.189	1.00
296_I	299_E	1.184	1.00
137_A	423_R	1.179	1.00
375_E	380_K	1.176	1.00
40_I	208_A	1.176	1.00
51_Q	55_E	1.175	1.00
443_P	446_F	1.172	1.00
179_E	208_A	1.170	1.00
140_R	474_K	1.169	1.00
337_S	341_K	1.168	1.00
303_K	307_K	1.160	1.00
465_K	469_D	1.159	1.00
200_G	203_N	1.152	1.00
63_V	71_I	1.149	1.00
50_A	220_E	1.149	1.00
314_G	321_V	1.146	1.00
304_L	388_L	1.141	1.00
306_E	310_D	1.138	1.00
374_T	405_K	1.137	1.00
88_H	98_T	1.137	1.00
301_M	370_D	1.136	1.00
342_G	369_F	1.136	1.00
50_A	221_I	1.133	1.00
426_R	477_V	1.133	1.00
412_A	434_L	1.132	1.00
86_L	187_K	1.130	1.00
91_T	316_G	1.129	1.00
232_V	235_Y	1.125	1.00
300_F	304_L	1.122	1.00
52_T	203_N	1.119	1.00
74_N	78_L	1.117	1.00
125_D	465_K	1.110	1.00
75_F	191_L	1.108	1.00
235_Y	239_K	1.108	1.00
397_K	424_Y	1.105	1.00
422_I	436_I	1.103	1.00
143_I	223_A	1.101	1.00
380_K	407_E	1.100	1.00
231_P	235_Y	1.099	1.00
83_K	102_L	1.096	1.00
301_M	350_V	1.094	1.00
257_T	287_C	1.084	1.00
163_F	202_F	1.082	1.00
186_E	206_Y	1.077	1.00
345_E	376_M	1.076	1.00
397_K	401_E	1.075	1.00
75_F	197_L	1.074	1.00
147_G	215_I	1.072	1.00
24_E	40_I	1.072	1.00
380_K	405_K	1.069	1.00
73_F	117_G	1.064	1.00
148_G	225_S	1.062	1.00
217_E	242_E	1.060	1.00
75_F	112_V	1.060	1.00
264_N	417_S	1.059	1.00
237_Y	247_V	1.058	1.00
28_N	315_N	1.057	1.00
36_C	183_L	1.057	1.00
466_D	474_K	1.051	1.00
258_I	425_F	1.050	1.00
311_I	323_L	1.048	1.00
309_A	365_G	1.045	1.00
179_E	209_H	1.044	1.00
163_F	173_F	1.042	1.00
400_I	428_N	1.042	1.00
305_Q	351_C	1.031	1.00
396_L	425_F	1.028	1.00
214_G	218_H	1.027	1.00
332_K	362_Y	1.024	1.00
147_G	221_I	1.023	1.00
125_D	466_D	1.022	1.00
254_K	288_A	1.022	1.00
258_I	403_A	1.021	1.00
347_A	369_F	1.013	1.00
154_F	283_R	1.007	1.00
393_V	399_A	1.005	1.00
418_N	421_A	1.002	1.00
59_T	63_V	1.001	1.00
86_L	191_L	0.999	1.00
459_T	473_R	0.999	1.00
315_N	318_D	0.996	1.00
30_A	316_G	0.995	1.00
56_A	172_T	0.993	1.00
264_N	267_D	0.991	1.00
234_E	244_L	0.989	1.00
32_K	362_Y	0.983	1.00
69_A	120_S	0.979	1.00
352_D	367_T	0.975	1.00
450_S	459_T	0.973	1.00
58_K	430_D	0.970	1.00
58_K	401_E	0.969	1.00
81_Q	194_K	0.969	1.00
139_Y	477_V	0.963	1.00
108_G	160_C	0.962	1.00
190_E	193_E	0.962	1.00
335_T	387_V	0.961	1.00
40_I	210_D	0.959	1.00
82_H	191_L	0.958	1.00
145_V	172_T	0.956	1.00
186_E	204_V	0.956	1.00
452_W	473_R	0.953	1.00
352_D	365_G	0.952	1.00
119_P	168_A	0.950	1.00
54_A	58_K	0.949	1.00
82_H	190_E	0.948	1.00
267_D	271_N	0.943	1.00
237_Y	241_S	0.943	1.00
85_E	88_H	0.941	1.00
413_C	439_G	0.941	1.00
256_H	412_A	0.939	1.00
275_A	287_C	0.938	1.00
143_I	246_R	0.936	1.00
273_V	307_K	0.931	1.00
372_V	376_M	0.928	1.00
401_E	405_K	0.926	1.00
341_K	344_E	0.924	1.00
266_E	299_E	0.923	1.00
276_A	288_A	0.920	1.00
337_S	340_E	0.917	1.00
92_I	317_L	0.917	1.00
43_K	47_D	0.910	1.00
78_L	82_H	0.910	1.00
298_D	301_M	0.909	1.00
338_Y	341_K	0.908	1.00
136_A	447_F	0.906	1.00
423_R	427_E	0.904	1.00
28_N	92_I	0.902	1.00
73_F	116_A	0.901	1.00
222_K	430_D	0.898	1.00
141_Y	427_E	0.896	1.00
141_Y	452_W	0.889	1.00
94_N	181_T	0.887	1.00
61_S	430_D	0.887	1.00
145_V	221_I	0.886	1.00
146_V	223_A	0.885	1.00
297_A	390_V	0.884	1.00
257_T	415_F	0.884	1.00
108_G	156_M	0.883	1.00
69_A	73_F	0.883	1.00
65_V	69_A	0.882	1.00
58_K	62_K	0.882	1.00
265_L	269_V	0.882	1.00
28_N	33_E	0.877	1.00
237_Y	240_G	0.875	1.00
70_R	74_N	0.875	1.00
260_L	396_L	0.875	1.00
76_Q	116_A	0.872	1.00
234_E	238_K	0.870	1.00
43_K	210_D	0.869	1.00
335_T	383_I	0.867	1.00
96_K	104_E	0.867	1.00
333_K	336_L	0.866	1.00
27_V	362_Y	0.864	1.00
269_V	304_L	0.863	1.00
46_I	147_G	0.862	1.00
391_I	402_I	0.862	1.00
338_Y	377_T	0.861	1.00
180_R	330_D	0.859	1.00
260_L	416_T	0.858	1.00
269_V	307_K	0.857	1.00
48_Y	52_T	0.857	1.00
353_G	367_T	0.853	1.00
346_G	376_M	0.852	1.00
246_R	473_R	0.852	1.00
229_S	232_V	0.850	1.00
447_F	476_V	0.848	1.00
79_L	108_G	0.846	1.00
412_A	429_I	0.843	1.00
189_V	193_E	0.843	1.00
56_A	201_V	0.838	1.00
347_A	376_M	0.837	1.00
399_A	402_I	0.835	1.00
224_I	240_G	0.832	1.00
24_E	208_A	0.827	1.00
343_L	369_F	0.827	1.00
69_A	116_A	0.824	1.00
143_I	171_N	0.821	1.00
44_E	47_D	0.818	1.00
59_T	62_K	0.818	1.00
374_T	391_I	0.818	1.00
30_A	363_F	0.817	1.00
169_L	472_T	0.817	1.00
53_A	203_N	0.816	1.00
44_E	48_Y	0.815	1.00
207_G	211_V	0.815	1.00
165_M	467_S	0.814	1.00
143_I	473_R	0.813	1.00
414_L	425_F	0.811	1.00
62_K	427_E	0.810	1.00
237_Y	244_L	0.810	1.00
269_V	300_F	0.809	1.00
259_V	300_F	0.808	1.00
224_I	236_V	0.808	1.00
175_L	185_T	0.807	1.00
52_T	200_G	0.807	1.00
48_Y	51_Q	0.804	1.00
268_T	272_I	0.803	1.00
393_V	398_E	0.803	1.00
186_E	190_E	0.802	1.00
41_S	45_D	0.796	1.00
400_I	404_N	0.795	1.00
342_G	383_I	0.795	1.00
302_A	305_Q	0.791	1.00
419_S	422_I	0.790	1.00
87_A	102_L	0.789	1.00
370_D	392_R	0.788	1.00
233_G	251_T	0.788	1.00
339_I	387_V	0.784	1.00
159_P	163_F	0.784	1.00
166_A	173_F	0.778	1.00
255_N	288_A	0.777	1.00
73_F	77_Q	0.777	1.00
60_W	201_V	0.776	1.00
55_E	58_K	0.774	1.00
147_G	212_V	0.773	1.00
330_D	333_K	0.772	1.00
94_N	327_I	0.772	1.00
35_L	92_I	0.771	1.00
177_P	206_Y	0.770	1.00
335_T	364_V	0.769	1.00
233_G	249_S	0.769	1.00
431_A	434_L	0.767	1.00
160_C	188_L	0.762	1.00
216_L	236_V	0.760	1.00
197_L	202_F	0.759	1.00
162_M	462_A	0.757	1.00
72_L	168_A	0.755	1.00
91_T	98_T	0.755	1.00
148_G	162_M	0.755	1.00
304_L	368_I	0.754	1.00
234_E	242_E	0.754	1.00
41_S	49_A	0.752	1.00
293_E	396_L	0.746	1.00
268_T	300_F	0.746	1.00
297_A	371_N	0.745	1.00
99_K	322_F	0.745	1.00
311_I	322_F	0.744	1.00
226_F	232_V	0.742	1.00
80_S	83_K	0.742	1.00
265_L	296_I	0.740	1.00
216_L	239_K	0.740	1.00
256_H	403_A	0.738	1.00
87_A	91_T	0.737	1.00
197_L	201_V	0.736	1.00
79_L	109_I	0.735	1.00
66_P	120_S	0.734	1.00
92_I	183_L	0.734	1.00
230_K	454_S	0.733	1.00
240_G	247_V	0.733	1.00
87_A	98_T	0.730	1.00
156_M	184_L	0.730	1.00
102_L	106_G	0.730	1.00
266_E	307_K	0.729	1.00
216_L	224_I	0.728	1.00
147_G	224_I	0.725	1.00
269_V	273_V	0.725	1.00
308_V	351_C	0.719	1.00
74_N	195_A	0.715	1.00
338_Y	381_D	0.715	1.00
98_T	317_L	0.713	1.00
58_K	61_S	0.712	1.00
175_L	202_F	0.710	1.00
357_V	365_G	0.709	1.00
80_S	106_G	0.705	1.00
214_G	217_E	0.705	1.00
273_V	304_L	0.704	1.00
292_V	296_I	0.701	1.00
60_W	71_I	0.701	1.00
171_N	472_T	0.700	1.00
207_G	212_V	0.698	1.00
305_Q	308_V	0.696	1.00
136_A	476_V	0.696	1.00
212_V	216_L	0.696	1.00
27_V	32_K	0.695	1.00
53_A	172_T	0.693	1.00
180_R	327_I	0.689	1.00
260_L	293_E	0.689	1.00
262_D	416_T	0.689	1.00
46_I	214_G	0.689	1.00
159_P	185_T	0.686	1.00
417_S	420_N	0.683	1.00
343_L	354_R	0.683	1.00
54_A	57_F	0.682	1.00
210_D	213_N	0.681	1.00
85_E	190_E	0.680	1.00
238_K	241_S	0.679	1.00
90_I	93_E	0.679	1.00
179_E	334_R	0.678	1.00
56_A	59_T	0.675	1.00
290_V	300_F	0.675	1.00
331_N	334_R	0.675	1.00
150_A	159_P	0.674	1.00
328_R	331_N	0.674	1.00
308_V	311_I	0.674	1.00
32_K	329_E	0.674	1.00
143_I	222_K	0.672	1.00
246_R	470_F	0.667	1.00
334_R	337_S	0.666	1.00
71_I	195_A	0.666	1.00
374_T	379_W	0.666	1.00
89_L	183_L	0.664	1.00
46_I	50_A	0.663	1.00
77_Q	80_S	0.663	1.00
61_S	428_N	0.662	1.00
280_A	323_L	0.662	1.00
65_V	119_P	0.659	1.00
96_K	100_E	0.659	1.00
329_E	355_E	0.659	1.00
23_Y	39_P	0.656	1.00
22_Q	210_D	0.655	1.00
395_N	401_E	0.654	1.00
402_I	405_K	0.653	1.00
84_E	98_T	0.652	1.00
291_T	379_W	0.651	1.00
259_V	268_T	0.651	1.00
318_D	321_V	0.650	1.00
60_W	167_I	0.650	1.00
135_E	423_R	0.648	1.00
419_S	423_R	0.648	1.00
47_D	220_E	0.647	1.00
291_T	374_T	0.644	1.00
304_L	390_V	0.644	1.00
239_K	242_E	0.644	1.00
52_T	199_K	0.643	1.00
122_M	472_T	0.642	1.00
159_P	188_L	0.642	1.00
179_E	235_Y	0.641	1.00
339_I	369_F	0.641	1.00
426_R	436_I	0.641	1.00
139_Y	475_K	0.640	1.00
430_D	452_W	0.639	1.00
272_I	304_L	0.638	1.00
174_I	203_N	0.638	1.00
267_D	417_S	0.635	1.00
39_P	206_Y	0.635	1.00
76_Q	109_I	0.635	1.00
315_N	321_V	0.633	1.00
28_N	317_L	0.633	1.00
192_F	197_L	0.631	1.00
396_L	400_I	0.631	1.00
58_K	428_N	0.630	1.00
364_V	367_T	0.629	1.00
136_A	478_T	0.629	1.00
248_Q	470_F	0.629	1.00
469_D	474_K	0.627	1.00
267_D	270_T	0.626	1.00
345_E	375_E	0.626	1.00
336_L	339_I	0.626	1.00
265_L	299_E	0.624	1.00
313_I	323_L	0.624	1.00
208_A	211_V	0.623	1.00
86_L	156_M	0.622	1.00
67_R	71_I	0.622	1.00
91_T	317_L	0.621	1.00
273_V	311_I	0.621	1.00
71_I	196_G	0.620	1.00
351_C	368_I	0.620	1.00
369_F	372_V	0.620	1.00
285_M	442_A	0.620	1.00
61_S	141_Y	0.619	1.00
187_K	191_L	0.619	1.00
469_D	472_T	0.617	1.00
96_K	154_F	0.616	1.00
353_G	365_G	0.615	1.00
162_M	225_S	0.614	1.00
105_V	109_I	0.614	1.00
330_D	334_R	0.614	1.00
41_S	205_V	0.613	1.00
372_V	379_W	0.613	1.00
163_F	175_L	0.610	1.00
61_S	142_P	0.609	1.00
43_K	217_E	0.608	1.00
416_T	421_A	0.607	1.00
83_K	87_A	0.606	1.00
349_L	352_D	0.606	1.00
422_I	426_R	0.605	1.00
237_Y	249_S	0.605	1.00
137_A	477_V	0.605	1.00
355_E	365_G	0.604	1.00
90_I	184_L	0.603	1.00
262_D	417_S	0.602	1.00
90_I	104_E	0.601	1.00
420_N	423_R	0.598	1.00
383_I	387_V	0.597	1.00
122_M	468_V	0.594	1.00
26_V	93_E	0.594	1.00
51_Q	54_A	0.594	1.00
65_V	168_A	0.594	1.00
38_V	182_P	0.593	1.00
326_V	331_N	0.593	1.00
90_I	101_A	0.590	1.00
88_H	91_T	0.588	1.00
400_I	424_Y	0.585	1.00
262_D	418_N	0.585	1.00
76_Q	112_V	0.584	1.00
420_N	424_Y	0.584	1.00
26_V	36_C	0.584	1.00
49_A	205_V	0.582	1.00
117_G	120_S	0.582	1.00
172_T	203_N	0.582	1.00
414_L	422_I	0.581	1.00
257_T	290_V	0.579	1.00
292_V	390_V	0.578	1.00
146_V	171_N	0.578	1.00
275_A	439_G	0.578	1.00
313_I	322_F	0.577	1.00
216_L	243_N	0.576	1.00
349_L	367_T	0.576	1.00
79_L	112_V	0.576	1.00
156_M	188_L	0.576	1.00
78_L	196_G	0.575	1.00
372_V	378_I	0.575	1.00
79_L	156_M	0.575	1.00
223_A	470_F	0.573	1.00
400_I	429_I	0.573	1.00
188_L	192_F	0.573	1.00
374_T	401_E	0.572	1.00
257_T	413_C	0.571	1.00
371_N	392_R	0.570	1.00
292_V	297_A	0.570	1.00
283_R	286_A	0.569	1.00
35_L	183_L	0.569	1.00
230_K	234_E	0.569	1.00
79_L	188_L	0.567	1.00
55_E	59_T	0.567	1.00
114_F	118_A	0.562	1.00
434_L	475_K	0.560	1.00
87_A	105_V	0.559	1.00
403_A	429_I	0.558	1.00
265_L	268_T	0.557	1.00
179_E	231_P	0.556	1.00
209_H	213_N	0.554	1.00
266_E	306_E	0.553	1.00
169_L	468_V	0.552	1.00
105_V	156_M	0.552	1.00
339_I	367_T	0.552	1.00
305_Q	368_I	0.551	1.00
276_A	388_L	0.551	1.00
255_N	411_G	0.550	1.00
75_F	78_L	0.549	1.00
414_L	436_I	0.548	1.00
265_L	300_F	0.548	1.00
209_H	212_V	0.548	1.00
53_A	174_I	0.547	1.00
118_A	465_K	0.547	1.00
145_V	222_K	0.547	1.00
290_V	390_V	0.546	1.00
399_A	403_A	0.546	1.00
261_N	393_V	0.545	1.00
115_A	165_M	0.544	1.00
287_C	413_C	0.544	1.00
54_A	145_V	0.542	1.00
102_L	319_D	0.542	1.00
336_L	343_L	0.541	1.00
49_A	203_N	0.541	1.00
66_P	70_R	0.540	1.00
26_V	182_P	0.539	1.00
263_A	268_T	0.539	1.00
22_Q	42_T	0.539	1.00
52_T	56_A	0.539	1.00
326_V	364_V	0.538	1.00
65_V	123_M	0.538	1.00
294_E	297_A	0.537	1.00
86_L	105_V	0.537	1.00
435_G	438_L	0.536	1.00
312_K	318_D	0.535	1.00
146_V	173_F	0.535	1.00
396_L	428_N	0.535	1.00
378_I	383_I	0.534	1.00
193_E	200_G	0.533	1.00
157_M	161_W	0.533	1.00
71_I	75_F	0.532	1.00
148_G	163_F	0.531	1.00
350_V	371_N	0.531	1.00
231_P	330_D	0.530	1.00
141_Y	430_D	0.527	1.00
107_R	157_M	0.525	1.00
167_I	202_F	0.524	1.00
430_D	473_R	0.524	1.00
38_V	183_L	0.522	1.00
94_N	279_S	0.522	1.00
74_N	196_G	0.521	1.00
269_V	296_I	0.521	1.00
59_T	172_T	0.521	1.00
124_G	128_A	0.519	1.00
225_S	471_Y	0.519	1.00
425_F	429_I	0.519	1.00
104_E	154_F	0.516	1.00
277_F	311_I	0.516	1.00
247_V	457_F	0.516	1.00
147_G	174_I	0.515	1.00
349_L	353_G	0.515	1.00
70_R	73_F	0.514	1.00
345_E	373_T	0.512	1.00
411_G	435_G	0.512	1.00
53_A	145_V	0.512	1.00
79_L	86_L	0.512	1.00
83_K	109_I	0.511	1.00
87_A	101_A	0.511	1.00
111_N	463_N	0.511	1.00
106_G	109_I	0.510	1.00
167_I	197_L	0.507	1.00
26_V	35_L	0.507	1.00
219_P	407_E	0.507	1.00
379_W	402_I	0.506	1.00
149_I	236_V	0.502	1.00
40_I	179_E	0.500	1.00
52_T	55_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yweA	5	0.9671	100	0.038	Contact Map
1a4sA	4	0.9918	100	0.039	Contact Map
4o5hA	4	0.9815	100	0.04	Contact Map
3ek1A	5	0.9795	100	0.04	Contact Map
4pxlA	4	0.9877	100	0.043	Contact Map
4qf6A	4	0.9795	100	0.044	Contact Map
4wj9A	4	0.9877	100	0.044	Contact Map
4qtoA	4	0.9938	100	0.045	Contact Map
4iymA	6	0.9979	100	0.045	Contact Map
4lihA	5	0.9795	100	0.046	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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