GREMLIN Database
IOLA - Methylmalonate semialdehyde dehydrogenase [acylating]
UniProt: P42412 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 487 (452)
Sequences: 36374 (21622)
Seq/√Len: 1017.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_E394_K5.0451.00
238_K242_E3.5151.00
294_E392_R3.1841.00
266_E303_K3.1181.00
297_A392_R2.9651.00
25_D37_Q2.8091.00
354_R365_G2.7931.00
54_A220_E2.7841.00
261_N293_E2.7361.00
373_T376_M2.7081.00
329_E333_K2.6261.00
270_T307_K2.5931.00
341_K377_T2.5911.00
187_K190_E2.5601.00
340_E344_E2.5131.00
301_M390_V2.4971.00
261_N295_G2.4511.00
80_S113_E2.4191.00
82_H85_E2.4001.00
416_T422_I2.3481.00
25_D34_V2.3131.00
339_I364_V2.2451.00
54_A222_K2.2391.00
193_E199_K2.2001.00
42_T45_D2.1941.00
83_K106_G2.1381.00
336_L340_E2.1341.00
75_F192_F2.1331.00
78_L194_K2.0861.00
396_L421_A2.0741.00
407_E454_S2.0351.00
348_R371_N2.0221.00
217_E239_K2.0151.00
141_Y475_K2.0141.00
213_N217_E2.0011.00
180_R328_R1.9931.00
336_L355_E1.9811.00
341_K345_E1.9731.00
257_T272_I1.9371.00
305_Q309_A1.9361.00
326_V335_T1.9341.00
140_R469_D1.9301.00
424_Y428_N1.9221.00
336_L364_V1.9081.00
85_E187_K1.9061.00
299_E303_K1.9001.00
71_I197_L1.8681.00
350_V370_D1.8621.00
47_D214_G1.8551.00
235_Y238_K1.8281.00
343_L349_L1.8051.00
262_D421_A1.8001.00
51_Q220_E1.7951.00
291_T402_I1.7941.00
234_E454_S1.7931.00
82_H194_K1.7651.00
78_L81_Q1.7451.00
140_R472_T1.7431.00
430_D453_K1.7401.00
379_W391_I1.7381.00
84_E102_L1.7371.00
396_L424_Y1.7121.00
369_F378_I1.7081.00
78_L195_A1.6981.00
47_D51_Q1.6791.00
293_E393_V1.6731.00
34_V37_Q1.6541.00
291_T399_A1.6501.00
374_T402_I1.6501.00
348_R370_D1.6351.00
308_V368_I1.6351.00
78_L191_L1.6241.00
73_F113_E1.6111.00
89_L187_K1.6051.00
398_E401_E1.5971.00
189_V204_V1.5951.00
305_Q350_V1.5941.00
297_A301_M1.5811.00
112_V164_P1.5761.00
394_K398_E1.5741.00
272_I300_F1.5741.00
277_F308_V1.5611.00
377_T381_D1.5571.00
64_A67_R1.5561.00
302_A306_E1.5541.00
57_F61_S1.5531.00
80_S109_I1.5421.00
47_D218_H1.5381.00
172_T201_V1.5341.00
337_S377_T1.5231.00
77_Q81_Q1.5151.00
303_K306_E1.5151.00
329_E362_Y1.5131.00
265_L303_K1.5131.00
290_V388_L1.4991.00
74_N77_Q1.4821.00
269_V303_K1.4741.00
298_D392_R1.4741.00
23_Y37_Q1.4631.00
67_R70_R1.4541.00
260_L421_A1.4461.00
190_E194_K1.4411.00
291_T393_V1.4381.00
73_F120_S1.4331.00
297_A370_D1.4301.00
32_K360_D1.4251.00
349_L369_F1.4241.00
397_K428_N1.4221.00
271_N415_F1.4221.00
62_K428_N1.4191.00
88_H92_I1.4131.00
272_I290_V1.4051.00
412_A431_A1.4051.00
299_E302_A1.4041.00
307_K310_D1.4001.00
63_V67_R1.3971.00
398_E402_I1.3961.00
292_V300_F1.3951.00
118_A121_L1.3941.00
261_N421_A1.3941.00
76_Q113_E1.3891.00
84_E88_H1.3891.00
312_K320_G1.3821.00
77_Q113_E1.3811.00
139_Y427_E1.3801.00
112_V160_C1.3751.00
27_V34_V1.3701.00
148_G173_F1.3661.00
340_E343_L1.3611.00
82_H187_K1.3461.00
45_D48_Y1.3451.00
338_Y383_I1.3381.00
213_N239_K1.3271.00
88_H317_L1.3261.00
335_T385_A1.3251.00
237_Y457_F1.3231.00
33_E360_D1.3201.00
223_A248_Q1.3171.00
22_Q40_I1.3151.00
260_L393_V1.3141.00
91_T101_A1.3091.00
332_K336_L1.3081.00
393_V402_I1.2851.00
345_E377_T1.2841.00
28_N31_T1.2841.00
332_K355_E1.2771.00
332_K364_V1.2731.00
333_K337_S1.2661.00
159_P175_L1.2641.00
298_D302_A1.2631.00
57_F172_T1.2601.00
189_V202_F1.2531.00
260_L425_F1.2511.00
306_E309_A1.2491.00
98_T102_L1.2461.00
301_M305_Q1.2441.00
50_A218_H1.2261.00
400_I425_F1.2241.00
329_E332_K1.2211.00
258_I399_A1.2201.00
76_Q80_S1.2201.00
312_K322_F1.2121.00
293_E395_N1.2101.00
309_A351_C1.2101.00
46_I211_V1.2071.00
43_K214_G1.2071.00
192_F202_F1.2041.00
466_D469_D1.2031.00
293_E296_I1.1911.00
395_N398_E1.1901.00
213_N235_Y1.1891.00
296_I299_E1.1841.00
137_A423_R1.1791.00
375_E380_K1.1761.00
40_I208_A1.1761.00
51_Q55_E1.1751.00
443_P446_F1.1721.00
179_E208_A1.1701.00
140_R474_K1.1691.00
337_S341_K1.1681.00
303_K307_K1.1601.00
465_K469_D1.1591.00
200_G203_N1.1521.00
63_V71_I1.1491.00
50_A220_E1.1491.00
314_G321_V1.1461.00
304_L388_L1.1411.00
306_E310_D1.1381.00
374_T405_K1.1371.00
88_H98_T1.1371.00
301_M370_D1.1361.00
342_G369_F1.1361.00
50_A221_I1.1331.00
426_R477_V1.1331.00
412_A434_L1.1321.00
86_L187_K1.1301.00
91_T316_G1.1291.00
232_V235_Y1.1251.00
300_F304_L1.1221.00
52_T203_N1.1191.00
74_N78_L1.1171.00
125_D465_K1.1101.00
75_F191_L1.1081.00
235_Y239_K1.1081.00
397_K424_Y1.1051.00
422_I436_I1.1031.00
143_I223_A1.1011.00
380_K407_E1.1001.00
231_P235_Y1.0991.00
83_K102_L1.0961.00
301_M350_V1.0941.00
257_T287_C1.0841.00
163_F202_F1.0821.00
186_E206_Y1.0771.00
345_E376_M1.0761.00
397_K401_E1.0751.00
75_F197_L1.0741.00
147_G215_I1.0721.00
24_E40_I1.0721.00
380_K405_K1.0691.00
73_F117_G1.0641.00
148_G225_S1.0621.00
217_E242_E1.0601.00
75_F112_V1.0601.00
264_N417_S1.0591.00
237_Y247_V1.0581.00
28_N315_N1.0571.00
36_C183_L1.0571.00
466_D474_K1.0511.00
258_I425_F1.0501.00
311_I323_L1.0481.00
309_A365_G1.0451.00
179_E209_H1.0441.00
163_F173_F1.0421.00
400_I428_N1.0421.00
305_Q351_C1.0311.00
396_L425_F1.0281.00
214_G218_H1.0271.00
332_K362_Y1.0241.00
147_G221_I1.0231.00
125_D466_D1.0221.00
254_K288_A1.0221.00
258_I403_A1.0211.00
347_A369_F1.0131.00
154_F283_R1.0071.00
393_V399_A1.0051.00
418_N421_A1.0021.00
59_T63_V1.0011.00
86_L191_L0.9991.00
459_T473_R0.9991.00
315_N318_D0.9961.00
30_A316_G0.9951.00
56_A172_T0.9931.00
264_N267_D0.9911.00
234_E244_L0.9891.00
32_K362_Y0.9831.00
69_A120_S0.9791.00
352_D367_T0.9751.00
450_S459_T0.9731.00
58_K430_D0.9701.00
58_K401_E0.9691.00
81_Q194_K0.9691.00
139_Y477_V0.9631.00
108_G160_C0.9621.00
190_E193_E0.9621.00
335_T387_V0.9611.00
40_I210_D0.9591.00
82_H191_L0.9581.00
145_V172_T0.9561.00
186_E204_V0.9561.00
452_W473_R0.9531.00
352_D365_G0.9521.00
119_P168_A0.9501.00
54_A58_K0.9491.00
82_H190_E0.9481.00
267_D271_N0.9431.00
237_Y241_S0.9431.00
85_E88_H0.9411.00
413_C439_G0.9411.00
256_H412_A0.9391.00
275_A287_C0.9381.00
143_I246_R0.9361.00
273_V307_K0.9311.00
372_V376_M0.9281.00
401_E405_K0.9261.00
341_K344_E0.9241.00
266_E299_E0.9231.00
276_A288_A0.9201.00
337_S340_E0.9171.00
92_I317_L0.9171.00
43_K47_D0.9101.00
78_L82_H0.9101.00
298_D301_M0.9091.00
338_Y341_K0.9081.00
136_A447_F0.9061.00
423_R427_E0.9041.00
28_N92_I0.9021.00
73_F116_A0.9011.00
222_K430_D0.8981.00
141_Y427_E0.8961.00
141_Y452_W0.8891.00
94_N181_T0.8871.00
61_S430_D0.8871.00
145_V221_I0.8861.00
146_V223_A0.8851.00
297_A390_V0.8841.00
257_T415_F0.8841.00
108_G156_M0.8831.00
69_A73_F0.8831.00
65_V69_A0.8821.00
58_K62_K0.8821.00
265_L269_V0.8821.00
28_N33_E0.8771.00
237_Y240_G0.8751.00
70_R74_N0.8751.00
260_L396_L0.8751.00
76_Q116_A0.8721.00
234_E238_K0.8701.00
43_K210_D0.8691.00
335_T383_I0.8671.00
96_K104_E0.8671.00
333_K336_L0.8661.00
27_V362_Y0.8641.00
269_V304_L0.8631.00
46_I147_G0.8621.00
391_I402_I0.8621.00
338_Y377_T0.8611.00
180_R330_D0.8591.00
260_L416_T0.8581.00
269_V307_K0.8571.00
48_Y52_T0.8571.00
353_G367_T0.8531.00
346_G376_M0.8521.00
246_R473_R0.8521.00
229_S232_V0.8501.00
447_F476_V0.8481.00
79_L108_G0.8461.00
412_A429_I0.8431.00
189_V193_E0.8431.00
56_A201_V0.8381.00
347_A376_M0.8371.00
399_A402_I0.8351.00
224_I240_G0.8321.00
24_E208_A0.8271.00
343_L369_F0.8271.00
69_A116_A0.8241.00
143_I171_N0.8211.00
44_E47_D0.8181.00
59_T62_K0.8181.00
374_T391_I0.8181.00
30_A363_F0.8171.00
169_L472_T0.8171.00
53_A203_N0.8161.00
44_E48_Y0.8151.00
207_G211_V0.8151.00
165_M467_S0.8141.00
143_I473_R0.8131.00
414_L425_F0.8111.00
62_K427_E0.8101.00
237_Y244_L0.8101.00
269_V300_F0.8091.00
259_V300_F0.8081.00
224_I236_V0.8081.00
175_L185_T0.8071.00
52_T200_G0.8071.00
48_Y51_Q0.8041.00
268_T272_I0.8031.00
393_V398_E0.8031.00
186_E190_E0.8021.00
41_S45_D0.7961.00
400_I404_N0.7951.00
342_G383_I0.7951.00
302_A305_Q0.7911.00
419_S422_I0.7901.00
87_A102_L0.7891.00
370_D392_R0.7881.00
233_G251_T0.7881.00
339_I387_V0.7841.00
159_P163_F0.7841.00
166_A173_F0.7781.00
255_N288_A0.7771.00
73_F77_Q0.7771.00
60_W201_V0.7761.00
55_E58_K0.7741.00
147_G212_V0.7731.00
330_D333_K0.7721.00
94_N327_I0.7721.00
35_L92_I0.7711.00
177_P206_Y0.7701.00
335_T364_V0.7691.00
233_G249_S0.7691.00
431_A434_L0.7671.00
160_C188_L0.7621.00
216_L236_V0.7601.00
197_L202_F0.7591.00
162_M462_A0.7571.00
72_L168_A0.7551.00
91_T98_T0.7551.00
148_G162_M0.7551.00
304_L368_I0.7541.00
234_E242_E0.7541.00
41_S49_A0.7521.00
293_E396_L0.7461.00
268_T300_F0.7461.00
297_A371_N0.7451.00
99_K322_F0.7451.00
311_I322_F0.7441.00
226_F232_V0.7421.00
80_S83_K0.7421.00
265_L296_I0.7401.00
216_L239_K0.7401.00
256_H403_A0.7381.00
87_A91_T0.7371.00
197_L201_V0.7361.00
79_L109_I0.7351.00
66_P120_S0.7341.00
92_I183_L0.7341.00
230_K454_S0.7331.00
240_G247_V0.7331.00
87_A98_T0.7301.00
156_M184_L0.7301.00
102_L106_G0.7301.00
266_E307_K0.7291.00
216_L224_I0.7281.00
147_G224_I0.7251.00
269_V273_V0.7251.00
308_V351_C0.7191.00
74_N195_A0.7151.00
338_Y381_D0.7151.00
98_T317_L0.7131.00
58_K61_S0.7121.00
175_L202_F0.7101.00
357_V365_G0.7091.00
80_S106_G0.7051.00
214_G217_E0.7051.00
273_V304_L0.7041.00
292_V296_I0.7011.00
60_W71_I0.7011.00
171_N472_T0.7001.00
207_G212_V0.6981.00
305_Q308_V0.6961.00
136_A476_V0.6961.00
212_V216_L0.6961.00
27_V32_K0.6951.00
53_A172_T0.6931.00
180_R327_I0.6891.00
260_L293_E0.6891.00
262_D416_T0.6891.00
46_I214_G0.6891.00
159_P185_T0.6861.00
417_S420_N0.6831.00
343_L354_R0.6831.00
54_A57_F0.6821.00
210_D213_N0.6811.00
85_E190_E0.6801.00
238_K241_S0.6791.00
90_I93_E0.6791.00
179_E334_R0.6781.00
56_A59_T0.6751.00
290_V300_F0.6751.00
331_N334_R0.6751.00
150_A159_P0.6741.00
328_R331_N0.6741.00
308_V311_I0.6741.00
32_K329_E0.6741.00
143_I222_K0.6721.00
246_R470_F0.6671.00
334_R337_S0.6661.00
71_I195_A0.6661.00
374_T379_W0.6661.00
89_L183_L0.6641.00
46_I50_A0.6631.00
77_Q80_S0.6631.00
61_S428_N0.6621.00
280_A323_L0.6621.00
65_V119_P0.6591.00
96_K100_E0.6591.00
329_E355_E0.6591.00
23_Y39_P0.6561.00
22_Q210_D0.6551.00
395_N401_E0.6541.00
402_I405_K0.6531.00
84_E98_T0.6521.00
291_T379_W0.6511.00
259_V268_T0.6511.00
318_D321_V0.6501.00
60_W167_I0.6501.00
135_E423_R0.6481.00
419_S423_R0.6481.00
47_D220_E0.6471.00
291_T374_T0.6441.00
304_L390_V0.6441.00
239_K242_E0.6441.00
52_T199_K0.6431.00
122_M472_T0.6421.00
159_P188_L0.6421.00
179_E235_Y0.6411.00
339_I369_F0.6411.00
426_R436_I0.6411.00
139_Y475_K0.6401.00
430_D452_W0.6391.00
272_I304_L0.6381.00
174_I203_N0.6381.00
267_D417_S0.6351.00
39_P206_Y0.6351.00
76_Q109_I0.6351.00
315_N321_V0.6331.00
28_N317_L0.6331.00
192_F197_L0.6311.00
396_L400_I0.6311.00
58_K428_N0.6301.00
364_V367_T0.6291.00
136_A478_T0.6291.00
248_Q470_F0.6291.00
469_D474_K0.6271.00
267_D270_T0.6261.00
345_E375_E0.6261.00
336_L339_I0.6261.00
265_L299_E0.6241.00
313_I323_L0.6241.00
208_A211_V0.6231.00
86_L156_M0.6221.00
67_R71_I0.6221.00
91_T317_L0.6211.00
273_V311_I0.6211.00
71_I196_G0.6201.00
351_C368_I0.6201.00
369_F372_V0.6201.00
285_M442_A0.6201.00
61_S141_Y0.6191.00
187_K191_L0.6191.00
469_D472_T0.6171.00
96_K154_F0.6161.00
353_G365_G0.6151.00
162_M225_S0.6141.00
105_V109_I0.6141.00
330_D334_R0.6141.00
41_S205_V0.6131.00
372_V379_W0.6131.00
163_F175_L0.6101.00
61_S142_P0.6091.00
43_K217_E0.6081.00
416_T421_A0.6071.00
83_K87_A0.6061.00
349_L352_D0.6061.00
422_I426_R0.6051.00
237_Y249_S0.6051.00
137_A477_V0.6051.00
355_E365_G0.6041.00
90_I184_L0.6031.00
262_D417_S0.6021.00
90_I104_E0.6011.00
420_N423_R0.5981.00
383_I387_V0.5971.00
122_M468_V0.5941.00
26_V93_E0.5941.00
51_Q54_A0.5941.00
65_V168_A0.5941.00
38_V182_P0.5931.00
326_V331_N0.5931.00
90_I101_A0.5901.00
88_H91_T0.5881.00
400_I424_Y0.5851.00
262_D418_N0.5851.00
76_Q112_V0.5841.00
420_N424_Y0.5841.00
26_V36_C0.5841.00
49_A205_V0.5821.00
117_G120_S0.5821.00
172_T203_N0.5821.00
414_L422_I0.5811.00
257_T290_V0.5791.00
292_V390_V0.5781.00
146_V171_N0.5781.00
275_A439_G0.5781.00
313_I322_F0.5771.00
216_L243_N0.5761.00
349_L367_T0.5761.00
79_L112_V0.5761.00
156_M188_L0.5761.00
78_L196_G0.5751.00
372_V378_I0.5751.00
79_L156_M0.5751.00
223_A470_F0.5731.00
400_I429_I0.5731.00
188_L192_F0.5731.00
374_T401_E0.5721.00
257_T413_C0.5711.00
371_N392_R0.5701.00
292_V297_A0.5701.00
283_R286_A0.5691.00
35_L183_L0.5691.00
230_K234_E0.5691.00
79_L188_L0.5671.00
55_E59_T0.5671.00
114_F118_A0.5621.00
434_L475_K0.5601.00
87_A105_V0.5591.00
403_A429_I0.5581.00
265_L268_T0.5571.00
179_E231_P0.5561.00
209_H213_N0.5541.00
266_E306_E0.5531.00
169_L468_V0.5521.00
105_V156_M0.5521.00
339_I367_T0.5521.00
305_Q368_I0.5511.00
276_A388_L0.5511.00
255_N411_G0.5501.00
75_F78_L0.5491.00
414_L436_I0.5481.00
265_L300_F0.5481.00
209_H212_V0.5481.00
53_A174_I0.5471.00
118_A465_K0.5471.00
145_V222_K0.5471.00
290_V390_V0.5461.00
399_A403_A0.5461.00
261_N393_V0.5451.00
115_A165_M0.5441.00
287_C413_C0.5441.00
54_A145_V0.5421.00
102_L319_D0.5421.00
336_L343_L0.5411.00
49_A203_N0.5411.00
66_P70_R0.5401.00
26_V182_P0.5391.00
263_A268_T0.5391.00
22_Q42_T0.5391.00
52_T56_A0.5391.00
326_V364_V0.5381.00
65_V123_M0.5381.00
294_E297_A0.5371.00
86_L105_V0.5371.00
435_G438_L0.5361.00
312_K318_D0.5351.00
146_V173_F0.5351.00
396_L428_N0.5351.00
378_I383_I0.5341.00
193_E200_G0.5331.00
157_M161_W0.5331.00
71_I75_F0.5321.00
148_G163_F0.5311.00
350_V371_N0.5311.00
231_P330_D0.5301.00
141_Y430_D0.5271.00
107_R157_M0.5251.00
167_I202_F0.5241.00
430_D473_R0.5241.00
38_V183_L0.5221.00
94_N279_S0.5221.00
74_N196_G0.5211.00
269_V296_I0.5211.00
59_T172_T0.5211.00
124_G128_A0.5191.00
225_S471_Y0.5191.00
425_F429_I0.5191.00
104_E154_F0.5161.00
277_F311_I0.5161.00
247_V457_F0.5161.00
147_G174_I0.5151.00
349_L353_G0.5151.00
70_R73_F0.5141.00
345_E373_T0.5121.00
411_G435_G0.5121.00
53_A145_V0.5121.00
79_L86_L0.5121.00
83_K109_I0.5111.00
87_A101_A0.5111.00
111_N463_N0.5111.00
106_G109_I0.5101.00
167_I197_L0.5071.00
26_V35_L0.5071.00
219_P407_E0.5071.00
379_W402_I0.5061.00
149_I236_V0.5021.00
40_I179_E0.5001.00
52_T55_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yweA 5 0.9671 100 0.038 Contact Map
1a4sA 4 0.9918 100 0.039 Contact Map
4o5hA 4 0.9815 100 0.04 Contact Map
3ek1A 5 0.9795 100 0.04 Contact Map
4pxlA 4 0.9877 100 0.043 Contact Map
4qf6A 4 0.9795 100 0.044 Contact Map
4wj9A 4 0.9877 100 0.044 Contact Map
4qtoA 4 0.9938 100 0.045 Contact Map
4iymA 6 0.9979 100 0.045 Contact Map
4lihA 5 0.9795 100 0.046 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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