RSBT - BACSU - GREMLIN Contacts

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RSBT - Serine/threonine-protein kinase RsbT

UniProt:	P42411	Sequences: MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAISELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGAGLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	133 (118)
Sequences:	57542 (48072)
Seq/√Len:	4425.4

ECOLI - TORS RCSD ARCB BARA RCSC EVGS ATOS ZRAS DPIB DCUS KDPD GLRK CREC CPXA BAES PHOQ NARQ NARX PHOR ENVZ YPDA BASS RSTB CUSS QSEC UHPB YEDV NTRB
BACSU - RSBT KINA KINE PHOR RESE YYCG YVRG CITS LYTS DCTS MALK KIND KINB YCLK GLNK KINC BCES YVCQ DEGS YCBM COMP NATK YXDK YKOH YHCY YDFH CSSS YFIJ YXJM YESM LIAS YWPD YVFT DESK YRKQ YBDK
HALSA - Q9HQG5 Q9HQ16 Q9HR10 Q9HRG1 Q9HRE4 Q9HNM2 O51970 Q9HQE9 BAT Q9HQ15 Q9HQB9 Q9HNA6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
115_S	127_Q	2.859	1.00
54_A	79_Q	2.661	1.00
77_E	125_E	2.552	1.00
86_I	116_L	2.504	1.00
71_G	129_I	2.476	1.00
119_V	122_E	2.381	1.00
75_I	125_E	2.172	1.00
73_K	129_I	2.170	1.00
73_K	127_Q	1.966	1.00
62_E	75_I	1.831	1.00
24_N	62_E	1.825	1.00
84_P	120_A	1.820	1.00
75_I	127_Q	1.803	1.00
107_V	114_F	1.788	1.00
60_G	77_E	1.739	1.00
42_A	110_L	1.734	1.00
62_E	77_E	1.729	1.00
117_N	125_E	1.724	1.00
22_G	60_G	1.716	1.00
22_G	58_Q	1.691	1.00
113_E	129_I	1.678	1.00
34_V	39_I	1.664	1.00
38_R	41_T	1.663	1.00
85_D	88_K	1.661	1.00
116_L	126_I	1.606	1.00
90_M	114_F	1.593	1.00
118_S	122_E	1.582	1.00
86_I	118_S	1.559	1.00
35_D	38_R	1.541	1.00
42_A	107_V	1.537	1.00
24_N	60_G	1.513	1.00
58_Q	79_Q	1.439	1.00
43_I	74_I	1.423	1.00
66_D	73_K	1.397	1.00
74_I	128_A	1.394	1.00
117_N	127_Q	1.384	1.00
48_R	52_L	1.381	1.00
13_W	16_V	1.347	1.00
20_Q	58_Q	1.338	1.00
57_G	79_Q	1.337	1.00
118_S	121_G	1.331	1.00
54_A	59_I	1.327	1.00
38_R	110_L	1.307	1.00
14_D	51_Y	1.301	1.00
88_K	91_E	1.259	1.00
115_S	129_I	1.248	1.00
118_S	124_T	1.245	1.00
45_E	107_V	1.223	1.00
93_G	97_S	1.221	1.00
71_G	113_E	1.210	1.00
93_G	98_G	1.124	1.00
95_S	98_G	1.120	1.00
68_G	73_K	1.113	1.00
45_E	48_R	1.111	1.00
83_I	116_L	1.109	1.00
42_A	128_A	1.106	1.00
78_D	82_G	1.103	1.00
83_I	89_V	1.092	1.00
81_P	97_S	1.087	1.00
92_D	109_R	1.075	1.00
53_Y	81_P	1.061	1.00
112_D	128_A	1.034	1.00
78_D	123_G	1.034	1.00
54_A	57_G	1.031	1.00
40_T	44_S	1.012	1.00
26_A	29_L	0.986	1.00
41_T	110_L	0.976	1.00
90_M	116_L	0.974	1.00
59_I	79_Q	0.952	1.00
94_F	97_S	0.951	1.00
60_G	79_Q	0.923	1.00
83_I	87_R	0.922	1.00
70_K	131_W	0.920	1.00
36_Q	40_T	0.905	1.00
73_K	115_S	0.902	1.00
41_T	44_S	0.891	1.00
66_D	75_I	0.890	1.00
43_I	76_A	0.889	1.00
83_I	86_I	0.888	1.00
83_I	124_T	0.881	1.00
71_G	131_W	0.880	1.00
89_V	105_P	0.859	1.00
53_Y	97_S	0.855	1.00
46_L	114_F	0.849	1.00
37_A	40_T	0.842	1.00
93_G	96_T	0.842	1.00
89_V	116_L	0.842	1.00
26_A	30_G	0.830	1.00
19_R	23_R	0.807	1.00
46_L	128_A	0.802	1.00
112_D	131_W	0.801	1.00
68_G	71_G	0.800	1.00
52_L	97_S	0.796	1.00
14_D	21_L	0.785	1.00
92_D	102_A	0.782	1.00
17_A	51_Y	0.780	1.00
48_R	53_Y	0.778	1.00
12_E	15_I	0.777	1.00
112_D	130_K	0.777	1.00
43_I	47_A	0.776	1.00
41_T	106_G	0.759	1.00
46_L	107_V	0.752	1.00
56_K	59_I	0.743	1.00
86_I	90_M	0.735	1.00
115_S	128_A	0.733	1.00
47_A	61_I	0.730	1.00
58_Q	77_E	0.725	1.00
13_W	48_R	0.724	1.00
19_R	79_Q	0.705	1.00
19_R	51_Y	0.696	1.00
12_E	16_V	0.692	1.00
14_D	59_I	0.692	1.00
18_A	55_G	0.691	1.00
19_R	56_K	0.689	1.00
68_G	129_I	0.686	1.00
18_A	56_K	0.683	1.00
46_L	126_I	0.682	1.00
17_A	55_G	0.678	1.00
75_I	117_N	0.676	1.00
25_V	29_L	0.670	1.00
83_I	104_L	0.664	1.00
53_Y	93_G	0.663	1.00
13_W	17_A	0.659	1.00
83_I	118_S	0.658	1.00
92_D	105_P	0.654	1.00
102_A	106_G	0.651	1.00
39_I	43_I	0.651	1.00
19_R	57_G	0.650	1.00
26_A	62_E	0.641	1.00
50_I	59_I	0.638	1.00
52_L	98_G	0.630	1.00
20_Q	23_R	0.629	1.00
42_A	45_E	0.620	1.00
94_F	98_G	0.619	1.00
87_R	91_E	0.618	1.00
116_L	124_T	0.612	1.00
30_G	72_L	0.610	1.00
46_L	76_A	0.603	1.00
65_A	72_L	0.601	1.00
19_R	53_Y	0.600	1.00
67_R	70_K	0.595	1.00
81_P	124_T	0.593	1.00
92_D	100_L	0.589	1.00
66_D	69_K	0.585	1.00
27_K	30_G	0.583	1.00
14_D	19_R	0.577	1.00
112_D	115_S	0.575	1.00
102_A	105_P	0.573	1.00
120_A	123_G	0.571	1.00
14_D	18_A	0.565	1.00
85_D	93_G	0.563	1.00
86_I	117_N	0.557	1.00
52_L	94_F	0.555	1.00
53_Y	92_D	0.547	1.00
90_M	126_I	0.543	1.00
21_L	51_Y	0.540	1.00
15_I	18_A	0.537	1.00
61_I	74_I	0.537	1.00
52_L	99_G	0.532	1.00
42_A	46_L	0.532	1.00
86_I	89_V	0.530	1.00
25_V	65_A	0.529	1.00
32_G	70_K	0.528	1.00
87_R	92_D	0.524	1.00
44_S	48_R	0.520	1.00
55_G	96_T	0.520	1.00
105_P	109_R	0.520	1.00
14_D	17_A	0.517	1.00
62_E	66_D	0.516	1.00
30_G	65_A	0.516	1.00
78_D	124_T	0.515	1.00
19_R	54_A	0.514	1.00
33_T	36_Q	0.509	1.00
39_I	130_K	0.503	1.00
22_G	25_V	0.502	1.00
21_L	61_I	0.502	1.00
91_E	105_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2q8gA	2	0.985	99.9	0.347	Contact Map
4mpcA	2	0.9549	99.9	0.352	Contact Map
4i5sA	2	0.9248	99.9	0.359	Contact Map
2e0aA	2	0.985	99.9	0.361	Contact Map
4gczA	2	1	99.9	0.365	Contact Map
4bixA	2	0.9699	99.9	0.371	Contact Map
1y8oA	2	0.9549	99.9	0.371	Contact Map
4pl9A	1	0.9398	99.9	0.378	Contact Map
3a0rA	2	0.9323	99.9	0.381	Contact Map
4q20A	2	0.985	99.9	0.384	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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