GREMLIN Database
RSBT - Serine/threonine-protein kinase RsbT
UniProt: P42411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (118)
Sequences: 57542 (48072)
Seq/√Len: 4425.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_S127_Q2.8591.00
54_A79_Q2.6611.00
77_E125_E2.5521.00
86_I116_L2.5041.00
71_G129_I2.4761.00
119_V122_E2.3811.00
75_I125_E2.1721.00
73_K129_I2.1701.00
73_K127_Q1.9661.00
62_E75_I1.8311.00
24_N62_E1.8251.00
84_P120_A1.8201.00
75_I127_Q1.8031.00
107_V114_F1.7881.00
60_G77_E1.7391.00
42_A110_L1.7341.00
62_E77_E1.7291.00
117_N125_E1.7241.00
22_G60_G1.7161.00
22_G58_Q1.6911.00
113_E129_I1.6781.00
34_V39_I1.6641.00
38_R41_T1.6631.00
85_D88_K1.6611.00
116_L126_I1.6061.00
90_M114_F1.5931.00
118_S122_E1.5821.00
86_I118_S1.5591.00
35_D38_R1.5411.00
42_A107_V1.5371.00
24_N60_G1.5131.00
58_Q79_Q1.4391.00
43_I74_I1.4231.00
66_D73_K1.3971.00
74_I128_A1.3941.00
117_N127_Q1.3841.00
48_R52_L1.3811.00
13_W16_V1.3471.00
20_Q58_Q1.3381.00
57_G79_Q1.3371.00
118_S121_G1.3311.00
54_A59_I1.3271.00
38_R110_L1.3071.00
14_D51_Y1.3011.00
88_K91_E1.2591.00
115_S129_I1.2481.00
118_S124_T1.2451.00
45_E107_V1.2231.00
93_G97_S1.2211.00
71_G113_E1.2101.00
93_G98_G1.1241.00
95_S98_G1.1201.00
68_G73_K1.1131.00
45_E48_R1.1111.00
83_I116_L1.1091.00
42_A128_A1.1061.00
78_D82_G1.1031.00
83_I89_V1.0921.00
81_P97_S1.0871.00
92_D109_R1.0751.00
53_Y81_P1.0611.00
112_D128_A1.0341.00
78_D123_G1.0341.00
54_A57_G1.0311.00
40_T44_S1.0121.00
26_A29_L0.9861.00
41_T110_L0.9761.00
90_M116_L0.9741.00
59_I79_Q0.9521.00
94_F97_S0.9511.00
60_G79_Q0.9231.00
83_I87_R0.9221.00
70_K131_W0.9201.00
36_Q40_T0.9051.00
73_K115_S0.9021.00
41_T44_S0.8911.00
66_D75_I0.8901.00
43_I76_A0.8891.00
83_I86_I0.8881.00
83_I124_T0.8811.00
71_G131_W0.8801.00
89_V105_P0.8591.00
53_Y97_S0.8551.00
46_L114_F0.8491.00
37_A40_T0.8421.00
93_G96_T0.8421.00
89_V116_L0.8421.00
26_A30_G0.8301.00
19_R23_R0.8071.00
46_L128_A0.8021.00
112_D131_W0.8011.00
68_G71_G0.8001.00
52_L97_S0.7961.00
14_D21_L0.7851.00
92_D102_A0.7821.00
17_A51_Y0.7801.00
48_R53_Y0.7781.00
12_E15_I0.7771.00
112_D130_K0.7771.00
43_I47_A0.7761.00
41_T106_G0.7591.00
46_L107_V0.7521.00
56_K59_I0.7431.00
86_I90_M0.7351.00
115_S128_A0.7331.00
47_A61_I0.7301.00
58_Q77_E0.7251.00
13_W48_R0.7241.00
19_R79_Q0.7051.00
19_R51_Y0.6961.00
12_E16_V0.6921.00
14_D59_I0.6921.00
18_A55_G0.6911.00
19_R56_K0.6891.00
68_G129_I0.6861.00
18_A56_K0.6831.00
46_L126_I0.6821.00
17_A55_G0.6781.00
75_I117_N0.6761.00
25_V29_L0.6701.00
83_I104_L0.6641.00
53_Y93_G0.6631.00
13_W17_A0.6591.00
83_I118_S0.6581.00
92_D105_P0.6541.00
102_A106_G0.6511.00
39_I43_I0.6511.00
19_R57_G0.6501.00
26_A62_E0.6411.00
50_I59_I0.6381.00
52_L98_G0.6301.00
20_Q23_R0.6291.00
42_A45_E0.6201.00
94_F98_G0.6191.00
87_R91_E0.6181.00
116_L124_T0.6121.00
30_G72_L0.6101.00
46_L76_A0.6031.00
65_A72_L0.6011.00
19_R53_Y0.6001.00
67_R70_K0.5951.00
81_P124_T0.5931.00
92_D100_L0.5891.00
66_D69_K0.5851.00
27_K30_G0.5831.00
14_D19_R0.5771.00
112_D115_S0.5751.00
102_A105_P0.5731.00
120_A123_G0.5711.00
14_D18_A0.5651.00
85_D93_G0.5631.00
86_I117_N0.5571.00
52_L94_F0.5551.00
53_Y92_D0.5471.00
90_M126_I0.5431.00
21_L51_Y0.5401.00
15_I18_A0.5371.00
61_I74_I0.5371.00
52_L99_G0.5321.00
42_A46_L0.5321.00
86_I89_V0.5301.00
25_V65_A0.5291.00
32_G70_K0.5281.00
87_R92_D0.5241.00
44_S48_R0.5201.00
55_G96_T0.5201.00
105_P109_R0.5201.00
14_D17_A0.5171.00
62_E66_D0.5161.00
30_G65_A0.5161.00
78_D124_T0.5151.00
19_R54_A0.5141.00
33_T36_Q0.5091.00
39_I130_K0.5031.00
22_G25_V0.5021.00
21_L61_I0.5021.00
91_E105_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q8gA 2 0.985 99.9 0.347 Contact Map
4mpcA 2 0.9549 99.9 0.352 Contact Map
4i5sA 2 0.9248 99.9 0.359 Contact Map
2e0aA 2 0.985 99.9 0.361 Contact Map
4gczA 2 1 99.9 0.365 Contact Map
4bixA 2 0.9699 99.9 0.371 Contact Map
1y8oA 2 0.9549 99.9 0.371 Contact Map
4pl9A 1 0.9398 99.9 0.378 Contact Map
3a0rA 2 0.9323 99.9 0.381 Contact Map
4q20A 2 0.985 99.9 0.384 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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