GREMLIN Database
RSBS - RsbT antagonist protein RsbS
UniProt: P42410 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (112)
Sequences: 1385 (971)
Seq/√Len: 91.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_I72_S5.0671.00
82_T111_G3.6531.00
36_L71_M3.2131.00
35_L47_V2.8841.00
10_K16_L2.5221.00
38_K41_E2.4651.00
105_A114_T2.2821.00
23_L31_F2.2381.00
17_V31_F2.1601.00
63_K67_D2.1061.00
78_K103_E2.0861.00
59_S95_L2.0601.00
59_S91_T2.0481.00
48_V111_G2.0171.00
13_N109_E1.9391.00
28_A64_V1.9101.00
73_K78_K1.8171.00
84_I89_A1.7631.00
51_L57_I1.5841.00
8_I38_K1.5741.00
15_L44_A1.5631.00
46_G115_L1.4851.00
24_D27_T1.4611.00
21_W27_T1.4521.00
91_T95_L1.4440.99
10_K109_E1.4420.99
51_L88_V1.4330.99
48_V108_L1.4070.99
21_W53_S1.4000.99
56_M91_T1.3990.99
37_N41_E1.3650.99
25_D60_F1.3430.99
17_V35_L1.3260.99
48_V82_T1.2890.99
38_K42_T1.2890.99
62_A91_T1.2380.98
6_I31_F1.2370.98
29_L33_E1.1840.98
80_V114_T1.1620.98
111_G114_T1.1430.97
18_S21_W1.1380.97
46_G80_V1.1280.97
107_D110_Q1.1220.97
9_L107_D1.1200.97
73_K101_E1.1010.97
58_D91_T1.0990.97
47_V77_A1.0960.97
72_S79_V1.0850.96
39_I77_A1.0700.96
90_V94_E1.0680.96
23_L32_Q1.0670.96
23_L28_A1.0350.95
12_Y16_L1.0140.95
19_I31_F1.0080.94
103_E114_T0.9870.94
90_V93_I0.9700.93
19_I23_L0.9650.93
70_T73_K0.9580.93
80_V105_A0.9500.92
40_Y75_M0.9460.92
32_Q71_M0.9420.92
32_Q64_V0.9380.92
23_L54_V0.9180.91
57_I88_V0.8990.90
17_V47_V0.8920.90
25_D59_S0.8920.90
57_I61_I0.8830.89
80_V103_E0.8800.89
39_I44_A0.8670.89
12_Y113_E0.8650.88
54_V88_V0.8620.88
44_A52_T0.8620.88
46_G114_T0.8590.88
10_K42_T0.8400.87
54_V64_V0.8390.87
14_C115_L0.8380.87
11_L112_L0.8370.87
36_L75_M0.8290.86
25_D29_L0.8280.86
35_L39_I0.8180.86
37_N113_E0.8170.85
39_I75_M0.8110.85
59_S97_I0.8060.85
82_T106_L0.8040.85
25_D56_M0.8020.84
15_L75_M0.7890.83
16_L108_L0.7770.83
34_D38_K0.7770.83
9_L51_L0.7750.82
111_G115_L0.7720.82
91_T96_G0.7690.82
73_K86_P0.7650.82
18_S53_S0.7570.81
20_Q53_S0.7510.80
28_A32_Q0.7470.80
62_A97_I0.7380.79
8_I53_S0.7330.79
12_Y112_L0.7260.78
22_E43_G0.7190.77
21_W74_L0.7140.77
29_L45_N0.7110.77
19_I54_V0.7100.76
93_I96_G0.7060.76
5_K17_V0.7050.76
17_V23_L0.7020.76
15_L52_T0.6830.74
51_L108_L0.6750.73
9_L12_Y0.6650.72
58_D62_A0.6620.71
9_L108_L0.6620.71
67_D70_T0.6600.71
30_T34_D0.6550.71
14_C46_G0.6490.70
4_P24_D0.6470.70
105_A111_G0.6470.70
84_I104_T0.6400.69
59_S90_V0.6400.69
68_V72_S0.6380.69
49_I84_I0.6340.68
37_N40_Y0.6330.68
11_L16_L0.6320.68
52_T108_L0.6320.68
39_I48_V0.6250.67
41_E48_V0.6170.66
47_V79_V0.6100.65
82_T114_T0.6080.65
35_L68_V0.6040.64
22_E54_V0.6000.64
18_S27_T0.5940.63
106_L110_Q0.5850.62
15_L42_T0.5850.62
14_C45_N0.5830.62
11_L14_C0.5790.61
15_L49_I0.5780.61
26_Q74_L0.5740.60
51_L84_I0.5710.60
59_S62_A0.5660.59
10_K43_G0.5650.59
24_D61_I0.5630.59
72_S77_A0.5610.59
9_L52_T0.5560.58
7_P20_Q0.5510.57
17_V22_E0.5510.57
34_D88_V0.5450.57
15_L77_A0.5410.56
92_L102_I0.5400.56
9_L31_F0.5370.55
7_P27_T0.5360.55
29_L70_T0.5360.55
32_Q68_V0.5360.55
52_T115_L0.5360.55
15_L47_V0.5340.55
34_D113_E0.5280.54
13_N113_E0.5270.54
65_L95_L0.5260.54
45_N86_P0.5260.54
8_I30_T0.5240.54
27_T76_G0.5170.53
41_E100_E0.5160.53
96_G104_T0.5130.52
82_T105_A0.5120.52
59_S63_K0.5120.52
98_A101_E0.5070.51
75_M108_L0.5060.51
21_W76_G0.5060.51
57_I62_A0.5040.51
59_S96_G0.5040.51
40_Y73_K0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zxnA 1 0.9752 99.6 0.564 Contact Map
3ny7A 1 0.9256 99 0.679 Contact Map
1th8B 1 0.9504 99 0.681 Contact Map
4dgfA 1 0.9835 99 0.683 Contact Map
1h4xA 1 0.9091 98.9 0.691 Contact Map
4qtpA 2 0.9421 98.9 0.692 Contact Map
4dghA 4 0.9835 98.9 0.693 Contact Map
2ka5A 1 0.9669 98.9 0.693 Contact Map
1sboA 1 0.9091 98.8 0.699 Contact Map
3lloA 1 0.9256 98.8 0.7 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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