RSBRA - BACSU - GREMLIN Contacts

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RSBRA - RsbT co-antagonist protein RsbRA

UniProt:	P42409	Sequences: MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYENISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDKRLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENITVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAVRLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	274 (256)
Sequences:	867 (681)
Seq/√Len:	42.6

BACSU - RSBRA RSBRC RSBRD RSBRB RSBS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_N	17_E	5.151	1.00
92_W	121_S	5.123	1.00
228_A	257_G	3.869	1.00
197_I	203_V	3.706	1.00
205_T	237_T	3.661	1.00
9_Q	13_E	3.592	1.00
171_T	202_V	2.821	1.00
169_I	174_A	2.752	1.00
171_T	206_M	2.709	1.00
21_L	97_T	2.692	1.00
182_L	217_A	2.659	1.00
89_A	124_N	2.582	1.00
169_I	177_I	2.567	1.00
200_V	234_I	2.505	1.00
20_Q	24_D	2.476	1.00
184_G	187_K	2.468	1.00
205_T	241_L	2.277	1.00
237_T	241_L	2.263	1.00
146_L	154_I	2.245	1.00
97_T	114_W	2.058	0.99
47_K	51_D	2.038	0.99
161_T	190_S	2.011	0.99
181_L	193_V	2.004	0.99
155_P	162_V	1.994	0.99
40_Q	44_N	1.982	0.99
205_T	208_A	1.979	0.99
203_V	234_I	1.965	0.99
192_V	226_L	1.956	0.99
208_A	237_T	1.911	0.99
66_Q	218_V	1.789	0.98
183_N	187_K	1.775	0.98
105_P	108_E	1.761	0.98
49_Y	163_M	1.679	0.97
197_I	234_I	1.673	0.97
81_M	129_N	1.670	0.97
207_V	235_A	1.668	0.97
215_S	227_L	1.663	0.97
191_Q	195_I	1.655	0.97
142_Q	154_I	1.638	0.97
15_Q	51_D	1.588	0.96
165_L	207_V	1.575	0.96
26_L	46_S	1.573	0.96
131_Y	134_S	1.568	0.96
48_E	69_E	1.554	0.95
161_T	185_V	1.528	0.95
162_V	214_A	1.528	0.95
158_E	189_R	1.522	0.95
82_K	132_S	1.517	0.95
171_T	175_K	1.484	0.94
171_T	200_V	1.461	0.94
218_V	223_A	1.434	0.93
193_V	223_A	1.411	0.92
190_S	198_T	1.406	0.92
26_L	32_Q	1.404	0.92
198_T	262_L	1.386	0.92
205_T	209_H	1.386	0.92
144_I	172_E	1.366	0.91
238_I	245_L	1.365	0.91
238_I	243_I	1.343	0.90
104_L	108_E	1.343	0.90
93_K	118_R	1.335	0.90
67_I	123_I	1.332	0.90
198_T	218_V	1.326	0.90
251_K	260_T	1.318	0.90
44_N	48_E	1.308	0.89
120_F	124_N	1.306	0.89
158_E	255_Q	1.302	0.89
198_T	223_A	1.302	0.89
23_T	26_L	1.297	0.89
171_T	205_T	1.292	0.89
58_K	61_N	1.292	0.89
7_V	15_Q	1.290	0.89
91_F	142_Q	1.270	0.88
219_R	224_K	1.260	0.87
198_T	261_A	1.254	0.87
178_M	217_A	1.240	0.87
205_T	243_I	1.229	0.86
153_L	163_M	1.195	0.84
204_D	235_A	1.194	0.84
159_N	191_Q	1.194	0.84
39_D	131_Y	1.190	0.84
24_D	39_D	1.189	0.84
226_L	260_T	1.183	0.84
17_E	20_Q	1.183	0.84
205_T	242_G	1.179	0.84
200_V	237_T	1.179	0.84
11_I	18_L	1.179	0.84
14_N	36_Q	1.147	0.82
49_Y	53_L	1.145	0.82
149_L	170_D	1.142	0.82
195_I	218_V	1.140	0.82
48_E	52_I	1.135	0.81
9_Q	12_A	1.134	0.81
175_K	207_V	1.134	0.81
16_N	47_K	1.131	0.81
61_N	239_V	1.129	0.81
21_L	98_K	1.125	0.81
174_A	177_I	1.122	0.80
174_A	205_T	1.122	0.80
120_F	137_K	1.121	0.80
117_D	121_S	1.115	0.80
133_I	137_K	1.114	0.80
217_A	253_T	1.110	0.80
214_A	223_A	1.107	0.80
46_S	49_Y	1.107	0.80
126_E	130_Q	1.098	0.79
60_E	166_V	1.096	0.79
153_L	242_G	1.089	0.78
44_N	258_I	1.084	0.78
100_N	111_E	1.080	0.78
11_I	63_A	1.071	0.77
120_F	252_N	1.052	0.76
143_K	216_E	1.048	0.76
118_R	153_L	1.047	0.76
209_H	213_Q	1.047	0.76
194_L	254_L	1.043	0.75
157_F	228_A	1.041	0.75
21_L	25_T	1.036	0.75
140_S	144_I	1.036	0.75
206_M	237_T	1.034	0.75
228_A	255_Q	1.028	0.74
11_I	96_Y	1.025	0.74
139_V	175_K	1.023	0.74
157_F	162_V	1.023	0.74
184_G	198_T	1.020	0.74
198_T	214_A	1.015	0.73
197_I	238_I	1.012	0.73
89_A	125_T	1.011	0.73
22_W	142_Q	1.005	0.73
40_Q	253_T	0.994	0.72
174_A	235_A	0.988	0.71
106_D	109_S	0.986	0.71
71_A	84_L	0.985	0.71
194_L	214_A	0.979	0.71
230_I	235_A	0.975	0.70
22_W	67_I	0.973	0.70
184_G	188_H	0.972	0.70
52_I	74_A	0.972	0.70
202_V	205_T	0.968	0.70
23_T	46_S	0.966	0.70
16_N	21_L	0.964	0.69
200_V	241_L	0.963	0.69
85_A	124_N	0.961	0.69
249_I	252_N	0.958	0.69
96_Y	113_I	0.953	0.68
148_E	205_T	0.951	0.68
23_T	35_Y	0.939	0.67
205_T	232_P	0.937	0.67
148_E	212_I	0.931	0.67
173_R	235_A	0.922	0.66
108_E	115_Q	0.916	0.65
148_E	171_T	0.916	0.65
26_L	62_A	0.914	0.65
99_M	158_E	0.913	0.65
185_V	218_V	0.913	0.65
213_Q	218_V	0.907	0.65
42_Y	45_I	0.906	0.65
86_T	111_E	0.905	0.64
185_V	190_S	0.904	0.64
192_V	261_A	0.904	0.64
190_S	197_I	0.903	0.64
44_N	110_T	0.902	0.64
225_C	239_V	0.902	0.64
204_D	207_V	0.899	0.64
171_T	210_H	0.893	0.63
257_G	261_A	0.892	0.63
165_L	218_V	0.891	0.63
12_A	17_E	0.890	0.63
64_E	68_S	0.889	0.63
202_V	237_T	0.889	0.63
11_I	75_V	0.882	0.62
213_Q	239_V	0.880	0.62
21_L	61_N	0.868	0.61
180_N	259_Q	0.863	0.61
81_M	124_N	0.861	0.61
151_A	177_I	0.861	0.61
182_L	241_L	0.860	0.60
165_L	262_L	0.859	0.60
80_S	131_Y	0.857	0.60
196_D	222_G	0.851	0.60
50_I	245_L	0.850	0.60
80_S	230_I	0.848	0.59
171_T	237_T	0.842	0.59
193_V	198_T	0.837	0.58
196_D	229_G	0.835	0.58
81_M	131_Y	0.831	0.58
87_A	90_E	0.830	0.58
84_L	127_I	0.826	0.57
7_V	93_K	0.826	0.57
149_L	231_R	0.825	0.57
179_E	254_L	0.825	0.57
171_T	207_V	0.820	0.57
143_K	172_E	0.819	0.57
160_I	261_A	0.811	0.56
78_G	239_V	0.810	0.56
69_E	156_V	0.805	0.55
210_H	250_T	0.804	0.55
192_V	243_I	0.797	0.55
14_N	101_D	0.795	0.54
23_T	28_E	0.795	0.54
162_V	169_I	0.794	0.54
15_Q	19_L	0.793	0.54
200_V	242_G	0.790	0.54
179_E	204_D	0.788	0.54
193_V	206_M	0.788	0.54
39_D	43_E	0.787	0.54
182_L	254_L	0.787	0.54
194_L	228_A	0.784	0.53
194_L	257_G	0.784	0.53
189_R	253_T	0.780	0.53
26_L	39_D	0.780	0.53
127_I	145_A	0.780	0.53
128_F	132_S	0.777	0.53
200_V	207_V	0.776	0.53
237_T	262_L	0.774	0.52
231_R	242_G	0.773	0.52
48_E	57_V	0.764	0.52
39_D	49_Y	0.763	0.51
222_G	229_G	0.762	0.51
103_R	106_D	0.758	0.51
153_L	204_D	0.754	0.51
155_P	256_K	0.752	0.50
169_I	236_Q	0.752	0.50
101_D	158_E	0.749	0.50
166_V	240_N	0.748	0.50
71_A	85_A	0.745	0.50
167_G	196_D	0.744	0.50
174_A	206_M	0.743	0.50
84_L	142_Q	0.741	0.49
14_N	20_Q	0.740	0.49
101_D	111_E	0.738	0.49
88_L	124_N	0.737	0.49
42_Y	57_V	0.736	0.49
226_L	249_I	0.734	0.49
7_V	141_L	0.731	0.48
121_S	150_S	0.731	0.48
160_I	213_Q	0.731	0.48
100_N	114_W	0.727	0.48
206_M	231_R	0.725	0.48
218_V	261_A	0.724	0.48
159_N	190_S	0.723	0.48
208_A	236_Q	0.723	0.48
181_L	190_S	0.720	0.47
194_L	227_L	0.716	0.47
25_T	94_R	0.714	0.47
154_I	231_R	0.708	0.46
223_A	257_G	0.704	0.46
42_Y	197_I	0.702	0.46
224_K	249_I	0.701	0.46
51_D	58_K	0.700	0.45
164_P	196_D	0.699	0.45
100_N	107_Q	0.698	0.45
184_G	195_I	0.694	0.45
198_T	257_G	0.692	0.45
171_T	201_P	0.687	0.44
19_L	46_S	0.684	0.44
45_I	57_V	0.681	0.44
216_E	240_N	0.676	0.43
27_K	224_K	0.676	0.43
167_G	222_G	0.671	0.43
157_F	193_V	0.670	0.43
244_D	247_Q	0.667	0.42
191_Q	227_L	0.667	0.42
184_G	227_L	0.665	0.42
139_V	142_Q	0.662	0.42
156_V	250_T	0.659	0.42
167_G	229_G	0.655	0.41
171_T	212_I	0.655	0.41
121_S	127_I	0.651	0.41
9_Q	24_D	0.651	0.41
170_D	251_K	0.650	0.41
161_T	193_V	0.648	0.41
237_T	242_G	0.646	0.40
187_K	194_L	0.645	0.40
58_K	116_I	0.645	0.40
83_F	180_N	0.639	0.40
176_R	225_C	0.636	0.40
21_L	101_D	0.635	0.39
9_Q	40_Q	0.634	0.39
207_V	242_G	0.634	0.39
145_A	166_V	0.630	0.39
148_E	235_A	0.628	0.39
174_A	241_L	0.627	0.39
42_Y	49_Y	0.627	0.39
112_L	115_Q	0.627	0.39
164_P	222_G	0.625	0.39
51_D	62_A	0.624	0.38
72_L	156_V	0.618	0.38
89_A	92_W	0.618	0.38
29_L	57_V	0.617	0.38
14_N	28_E	0.616	0.38
16_N	20_Q	0.614	0.38
158_E	230_I	0.612	0.37
8_Y	54_L	0.611	0.37
55_L	62_A	0.610	0.37
164_P	229_G	0.609	0.37
43_E	50_I	0.608	0.37
10_F	102_K	0.604	0.37
158_E	191_Q	0.600	0.36
181_L	223_A	0.600	0.36
40_Q	160_I	0.599	0.36
17_E	60_E	0.597	0.36
13_E	24_D	0.596	0.36
120_F	231_R	0.595	0.36
197_I	228_A	0.595	0.36
198_T	258_I	0.593	0.36
200_V	250_T	0.593	0.36
93_K	114_W	0.591	0.36
139_V	181_L	0.587	0.35
204_D	234_I	0.584	0.35
228_A	238_I	0.582	0.35
20_Q	43_E	0.582	0.35
21_L	259_Q	0.581	0.35
49_Y	84_L	0.581	0.35
47_K	111_E	0.579	0.35
161_T	221_V	0.579	0.35
172_E	243_I	0.579	0.35
190_S	261_A	0.578	0.34
66_Q	82_K	0.577	0.34
137_K	141_L	0.575	0.34
133_I	165_L	0.572	0.34
24_D	101_D	0.570	0.34
161_T	216_E	0.570	0.34
45_I	74_A	0.569	0.34
12_A	58_K	0.569	0.34
151_A	181_L	0.568	0.34
205_T	236_Q	0.568	0.34
248_V	252_N	0.567	0.34
181_L	201_P	0.565	0.33
10_F	54_L	0.564	0.33
195_I	227_L	0.562	0.33
234_I	242_G	0.562	0.33
84_L	104_L	0.562	0.33
193_V	236_Q	0.560	0.33
70_L	146_L	0.558	0.33
46_S	82_K	0.556	0.33
205_T	212_I	0.556	0.33
165_L	193_V	0.554	0.32
153_L	224_K	0.552	0.32
60_E	93_K	0.552	0.32
61_N	249_I	0.550	0.32
17_E	27_K	0.549	0.32
186_V	203_V	0.548	0.32
112_L	138_T	0.548	0.32
171_T	174_A	0.548	0.32
148_E	153_L	0.547	0.32
140_S	143_K	0.545	0.32
82_K	128_F	0.545	0.32
104_L	111_E	0.544	0.32
29_L	191_Q	0.542	0.31
61_N	183_N	0.542	0.31
164_P	220_L	0.540	0.31
35_Y	39_D	0.540	0.31
155_P	255_Q	0.539	0.31
171_T	221_V	0.539	0.31
208_A	214_A	0.538	0.31
10_F	28_E	0.528	0.30
55_L	58_K	0.527	0.30
125_T	185_V	0.527	0.30
173_R	182_L	0.524	0.30
81_M	128_F	0.524	0.30
128_F	253_T	0.520	0.30
14_N	32_Q	0.520	0.30
67_I	228_A	0.519	0.30
80_S	124_N	0.518	0.30
219_R	234_I	0.518	0.30
48_E	243_I	0.516	0.29
155_P	188_H	0.516	0.29
201_P	245_L	0.515	0.29
18_L	47_K	0.515	0.29
164_P	167_G	0.514	0.29
100_N	110_T	0.514	0.29
115_Q	122_P	0.513	0.29
13_E	60_E	0.513	0.29
44_N	129_N	0.511	0.29
142_Q	151_A	0.510	0.29
212_I	223_A	0.509	0.29
105_P	183_N	0.507	0.29
7_V	10_F	0.506	0.29
131_Y	153_L	0.506	0.29
145_A	206_M	0.504	0.28
70_L	85_A	0.501	0.28
161_T	188_H	0.500	0.28
217_A	254_L	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zxnA	1	0.4307	99.7	0.76	Contact Map
4dgfA	1	0.4489	99.2	0.813	Contact Map
3ny7A	1	0.4234	99.2	0.814	Contact Map
2bnlA	2	0.4854	99.1	0.82	Contact Map
4dghA	4	0.4599	99.1	0.825	Contact Map
2ka5A	1	0.4562	99.1	0.826	Contact Map
3t6oA	5	0.4051	99.1	0.827	Contact Map
1h4xA	1	0.4051	99	0.827	Contact Map
1th8B	1	0.4161	99	0.828	Contact Map
3lloA	1	0.4672	99	0.829	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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