GREMLIN Database
RSBRA - RsbT co-antagonist protein RsbRA
UniProt: P42409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (256)
Sequences: 867 (681)
Seq/√Len: 42.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_N17_E5.1511.00
92_W121_S5.1231.00
228_A257_G3.8691.00
197_I203_V3.7061.00
205_T237_T3.6611.00
9_Q13_E3.5921.00
171_T202_V2.8211.00
169_I174_A2.7521.00
171_T206_M2.7091.00
21_L97_T2.6921.00
182_L217_A2.6591.00
89_A124_N2.5821.00
169_I177_I2.5671.00
200_V234_I2.5051.00
20_Q24_D2.4761.00
184_G187_K2.4681.00
205_T241_L2.2771.00
237_T241_L2.2631.00
146_L154_I2.2451.00
97_T114_W2.0580.99
47_K51_D2.0380.99
161_T190_S2.0110.99
181_L193_V2.0040.99
155_P162_V1.9940.99
40_Q44_N1.9820.99
205_T208_A1.9790.99
203_V234_I1.9650.99
192_V226_L1.9560.99
208_A237_T1.9110.99
66_Q218_V1.7890.98
183_N187_K1.7750.98
105_P108_E1.7610.98
49_Y163_M1.6790.97
197_I234_I1.6730.97
81_M129_N1.6700.97
207_V235_A1.6680.97
215_S227_L1.6630.97
191_Q195_I1.6550.97
142_Q154_I1.6380.97
15_Q51_D1.5880.96
165_L207_V1.5750.96
26_L46_S1.5730.96
131_Y134_S1.5680.96
48_E69_E1.5540.95
161_T185_V1.5280.95
162_V214_A1.5280.95
158_E189_R1.5220.95
82_K132_S1.5170.95
171_T175_K1.4840.94
171_T200_V1.4610.94
218_V223_A1.4340.93
193_V223_A1.4110.92
190_S198_T1.4060.92
26_L32_Q1.4040.92
198_T262_L1.3860.92
205_T209_H1.3860.92
144_I172_E1.3660.91
238_I245_L1.3650.91
238_I243_I1.3430.90
104_L108_E1.3430.90
93_K118_R1.3350.90
67_I123_I1.3320.90
198_T218_V1.3260.90
251_K260_T1.3180.90
44_N48_E1.3080.89
120_F124_N1.3060.89
158_E255_Q1.3020.89
198_T223_A1.3020.89
23_T26_L1.2970.89
171_T205_T1.2920.89
58_K61_N1.2920.89
7_V15_Q1.2900.89
91_F142_Q1.2700.88
219_R224_K1.2600.87
198_T261_A1.2540.87
178_M217_A1.2400.87
205_T243_I1.2290.86
153_L163_M1.1950.84
204_D235_A1.1940.84
159_N191_Q1.1940.84
39_D131_Y1.1900.84
24_D39_D1.1890.84
226_L260_T1.1830.84
17_E20_Q1.1830.84
205_T242_G1.1790.84
200_V237_T1.1790.84
11_I18_L1.1790.84
14_N36_Q1.1470.82
49_Y53_L1.1450.82
149_L170_D1.1420.82
195_I218_V1.1400.82
48_E52_I1.1350.81
9_Q12_A1.1340.81
175_K207_V1.1340.81
16_N47_K1.1310.81
61_N239_V1.1290.81
21_L98_K1.1250.81
174_A177_I1.1220.80
174_A205_T1.1220.80
120_F137_K1.1210.80
117_D121_S1.1150.80
133_I137_K1.1140.80
217_A253_T1.1100.80
214_A223_A1.1070.80
46_S49_Y1.1070.80
126_E130_Q1.0980.79
60_E166_V1.0960.79
153_L242_G1.0890.78
44_N258_I1.0840.78
100_N111_E1.0800.78
11_I63_A1.0710.77
120_F252_N1.0520.76
143_K216_E1.0480.76
118_R153_L1.0470.76
209_H213_Q1.0470.76
194_L254_L1.0430.75
157_F228_A1.0410.75
21_L25_T1.0360.75
140_S144_I1.0360.75
206_M237_T1.0340.75
228_A255_Q1.0280.74
11_I96_Y1.0250.74
139_V175_K1.0230.74
157_F162_V1.0230.74
184_G198_T1.0200.74
198_T214_A1.0150.73
197_I238_I1.0120.73
89_A125_T1.0110.73
22_W142_Q1.0050.73
40_Q253_T0.9940.72
174_A235_A0.9880.71
106_D109_S0.9860.71
71_A84_L0.9850.71
194_L214_A0.9790.71
230_I235_A0.9750.70
22_W67_I0.9730.70
184_G188_H0.9720.70
52_I74_A0.9720.70
202_V205_T0.9680.70
23_T46_S0.9660.70
16_N21_L0.9640.69
200_V241_L0.9630.69
85_A124_N0.9610.69
249_I252_N0.9580.69
96_Y113_I0.9530.68
148_E205_T0.9510.68
23_T35_Y0.9390.67
205_T232_P0.9370.67
148_E212_I0.9310.67
173_R235_A0.9220.66
108_E115_Q0.9160.65
148_E171_T0.9160.65
26_L62_A0.9140.65
99_M158_E0.9130.65
185_V218_V0.9130.65
213_Q218_V0.9070.65
42_Y45_I0.9060.65
86_T111_E0.9050.64
185_V190_S0.9040.64
192_V261_A0.9040.64
190_S197_I0.9030.64
44_N110_T0.9020.64
225_C239_V0.9020.64
204_D207_V0.8990.64
171_T210_H0.8930.63
257_G261_A0.8920.63
165_L218_V0.8910.63
12_A17_E0.8900.63
64_E68_S0.8890.63
202_V237_T0.8890.63
11_I75_V0.8820.62
213_Q239_V0.8800.62
21_L61_N0.8680.61
180_N259_Q0.8630.61
81_M124_N0.8610.61
151_A177_I0.8610.61
182_L241_L0.8600.60
165_L262_L0.8590.60
80_S131_Y0.8570.60
196_D222_G0.8510.60
50_I245_L0.8500.60
80_S230_I0.8480.59
171_T237_T0.8420.59
193_V198_T0.8370.58
196_D229_G0.8350.58
81_M131_Y0.8310.58
87_A90_E0.8300.58
84_L127_I0.8260.57
7_V93_K0.8260.57
149_L231_R0.8250.57
179_E254_L0.8250.57
171_T207_V0.8200.57
143_K172_E0.8190.57
160_I261_A0.8110.56
78_G239_V0.8100.56
69_E156_V0.8050.55
210_H250_T0.8040.55
192_V243_I0.7970.55
14_N101_D0.7950.54
23_T28_E0.7950.54
162_V169_I0.7940.54
15_Q19_L0.7930.54
200_V242_G0.7900.54
179_E204_D0.7880.54
193_V206_M0.7880.54
39_D43_E0.7870.54
182_L254_L0.7870.54
194_L228_A0.7840.53
194_L257_G0.7840.53
189_R253_T0.7800.53
26_L39_D0.7800.53
127_I145_A0.7800.53
128_F132_S0.7770.53
200_V207_V0.7760.53
237_T262_L0.7740.52
231_R242_G0.7730.52
48_E57_V0.7640.52
39_D49_Y0.7630.51
222_G229_G0.7620.51
103_R106_D0.7580.51
153_L204_D0.7540.51
155_P256_K0.7520.50
169_I236_Q0.7520.50
101_D158_E0.7490.50
166_V240_N0.7480.50
71_A85_A0.7450.50
167_G196_D0.7440.50
174_A206_M0.7430.50
84_L142_Q0.7410.49
14_N20_Q0.7400.49
101_D111_E0.7380.49
88_L124_N0.7370.49
42_Y57_V0.7360.49
226_L249_I0.7340.49
7_V141_L0.7310.48
121_S150_S0.7310.48
160_I213_Q0.7310.48
100_N114_W0.7270.48
206_M231_R0.7250.48
218_V261_A0.7240.48
159_N190_S0.7230.48
208_A236_Q0.7230.48
181_L190_S0.7200.47
194_L227_L0.7160.47
25_T94_R0.7140.47
154_I231_R0.7080.46
223_A257_G0.7040.46
42_Y197_I0.7020.46
224_K249_I0.7010.46
51_D58_K0.7000.45
164_P196_D0.6990.45
100_N107_Q0.6980.45
184_G195_I0.6940.45
198_T257_G0.6920.45
171_T201_P0.6870.44
19_L46_S0.6840.44
45_I57_V0.6810.44
216_E240_N0.6760.43
27_K224_K0.6760.43
167_G222_G0.6710.43
157_F193_V0.6700.43
244_D247_Q0.6670.42
191_Q227_L0.6670.42
184_G227_L0.6650.42
139_V142_Q0.6620.42
156_V250_T0.6590.42
167_G229_G0.6550.41
171_T212_I0.6550.41
121_S127_I0.6510.41
9_Q24_D0.6510.41
170_D251_K0.6500.41
161_T193_V0.6480.41
237_T242_G0.6460.40
187_K194_L0.6450.40
58_K116_I0.6450.40
83_F180_N0.6390.40
176_R225_C0.6360.40
21_L101_D0.6350.39
9_Q40_Q0.6340.39
207_V242_G0.6340.39
145_A166_V0.6300.39
148_E235_A0.6280.39
174_A241_L0.6270.39
42_Y49_Y0.6270.39
112_L115_Q0.6270.39
164_P222_G0.6250.39
51_D62_A0.6240.38
72_L156_V0.6180.38
89_A92_W0.6180.38
29_L57_V0.6170.38
14_N28_E0.6160.38
16_N20_Q0.6140.38
158_E230_I0.6120.37
8_Y54_L0.6110.37
55_L62_A0.6100.37
164_P229_G0.6090.37
43_E50_I0.6080.37
10_F102_K0.6040.37
158_E191_Q0.6000.36
181_L223_A0.6000.36
40_Q160_I0.5990.36
17_E60_E0.5970.36
13_E24_D0.5960.36
120_F231_R0.5950.36
197_I228_A0.5950.36
198_T258_I0.5930.36
200_V250_T0.5930.36
93_K114_W0.5910.36
139_V181_L0.5870.35
204_D234_I0.5840.35
228_A238_I0.5820.35
20_Q43_E0.5820.35
21_L259_Q0.5810.35
49_Y84_L0.5810.35
47_K111_E0.5790.35
161_T221_V0.5790.35
172_E243_I0.5790.35
190_S261_A0.5780.34
66_Q82_K0.5770.34
137_K141_L0.5750.34
133_I165_L0.5720.34
24_D101_D0.5700.34
161_T216_E0.5700.34
45_I74_A0.5690.34
12_A58_K0.5690.34
151_A181_L0.5680.34
205_T236_Q0.5680.34
248_V252_N0.5670.34
181_L201_P0.5650.33
10_F54_L0.5640.33
195_I227_L0.5620.33
234_I242_G0.5620.33
84_L104_L0.5620.33
193_V236_Q0.5600.33
70_L146_L0.5580.33
46_S82_K0.5560.33
205_T212_I0.5560.33
165_L193_V0.5540.32
153_L224_K0.5520.32
60_E93_K0.5520.32
61_N249_I0.5500.32
17_E27_K0.5490.32
186_V203_V0.5480.32
112_L138_T0.5480.32
171_T174_A0.5480.32
148_E153_L0.5470.32
140_S143_K0.5450.32
82_K128_F0.5450.32
104_L111_E0.5440.32
29_L191_Q0.5420.31
61_N183_N0.5420.31
164_P220_L0.5400.31
35_Y39_D0.5400.31
155_P255_Q0.5390.31
171_T221_V0.5390.31
208_A214_A0.5380.31
10_F28_E0.5280.30
55_L58_K0.5270.30
125_T185_V0.5270.30
173_R182_L0.5240.30
81_M128_F0.5240.30
128_F253_T0.5200.30
14_N32_Q0.5200.30
67_I228_A0.5190.30
80_S124_N0.5180.30
219_R234_I0.5180.30
48_E243_I0.5160.29
155_P188_H0.5160.29
201_P245_L0.5150.29
18_L47_K0.5150.29
164_P167_G0.5140.29
100_N110_T0.5140.29
115_Q122_P0.5130.29
13_E60_E0.5130.29
44_N129_N0.5110.29
142_Q151_A0.5100.29
212_I223_A0.5090.29
105_P183_N0.5070.29
7_V10_F0.5060.29
131_Y153_L0.5060.29
145_A206_M0.5040.28
70_L85_A0.5010.28
161_T188_H0.5000.28
217_A254_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zxnA 1 0.4307 99.7 0.76 Contact Map
4dgfA 1 0.4489 99.2 0.813 Contact Map
3ny7A 1 0.4234 99.2 0.814 Contact Map
2bnlA 2 0.4854 99.1 0.82 Contact Map
4dghA 4 0.4599 99.1 0.825 Contact Map
2ka5A 1 0.4562 99.1 0.826 Contact Map
3t6oA 5 0.4051 99.1 0.827 Contact Map
1h4xA 1 0.4051 99 0.827 Contact Map
1th8B 1 0.4161 99 0.828 Contact Map
3lloA 1 0.4672 99 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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