GREMLIN Database
YTDA - Putative UTP--glucose-1-phosphate uridylyltransferase
UniProt: P42407 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (233)
Sequences: 22940 (14323)
Seq/√Len: 938.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_K41_E3.4161.00
114_K214_E3.3821.00
171_K183_Q2.7211.00
171_K184_D2.6751.00
37_H65_Y2.6151.00
173_E179_L2.5831.00
4_K50_D2.5631.00
104_K108_D2.5571.00
50_D94_R2.5441.00
173_E181_R2.3521.00
121_P206_T2.3191.00
181_R240_Y2.1601.00
151_S240_Y2.1161.00
50_D96_H2.1141.00
173_E183_Q2.1061.00
5_A48_I2.0791.00
212_E232_A2.0761.00
121_P147_T2.0011.00
5_A43_L2.0001.00
60_N64_D1.9571.00
40_V51_I1.9461.00
111_S114_K1.9281.00
158_E196_H1.8891.00
98_V112_F1.8651.00
231_K235_G1.8221.00
145_A242_K1.8191.00
138_A141_Q1.7951.00
43_L125_V1.7781.00
149_Y240_Y1.7731.00
232_A235_G1.7721.00
212_E236_A1.7671.00
197_F243_L1.7541.00
37_H41_E1.7401.00
9_A53_M1.7361.00
55_V59_K1.7091.00
17_L21_K1.6741.00
110_I124_V1.6611.00
156_L241_G1.6551.00
23_I29_P1.6471.00
145_A149_Y1.6411.00
140_G144_E1.6401.00
182_I241_G1.6381.00
249_Y259_K1.6201.00
172_G197_F1.6001.00
61_L64_D1.5711.00
163_D166_H1.5681.00
23_I61_L1.5561.00
184_D231_K1.5251.00
52_L116_F1.5231.00
158_E243_L1.5151.00
63_V99_R1.4851.00
34_P37_H1.4761.00
228_D231_K1.4511.00
6_I113_G1.4421.00
154_I157_K1.4231.00
108_D112_F1.4151.00
27_M61_L1.3881.00
96_H116_F1.3841.00
192_N195_S1.3801.00
44_K93_I1.3771.00
144_E148_K1.3771.00
152_S206_T1.3681.00
257_Y261_I1.3621.00
151_S238_T1.3591.00
141_Q144_E1.3581.00
146_Y154_I1.3501.00
121_P204_I1.3431.00
188_K193_P1.3361.00
146_Y153_V1.3281.00
12_F103_A1.3131.00
59_K99_R1.3001.00
117_A122_F1.2961.00
170_I182_I1.2931.00
253_L256_D1.2861.00
174_P179_L1.2851.00
182_I239_V1.2731.00
120_E207_P1.2681.00
51_I93_I1.2671.00
247_E263_D1.2661.00
52_L98_V1.2651.00
171_K186_V1.2591.00
172_G241_G1.2341.00
186_V194_P1.2321.00
208_D211_N1.2291.00
121_P207_P1.2281.00
111_S214_E1.2251.00
258_L262_Y1.2211.00
215_A232_A1.2191.00
122_F207_P1.2091.00
126_L201_G1.1991.00
59_K63_V1.1901.00
37_H69_S1.1871.00
227_T231_K1.1861.00
52_L113_G1.1731.00
123_A204_I1.1711.00
33_K38_Y1.1651.00
152_S238_T1.1611.00
249_Y263_D1.1591.00
55_V63_V1.1531.00
181_R238_T1.1521.00
32_S38_Y1.1491.00
211_N215_A1.1471.00
16_N28_F1.1461.00
108_D111_S1.1371.00
55_V99_R1.1201.00
251_I260_L1.1201.00
58_H61_L1.0961.00
256_D259_K1.0931.00
67_D97_Y1.0891.00
27_M65_Y1.0881.00
55_V97_Y1.0791.00
211_N214_E1.0761.00
212_E215_A1.0711.00
232_A236_A1.0681.00
172_G180_Y1.0631.00
142_L204_I1.0561.00
236_A239_V1.0551.00
154_I158_E1.0541.00
152_S237_C1.0431.00
141_Q145_A1.0381.00
48_I123_A1.0371.00
193_P196_H1.0261.00
124_V205_F1.0241.00
174_P180_Y1.0231.00
35_V251_I1.0181.00
205_F230_I1.0131.00
145_A240_Y1.0061.00
55_V62_I1.0051.00
56_S59_K1.0051.00
145_A148_K1.0021.00
10_G54_V0.9891.00
36_I66_F0.9881.00
168_G187_E0.9851.00
36_I53_M0.9781.00
6_I122_F0.9761.00
52_L96_H0.9701.00
192_N196_H0.9681.00
33_K37_H0.9651.00
36_I62_I0.9521.00
149_Y152_S0.9511.00
63_V97_Y0.9511.00
180_Y243_L0.9501.00
259_K262_Y0.9481.00
132_F247_E0.9471.00
111_S213_L0.9441.00
166_H256_D0.9381.00
255_K259_K0.9331.00
199_A203_Y0.9261.00
7_I127_P0.9211.00
258_L261_I0.9201.00
262_Y265_L0.9191.00
165_H188_K0.9171.00
119_G208_D0.9151.00
171_K195_S0.9101.00
180_Y183_Q0.9101.00
233_S237_C0.8971.00
60_N63_V0.8941.00
64_D67_D0.8911.00
26_E127_P0.8911.00
156_L197_F0.8831.00
240_Y243_L0.8791.00
41_E44_K0.8731.00
153_V157_K0.8701.00
165_H190_K0.8641.00
146_Y204_I0.8611.00
212_E229_A0.8611.00
146_Y206_T0.8611.00
133_S247_E0.8611.00
63_V67_D0.8591.00
93_I97_Y0.8551.00
259_K263_D0.8551.00
155_G158_E0.8511.00
114_K210_F0.8491.00
29_P34_P0.8491.00
4_K52_L0.8491.00
139_L142_L0.8471.00
249_Y260_L0.8451.00
144_E147_T0.8411.00
169_V198_A0.8401.00
141_Q242_K0.8331.00
34_P65_Y0.8331.00
4_K120_E0.8321.00
184_D192_N0.8291.00
16_N20_T0.8211.00
4_K118_G0.8111.00
40_V66_F0.8091.00
123_A143_I0.8031.00
31_G38_Y0.7981.00
129_D248_R0.7941.00
212_E233_S0.7921.00
261_I265_L0.7881.00
35_V39_L0.7871.00
183_Q186_V0.7831.00
106_L126_L0.7811.00
143_I147_T0.7791.00
156_L170_I0.7761.00
28_F257_Y0.7751.00
34_P38_Y0.7731.00
8_P126_L0.7721.00
69_S91_P0.7671.00
42_E46_S0.7661.00
41_E91_P0.7631.00
46_S140_G0.7531.00
20_T28_F0.7451.00
44_K51_I0.7451.00
92_D95_I0.7411.00
119_G207_P0.7401.00
229_A232_A0.7361.00
114_K117_A0.7361.00
208_D236_A0.7361.00
142_L242_K0.7341.00
31_G261_I0.7321.00
133_S138_A0.7281.00
208_D212_E0.7261.00
24_P61_L0.7251.00
217_E224_V0.7211.00
130_L260_L0.7191.00
6_I52_L0.7181.00
114_K118_G0.7141.00
67_D70_L0.7141.00
186_V189_P0.7131.00
143_I146_Y0.7111.00
44_K69_S0.7091.00
146_Y150_Q0.7091.00
44_K49_E0.7061.00
227_T230_I0.7041.00
48_I143_I0.7031.00
230_I239_V0.7031.00
49_E94_R0.7021.00
19_V254_Q0.6941.00
118_G207_P0.6931.00
70_L91_P0.6931.00
185_I199_A0.6891.00
209_I233_S0.6881.00
38_Y41_E0.6881.00
54_V109_A0.6881.00
113_G116_F0.6861.00
38_Y264_M0.6861.00
98_V113_G0.6851.00
19_V23_I0.6831.00
53_M66_F0.6821.00
98_V116_F0.6801.00
161_T196_H0.6761.00
37_H66_F0.6751.00
103_A108_D0.6751.00
216_L224_V0.6681.00
90_I93_I0.6651.00
19_V22_V0.6621.00
7_I125_V0.6611.00
138_A247_E0.6601.00
125_V139_L0.6561.00
110_I209_I0.6551.00
115_Q118_G0.6541.00
54_V113_G0.6491.00
93_I96_H0.6491.00
186_V192_N0.6491.00
166_H188_K0.6461.00
216_L232_A0.6451.00
6_I54_V0.6411.00
55_V60_N0.6411.00
13_G25_K0.6401.00
140_G143_I0.6371.00
138_A142_L0.6361.00
40_V53_M0.6361.00
56_S103_A0.6361.00
126_L129_D0.6351.00
111_S224_V0.6341.00
96_H99_R0.6331.00
108_D224_V0.6331.00
30_V261_I0.6311.00
186_V196_H0.6311.00
15_R25_K0.6291.00
208_D238_T0.6261.00
208_D237_C0.6251.00
7_I39_L0.6201.00
207_P210_F0.6191.00
39_L42_E0.6181.00
223_E228_D0.6161.00
143_I204_I0.6161.00
147_T150_Q0.6151.00
31_G264_M0.6141.00
117_A210_F0.6111.00
114_K122_F0.6101.00
153_V156_L0.6081.00
170_I241_G0.6081.00
40_V93_I0.6081.00
254_Q258_L0.6071.00
43_L123_A0.5991.00
125_V202_R0.5971.00
184_D235_G0.5941.00
40_V95_I0.5941.00
166_H253_L0.5911.00
53_M95_I0.5861.00
102_Y108_D0.5771.00
98_V101_P0.5731.00
114_K211_N0.5731.00
19_V28_F0.5721.00
61_L65_Y0.5721.00
197_F241_G0.5711.00
8_P106_L0.5711.00
120_E206_T0.5711.00
216_L229_A0.5691.00
182_I185_I0.5691.00
38_Y42_E0.5681.00
97_Y100_Q0.5641.00
41_E69_S0.5631.00
142_L146_Y0.5621.00
42_E202_R0.5611.00
42_E45_E0.5611.00
43_L48_I0.5591.00
217_E220_S0.5581.00
12_F17_L0.5561.00
9_A36_I0.5551.00
213_L216_L0.5531.00
131_I200_A0.5511.00
219_D222_G0.5501.00
100_Q104_K0.5501.00
255_K258_L0.5491.00
4_K117_A0.5451.00
27_M62_I0.5411.00
250_D256_D0.5391.00
44_K92_D0.5371.00
258_L265_L0.5371.00
4_K122_F0.5361.00
212_E237_C0.5351.00
249_Y256_D0.5341.00
173_E180_Y0.5341.00
40_V44_K0.5311.00
41_E45_E0.5311.00
25_K128_D0.5301.00
45_E140_G0.5301.00
155_G244_L0.5301.00
123_A139_L0.5271.00
54_V98_V0.5251.00
153_V158_E0.5211.00
49_E92_D0.5201.00
174_P181_R0.5201.00
95_I98_V0.5201.00
29_P32_S0.5141.00
214_E218_A0.5141.00
228_D232_A0.5131.00
153_V205_F0.5111.00
6_I117_A0.5101.00
164_L167_Y0.5081.00
164_L169_V0.5071.00
28_F261_I0.5051.00
26_E62_I0.5041.00
104_K224_V0.5021.00
10_G103_A0.5011.00
146_Y242_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jukA 3 0.9412 100 0.284 Contact Map
2e3dA 3 0.9853 100 0.306 Contact Map
2ux8A 4 0.989 100 0.307 Contact Map
1iimA 3 0.8934 100 0.324 Contact Map
2pa4A 3 0.9926 100 0.325 Contact Map
1lvwA 3 0.8934 100 0.328 Contact Map
1mc3A 3 0.8897 100 0.332 Contact Map
4ho4A 3 0.886 100 0.336 Contact Map
4ecmA 3 0.886 100 0.342 Contact Map
3brkX 2 0.875 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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