GREMLIN Database
HXLR - HTH-type transcriptional activator HxlR
UniProt: P42406 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (99)
Sequences: 9992 (6023)
Seq/√Len: 605.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_H83_S2.7751.00
44_K52_Q2.7511.00
53_K57_N2.6311.00
90_S104_G2.5801.00
33_G92_M2.5431.00
71_E83_S2.4651.00
75_V79_K2.4541.00
32_L68_V2.2801.00
31_H46_L2.1121.00
69_H85_T2.0441.00
73_Y81_E1.8901.00
87_H105_Y1.8411.00
73_Y79_K1.7141.00
32_L43_L1.6781.00
28_I58_Q1.6631.00
94_I97_A1.6601.00
97_A100_E1.6591.00
93_P97_A1.6441.00
84_L88_G1.6091.00
60_R63_E1.5641.00
38_K46_L1.5391.00
37_T83_S1.5121.00
37_T81_E1.5051.00
54_I57_N1.4521.00
89_E92_M1.3581.00
25_K61_E1.3561.00
67_I88_G1.3221.00
25_K58_Q1.3121.00
90_S101_W1.3081.00
86_P89_E1.3021.00
70_R80_V1.2971.00
16_T98_M1.2961.00
87_H90_S1.2731.00
22_G61_E1.2561.00
52_Q56_V1.1661.00
99_Y103_K1.1551.00
87_H108_L1.1251.00
63_E68_V1.1181.00
19_V65_D1.1181.00
16_T102_G1.1171.00
15_L106_M1.1011.00
25_K62_L1.0961.00
32_L38_K1.0921.00
73_Y77_P1.0881.00
71_E81_E1.0821.00
38_K42_E1.0811.00
22_G58_Q1.0761.00
41_N45_T1.0511.00
72_V78_P1.0461.00
22_G25_K1.0451.00
39_R81_E1.0431.00
83_S89_E1.0391.00
72_V80_V1.0241.00
90_S105_Y1.0111.00
29_L84_L1.0061.00
72_V77_P1.0061.00
67_I91_L1.0041.00
74_P77_P0.9951.00
40_F56_V0.9791.00
56_V60_R0.9741.00
19_V67_I0.9721.00
26_M95_L0.9651.00
73_Y76_V0.9581.00
28_I47_I0.9351.00
54_I58_Q0.9311.00
73_Y78_P0.9221.00
92_M96_E0.9081.00
91_L101_W0.9011.00
41_N44_K0.8951.00
42_E45_T0.8901.00
93_P100_E0.8801.00
33_G84_L0.8661.00
40_F52_Q0.8621.00
50_I55_L0.8601.00
66_M87_H0.8481.00
100_E104_G0.8481.00
35_E38_K0.8401.00
31_H43_L0.8361.00
14_E18_A0.8101.00
61_E65_D0.7971.00
51_T54_I0.7931.00
72_V76_V0.7921.00
47_I50_I0.7891.00
30_W99_Y0.7881.00
12_E103_K0.7761.00
25_K65_D0.7661.00
96_E100_E0.7611.00
33_G96_E0.7521.00
9_F18_A0.7331.00
94_I98_M0.7331.00
28_I50_I0.7241.00
38_K43_L0.7061.00
102_G106_M0.6881.00
30_W33_G0.6831.00
15_L105_Y0.6791.00
75_V78_P0.6741.00
9_F14_E0.6731.00
76_V80_V0.6641.00
24_W50_I0.6621.00
72_V75_V0.6601.00
105_Y108_L0.6541.00
36_G89_E0.6511.00
9_F15_L0.6421.00
103_K106_M0.6391.00
27_L31_H0.6271.00
96_E99_Y0.6251.00
50_I80_V0.6251.00
57_N61_E0.6221.00
100_E103_K0.6181.00
62_L67_I0.6151.00
44_K55_L0.6141.00
91_L94_I0.6071.00
31_H35_E0.6051.00
27_L47_I0.6031.00
39_R73_Y0.6011.00
17_L26_M0.5981.00
31_H38_K0.5921.00
29_L91_L0.5921.00
39_R42_E0.5921.00
101_W105_Y0.5901.00
75_V81_E0.5871.00
40_F44_K0.5791.00
17_L98_M0.5761.00
17_L91_L0.5751.00
37_T71_E0.5731.00
13_K106_M0.5691.00
42_E46_L0.5641.00
32_L37_T0.5631.00
87_H106_M0.5561.00
63_E70_R0.5561.00
86_P90_S0.5530.99
41_N52_Q0.5510.99
13_K30_W0.5400.99
16_T67_I0.5390.99
15_L18_A0.5370.99
94_I102_G0.5340.99
14_E48_P0.5310.99
93_P96_E0.5300.99
32_L63_E0.5300.99
90_S93_P0.5250.99
77_P80_V0.5240.99
63_E72_V0.5220.99
104_G107_E0.5210.99
14_E26_M0.5150.99
75_V80_V0.5130.99
35_E46_L0.5110.99
83_S86_P0.5070.99
89_E93_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gcvA 3 0.9 99.9 0.381 Contact Map
1yyvA 2 0.925 99.7 0.479 Contact Map
4a5nA 2 0.875 99.7 0.49 Contact Map
2hztA 2 0.7917 99.7 0.504 Contact Map
2fswA 2 0.8583 99.7 0.507 Contact Map
1z7uA 2 0.925 99.7 0.507 Contact Map
2f2eA 4 0.95 99.7 0.509 Contact Map
4hw0A 2 0.775 99.5 0.557 Contact Map
3df8A 2 0.85 99.5 0.561 Contact Map
4hqeA 2 0.8917 99.4 0.595 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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