GREMLIN Database
HPS - 3-hexulose-6-phosphate synthase
UniProt: P42405 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (201)
Sequences: 3252 (2135)
Seq/√Len: 150.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_K50_A3.7871.00
11_N14_E3.5871.00
195_D198_E3.4071.00
85_G107_L3.2581.00
48_K79_D3.2391.00
87_T91_T2.5081.00
42_R45_K2.4921.00
197_A201_S2.3071.00
115_D118_S2.2901.00
174_P206_L2.2861.00
89_D93_K2.2701.00
16_I46_E2.2621.00
198_E202_K2.2141.00
193_A199_T2.1911.00
12_I46_E2.1421.00
89_D122_E2.1401.00
3_L186_V2.1101.00
96_V100_K2.1041.00
170_L189_G2.0321.00
33_T37_I2.0211.00
154_K182_D2.0101.00
174_P178_Q1.8861.00
70_I73_A1.8831.00
92_I144_K1.8621.00
153_I163_A1.8031.00
25_Y201_S1.7881.00
117_E128_V1.7501.00
127_G130_Y1.6811.00
9_L18_L1.6681.00
154_K163_A1.6631.00
140_Q158_K1.6571.00
175_E178_Q1.6561.00
181_P184_V1.6121.00
117_E121_K1.6071.00
133_V156_T1.6061.00
12_I43_A1.5921.00
31_I47_I1.5121.00
90_A93_K1.4961.00
12_I39_E1.4931.00
4_Q28_V1.4861.00
37_I62_I1.4841.00
55_K79_D1.4781.00
18_L22_V1.4701.00
17_E21_E1.4521.00
62_I73_A1.4331.00
3_L200_A1.4291.00
14_E17_E1.4071.00
35_V39_E1.3791.00
46_E49_E1.3661.00
93_K97_E1.3611.00
89_D142_E1.3581.00
21_E196_K1.3571.00
170_L203_M1.3551.00
89_D141_A1.3331.00
147_F168_I1.3301.00
71_M101_K1.3241.00
21_E195_D1.3211.00
201_S205_Q1.3161.00
126_L134_H1.3131.00
89_D138_D1.2871.00
140_Q157_V1.2791.00
6_A187_G1.2771.00
198_E201_S1.2751.00
15_A35_V1.2641.00
106_I144_K1.2601.00
175_E179_Q1.2591.00
19_V29_V1.2531.00
45_K49_E1.2461.00
29_V54_L1.2391.00
5_L26_I1.2231.00
12_I16_I1.2131.00
69_E95_A1.2071.00
110_M114_K1.2021.00
4_Q183_L1.1741.00
202_K205_Q1.1711.00
202_K206_L1.1711.00
38_N72_K1.1691.00
70_I81_I1.1671.00
165_A181_P1.1651.00
69_E91_T1.1581.00
151_T155_N1.1571.00
163_A182_D1.1541.00
137_Y156_T1.1471.00
28_V55_K1.1451.00
5_L191_T1.1391.00
10_V14_E1.1361.00
119_R123_I1.1341.00
94_G97_E1.1321.00
21_E197_A1.1271.00
98_E102_Q1.1200.99
152_T156_T1.1150.99
199_T202_K1.1090.99
82_T108_V1.0980.99
110_M131_I1.0890.99
82_T106_I1.0860.99
35_V43_A1.0860.99
126_L130_Y1.0800.99
151_T179_Q1.0720.99
131_I135_T1.0690.99
19_V47_I1.0670.99
62_I69_E1.0670.99
66_G91_T1.0650.99
177_I184_V1.0480.99
26_I200_A1.0300.99
28_V80_I1.0190.99
120_A126_L1.0140.99
150_L163_A0.9970.99
27_D54_L0.9960.99
118_S122_E0.9880.99
72_K75_E0.9830.99
16_I20_K0.9820.99
171_D206_L0.9810.99
24_Q197_A0.9760.99
90_A94_G0.9730.99
153_I157_V0.9540.98
86_A135_T0.9290.98
38_N75_E0.9280.98
133_V152_T0.9280.98
162_T182_D0.9230.98
102_Q105_K0.9190.98
58_A78_A0.9170.98
75_E102_Q0.9120.98
146_S149_E0.9070.98
44_V76_A0.9050.98
96_V145_N0.9030.98
3_L204_K0.8990.98
190_I200_A0.8930.97
86_A131_I0.8930.97
39_E42_R0.8930.97
117_E127_G0.8880.97
200_A204_K0.8860.97
29_V47_I0.8850.97
25_Y197_A0.8760.97
69_E87_T0.8720.97
71_M98_E0.8710.97
133_V137_Y0.8700.97
16_I19_V0.8690.97
81_I99_A0.8660.97
150_L181_P0.8610.97
106_I164_I0.8600.97
41_L44_V0.8580.97
36_V60_L0.8520.97
92_I142_E0.8480.96
197_A200_A0.8470.96
83_V92_I0.8400.96
36_V41_L0.8300.96
114_K119_R0.8280.96
86_A110_M0.8270.96
82_T92_I0.8260.96
71_M75_E0.8250.96
89_D92_I0.8240.96
94_G98_E0.8140.96
22_V197_A0.8130.96
70_I99_A0.8060.95
71_M102_Q0.8010.95
7_L31_I0.8010.95
12_I42_R0.8000.95
157_V161_K0.7980.95
9_L15_A0.7930.95
129_D152_T0.7910.95
27_D200_A0.7910.95
137_Y157_V0.7900.95
126_L131_I0.7830.95
85_G139_L0.7730.94
163_A183_L0.7730.94
47_I54_L0.7720.94
100_K103_K0.7700.94
118_S121_K0.7680.94
43_A46_E0.7620.94
44_V56_V0.7590.94
107_L139_L0.7590.94
5_L22_V0.7590.94
23_E29_V0.7590.94
34_P191_T0.7580.94
80_I183_L0.7580.94
16_I50_A0.7530.93
39_E43_A0.7500.93
170_L206_L0.7500.93
170_L199_T0.7430.93
23_E26_I0.7430.93
107_L144_K0.7410.93
74_S103_K0.7340.92
14_E21_E0.7330.92
57_L82_T0.7280.92
195_D199_T0.7250.92
9_L191_T0.7250.92
42_R46_E0.7230.92
134_H138_D0.7210.92
90_A119_R0.7210.92
133_V157_V0.7180.92
13_P16_I0.7170.92
186_V203_M0.7170.92
203_M206_L0.7120.91
162_T183_L0.7120.91
18_L21_E0.7110.91
86_A114_K0.7060.91
82_T161_K0.7020.91
115_D119_R0.7000.91
17_E20_K0.6940.90
5_L18_L0.6930.90
28_V79_D0.6920.90
199_T203_M0.6900.90
24_Q27_D0.6900.90
5_L190_I0.6840.90
136_G140_Q0.6800.89
80_I106_I0.6790.89
119_R128_V0.6740.89
139_L144_K0.6740.89
19_V39_E0.6730.89
7_L47_I0.6700.89
56_V78_A0.6690.88
171_D174_P0.6660.88
37_I73_A0.6650.88
33_T62_I0.6640.88
7_L19_V0.6640.88
100_K105_K0.6540.87
63_M86_A0.6540.87
31_I35_V0.6530.87
18_L196_K0.6510.87
42_R49_E0.6460.87
101_K104_K0.6460.87
173_L184_V0.6460.87
4_Q164_I0.6440.87
23_E54_L0.6430.86
119_R122_E0.6420.86
74_S81_I0.6370.86
110_M135_T0.6350.86
26_I54_L0.6330.86
84_L166_G0.6310.85
189_G203_M0.6300.85
120_A128_V0.6290.85
13_P17_E0.6280.85
22_V200_A0.6250.85
152_T155_N0.6230.85
74_S102_Q0.6160.84
84_L111_I0.6130.84
58_A73_A0.6110.84
46_E50_A0.6090.83
137_Y141_A0.6060.83
31_I43_A0.6060.83
123_I131_I0.6050.83
61_K64_D0.6010.83
26_I204_K0.6000.82
63_M84_L0.5980.82
173_L203_M0.5950.82
24_Q54_L0.5930.82
48_K56_V0.5920.82
124_D131_I0.5920.82
117_E125_A0.5920.82
95_A98_E0.5900.81
131_I134_H0.5870.81
173_L180_K0.5850.81
10_V72_K0.5840.81
199_T206_L0.5820.80
85_G132_C0.5810.80
22_V54_L0.5810.80
109_D112_N0.5790.80
34_P68_Y0.5790.80
97_E101_K0.5770.80
70_I95_A0.5710.79
120_A123_I0.5700.79
169_K189_G0.5690.79
4_Q80_I0.5670.79
65_A166_G0.5640.78
137_Y140_Q0.5640.78
98_E101_K0.5570.78
28_V54_L0.5550.77
111_I114_K0.5540.77
31_I36_V0.5520.77
19_V22_V0.5520.77
47_I50_A0.5500.77
97_E100_K0.5430.76
197_A205_Q0.5410.76
57_L112_N0.5380.75
109_D113_V0.5370.75
96_V99_A0.5360.75
74_S98_E0.5360.75
35_V38_N0.5340.75
63_M114_K0.5330.74
28_V183_L0.5310.74
150_L154_K0.5310.74
86_A124_D0.5300.74
25_Y204_K0.5300.74
34_P71_M0.5290.74
30_E166_G0.5260.73
31_I41_L0.5210.73
90_A97_E0.5210.73
112_N115_D0.5200.73
83_V95_A0.5190.72
121_K125_A0.5160.72
64_D111_I0.5140.72
92_I139_L0.5090.71
162_T165_A0.5090.71
74_S99_A0.5080.71
85_G92_I0.5060.71
129_D148_E0.5040.70
7_L15_A0.5040.70
140_Q160_A0.5030.70
169_K185_I0.5030.70
154_K183_L0.5020.70
3_L15_A0.5010.70
187_G191_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qw4B 4 0.9667 100 0.297 Contact Map
3gdmA 2 0.9571 100 0.301 Contact Map
3qw3A 2 0.9619 100 0.308 Contact Map
3r89A 2 0.9952 100 0.325 Contact Map
4mjzA 2 0.981 100 0.332 Contact Map
3ldvA 2 0.9762 100 0.339 Contact Map
3tr2A 2 0.981 100 0.34 Contact Map
1eixA 2 0.981 100 0.34 Contact Map
2ffcA 2 0.9857 100 0.343 Contact Map
1dbtA 2 0.9857 100 0.346 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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