GREMLIN Database
PHI - 3-hexulose-6-phosphate isomerase
UniProt: P42404 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (158)
Sequences: 11745 (7957)
Seq/√Len: 633.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_E118_S3.5381.00
37_H79_G3.1671.00
110_A123_A3.1291.00
102_K124_D3.1081.00
32_H107_I2.9921.00
99_A122_Q2.8891.00
11_L15_H2.4211.00
100_K103_S2.3591.00
148_G151_F1.9651.00
84_I98_A1.9311.00
107_I125_L1.9031.00
38_Q64_N1.8621.00
85_G159_Y1.8291.00
12_N15_H1.7861.00
37_H77_A1.7701.00
41_T51_A1.7671.00
42_A82_V1.7581.00
57_R60_H1.7381.00
82_V101_A1.7341.00
92_K96_H1.6991.00
41_T83_I1.6121.00
34_L169_K1.6071.00
107_I124_D1.6051.00
51_A85_G1.5991.00
98_A108_V1.5971.00
129_M158_F1.5531.00
100_K104_L1.5361.00
15_H19_A1.5201.00
54_F159_Y1.4631.00
32_H125_L1.4551.00
42_A97_T1.4451.00
81_L109_A1.4351.00
110_A126_I1.4331.00
120_G128_R1.4271.00
37_H80_D1.4261.00
108_V123_A1.4111.00
54_F58_L1.4071.00
86_S119_I1.3901.00
85_G155_L1.3831.00
129_M155_L1.3831.00
76_L106_G1.3791.00
8_A12_N1.3711.00
115_P128_R1.3681.00
12_N16_N1.3671.00
28_Q32_H1.3401.00
55_A59_M1.3221.00
29_L109_A1.3211.00
165_K169_K1.2911.00
98_A119_I1.2901.00
77_A80_D1.2891.00
53_S56_M1.2821.00
8_A18_A1.2741.00
19_A23_N1.2711.00
49_L52_K1.2561.00
28_Q125_L1.2511.00
120_G126_I1.2481.00
101_A106_G1.2401.00
36_S81_L1.2371.00
112_T126_I1.2281.00
25_E28_Q1.2081.00
54_F57_R1.1831.00
44_A71_I1.1811.00
10_I149_S1.1751.00
110_A119_I1.1681.00
36_S79_G1.1641.00
53_S57_R1.1611.00
14_L17_S1.1561.00
31_D169_K1.1521.00
127_I158_F1.1371.00
84_I94_L1.1351.00
46_R148_G1.1281.00
35_S79_G1.1191.00
38_Q80_D1.1171.00
56_M59_M1.1041.00
112_T120_G1.0961.00
30_A34_L1.0701.00
117_S120_G1.0651.00
42_A84_I1.0591.00
11_L14_L1.0591.00
39_I83_I1.0471.00
10_I13_E1.0381.00
11_L18_A1.0361.00
24_E27_D1.0311.00
52_K55_A1.0151.00
61_M64_N1.0121.00
28_Q31_D1.0041.00
102_K122_Q0.9961.00
82_V106_G0.9921.00
30_A169_K0.9851.00
116_E121_K0.9791.00
27_D169_K0.9781.00
52_K56_M0.9721.00
10_I14_L0.9721.00
84_I108_V0.9671.00
96_H99_A0.9621.00
165_K168_E0.9551.00
13_E16_N0.9541.00
95_I99_A0.9441.00
15_H18_A0.9421.00
50_M53_S0.9411.00
25_E109_A0.9381.00
16_N19_A0.9231.00
95_I118_S0.9221.00
16_N20_Y0.9191.00
41_T54_F0.9181.00
13_E20_Y0.9181.00
34_L170_K0.9051.00
40_F74_P0.8971.00
129_M154_T0.8971.00
42_A94_L0.8931.00
17_S20_Y0.8911.00
22_S25_E0.8901.00
29_L125_L0.8771.00
57_R163_I0.8721.00
67_I70_E0.8671.00
14_L18_A0.8651.00
27_D31_D0.8611.00
47_S155_L0.8601.00
99_A103_S0.8581.00
81_L107_I0.8481.00
85_G111_L0.8481.00
25_E125_L0.8431.00
66_H72_L0.8401.00
29_L32_H0.8301.00
115_P130_P0.8291.00
118_S122_Q0.8151.00
56_M60_H0.8151.00
86_S91_T0.8151.00
111_L158_F0.8131.00
26_A30_A0.8101.00
118_S121_K0.8091.00
16_N132_S0.8081.00
50_M156_L0.8011.00
110_A120_G0.7961.00
8_A11_L0.7921.00
13_E18_A0.7901.00
28_Q107_I0.7851.00
44_A70_E0.7671.00
131_G154_T0.7661.00
32_H81_L0.7631.00
31_D34_L0.7571.00
102_K108_V0.7571.00
40_F80_D0.7561.00
83_I111_L0.7551.00
49_L53_S0.7521.00
20_Y128_R0.7471.00
24_E28_Q0.7421.00
54_F160_D0.7401.00
9_E13_E0.7371.00
83_I162_V0.7341.00
52_K57_R0.7321.00
87_G113_I0.7311.00
84_I101_A0.7211.00
111_L159_Y0.7201.00
10_I18_A0.7181.00
15_H22_S0.7171.00
44_A91_T0.7141.00
62_G65_A0.7061.00
55_A65_A0.7031.00
49_L56_M0.7021.00
78_E105_H0.6951.00
25_E34_L0.6951.00
76_L82_V0.6941.00
8_A15_H0.6941.00
62_G71_I0.6791.00
47_S85_G0.6781.00
109_A127_I0.6771.00
113_I131_G0.6731.00
18_A157_L0.6691.00
110_A117_S0.6681.00
38_Q77_A0.6671.00
95_I122_Q0.6641.00
35_S81_L0.6631.00
39_I81_L0.6611.00
27_D165_K0.6601.00
33_I166_L0.6561.00
57_R73_T0.6541.00
65_A68_V0.6521.00
25_E29_L0.6491.00
26_A29_L0.6441.00
48_G52_K0.6431.00
86_S89_G0.6391.00
33_I81_L0.6371.00
68_V71_I0.6371.00
38_Q62_G0.6331.00
18_A22_S0.6311.00
164_L167_M0.6281.00
76_L80_D0.6251.00
30_A166_L0.6251.00
9_E12_N0.6201.00
13_E150_L0.6141.00
62_G67_I0.6121.00
25_E32_H0.6121.00
17_S154_T0.6051.00
13_E17_S0.5951.00
19_A22_S0.5891.00
109_A125_L0.5881.00
55_A63_F0.5851.00
161_A165_K0.5851.00
125_L128_R0.5821.00
29_L162_V0.5811.00
61_M70_E0.5741.00
152_E156_L0.5731.00
61_M65_A0.5691.00
29_L33_I0.5621.00
65_A70_E0.5571.00
53_S60_H0.5551.00
62_G70_E0.5541.00
115_P126_I0.5541.00
163_I167_M0.5531.00
123_A126_I0.5501.00
47_S86_S0.5491.00
156_L160_D0.5421.00
61_M66_H0.5370.99
63_F70_E0.5370.99
33_I39_I0.5360.99
9_E150_L0.5360.99
55_A163_I0.5360.99
25_E30_A0.5270.99
61_M170_K0.5230.99
154_T157_L0.5230.99
80_D106_G0.5210.99
94_L97_T0.5200.99
53_S59_M0.5180.99
48_G51_A0.5170.99
111_L155_L0.5150.99
113_I129_M0.5140.99
96_H100_K0.5120.99
39_I63_F0.5120.99
164_L168_E0.5110.99
53_S152_E0.5100.99
87_G129_M0.5100.99
40_F76_L0.5070.99
148_G152_E0.5060.99
36_S80_D0.5030.99
152_E155_L0.5020.99
59_M75_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m3sA 4 0.9892 100 0.267 Contact Map
1vimA 4 0.9946 100 0.296 Contact Map
1jeoA 4 0.9297 100 0.326 Contact Map
3fxaA 4 0.9676 100 0.33 Contact Map
3etnA 4 0.9676 100 0.341 Contact Map
2pocA 4 0.9351 100 0.348 Contact Map
4amvA 2 0.9514 100 0.356 Contact Map
1moqA 2 0.9514 100 0.361 Contact Map
3tbfA 2 0.9514 100 0.372 Contact Map
4ivnA 2 0.9568 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.