GREMLIN Database
BGLC - Aryl-phospho-beta-D-glucosidase BglC
UniProt: P42403 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 477 (439)
Sequences: 6717 (4193)
Seq/√Len: 200.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_D99_A4.2181.00
393_Q461_K4.1011.00
109_D161_R3.6301.00
408_C418_L3.2091.00
105_D161_R3.1911.00
72_A114_H3.0911.00
65_K110_E3.0341.00
105_D157_R2.9921.00
122_L154_L2.9291.00
459_K463_F2.9031.00
110_E113_S2.8821.00
59_D62_H2.8261.00
98_E102_A2.8131.00
102_A106_S2.8031.00
98_E157_R2.7621.00
89_F153_T2.7401.00
300_Y404_H2.7371.00
407_Q410_Q2.6791.00
30_E62_H2.6661.00
234_S239_D2.6201.00
152_I156_K2.5951.00
17_S76_L2.4431.00
401_L423_S2.4001.00
129_Q133_D2.3591.00
360_R414_D2.3331.00
69_A114_H2.3281.00
212_F221_I2.3031.00
364_R414_D2.2981.00
43_K55_E2.2981.00
141_R284_D2.2711.00
399_D403_S2.2661.00
145_E207_K2.2091.00
395_D461_K2.1921.00
210_E214_E2.1721.00
444_Y458_L2.1591.00
108_I158_F2.1551.00
60_H103_F2.1401.00
65_K106_S2.1381.00
78_A422_C2.0901.00
60_H79_Y2.0491.00
117_E163_K2.0471.00
467_Q471_K2.0431.00
68_V107_L2.0171.00
83_V120_L2.0001.00
99_A102_A1.9251.00
148_N211_S1.9141.00
152_I215_Y1.8981.00
112_L161_R1.8931.00
81_F108_I1.8911.00
68_V114_H1.8811.00
265_Q269_R1.8671.00
152_I211_S1.8651.00
28_W35_P1.8441.00
283_G286_D1.8421.00
40_V133_D1.8421.00
199_H263_Y1.8411.00
36_S86_P1.8211.00
40_V129_Q1.8171.00
212_F219_G1.7991.00
360_R410_Q1.7991.00
105_D109_D1.7781.00
231_Y361_I1.7741.00
35_P40_V1.7701.00
207_K287_L1.7621.00
388_E391_T1.7471.00
19_S24_I1.7221.00
110_E114_H1.7121.00
27_A30_E1.7021.00
81_F107_L1.6761.00
387_V458_L1.6721.00
117_E164_Y1.6661.00
15_W473_N1.6621.00
108_I112_L1.6591.00
109_D112_L1.6551.00
111_L116_I1.6331.00
363_L416_V1.6311.00
468_D471_K1.6291.00
105_D158_F1.6261.00
280_I285_M1.6211.00
357_I407_Q1.6151.00
135_Y146_D1.6101.00
69_A110_E1.5971.00
216_V219_G1.5941.00
148_N207_K1.5921.00
360_R364_R1.5821.00
68_V110_E1.5721.00
64_F106_S1.5711.00
300_Y358_G1.5691.00
365_R369_R1.5441.00
375_F419_I1.5411.00
78_A119_V1.5341.00
14_L78_A1.5261.00
34_G92_G1.5241.00
143_I146_D1.5121.00
166_V224_S1.5101.00
248_E266_I1.5061.00
44_I47_K1.4931.00
188_V193_R1.4921.00
22_Y54_G1.4921.00
446_N454_D1.4871.00
198_N254_W1.4861.00
155_Y212_F1.4841.00
68_V111_L1.4701.00
255_L296_V1.4691.00
253_W267_P1.4671.00
19_S79_Y1.4631.00
160_D216_V1.4421.00
139_E193_R1.4411.00
359_L408_C1.4321.00
101_L153_T1.4301.00
286_D290_K1.4301.00
63_R66_E1.4231.00
71_M76_L1.4221.00
260_W371_Q1.4211.00
379_N421_Y1.4171.00
73_E463_F1.4031.00
166_V295_F1.4031.00
423_S442_F1.3981.00
81_F120_L1.3881.00
89_F96_I1.3771.00
211_S214_E1.3741.00
119_V422_C1.3721.00
59_D63_R1.3451.00
163_K218_E1.3351.00
136_G140_S1.3321.00
363_L408_C1.3271.00
93_K135_Y1.3261.00
27_A62_H1.3201.00
164_Y220_K1.3181.00
223_P258_Y1.3091.00
459_K464_Y1.3081.00
465_W469_V1.3081.00
262_T371_Q1.3011.00
468_D472_T1.3011.00
262_T268_F1.2961.00
83_V154_L1.2761.00
405_L408_C1.2621.00
93_K146_D1.2521.00
168_L201_A1.2451.00
145_E148_N1.2431.00
190_D193_R1.2411.00
71_M443_V1.2401.00
168_L204_A1.2371.00
69_A73_E1.2321.00
402_R406_E1.2231.00
464_Y467_Q1.2211.00
403_S406_E1.2171.00
141_R200_I1.2161.00
285_M288_L1.2141.00
349_N384_F1.2121.00
83_V88_V1.2081.00
364_R416_V1.2071.00
142_N145_E1.2021.00
210_E290_K1.2021.00
91_K130_A1.1991.00
101_L157_R1.1951.00
409_R413_S1.1901.00
60_H107_L1.1821.00
391_T461_K1.1751.00
155_Y208_A1.1751.00
174_N201_A1.1711.00
64_F110_E1.1581.00
19_S81_F1.1551.00
138_F143_I1.1491.00
367_T417_D1.1471.00
58_V427_T1.1461.00
127_L143_I1.1431.00
132_M188_V1.1371.00
281_E284_D1.1341.00
447_R455_L1.1331.00
105_D160_D1.1321.00
156_K215_Y1.1241.00
28_W33_K1.1201.00
232_P240_I1.1191.00
34_G130_A1.1191.00
148_N208_A1.1151.00
10_P412_I1.1111.00
256_D369_R1.1101.00
122_L147_F1.1101.00
247_E365_R1.1081.00
142_N146_D1.0961.00
237_P241_L1.0941.00
390_G458_L1.0921.00
232_P243_F1.0881.00
230_A246_A1.0881.00
148_N152_I1.0871.00
151_C208_A1.0861.00
409_R412_I1.0851.00
227_Y362_G1.0851.00
256_D260_W1.0831.00
101_L105_D1.0781.00
73_E459_K1.0771.00
238_E357_I1.0761.00
108_I161_R1.0741.00
155_Y221_I1.0731.00
108_I120_L1.0731.00
388_E393_Q1.0711.00
209_I213_R1.0691.00
357_I361_I1.0681.00
207_K211_S1.0681.00
233_L307_E1.0651.00
237_P240_I1.0621.00
27_A31_D1.0591.00
135_Y142_N1.0481.00
212_F217_P1.0481.00
96_I153_T1.0441.00
132_M179_F1.0441.00
359_L376_I1.0381.00
211_S215_Y1.0351.00
282_A285_M1.0341.00
238_E308_R1.0331.00
200_I203_L1.0321.00
94_G149_H1.0311.00
9_F412_I1.0301.00
63_R456_K1.0211.00
359_L418_L1.0201.00
241_L245_N1.0191.00
387_V392_V1.0181.00
91_K95_E1.0171.00
239_D308_R1.0171.00
466_Y470_I1.0161.00
269_R272_E1.0121.00
399_D402_R1.0101.00
105_D112_L1.0091.00
9_F409_R1.0081.00
34_G90_P1.0071.00
159_G219_G1.0031.00
17_S71_M1.0011.00
248_E267_P1.0001.00
88_V153_T0.9991.00
56_I447_R0.9991.00
262_T265_Q0.9991.00
446_N456_K0.9971.00
151_C211_S0.9971.00
259_C372_L0.9971.00
384_F437_Q0.9931.00
210_E291_G0.9921.00
240_I243_F0.9891.00
241_L244_E0.9891.00
127_L137_G0.9871.00
244_E248_E0.9861.00
153_T157_R0.9831.00
236_H240_I0.9831.00
146_D149_H0.9801.00
387_V391_T0.9751.00
119_V164_Y0.9730.99
383_E396_Y0.9700.99
398_I465_W0.9690.99
246_A306_Y0.9620.99
56_I455_L0.9580.99
14_L119_V0.9570.99
141_R281_E0.9560.99
230_A243_F0.9510.99
247_E251_N0.9450.99
24_I60_H0.9450.99
144_I207_K0.9430.99
439_R447_R0.9420.99
130_A133_D0.9410.99
102_A105_D0.9390.99
119_V375_F0.9380.99
136_G139_E0.9380.99
248_E252_N0.9220.99
154_L158_F0.9210.99
222_G297_G0.9210.99
77_K473_N0.9180.99
12_H419_I0.9150.99
209_I221_I0.9140.99
410_Q413_S0.9060.99
151_C155_Y0.9010.99
52_T437_Q0.9000.99
66_E69_A0.8990.99
155_Y219_G0.8960.99
175_F197_A0.8930.99
225_F255_L0.8900.99
106_S109_D0.8900.99
157_R161_R0.8900.99
32_G97_N0.8860.99
150_Y154_L0.8830.99
427_T445_V0.8830.99
33_K86_P0.8820.99
235_S240_I0.8810.99
160_D219_G0.8770.99
247_E252_N0.8760.99
101_L154_L0.8760.99
69_A72_A0.8730.99
8_S11_K0.8720.99
76_L426_F0.8720.99
244_E266_I0.8720.99
208_A211_S0.8680.99
37_V132_M0.8660.99
346_T403_S0.8650.99
105_D108_I0.8630.99
283_G287_L0.8610.99
256_D370_Y0.8600.99
367_T371_Q0.8580.99
469_V473_N0.8570.99
210_E287_L0.8540.99
166_V297_G0.8530.99
123_Y127_L0.8520.99
381_L396_Y0.8510.99
359_L407_Q0.8510.99
412_I418_L0.8510.99
222_G295_F0.8480.99
355_D358_G0.8480.99
269_R273_K0.8450.99
406_E410_Q0.8440.99
205_N209_I0.8410.99
298_V374_V0.8410.99
212_F216_V0.8400.99
112_L118_P0.8400.99
464_Y468_D0.8400.99
103_F107_L0.8400.99
173_Y226_A0.8370.98
382_G438_K0.8330.98
303_T353_T0.8310.98
341_K347_T0.8280.98
192_K278_P0.8260.98
367_T372_L0.8260.98
15_W405_L0.8230.98
168_L174_N0.8210.98
207_K210_E0.8210.98
302_Q353_T0.8210.98
139_E188_V0.8200.98
347_T353_T0.8200.98
144_I203_L0.8200.98
357_I410_Q0.8190.98
395_D399_D0.8170.98
159_G216_V0.8160.98
135_Y143_I0.8150.98
129_Q132_M0.8140.98
140_S146_D0.8130.98
123_Y126_D0.8120.98
360_R407_Q0.8110.98
71_M116_I0.8100.98
73_E467_Q0.8080.98
339_T343_P0.8030.98
93_K130_A0.7990.98
196_E279_T0.7970.98
167_T223_P0.7970.98
227_Y298_V0.7960.98
364_R368_S0.7960.98
303_T355_D0.7950.98
303_T358_G0.7920.98
33_K36_S0.7910.98
461_K464_Y0.7910.98
76_L466_Y0.7910.98
392_V458_L0.7880.98
167_T205_N0.7880.98
259_C293_P0.7880.98
24_I58_V0.7870.98
10_P417_D0.7820.98
74_M459_K0.7810.98
153_T156_K0.7810.98
14_L117_E0.7790.98
230_A306_Y0.7780.98
64_F68_V0.7760.98
192_K196_E0.7720.97
21_A84_S0.7720.97
37_V127_L0.7700.97
159_G215_Y0.7690.97
244_E365_R0.7650.97
252_N369_R0.7630.97
236_H239_D0.7630.97
8_S409_R0.7630.97
364_R367_T0.7610.97
120_L162_V0.7600.97
363_L418_L0.7600.97
233_L239_D0.7600.97
367_T416_V0.7600.97
354_I383_E0.7500.97
88_V154_L0.7490.97
56_I59_D0.7480.97
92_G130_A0.7480.97
265_Q268_F0.7460.97
98_E105_D0.7450.97
147_F151_C0.7400.97
443_V459_K0.7400.97
72_A115_H0.7380.97
167_T221_I0.7370.97
177_H183_M0.7350.97
96_I101_L0.7330.96
429_L440_Y0.7310.96
374_V416_V0.7300.96
229_P361_I0.7300.96
112_L117_E0.7280.96
89_F95_E0.7250.96
29_N35_P0.7230.96
259_C296_V0.7220.96
84_S126_D0.7210.96
267_P271_L0.7180.96
145_E149_H0.7170.96
19_S427_T0.7160.96
405_L423_S0.7150.96
202_F258_Y0.7150.96
202_F288_L0.7130.96
241_L357_I0.7130.96
198_N253_W0.7120.96
112_L163_K0.7120.96
155_Y215_Y0.7100.96
50_K437_Q0.7100.96
398_I461_K0.7090.96
12_H473_N0.7080.96
224_S299_N0.7080.96
67_D457_R0.7060.96
411_A416_V0.7050.96
348_S382_G0.7050.96
118_P163_K0.7050.96
24_I429_L0.7020.96
63_R455_L0.6970.95
350_W438_K0.6970.95
192_K277_A0.6960.95
357_I360_R0.6960.95
204_A208_A0.6950.95
387_V390_G0.6940.95
15_W77_K0.6920.95
27_A61_Y0.6920.95
46_G51_G0.6920.95
31_D61_Y0.6900.95
91_K94_G0.6890.95
139_E197_A0.6860.95
172_N226_A0.6860.95
100_G103_F0.6850.95
147_F168_L0.6820.95
348_S381_L0.6820.95
345_L353_T0.6810.95
35_P43_K0.6800.95
111_L114_H0.6800.95
431_S440_Y0.6800.95
141_R283_G0.6790.95
240_I244_E0.6780.95
262_T285_M0.6770.95
154_L165_W0.6760.95
296_V372_L0.6730.94
156_K211_S0.6720.94
391_T458_L0.6700.94
74_M442_F0.6690.94
54_G57_A0.6690.94
93_K149_H0.6670.94
231_Y303_T0.6610.94
227_Y255_L0.6600.94
14_L77_K0.6600.94
132_M139_E0.6600.94
81_F111_L0.6590.94
298_V366_I0.6580.94
225_F254_W0.6580.94
405_L469_V0.6560.94
272_E277_A0.6550.94
68_V116_I0.6540.93
77_K117_E0.6520.93
469_V472_T0.6500.93
28_W55_E0.6500.93
71_M426_F0.6490.93
151_C154_L0.6480.93
108_I162_V0.6480.93
299_N377_T0.6470.93
442_F466_Y0.6460.93
309_N312_D0.6450.93
189_K192_K0.6440.93
236_H308_R0.6420.93
65_K69_A0.6410.93
206_A288_L0.6400.93
152_I214_E0.6400.93
144_I204_A0.6400.93
282_A286_D0.6390.93
173_Y177_H0.6390.93
410_Q414_D0.6370.93
375_F420_G0.6360.93
210_E292_K0.6350.92
346_T396_Y0.6350.92
48_T52_T0.6350.92
123_Y174_N0.6340.92
363_L411_A0.6330.92
200_I281_E0.6320.92
391_T464_Y0.6290.92
112_L115_H0.6280.92
18_A422_C0.6280.92
408_C412_I0.6270.92
227_Y251_N0.6260.92
141_R203_L0.6260.92
28_W84_S0.6240.92
122_L155_Y0.6230.92
91_K146_D0.6230.92
347_T351_D0.6220.92
149_H153_T0.6210.92
242_A246_A0.6190.92
89_F149_H0.6190.92
88_V101_L0.6180.91
300_Y359_L0.6180.91
119_V166_V0.6170.91
395_D398_I0.6170.91
215_Y219_G0.6170.91
130_A146_D0.6150.91
455_L459_K0.6150.91
35_P129_Q0.6140.91
111_L115_H0.6120.91
185_P188_V0.6120.91
83_V108_I0.6120.91
206_A291_G0.6120.91
139_E196_E0.6120.91
426_F443_V0.6110.91
444_Y460_K0.6100.91
195_Y271_L0.6090.91
80_R169_N0.6090.91
220_K419_I0.6090.91
430_L447_R0.6070.91
42_T430_L0.6070.91
162_V165_W0.6050.91
348_S383_E0.6030.90
49_F52_T0.6020.90
9_F473_N0.6000.90
261_G290_K0.6000.90
444_Y456_K0.6000.90
269_R410_Q0.5980.90
267_P270_C0.5960.90
390_G456_K0.5960.90
144_I148_N0.5950.90
101_L158_F0.5950.90
346_T399_D0.5950.90
387_V444_Y0.5950.90
54_G435_G0.5940.90
233_L305_T0.5930.90
253_W271_L0.5920.90
349_N383_E0.5920.90
49_F434_N0.5920.90
70_L443_V0.5920.90
196_E200_I0.5910.90
16_G422_C0.5910.90
307_E338_K0.5900.89
106_S110_E0.5890.89
350_W434_N0.5890.89
131_L146_D0.5890.89
35_P86_P0.5880.89
12_H412_I0.5880.89
252_N365_R0.5870.89
77_K470_I0.5860.89
227_Y366_I0.5850.89
27_A33_K0.5840.89
301_Y378_E0.5830.89
192_K276_W0.5830.89
70_L427_T0.5820.89
57_A455_L0.5820.89
24_I79_Y0.5800.89
92_G131_L0.5790.89
210_E213_R0.5790.89
164_Y375_F0.5780.89
109_D160_D0.5780.89
287_L291_G0.5770.88
199_H280_I0.5770.88
429_L432_W0.5770.88
49_F437_Q0.5750.88
430_L436_Y0.5730.88
19_S426_F0.5720.88
349_N438_K0.5700.88
340_K343_P0.5700.88
159_G217_P0.5690.88
205_N258_Y0.5690.88
135_Y140_S0.5680.88
228_S304_I0.5680.88
248_E365_R0.5670.88
209_I293_P0.5660.87
65_K68_V0.5660.87
72_A113_S0.5630.87
179_F197_A0.5630.87
75_G467_Q0.5620.87
222_G375_F0.5610.87
37_V123_Y0.5610.87
372_L417_D0.5600.87
425_S429_L0.5600.87
366_I374_V0.5590.87
281_E285_M0.5580.87
109_D113_S0.5580.87
255_L366_I0.5580.87
183_M186_P0.5560.87
234_S307_E0.5560.87
229_P247_E0.5560.87
76_L116_I0.5550.86
280_I283_G0.5550.86
127_L132_M0.5550.86
297_G377_T0.5540.86
361_I364_R0.5540.86
245_N308_R0.5520.86
60_H71_M0.5520.86
231_Y355_D0.5520.86
206_A292_K0.5510.86
79_Y111_L0.5490.86
249_F267_P0.5480.86
375_F422_C0.5460.86
34_G89_F0.5460.86
9_F15_W0.5450.85
73_E464_Y0.5440.85
373_P417_D0.5440.85
74_M463_F0.5440.85
374_V418_L0.5430.85
246_A250_T0.5430.85
232_P239_D0.5420.85
119_V419_I0.5400.85
271_L276_W0.5400.85
41_F187_G0.5400.85
71_M79_Y0.5390.85
464_Y471_K0.5390.85
19_S429_L0.5380.85
122_L151_C0.5380.85
60_H64_F0.5370.85
28_W43_K0.5360.85
12_H77_K0.5360.85
203_L287_L0.5350.84
131_L143_I0.5350.84
179_F188_V0.5350.84
195_Y276_W0.5330.84
33_K126_D0.5320.84
179_F186_P0.5320.84
398_I402_R0.5310.84
89_F93_K0.5300.84
167_T208_A0.5290.84
42_T54_G0.5290.84
60_H68_V0.5280.84
33_K39_D0.5270.84
348_S351_D0.5270.84
342_N345_L0.5260.83
343_P346_T0.5260.83
203_L288_L0.5260.83
401_L405_L0.5250.83
19_S60_H0.5250.83
256_D262_T0.5240.83
63_R454_D0.5240.83
439_R444_Y0.5230.83
268_F285_M0.5230.83
41_F185_P0.5220.83
276_W279_T0.5200.83
234_S240_I0.5200.83
130_A135_Y0.5190.83
40_V44_I0.5180.82
224_S295_F0.5180.82
424_W429_L0.5180.82
425_S447_R0.5170.82
392_V444_Y0.5170.82
443_V463_F0.5150.82
132_M137_G0.5150.82
252_N256_D0.5150.82
191_R276_W0.5140.82
183_M434_N0.5130.82
56_I62_H0.5120.82
260_W370_Y0.5120.82
200_I279_T0.5120.82
448_D456_K0.5110.82
255_L259_C0.5090.81
242_A245_N0.5090.81
224_S377_T0.5090.81
170_E301_Y0.5080.81
209_I291_G0.5050.81
407_Q414_D0.5050.81
236_H309_N0.5040.81
406_E409_R0.5030.81
209_I212_F0.5020.80
270_C276_W0.5010.80
22_Y42_T0.5010.80
179_F182_A0.5000.80
231_Y357_I0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v02A 2 0.9602 100 0.115 Contact Map
2jf7A 5 0.9413 100 0.117 Contact Map
3ptmA 1 0.9539 100 0.117 Contact Map
2dgaA 5 0.9686 100 0.118 Contact Map
1v08A 2 0.9623 100 0.12 Contact Map
3wq5A 1 0.9497 100 0.123 Contact Map
1cbgA 2 0.9581 100 0.124 Contact Map
3f5lA 2 0.956 100 0.129 Contact Map
3w53A 1 0.9665 100 0.13 Contact Map
3viiA 2 0.9392 100 0.133 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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