GREMLIN Database
YCKC - Uncharacterized protein YckC
UniProt: P42401 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (124)
Sequences: 2760 (2214)
Seq/√Len: 198.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_L65_I3.8051.00
11_I133_Y3.5961.00
120_R125_L3.4691.00
116_R125_L3.2831.00
76_K86_T2.9261.00
113_I121_T2.7591.00
82_V87_M2.6761.00
18_L70_C2.6171.00
7_A72_I2.4571.00
55_L59_F2.3901.00
75_V132_T2.2771.00
82_V129_T2.2521.00
112_L122_L2.2431.00
63_Y68_R2.1991.00
94_A126_I2.0521.00
14_G70_C1.9951.00
112_L116_R1.9451.00
77_K120_R1.7871.00
58_M84_L1.7661.00
32_W36_G1.7211.00
116_R120_R1.6251.00
118_D130_Y1.5621.00
75_V130_Y1.4931.00
56_L60_W1.4671.00
73_R134_A1.4541.00
83_S86_T1.4501.00
76_K80_S1.4431.00
50_L88_F1.4011.00
98_Y123_H1.3861.00
104_L107_I1.3761.00
5_K133_Y1.3331.00
89_L93_V1.3171.00
18_L69_I1.3001.00
61_R68_R1.2651.00
53_S57_P1.2551.00
24_S28_L1.2541.00
71_G135_T1.2471.00
89_L126_I1.2191.00
52_Y57_P1.2091.00
76_K83_S1.2051.00
63_Y134_A1.2021.00
98_Y106_L1.1931.00
21_I25_V1.1911.00
6_P9_F1.1911.00
15_A72_I1.1791.00
85_L89_L1.1781.00
11_I70_C1.1451.00
56_L68_R1.1431.00
77_K130_Y1.1381.00
9_F113_I1.1341.00
9_F114_A1.1331.00
16_A53_S1.1201.00
57_P74_I1.0941.00
58_M87_M1.0821.00
8_G11_I1.0481.00
120_R130_Y1.0471.00
95_G98_Y1.0461.00
26_P48_V1.0461.00
77_K128_G1.0121.00
6_P130_Y1.0081.00
57_P67_K1.0061.00
101_T122_L1.0021.00
57_P121_T0.9921.00
98_Y101_T0.9750.99
92_I95_G0.9540.99
17_L21_I0.9380.99
53_S64_L0.9340.99
15_A67_K0.9310.99
93_V102_F0.9240.99
62_G73_R0.9230.99
38_D41_D0.9010.99
98_Y121_T0.8830.99
105_G122_L0.8620.99
59_F62_G0.8540.99
19_D66_G0.8510.99
65_I69_I0.8500.99
18_L22_I0.8460.99
51_L55_L0.8400.98
11_I14_G0.8350.98
54_I87_M0.8340.98
54_I88_F0.8320.98
16_A20_Y0.8220.98
74_I87_M0.8080.98
124_D127_A0.8040.98
97_V101_T0.8030.98
13_L113_I0.8020.98
6_P119_K0.7950.98
33_L36_G0.7900.98
72_I131_V0.7740.97
99_C106_L0.7710.97
88_F93_V0.7680.97
50_L54_I0.7660.97
76_K128_G0.7660.97
112_L115_V0.7520.97
52_Y58_M0.7500.97
54_I92_I0.7480.97
35_T41_D0.7460.97
8_G113_I0.7380.97
76_K82_V0.7300.96
49_V53_S0.7270.96
26_P29_L0.7270.96
118_D125_L0.7200.96
104_L112_L0.7200.96
101_T105_G0.7160.96
31_Y35_T0.7110.96
60_W63_Y0.7060.96
57_P92_I0.7050.96
10_W14_G0.6960.95
94_A127_A0.6950.95
54_I58_M0.6950.95
19_D64_L0.6950.95
60_W65_I0.6930.95
63_Y87_M0.6920.95
90_R124_D0.6870.95
94_A98_Y0.6860.95
8_G114_A0.6840.95
76_K129_T0.6820.95
7_A133_Y0.6710.94
84_L88_F0.6690.94
67_K131_V0.6670.94
86_T89_L0.6650.94
21_I24_S0.6650.94
67_K74_I0.6630.94
43_M47_L0.6630.94
102_F105_G0.6570.94
22_I26_P0.6550.93
57_P123_H0.6540.93
58_M83_S0.6540.93
62_G75_V0.6490.93
20_Y34_I0.6470.93
57_P95_G0.6420.93
98_Y105_G0.6390.93
84_L87_M0.6380.93
57_P128_G0.6360.92
112_L125_L0.6330.92
93_V98_Y0.6290.92
130_Y133_Y0.6280.92
102_F113_I0.6250.92
8_G119_K0.6180.91
10_W17_L0.6150.91
22_I69_I0.6140.91
59_F84_L0.6120.91
87_M92_I0.6120.91
82_V96_L0.6060.91
112_L117_E0.6050.90
113_I119_K0.6030.90
51_L84_L0.6010.90
97_V100_I0.6000.90
59_F81_Q0.5960.90
37_K45_I0.5940.90
51_L54_I0.5890.89
92_I105_G0.5880.89
107_I114_A0.5860.89
27_L49_V0.5850.89
7_A131_V0.5830.89
103_G106_L0.5830.89
29_L33_L0.5810.89
101_T104_L0.5800.89
48_V51_L0.5790.88
11_I72_I0.5780.88
7_A11_I0.5720.88
22_I25_V0.5710.88
27_L45_I0.5680.87
24_S36_G0.5650.87
95_G123_H0.5650.87
85_L126_I0.5620.87
56_L63_Y0.5610.87
60_W68_R0.5520.86
13_L17_L0.5450.85
13_L16_A0.5410.85
55_L60_W0.5370.84
9_F13_L0.5330.84
11_I71_G0.5310.84
68_R134_A0.5290.84
96_L101_T0.5290.84
63_Y72_I0.5280.83
35_T38_D0.5260.83
75_V81_Q0.5240.83
74_I131_V0.5210.83
30_I42_S0.5160.82
94_A123_H0.5100.81
112_L118_D0.5090.81
62_G81_Q0.5050.81
113_I131_V0.5030.80
21_I69_I0.5010.80
107_I115_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tr3A 1 0.6556 13.1 0.932 Contact Map
2cvbA 1 0.5762 8.9 0.937 Contact Map
3kijA 1 0.5629 7.8 0.939 Contact Map
2p5qA 3 0.5232 7.2 0.94 Contact Map
4hdeA 1 0.5894 6.1 0.942 Contact Map
1xzoA 3 0.596 5.5 0.943 Contact Map
3hczA 2 0.5695 5 0.944 Contact Map
3j8eG 3 0.8675 4.9 0.944 Contact Map
2v1mA 1 0.5364 4.8 0.944 Contact Map
2lrnA 1 0.5629 4.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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