GREMLIN Database
YXJH - Uncharacterized protein YxjH
UniProt: P42319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (318)
Sequences: 4936 (2881)
Seq/√Len: 161.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_T50_Q4.8121.00
318_E323_V3.4581.00
40_K45_E3.3821.00
89_L155_L3.2921.00
64_E68_E3.1101.00
65_K362_W2.9961.00
58_E61_R2.9001.00
324_K374_D2.8521.00
60_T64_E2.8091.00
36_E40_K2.6791.00
320_P370_D2.6711.00
76_D145_P2.5171.00
41_K48_A2.4921.00
48_A52_R2.4741.00
327_I341_L2.4471.00
320_P374_D2.4341.00
133_Y159_E2.4281.00
85_H150_P2.4211.00
167_D172_Y2.4121.00
168_D171_E2.3541.00
93_D123_D2.3451.00
319_N322_D2.2871.00
181_K238_D2.2831.00
63_V145_P2.2271.00
53_D57_Q2.1331.00
37_A54_I2.1241.00
232_I235_A2.0531.00
233_N236_V2.0431.00
50_Q53_D2.0341.00
52_R131_G2.0231.00
185_K189_D2.0181.00
316_E322_D1.9781.00
184_I195_L1.9751.00
92_L179_A1.9671.00
144_T193_R1.9341.00
323_V371_I1.9331.00
57_Q61_R1.8921.00
286_D289_S1.8831.00
369_I373_N1.8681.00
124_F186_A1.8331.00
80_R87_D1.8091.00
41_K101_A1.7871.00
64_E67_K1.7701.00
150_P154_M1.7611.00
229_A233_N1.7521.00
254_F271_I1.7511.00
55_E81_R1.7251.00
122_L179_A1.7031.00
32_V36_E1.7021.00
228_F232_I1.7021.00
25_V343_P1.7021.00
299_K303_L1.7011.00
33_P57_Q1.6941.00
95_V155_L1.6521.00
197_L236_V1.6521.00
335_S338_Q1.6471.00
63_V139_I1.6461.00
359_E363_A1.6321.00
230_K234_D1.6271.00
269_E297_F1.6241.00
46_M50_Q1.5941.00
324_K328_N1.5701.00
84_W150_P1.5661.00
28_L362_W1.5621.00
60_T135_F1.5541.00
232_I236_V1.5421.00
33_P58_E1.5361.00
131_G134_Q1.5301.00
174_H234_D1.5121.00
57_Q60_T1.5031.00
226_A230_K1.5021.00
331_A339_L1.5011.00
343_P368_V1.4971.00
174_H231_T1.4821.00
73_V146_K1.4471.00
334_V338_Q1.4431.00
234_D237_A1.4341.00
307_L330_A1.4291.00
133_Y192_C1.4251.00
280_L303_L1.4251.00
296_R333_F1.4241.00
93_D125_T1.4131.00
184_I197_L1.4001.00
121_K175_D1.3931.00
310_I318_E1.3821.00
320_P371_I1.3811.00
186_A189_D1.3701.00
321_E325_R1.3681.00
60_T139_I1.3681.00
320_P367_H1.3631.00
40_K46_M1.3611.00
65_K68_E1.3581.00
37_A46_M1.3561.00
229_A232_I1.3551.00
233_N276_N1.3521.00
360_Q363_A1.3381.00
302_D338_Q1.3261.00
334_V339_L1.3261.00
58_E62_I1.3261.00
193_R244_T1.3181.00
96_E117_K1.3151.00
194_Y246_T1.3131.00
163_K167_D1.3111.00
69_I366_R1.3061.00
246_T279_G1.2951.00
53_D56_N1.2921.00
324_K371_I1.2891.00
328_N332_R1.2881.00
52_R132_D1.2721.00
175_D178_Q1.2691.00
320_P324_K1.2641.00
362_W366_R1.2561.00
67_K143_A1.2471.00
28_L65_K1.2391.00
25_V75_T1.2261.00
91_G128_P1.2261.00
39_Q43_A1.2231.00
117_K160_K1.2221.00
170_E174_H1.2121.00
304_Q340_C1.2101.00
149_I183_A1.1871.00
173_F227_I1.1841.00
195_L243_L1.1841.00
68_E366_R1.1741.00
106_F116_I1.1721.00
370_D373_N1.1701.00
363_A366_R1.1691.00
186_A190_A1.1681.00
54_I57_Q1.1651.00
88_F92_L1.1601.00
250_C345_C1.1561.00
61_R65_K1.1521.00
94_G155_L1.1271.00
185_K239_R1.1261.00
298_V303_L1.1231.00
167_D171_E1.1151.00
341_L368_V1.1141.00
28_L62_I1.1101.00
71_L365_L1.1061.00
310_I368_V1.0981.00
306_V342_S1.0951.00
271_I280_L1.0941.00
49_E53_D1.0800.99
154_M201_S1.0710.99
279_G304_Q1.0700.99
309_L327_I1.0700.99
306_V340_C1.0670.99
135_F139_I1.0620.99
310_I323_V1.0560.99
52_R81_R1.0510.99
52_R56_N1.0280.99
89_L116_I1.0210.99
75_T148_T1.0200.99
123_D286_D1.0110.99
331_A336_L1.0110.99
185_K238_D1.0090.99
181_K185_K1.0070.99
116_I129_A1.0010.99
173_F231_T0.9990.99
183_A187_F0.9950.99
326_R329_E0.9920.99
366_R370_D0.9880.99
148_T198_D0.9870.99
123_D182_K0.9860.99
96_E119_T0.9840.99
124_F182_K0.9820.99
65_K69_I0.9790.99
179_A182_K0.9760.99
180_Y200_T0.9750.99
200_T275_L0.9730.99
188_Y243_L0.9680.99
24_H146_K0.9680.99
63_V136_L0.9650.99
95_V106_F0.9640.99
228_F233_N0.9630.99
54_I58_E0.9620.99
291_N294_P0.9600.99
188_Y240_P0.9570.99
41_K46_M0.9570.99
328_N331_A0.9540.99
170_E230_K0.9540.99
248_H281_F0.9520.99
151_S199_D0.9510.99
203_S249_I0.9470.99
309_L323_V0.9460.99
135_F138_E0.9430.99
247_M271_I0.9330.98
330_A339_L0.9250.98
177_A181_K0.9240.98
255_R294_P0.9200.98
229_A235_A0.9190.98
237_A276_N0.9170.98
156_F173_F0.9170.98
56_N80_R0.9060.98
231_T235_A0.9050.98
34_V79_F0.8910.98
67_K141_G0.8890.98
289_S326_R0.8860.98
272_L302_D0.8840.98
201_S204_L0.8780.98
62_I79_F0.8780.98
329_E332_R0.8760.98
321_E324_K0.8740.98
156_F228_F0.8730.98
82_S112_K0.8710.98
72_D372_A0.8700.98
247_M277_L0.8670.98
26_G248_H0.8670.98
269_E273_D0.8660.98
34_V55_E0.8650.97
174_H230_K0.8640.97
86_Y114_R0.8630.97
92_L183_A0.8600.97
183_A186_A0.8570.97
157_F204_L0.8510.97
153_N206_F0.8510.97
326_R330_A0.8510.97
177_A235_A0.8470.97
226_A270_T0.8460.97
287_D290_G0.8440.97
134_Q137_H0.8430.97
133_Y172_Y0.8420.97
192_C195_L0.8410.97
161_A167_D0.8410.97
172_Y175_D0.8400.97
157_F201_S0.8380.97
74_V143_A0.8370.97
236_V239_R0.8330.97
154_M200_T0.8290.97
146_K340_C0.8290.97
50_Q54_I0.8290.97
73_V340_C0.8220.97
48_A101_A0.8200.97
322_D325_R0.8170.96
70_G143_A0.8140.96
25_V365_L0.8100.96
98_F102_E0.8100.96
193_R242_D0.8100.96
161_A172_Y0.8050.96
298_V305_I0.8020.96
323_V326_R0.8000.96
178_Q234_D0.7980.96
291_N295_L0.7940.96
170_E227_I0.7920.96
66_Q365_L0.7920.96
37_A55_E0.7910.96
177_A234_D0.7850.96
188_Y242_D0.7850.96
100_P103_G0.7830.95
284_Y307_L0.7800.95
286_D311_T0.7790.95
178_Q182_K0.7770.95
368_V372_A0.7760.95
181_K235_A0.7720.95
236_V240_P0.7690.95
161_A169_Q0.7680.95
56_N131_G0.7670.95
126_S131_G0.7640.95
228_F235_A0.7580.95
267_V271_I0.7570.95
110_K113_A0.7560.95
127_H186_A0.7510.94
146_K196_Q0.7500.94
62_I65_K0.7500.94
102_E106_F0.7470.94
202_W247_M0.7440.94
92_L176_M0.7440.94
292_F329_E0.7430.94
272_L297_F0.7420.94
370_D374_D0.7370.94
185_K188_Y0.7360.94
80_R103_G0.7350.94
174_H178_Q0.7300.93
317_L357_T0.7300.93
113_A116_I0.7300.93
73_V194_Y0.7280.93
56_N59_I0.7280.93
130_L190_A0.7270.93
280_L305_I0.7270.93
276_N303_L0.7260.93
69_I369_I0.7250.93
367_H371_I0.7250.93
68_E362_W0.7230.93
67_K140_A0.7190.93
182_K185_K0.7090.92
293_D296_R0.7050.92
227_I232_I0.7020.92
272_L303_L0.7020.92
311_T314_Y0.6970.92
366_R369_I0.6950.92
28_L365_L0.6930.92
25_V342_S0.6920.92
56_N135_F0.6890.91
169_Q173_F0.6860.91
268_A298_V0.6860.91
118_V122_L0.6850.91
51_L55_E0.6830.91
268_A294_P0.6820.91
62_I66_Q0.6800.91
40_K50_Q0.6790.91
93_D126_S0.6790.91
29_L361_Q0.6790.91
61_R358_E0.6770.91
231_T236_V0.6730.90
88_F91_G0.6720.90
127_H130_L0.6720.90
157_F200_T0.6700.90
23_D372_A0.6690.90
102_E105_Q0.6680.90
130_L183_A0.6670.90
343_P365_L0.6650.90
249_I254_F0.6630.90
60_T63_V0.6620.90
159_E162_D0.6620.90
270_T273_D0.6620.90
46_M54_I0.6610.90
244_T278_D0.6560.89
154_M157_F0.6510.89
239_R278_D0.6510.89
55_E59_I0.6510.89
240_P243_L0.6500.89
36_E39_Q0.6490.89
295_L330_A0.6470.89
120_G125_T0.6460.89
138_E175_D0.6440.88
39_Q42_A0.6430.88
201_S229_A0.6420.88
310_I364_K0.6410.88
153_N201_S0.6400.88
69_I362_W0.6400.88
187_F190_A0.6390.88
296_R329_E0.6370.88
146_K194_Y0.6350.88
77_G145_P0.6340.88
71_L74_V0.6320.87
284_Y291_N0.6300.87
52_R55_E0.6290.87
35_K39_Q0.6290.87
289_S293_D0.6280.87
157_F207_E0.6280.87
100_P104_I0.6270.87
157_F169_Q0.6270.87
153_N228_F0.6270.87
70_G369_I0.6270.87
49_E52_R0.6250.87
357_T363_A0.6220.87
70_G373_N0.6210.87
323_V341_L0.6210.87
71_L369_I0.6210.87
171_E174_H0.6210.87
253_N290_G0.6200.86
198_D345_C0.6190.86
90_E98_F0.6160.86
74_V145_P0.6160.86
123_D126_S0.6160.86
292_F295_L0.6150.86
251_R346_G0.6140.86
105_Q110_K0.6140.86
281_F342_S0.6130.86
279_G340_C0.6110.86
281_F306_V0.6100.86
164_G167_D0.6080.85
357_T361_Q0.6070.85
24_H73_V0.6070.85
34_V54_I0.6060.85
24_H71_L0.6040.85
244_T304_Q0.6040.85
268_A272_L0.6010.85
194_Y244_T0.6000.85
365_L369_I0.5980.84
56_N60_T0.5970.84
75_T147_L0.5950.84
133_Y137_H0.5930.84
152_P197_L0.5910.84
89_L94_G0.5910.84
327_I371_I0.5900.84
48_A98_F0.5900.84
34_V58_E0.5870.83
174_H177_A0.5840.83
136_L140_A0.5840.83
319_N371_I0.5830.83
157_F206_F0.5820.83
198_D248_H0.5800.83
315_G355_L0.5800.83
229_A270_T0.5770.82
32_V39_Q0.5770.82
89_L97_P0.5760.82
284_Y330_A0.5750.82
194_Y279_G0.5750.82
225_P270_T0.5750.82
202_W249_I0.5750.82
296_R332_R0.5740.82
24_H28_L0.5730.82
335_S339_L0.5730.82
146_K198_D0.5720.82
233_N237_A0.5720.82
63_V74_V0.5720.82
39_Q316_E0.5710.82
78_E81_R0.5710.82
97_P134_Q0.5710.82
341_L372_A0.5700.82
90_E103_G0.5700.82
65_K358_E0.5650.81
94_G133_Y0.5630.81
69_I365_L0.5630.81
290_G330_A0.5620.81
33_P61_R0.5610.80
249_I280_L0.5600.80
317_L321_E0.5590.80
42_A86_Y0.5580.80
253_N266_A0.5570.80
228_F231_T0.5560.80
141_G179_A0.5550.80
203_S252_G0.5530.80
292_F307_L0.5520.79
85_H88_F0.5520.79
158_G162_D0.5520.79
119_T123_D0.5510.79
88_F150_P0.5500.79
86_Y104_I0.5480.79
253_N289_S0.5480.79
28_L361_Q0.5470.79
250_C283_E0.5450.79
124_F183_A0.5450.79
31_S58_E0.5450.79
24_H365_L0.5450.79
357_T360_Q0.5430.78
238_D241_D0.5430.78
124_F127_H0.5410.78
172_Y176_M0.5410.78
106_F109_T0.5390.78
325_R329_E0.5390.78
181_K237_A0.5380.78
307_L327_I0.5380.78
235_A238_D0.5380.78
99_I102_E0.5380.78
202_W252_G0.5360.77
21_R340_C0.5350.77
149_I197_L0.5350.77
81_R84_W0.5340.77
304_Q338_Q0.5330.77
55_E80_R0.5310.77
323_V368_V0.5300.77
153_N173_F0.5300.77
299_K338_Q0.5290.77
63_V67_K0.5280.76
41_K51_L0.5260.76
294_P297_F0.5240.76
124_F130_L0.5240.76
118_V172_Y0.5230.76
85_H155_L0.5220.76
64_E143_A0.5210.75
22_A369_I0.5200.75
95_V118_V0.5180.75
23_D71_L0.5160.75
59_I79_F0.5160.75
105_Q116_I0.5150.75
307_L339_L0.5150.75
83_W86_Y0.5140.74
75_T146_K0.5130.74
94_G139_I0.5120.74
126_S130_L0.5110.74
289_S329_E0.5100.74
30_R84_W0.5090.74
23_D341_L0.5080.74
88_F183_A0.5060.73
324_K367_H0.5050.73
194_Y281_F0.5050.73
104_I111_T0.5040.73
250_C346_G0.5040.73
105_Q113_A0.5030.73
38_R55_E0.5030.73
40_K54_I0.5010.73
323_V367_H0.5010.73
249_I271_I0.5000.72
24_H340_C0.5000.72
333_F339_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ypxA 1 0.8329 100 0.241 Contact Map
2nq5A 1 0.8223 100 0.309 Contact Map
1t7lA 1 0.9178 100 0.314 Contact Map
4l6hA 1 0.9019 100 0.316 Contact Map
1u1jA 1 0.8753 100 0.318 Contact Map
3rpdA 1 0.878 100 0.326 Contact Map
1j93A 2 0.8435 99.8 0.796 Contact Map
4exqA 2 0.8462 99.8 0.803 Contact Map
2ejaA 2 0.8302 99.8 0.806 Contact Map
4ay7A 1 0.8408 99.8 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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