YXJH - BACSU - GREMLIN Contacts

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YXJH - Uncharacterized protein YxjH

UniProt:	P42319	Sequences: MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAGEMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAEGIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEKADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALGGDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLNLDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFVSLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	377 (318)
Sequences:	4936 (2881)
Seq/√Len:	161.5

ECOLI - METE
BACSU - YXJH YXJG METE
HALSA - Q9HQH4
SULSO - METE Q980B0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_T	50_Q	4.812	1.00
318_E	323_V	3.458	1.00
40_K	45_E	3.382	1.00
89_L	155_L	3.292	1.00
64_E	68_E	3.110	1.00
65_K	362_W	2.996	1.00
58_E	61_R	2.900	1.00
324_K	374_D	2.852	1.00
60_T	64_E	2.809	1.00
36_E	40_K	2.679	1.00
320_P	370_D	2.671	1.00
76_D	145_P	2.517	1.00
41_K	48_A	2.492	1.00
48_A	52_R	2.474	1.00
327_I	341_L	2.447	1.00
320_P	374_D	2.434	1.00
133_Y	159_E	2.428	1.00
85_H	150_P	2.421	1.00
167_D	172_Y	2.412	1.00
168_D	171_E	2.354	1.00
93_D	123_D	2.345	1.00
319_N	322_D	2.287	1.00
181_K	238_D	2.283	1.00
63_V	145_P	2.227	1.00
53_D	57_Q	2.133	1.00
37_A	54_I	2.124	1.00
232_I	235_A	2.053	1.00
233_N	236_V	2.043	1.00
50_Q	53_D	2.034	1.00
52_R	131_G	2.023	1.00
185_K	189_D	2.018	1.00
316_E	322_D	1.978	1.00
184_I	195_L	1.975	1.00
92_L	179_A	1.967	1.00
144_T	193_R	1.934	1.00
323_V	371_I	1.933	1.00
57_Q	61_R	1.892	1.00
286_D	289_S	1.883	1.00
369_I	373_N	1.868	1.00
124_F	186_A	1.833	1.00
80_R	87_D	1.809	1.00
41_K	101_A	1.787	1.00
64_E	67_K	1.770	1.00
150_P	154_M	1.761	1.00
229_A	233_N	1.752	1.00
254_F	271_I	1.751	1.00
55_E	81_R	1.725	1.00
122_L	179_A	1.703	1.00
32_V	36_E	1.702	1.00
228_F	232_I	1.702	1.00
25_V	343_P	1.702	1.00
299_K	303_L	1.701	1.00
33_P	57_Q	1.694	1.00
95_V	155_L	1.652	1.00
197_L	236_V	1.652	1.00
335_S	338_Q	1.647	1.00
63_V	139_I	1.646	1.00
359_E	363_A	1.632	1.00
230_K	234_D	1.627	1.00
269_E	297_F	1.624	1.00
46_M	50_Q	1.594	1.00
324_K	328_N	1.570	1.00
84_W	150_P	1.566	1.00
28_L	362_W	1.562	1.00
60_T	135_F	1.554	1.00
232_I	236_V	1.542	1.00
33_P	58_E	1.536	1.00
131_G	134_Q	1.530	1.00
174_H	234_D	1.512	1.00
57_Q	60_T	1.503	1.00
226_A	230_K	1.502	1.00
331_A	339_L	1.501	1.00
343_P	368_V	1.497	1.00
174_H	231_T	1.482	1.00
73_V	146_K	1.447	1.00
334_V	338_Q	1.443	1.00
234_D	237_A	1.434	1.00
307_L	330_A	1.429	1.00
133_Y	192_C	1.425	1.00
280_L	303_L	1.425	1.00
296_R	333_F	1.424	1.00
93_D	125_T	1.413	1.00
184_I	197_L	1.400	1.00
121_K	175_D	1.393	1.00
310_I	318_E	1.382	1.00
320_P	371_I	1.381	1.00
186_A	189_D	1.370	1.00
321_E	325_R	1.368	1.00
60_T	139_I	1.368	1.00
320_P	367_H	1.363	1.00
40_K	46_M	1.361	1.00
65_K	68_E	1.358	1.00
37_A	46_M	1.356	1.00
229_A	232_I	1.355	1.00
233_N	276_N	1.352	1.00
360_Q	363_A	1.338	1.00
302_D	338_Q	1.326	1.00
334_V	339_L	1.326	1.00
58_E	62_I	1.326	1.00
193_R	244_T	1.318	1.00
96_E	117_K	1.315	1.00
194_Y	246_T	1.313	1.00
163_K	167_D	1.311	1.00
69_I	366_R	1.306	1.00
246_T	279_G	1.295	1.00
53_D	56_N	1.292	1.00
324_K	371_I	1.289	1.00
328_N	332_R	1.288	1.00
52_R	132_D	1.272	1.00
175_D	178_Q	1.269	1.00
320_P	324_K	1.264	1.00
362_W	366_R	1.256	1.00
67_K	143_A	1.247	1.00
28_L	65_K	1.239	1.00
25_V	75_T	1.226	1.00
91_G	128_P	1.226	1.00
39_Q	43_A	1.223	1.00
117_K	160_K	1.222	1.00
170_E	174_H	1.212	1.00
304_Q	340_C	1.210	1.00
149_I	183_A	1.187	1.00
173_F	227_I	1.184	1.00
195_L	243_L	1.184	1.00
68_E	366_R	1.174	1.00
106_F	116_I	1.172	1.00
370_D	373_N	1.170	1.00
363_A	366_R	1.169	1.00
186_A	190_A	1.168	1.00
54_I	57_Q	1.165	1.00
88_F	92_L	1.160	1.00
250_C	345_C	1.156	1.00
61_R	65_K	1.152	1.00
94_G	155_L	1.127	1.00
185_K	239_R	1.126	1.00
298_V	303_L	1.123	1.00
167_D	171_E	1.115	1.00
341_L	368_V	1.114	1.00
28_L	62_I	1.110	1.00
71_L	365_L	1.106	1.00
310_I	368_V	1.098	1.00
306_V	342_S	1.095	1.00
271_I	280_L	1.094	1.00
49_E	53_D	1.080	0.99
154_M	201_S	1.071	0.99
279_G	304_Q	1.070	0.99
309_L	327_I	1.070	0.99
306_V	340_C	1.067	0.99
135_F	139_I	1.062	0.99
310_I	323_V	1.056	0.99
52_R	81_R	1.051	0.99
52_R	56_N	1.028	0.99
89_L	116_I	1.021	0.99
75_T	148_T	1.020	0.99
123_D	286_D	1.011	0.99
331_A	336_L	1.011	0.99
185_K	238_D	1.009	0.99
181_K	185_K	1.007	0.99
116_I	129_A	1.001	0.99
173_F	231_T	0.999	0.99
183_A	187_F	0.995	0.99
326_R	329_E	0.992	0.99
366_R	370_D	0.988	0.99
148_T	198_D	0.987	0.99
123_D	182_K	0.986	0.99
96_E	119_T	0.984	0.99
124_F	182_K	0.982	0.99
65_K	69_I	0.979	0.99
179_A	182_K	0.976	0.99
180_Y	200_T	0.975	0.99
200_T	275_L	0.973	0.99
188_Y	243_L	0.968	0.99
24_H	146_K	0.968	0.99
63_V	136_L	0.965	0.99
95_V	106_F	0.964	0.99
228_F	233_N	0.963	0.99
54_I	58_E	0.962	0.99
291_N	294_P	0.960	0.99
188_Y	240_P	0.957	0.99
41_K	46_M	0.957	0.99
328_N	331_A	0.954	0.99
170_E	230_K	0.954	0.99
248_H	281_F	0.952	0.99
151_S	199_D	0.951	0.99
203_S	249_I	0.947	0.99
309_L	323_V	0.946	0.99
135_F	138_E	0.943	0.99
247_M	271_I	0.933	0.98
330_A	339_L	0.925	0.98
177_A	181_K	0.924	0.98
255_R	294_P	0.920	0.98
229_A	235_A	0.919	0.98
237_A	276_N	0.917	0.98
156_F	173_F	0.917	0.98
56_N	80_R	0.906	0.98
231_T	235_A	0.905	0.98
34_V	79_F	0.891	0.98
67_K	141_G	0.889	0.98
289_S	326_R	0.886	0.98
272_L	302_D	0.884	0.98
201_S	204_L	0.878	0.98
62_I	79_F	0.878	0.98
329_E	332_R	0.876	0.98
321_E	324_K	0.874	0.98
156_F	228_F	0.873	0.98
82_S	112_K	0.871	0.98
72_D	372_A	0.870	0.98
247_M	277_L	0.867	0.98
26_G	248_H	0.867	0.98
269_E	273_D	0.866	0.98
34_V	55_E	0.865	0.97
174_H	230_K	0.864	0.97
86_Y	114_R	0.863	0.97
92_L	183_A	0.860	0.97
183_A	186_A	0.857	0.97
157_F	204_L	0.851	0.97
153_N	206_F	0.851	0.97
326_R	330_A	0.851	0.97
177_A	235_A	0.847	0.97
226_A	270_T	0.846	0.97
287_D	290_G	0.844	0.97
134_Q	137_H	0.843	0.97
133_Y	172_Y	0.842	0.97
192_C	195_L	0.841	0.97
161_A	167_D	0.841	0.97
172_Y	175_D	0.840	0.97
157_F	201_S	0.838	0.97
74_V	143_A	0.837	0.97
236_V	239_R	0.833	0.97
154_M	200_T	0.829	0.97
146_K	340_C	0.829	0.97
50_Q	54_I	0.829	0.97
73_V	340_C	0.822	0.97
48_A	101_A	0.820	0.97
322_D	325_R	0.817	0.96
70_G	143_A	0.814	0.96
25_V	365_L	0.810	0.96
98_F	102_E	0.810	0.96
193_R	242_D	0.810	0.96
161_A	172_Y	0.805	0.96
298_V	305_I	0.802	0.96
323_V	326_R	0.800	0.96
178_Q	234_D	0.798	0.96
291_N	295_L	0.794	0.96
170_E	227_I	0.792	0.96
66_Q	365_L	0.792	0.96
37_A	55_E	0.791	0.96
177_A	234_D	0.785	0.96
188_Y	242_D	0.785	0.96
100_P	103_G	0.783	0.95
284_Y	307_L	0.780	0.95
286_D	311_T	0.779	0.95
178_Q	182_K	0.777	0.95
368_V	372_A	0.776	0.95
181_K	235_A	0.772	0.95
236_V	240_P	0.769	0.95
161_A	169_Q	0.768	0.95
56_N	131_G	0.767	0.95
126_S	131_G	0.764	0.95
228_F	235_A	0.758	0.95
267_V	271_I	0.757	0.95
110_K	113_A	0.756	0.95
127_H	186_A	0.751	0.94
146_K	196_Q	0.750	0.94
62_I	65_K	0.750	0.94
102_E	106_F	0.747	0.94
202_W	247_M	0.744	0.94
92_L	176_M	0.744	0.94
292_F	329_E	0.743	0.94
272_L	297_F	0.742	0.94
370_D	374_D	0.737	0.94
185_K	188_Y	0.736	0.94
80_R	103_G	0.735	0.94
174_H	178_Q	0.730	0.93
317_L	357_T	0.730	0.93
113_A	116_I	0.730	0.93
73_V	194_Y	0.728	0.93
56_N	59_I	0.728	0.93
130_L	190_A	0.727	0.93
280_L	305_I	0.727	0.93
276_N	303_L	0.726	0.93
69_I	369_I	0.725	0.93
367_H	371_I	0.725	0.93
68_E	362_W	0.723	0.93
67_K	140_A	0.719	0.93
182_K	185_K	0.709	0.92
293_D	296_R	0.705	0.92
227_I	232_I	0.702	0.92
272_L	303_L	0.702	0.92
311_T	314_Y	0.697	0.92
366_R	369_I	0.695	0.92
28_L	365_L	0.693	0.92
25_V	342_S	0.692	0.92
56_N	135_F	0.689	0.91
169_Q	173_F	0.686	0.91
268_A	298_V	0.686	0.91
118_V	122_L	0.685	0.91
51_L	55_E	0.683	0.91
268_A	294_P	0.682	0.91
62_I	66_Q	0.680	0.91
40_K	50_Q	0.679	0.91
93_D	126_S	0.679	0.91
29_L	361_Q	0.679	0.91
61_R	358_E	0.677	0.91
231_T	236_V	0.673	0.90
88_F	91_G	0.672	0.90
127_H	130_L	0.672	0.90
157_F	200_T	0.670	0.90
23_D	372_A	0.669	0.90
102_E	105_Q	0.668	0.90
130_L	183_A	0.667	0.90
343_P	365_L	0.665	0.90
249_I	254_F	0.663	0.90
60_T	63_V	0.662	0.90
159_E	162_D	0.662	0.90
270_T	273_D	0.662	0.90
46_M	54_I	0.661	0.90
244_T	278_D	0.656	0.89
154_M	157_F	0.651	0.89
239_R	278_D	0.651	0.89
55_E	59_I	0.651	0.89
240_P	243_L	0.650	0.89
36_E	39_Q	0.649	0.89
295_L	330_A	0.647	0.89
120_G	125_T	0.646	0.89
138_E	175_D	0.644	0.88
39_Q	42_A	0.643	0.88
201_S	229_A	0.642	0.88
310_I	364_K	0.641	0.88
153_N	201_S	0.640	0.88
69_I	362_W	0.640	0.88
187_F	190_A	0.639	0.88
296_R	329_E	0.637	0.88
146_K	194_Y	0.635	0.88
77_G	145_P	0.634	0.88
71_L	74_V	0.632	0.87
284_Y	291_N	0.630	0.87
52_R	55_E	0.629	0.87
35_K	39_Q	0.629	0.87
289_S	293_D	0.628	0.87
157_F	207_E	0.628	0.87
100_P	104_I	0.627	0.87
157_F	169_Q	0.627	0.87
153_N	228_F	0.627	0.87
70_G	369_I	0.627	0.87
49_E	52_R	0.625	0.87
357_T	363_A	0.622	0.87
70_G	373_N	0.621	0.87
323_V	341_L	0.621	0.87
71_L	369_I	0.621	0.87
171_E	174_H	0.621	0.87
253_N	290_G	0.620	0.86
198_D	345_C	0.619	0.86
90_E	98_F	0.616	0.86
74_V	145_P	0.616	0.86
123_D	126_S	0.616	0.86
292_F	295_L	0.615	0.86
251_R	346_G	0.614	0.86
105_Q	110_K	0.614	0.86
281_F	342_S	0.613	0.86
279_G	340_C	0.611	0.86
281_F	306_V	0.610	0.86
164_G	167_D	0.608	0.85
357_T	361_Q	0.607	0.85
24_H	73_V	0.607	0.85
34_V	54_I	0.606	0.85
24_H	71_L	0.604	0.85
244_T	304_Q	0.604	0.85
268_A	272_L	0.601	0.85
194_Y	244_T	0.600	0.85
365_L	369_I	0.598	0.84
56_N	60_T	0.597	0.84
75_T	147_L	0.595	0.84
133_Y	137_H	0.593	0.84
152_P	197_L	0.591	0.84
89_L	94_G	0.591	0.84
327_I	371_I	0.590	0.84
48_A	98_F	0.590	0.84
34_V	58_E	0.587	0.83
174_H	177_A	0.584	0.83
136_L	140_A	0.584	0.83
319_N	371_I	0.583	0.83
157_F	206_F	0.582	0.83
198_D	248_H	0.580	0.83
315_G	355_L	0.580	0.83
229_A	270_T	0.577	0.82
32_V	39_Q	0.577	0.82
89_L	97_P	0.576	0.82
284_Y	330_A	0.575	0.82
194_Y	279_G	0.575	0.82
225_P	270_T	0.575	0.82
202_W	249_I	0.575	0.82
296_R	332_R	0.574	0.82
24_H	28_L	0.573	0.82
335_S	339_L	0.573	0.82
146_K	198_D	0.572	0.82
233_N	237_A	0.572	0.82
63_V	74_V	0.572	0.82
39_Q	316_E	0.571	0.82
78_E	81_R	0.571	0.82
97_P	134_Q	0.571	0.82
341_L	372_A	0.570	0.82
90_E	103_G	0.570	0.82
65_K	358_E	0.565	0.81
94_G	133_Y	0.563	0.81
69_I	365_L	0.563	0.81
290_G	330_A	0.562	0.81
33_P	61_R	0.561	0.80
249_I	280_L	0.560	0.80
317_L	321_E	0.559	0.80
42_A	86_Y	0.558	0.80
253_N	266_A	0.557	0.80
228_F	231_T	0.556	0.80
141_G	179_A	0.555	0.80
203_S	252_G	0.553	0.80
292_F	307_L	0.552	0.79
85_H	88_F	0.552	0.79
158_G	162_D	0.552	0.79
119_T	123_D	0.551	0.79
88_F	150_P	0.550	0.79
86_Y	104_I	0.548	0.79
253_N	289_S	0.548	0.79
28_L	361_Q	0.547	0.79
250_C	283_E	0.545	0.79
124_F	183_A	0.545	0.79
31_S	58_E	0.545	0.79
24_H	365_L	0.545	0.79
357_T	360_Q	0.543	0.78
238_D	241_D	0.543	0.78
124_F	127_H	0.541	0.78
172_Y	176_M	0.541	0.78
106_F	109_T	0.539	0.78
325_R	329_E	0.539	0.78
181_K	237_A	0.538	0.78
307_L	327_I	0.538	0.78
235_A	238_D	0.538	0.78
99_I	102_E	0.538	0.78
202_W	252_G	0.536	0.77
21_R	340_C	0.535	0.77
149_I	197_L	0.535	0.77
81_R	84_W	0.534	0.77
304_Q	338_Q	0.533	0.77
55_E	80_R	0.531	0.77
323_V	368_V	0.530	0.77
153_N	173_F	0.530	0.77
299_K	338_Q	0.529	0.77
63_V	67_K	0.528	0.76
41_K	51_L	0.526	0.76
294_P	297_F	0.524	0.76
124_F	130_L	0.524	0.76
118_V	172_Y	0.523	0.76
85_H	155_L	0.522	0.76
64_E	143_A	0.521	0.75
22_A	369_I	0.520	0.75
95_V	118_V	0.518	0.75
23_D	71_L	0.516	0.75
59_I	79_F	0.516	0.75
105_Q	116_I	0.515	0.75
307_L	339_L	0.515	0.75
83_W	86_Y	0.514	0.74
75_T	146_K	0.513	0.74
94_G	139_I	0.512	0.74
126_S	130_L	0.511	0.74
289_S	329_E	0.510	0.74
30_R	84_W	0.509	0.74
23_D	341_L	0.508	0.74
88_F	183_A	0.506	0.73
324_K	367_H	0.505	0.73
194_Y	281_F	0.505	0.73
104_I	111_T	0.504	0.73
250_C	346_G	0.504	0.73
105_Q	113_A	0.503	0.73
38_R	55_E	0.503	0.73
40_K	54_I	0.501	0.73
323_V	367_H	0.501	0.73
249_I	271_I	0.500	0.72
24_H	340_C	0.500	0.72
333_F	339_L	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ypxA	1	0.8329	100	0.241	Contact Map
2nq5A	1	0.8223	100	0.309	Contact Map
1t7lA	1	0.9178	100	0.314	Contact Map
4l6hA	1	0.9019	100	0.316	Contact Map
1u1jA	1	0.8753	100	0.318	Contact Map
3rpdA	1	0.878	100	0.326	Contact Map
1j93A	2	0.8435	99.8	0.796	Contact Map
4exqA	2	0.8462	99.8	0.803	Contact Map
2ejaA	2	0.8302	99.8	0.806	Contact Map
4ay7A	1	0.8408	99.8	0.811	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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