GREMLIN Database
YXJG - Uncharacterized protein YxjG
UniProt: P42318 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (317)
Sequences: 4931 (2870)
Seq/√Len: 161.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_T50_Q4.9541.00
319_E324_V3.5031.00
40_Q45_E3.4481.00
89_L155_L3.4021.00
64_E68_E3.1511.00
65_K363_W3.0691.00
325_K375_D2.9531.00
58_E61_R2.9451.00
60_I64_E2.8591.00
133_Y159_G2.8201.00
321_P371_E2.7451.00
36_K40_Q2.7081.00
76_D145_P2.5631.00
41_K48_A2.5181.00
48_A52_R2.5121.00
85_H150_P2.5091.00
328_I342_L2.4921.00
321_P375_D2.4841.00
165_E172_L2.3621.00
63_V145_P2.3551.00
93_D123_D2.3491.00
320_N323_D2.3221.00
182_K239_D2.2951.00
53_Q57_D2.1871.00
234_N237_I2.1421.00
37_A54_I2.1411.00
50_Q53_Q2.1221.00
52_R131_E2.0761.00
317_E323_D2.0531.00
186_Q190_D2.0441.00
185_I196_L2.0091.00
92_L180_A2.0031.00
57_D61_R1.9681.00
233_I236_A1.9441.00
144_T194_R1.9271.00
324_V372_I1.9201.00
287_D290_S1.9031.00
124_F187_A1.8991.00
370_V374_N1.8901.00
255_F272_I1.8441.00
80_R87_D1.8151.00
300_K304_L1.8121.00
150_P154_M1.8091.00
64_E67_K1.8091.00
230_A234_N1.7621.00
33_P57_D1.7581.00
25_V344_P1.7541.00
32_E36_K1.7251.00
270_E298_Y1.7081.00
55_E81_R1.7071.00
41_K101_E1.6981.00
95_V155_L1.6871.00
360_E364_A1.6661.00
122_I180_A1.6611.00
198_L237_I1.6551.00
63_V139_I1.6471.00
46_M50_Q1.6301.00
231_K235_D1.6111.00
28_L363_W1.6111.00
336_S339_Q1.6091.00
229_F233_I1.5901.00
325_K329_E1.5821.00
84_W150_P1.5701.00
344_P369_V1.5611.00
227_Q231_K1.5481.00
33_P58_E1.5441.00
230_A233_I1.5441.00
332_S340_L1.5271.00
60_I135_F1.5021.00
131_E134_S1.5001.00
281_L304_L1.4991.00
235_D238_A1.4931.00
335_V339_Q1.4691.00
175_H232_S1.4671.00
133_Y193_C1.4671.00
73_V146_K1.4531.00
57_D60_I1.4521.00
308_L331_A1.4491.00
233_I237_I1.4461.00
175_H235_D1.4451.00
185_I198_L1.4381.00
93_D125_S1.4301.00
65_K68_E1.4211.00
40_Q46_M1.4071.00
187_A190_D1.3961.00
311_V319_E1.3821.00
322_D326_R1.3741.00
96_E117_K1.3671.00
321_P372_I1.3621.00
321_P368_H1.3601.00
297_R334_Y1.3591.00
58_E62_I1.3581.00
37_A46_M1.3501.00
335_V340_L1.3461.00
60_I139_I1.3361.00
121_D176_D1.3351.00
194_R245_T1.3331.00
361_Q364_A1.3321.00
195_Y247_T1.3291.00
329_E333_R1.3231.00
53_Q56_N1.3171.00
69_T367_R1.3161.00
234_N277_N1.3061.00
67_K143_A1.3031.00
176_D179_K1.2811.00
325_K372_I1.2791.00
247_T280_G1.2681.00
299_V304_L1.2471.00
117_K160_K1.2441.00
170_Y175_H1.2411.00
363_W367_R1.2411.00
106_F116_I1.2401.00
52_R132_D1.2361.00
321_P325_K1.2351.00
28_L65_K1.2341.00
25_V75_T1.2271.00
68_E367_R1.2171.00
149_I184_A1.2101.00
305_Q341_C1.2081.00
91_N128_P1.2061.00
39_L43_A1.2051.00
116_I129_M1.2021.00
88_F92_L1.1971.00
54_I57_D1.1951.00
187_A191_R1.1891.00
251_C346_C1.1871.00
371_E374_N1.1861.00
173_F228_L1.1641.00
49_E53_Q1.1471.00
186_Q240_R1.1451.00
364_A367_R1.1381.00
272_I281_L1.1361.00
52_R81_R1.1341.00
311_V369_V1.1311.00
61_R65_K1.1231.00
28_L62_I1.1221.00
307_V343_S1.1191.00
342_L369_V1.1061.00
94_G155_L1.0991.00
71_L366_L1.0840.99
307_V341_C1.0760.99
154_M202_A1.0610.99
201_T276_L1.0590.99
89_L116_I1.0520.99
280_G305_Q1.0520.99
52_R56_N1.0520.99
310_L328_I1.0460.99
95_V106_F1.0460.99
311_V324_V1.0320.99
123_D287_D1.0240.99
123_D183_K1.0240.99
75_T148_T1.0230.99
135_F139_I1.0180.99
96_E119_T1.0180.99
181_Y201_T1.0140.99
65_K69_T1.0120.99
184_A188_F1.0110.99
327_R330_E1.0090.99
332_S337_L1.0050.99
367_R371_E0.9990.99
182_K186_Q0.9980.99
180_A183_K0.9930.99
196_L244_L0.9910.99
186_Q239_D0.9890.99
292_G295_P0.9880.99
148_T199_D0.9810.99
238_A277_N0.9780.99
290_S327_R0.9770.99
230_A236_A0.9740.99
204_A250_I0.9660.99
24_Q146_K0.9630.99
249_H282_F0.9610.99
310_L324_V0.9610.99
151_S200_D0.9560.99
41_K46_M0.9550.99
329_E332_S0.9550.99
54_I58_E0.9460.99
161_L165_E0.9400.99
173_F232_S0.9370.98
331_A340_L0.9360.98
34_V79_F0.9350.98
189_Y241_P0.9340.98
92_L184_A0.9340.98
189_Y244_L0.9330.98
124_F183_K0.9300.98
248_M278_L0.9280.98
178_S182_K0.9200.98
248_M272_I0.9200.98
153_N207_L0.9060.98
330_E333_R0.9000.98
156_F229_F0.8990.98
229_F234_N0.8980.98
56_N80_R0.8920.98
156_F173_F0.8910.98
98_F102_Q0.8900.98
232_S236_A0.8860.98
63_V136_L0.8850.98
157_F202_A0.8830.98
135_F138_S0.8780.98
133_Y172_L0.8760.98
237_I240_R0.8740.98
228_L233_I0.8700.98
82_A112_K0.8700.98
322_D325_K0.8680.98
163_K166_Y0.8660.97
227_Q271_T0.8570.97
327_R331_A0.8560.97
159_G162_E0.8560.97
172_L176_D0.8560.97
62_I79_F0.8540.97
72_N373_A0.8520.97
34_V55_E0.8520.97
256_Q295_P0.8520.97
170_Y231_K0.8510.97
202_A205_V0.8500.97
184_A187_A0.8480.97
154_M201_T0.8460.97
48_A101_E0.8390.97
86_F114_R0.8390.97
371_E375_D0.8390.97
26_G249_H0.8380.97
287_D312_T0.8350.97
182_K236_A0.8330.97
25_V366_L0.8300.97
323_D326_R0.8290.97
157_F205_V0.8290.97
193_C196_L0.8280.97
178_S236_A0.8270.97
146_K341_C0.8220.97
37_A55_E0.8220.97
161_L169_D0.8150.96
74_V143_A0.8130.96
178_S235_D0.8130.96
66_Q366_L0.8120.96
50_Q54_I0.8080.96
231_K275_G0.8070.96
175_H231_K0.8070.96
285_Y308_L0.8060.96
227_Q275_G0.8040.96
169_D173_F0.8030.96
179_K235_D0.8020.96
291_G294_E0.8010.96
100_P103_G0.7990.96
324_V327_R0.7970.96
48_A98_F0.7960.96
194_R243_D0.7940.96
92_L177_V0.7900.96
270_E275_G0.7890.96
288_S291_G0.7860.96
268_A272_I0.7830.95
70_G143_A0.7810.95
294_E297_R0.7760.95
186_Q189_Y0.7750.95
73_V341_C0.7750.95
292_G296_L0.7690.95
189_Y243_D0.7680.95
113_A116_I0.7650.95
56_N131_E0.7610.95
179_K183_K0.7610.95
170_Y228_L0.7590.95
62_I65_K0.7570.95
299_V306_L0.7530.94
118_V122_I0.7530.94
56_N59_I0.7510.94
369_V373_A0.7480.94
203_W248_M0.7420.94
134_S137_H0.7410.94
183_K186_Q0.7390.94
318_L358_T0.7350.94
126_T131_E0.7340.94
175_H179_K0.7320.94
89_L98_F0.7300.93
25_V343_S0.7270.93
109_V112_K0.7270.93
146_K197_Q0.7260.93
127_H187_A0.7230.93
73_V195_Y0.7230.93
28_L366_L0.7210.93
297_R330_E0.7200.93
157_F169_D0.7200.93
237_I241_P0.7190.93
51_L55_E0.7190.93
368_H372_I0.7120.93
232_S237_I0.7110.93
154_M157_F0.7100.92
300_K339_Q0.7050.92
69_T370_V0.7050.92
138_S176_D0.7040.92
367_R370_V0.7010.92
102_Q105_Q0.6970.92
277_N304_L0.6930.92
60_I63_V0.6860.91
281_L306_L0.6830.91
285_Y292_G0.6820.91
68_E363_W0.6820.91
130_L184_A0.6820.91
29_L362_Q0.6800.91
62_I66_Q0.6770.91
293_F330_E0.6760.91
312_T315_F0.6750.90
157_F208_S0.6740.90
80_R103_G0.6740.90
161_L172_L0.6720.90
40_Q50_Q0.6720.90
130_L191_R0.6680.90
250_I255_F0.6680.90
254_N291_G0.6680.90
46_M54_I0.6660.90
234_N238_A0.6650.90
344_P366_L0.6630.90
88_F91_N0.6610.90
120_G125_S0.6600.89
61_R359_E0.6590.89
55_E59_I0.6580.89
324_V342_L0.6550.89
358_T361_Q0.6520.89
89_L159_G0.6520.89
77_G145_P0.6500.89
93_D126_T0.6500.89
166_Y171_Q0.6490.89
240_R279_D0.6460.88
39_L42_A0.6430.88
311_V365_K0.6410.88
133_Y137_H0.6390.88
297_R333_R0.6390.88
202_A230_A0.6360.88
269_A299_V0.6350.88
157_F207_L0.6300.87
188_F191_R0.6290.87
245_T279_D0.6290.87
199_D346_C0.6290.87
71_L370_V0.6270.87
157_F201_T0.6270.87
241_P244_L0.6260.87
67_K140_A0.6260.87
153_N202_A0.6250.87
71_L74_V0.6240.87
110_Q113_A0.6210.86
269_A295_P0.6200.86
166_Y172_L0.6200.86
239_D242_D0.6190.86
74_V145_P0.6190.86
146_K195_Y0.6180.86
282_F307_V0.6180.86
75_T147_M0.6170.86
34_V54_I0.6170.86
271_T275_G0.6160.86
280_G341_C0.6120.86
161_L166_Y0.6120.86
252_R347_G0.6100.85
358_T362_Q0.6090.85
89_L94_G0.6070.85
358_T364_A0.6070.85
70_G370_V0.6050.85
282_F343_S0.6030.85
56_N135_F0.6020.85
52_R55_E0.6010.85
254_N267_A0.6010.85
229_F236_A0.6000.85
94_G133_Y0.5970.84
171_Q175_H0.5970.84
165_E171_Q0.5970.84
86_F104_I0.5960.84
90_E98_F0.5930.84
195_Y245_T0.5910.84
152_P198_L0.5910.84
24_Q73_V0.5910.84
34_V58_E0.5900.84
99_T104_I0.5900.84
69_T363_W0.5860.83
100_P104_I0.5830.83
35_K39_L0.5820.83
23_D373_A0.5800.83
366_L370_V0.5800.83
285_Y331_A0.5790.82
195_Y280_G0.5780.82
39_L317_E0.5770.82
250_I281_L0.5760.82
245_T305_Q0.5760.82
146_K199_D0.5750.82
305_Q339_Q0.5740.82
203_W250_I0.5740.82
24_Q71_L0.5730.82
153_N173_F0.5720.82
199_D249_H0.5710.82
328_I372_I0.5690.81
336_S340_L0.5690.81
21_R341_C0.5690.81
105_Q110_Q0.5670.81
175_H178_S0.5660.81
155_L159_G0.5650.81
85_H88_F0.5620.81
49_E52_R0.5620.81
291_G331_A0.5600.80
251_C284_E0.5590.80
24_Q28_L0.5570.80
69_T366_L0.5560.80
296_L331_A0.5560.80
78_E81_R0.5550.80
295_P298_Y0.5550.80
270_E274_D0.5550.80
226_R271_T0.5550.80
36_K39_L0.5530.79
316_G356_K0.5530.79
32_E39_L0.5530.79
56_N60_I0.5510.79
99_T102_Q0.5510.79
102_Q106_F0.5500.79
153_N229_F0.5490.79
28_L362_Q0.5480.79
70_G374_N0.5450.78
149_I198_L0.5440.78
75_T146_K0.5420.78
103_G107_H0.5420.78
182_K238_A0.5410.78
188_F196_L0.5400.78
22_A370_V0.5390.78
301_R304_L0.5370.77
318_L322_D0.5370.77
153_N233_I0.5360.77
90_E97_P0.5360.77
293_F296_L0.5350.77
151_S154_M0.5350.77
226_R230_A0.5350.77
98_F113_A0.5340.77
104_I107_H0.5340.77
326_R330_E0.5330.77
24_Q366_L0.5330.77
97_P134_S0.5330.77
55_E80_R0.5330.77
40_Q54_I0.5320.77
229_F232_S0.5310.77
63_V67_K0.5310.77
119_T123_D0.5310.77
88_F150_P0.5300.77
85_H155_L0.5300.77
106_F110_Q0.5300.77
63_V74_V0.5300.77
124_F184_A0.5290.76
320_N372_I0.5290.76
127_H130_L0.5280.76
324_V369_V0.5270.76
136_L139_I0.5260.76
129_M132_D0.5260.76
31_S58_E0.5250.76
65_K359_E0.5240.76
42_A86_F0.5230.76
162_E165_E0.5230.76
255_F283_L0.5220.75
254_N295_P0.5210.75
90_E103_G0.5210.75
204_A253_G0.5200.75
41_K51_L0.5200.75
236_A239_D0.5200.75
203_W253_G0.5200.75
94_G139_I0.5190.75
124_F130_L0.5190.75
88_F184_A0.5180.75
119_T160_K0.5180.75
293_F327_R0.5170.75
34_V39_L0.5170.75
172_L177_V0.5150.75
274_D338_D0.5150.75
33_P61_R0.5130.74
124_F127_H0.5120.74
104_I158_R0.5120.74
189_Y196_L0.5100.74
81_R84_W0.5090.74
251_C347_G0.5070.73
136_L140_A0.5060.73
83_W86_F0.5050.73
137_H142_D0.5050.73
274_D304_L0.5020.73
81_R283_L0.5010.73
177_V205_V0.5000.72
166_Y170_Y0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ypxA 1 0.8333 100 0.233 Contact Map
1t7lA 1 0.9127 100 0.302 Contact Map
2nq5A 1 0.8201 100 0.304 Contact Map
4l6hA 1 0.8995 100 0.311 Contact Map
1u1jA 1 0.8757 100 0.313 Contact Map
3rpdA 1 0.8757 100 0.324 Contact Map
1j93A 2 0.836 99.8 0.798 Contact Map
2ejaA 2 0.8333 99.8 0.802 Contact Map
4exqA 2 0.8466 99.8 0.804 Contact Map
4ay7A 1 0.8386 99.8 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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