GREMLIN Database
SCOB - Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit B
UniProt: P42316 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (207)
Sequences: 3148 (1441)
Seq/√Len: 100.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_S112_D4.0731.00
147_N151_E3.5691.00
197_E201_E3.2681.00
178_F207_F3.2211.00
84_D87_E3.2001.00
156_K204_E3.0971.00
170_R179_D3.0331.00
181_V184_R2.8791.00
190_L199_V2.6381.00
181_V186_T2.5761.00
109_E156_K2.5631.00
179_D188_T2.5621.00
190_L196_I2.5321.00
175_L202_K2.4111.00
187_L209_V2.3901.00
154_V185_M2.3761.00
76_E80_A2.3741.00
180_F185_M2.3741.00
196_I209_V2.3361.00
11_R189_E2.3171.00
198_E202_K2.2871.00
58_L61_T2.2341.00
17_K20_M2.1111.00
50_L76_E2.0651.00
12_A142_I2.0361.00
56_Y72_E1.8951.00
109_E206_D1.8931.00
110_Q157_T1.8891.00
76_E82_Y1.8791.00
195_T198_E1.8201.00
187_L196_I1.8081.00
186_T210_S1.7961.00
12_A101_I1.7611.00
8_M142_I1.7511.00
198_E201_E1.7491.00
175_L194_V1.7351.00
45_Q92_I1.7131.00
171_L180_F1.7111.00
158_C162_L1.7101.00
196_I200_Y1.7081.00
200_Y207_F1.7061.00
186_T208_A1.6961.00
20_M99_L1.6961.00
32_V101_I1.6571.00
12_A172_I1.6541.00
191_Q194_V1.6401.00
184_R208_A1.6231.00
6_K35_E1.6171.00
152_S204_E1.5601.00
188_T210_S1.5581.00
145_H203_T1.5411.00
16_I32_V1.5061.00
58_L62_E1.4961.00
156_K206_D1.4921.00
93_R131_D1.4861.00
200_Y206_D1.4751.00
106_E156_K1.4411.00
104_G143_M1.4311.00
106_E159_S1.4221.00
154_V171_L1.4161.00
170_R188_T1.3870.99
138_R168_V1.3710.99
106_E152_S1.3410.99
4_A7_R1.3090.99
15_E172_I1.3080.99
15_E170_R1.2900.99
171_L185_M1.2890.99
98_D137_K1.2840.99
203_T207_F1.2720.99
183_G208_A1.2630.99
18_D40_V1.2280.99
16_I22_V1.2250.99
106_E160_L1.2160.99
50_L53_I1.2110.99
176_A199_V1.2040.99
146_V202_K1.1960.98
197_E200_Y1.1940.98
179_D186_T1.1910.98
99_L140_V1.1880.98
140_V172_I1.1700.98
46_S50_L1.1410.98
190_L194_V1.1120.98
5_R31_L1.1010.97
106_E155_K1.0860.97
109_E153_K1.0850.97
104_G113_L1.0840.97
28_M142_I1.0740.97
138_R170_R1.0680.97
146_V174_D1.0500.97
177_V189_E1.0450.96
99_L138_R1.0410.96
178_F200_Y1.0360.96
18_D41_H1.0310.96
187_L199_V1.0260.96
51_L83_F1.0180.96
180_F184_R1.0060.96
194_V198_E0.9990.95
68_N72_E0.9980.95
153_K204_E0.9790.95
59_E62_E0.9770.95
7_R10_K0.9770.95
5_R144_E0.9730.95
33_A36_I0.9700.95
116_W119_P0.9600.94
91_M97_I0.9510.94
142_I172_I0.9480.94
140_V170_R0.9480.94
36_I44_L0.9460.94
187_L207_F0.9410.94
110_Q166_K0.9360.94
175_L198_E0.9350.94
54_G75_T0.9280.93
16_I42_V0.9260.93
5_R28_M0.9260.93
11_R177_V0.9160.93
55_P77_V0.9090.93
101_I142_I0.9080.92
18_D39_G0.9050.92
9_V32_V0.8980.92
185_M205_A0.8980.92
156_K205_A0.8930.92
37_P40_V0.8900.92
16_I101_I0.8810.91
133_V164_G0.8720.91
57_P75_T0.8650.91
29_P103_G0.8560.90
54_G57_P0.8540.90
183_G210_S0.8470.90
155_K159_S0.8470.90
146_V149_H0.8430.89
145_H175_L0.8410.89
117_M123_V0.8390.89
15_E138_R0.8380.89
26_I48_N0.8340.89
7_R192_D0.8320.89
196_I207_F0.8310.89
33_A56_Y0.8270.89
16_I99_L0.8230.88
12_A32_V0.8190.88
181_V208_A0.8090.87
178_F209_V0.8050.87
29_P48_N0.8010.87
101_I172_I0.8000.87
104_G107_V0.7920.86
83_F88_S0.7890.86
118_I121_K0.7870.86
109_E205_A0.7860.86
183_G186_T0.7850.86
168_V179_D0.7840.86
194_V199_V0.7770.85
50_L82_Y0.7740.85
21_N91_M0.7720.85
11_R15_E0.7610.84
200_Y208_A0.7520.83
10_K14_Q0.7520.83
149_H152_S0.7500.83
73_T124_K0.7500.83
10_K35_E0.7490.83
105_M119_P0.7480.83
162_L165_Q0.7460.83
200_Y209_V0.7450.83
28_M144_E0.7430.83
12_A140_V0.7420.82
164_G167_V0.7420.82
175_L203_T0.7390.82
6_K31_L0.7340.82
133_V167_V0.7260.81
175_L199_V0.7240.81
6_K10_K0.7180.80
146_V152_S0.7170.80
171_L178_F0.7050.79
156_K159_S0.6990.79
15_E140_V0.6980.78
106_E147_N0.6970.78
185_M207_F0.6950.78
28_M31_L0.6940.78
155_K204_E0.6910.78
138_R169_H0.6910.78
178_F185_M0.6890.78
190_L195_T0.6810.77
152_S205_A0.6810.77
108_S157_T0.6800.77
50_L80_A0.6770.76
50_L74_I0.6730.76
181_V210_S0.6640.75
122_M160_L0.6620.75
7_R191_Q0.6590.74
47_E89_F0.6510.73
191_Q199_V0.6490.73
9_V28_M0.6490.73
36_I40_V0.6470.73
20_M138_R0.6450.73
175_L191_Q0.6420.72
199_V202_K0.6390.72
176_A188_T0.6370.72
22_V42_V0.6360.72
11_R14_Q0.6360.72
118_I160_L0.6340.72
49_G127_G0.6310.71
107_V151_E0.6290.71
56_Y73_T0.6290.71
26_I30_T0.6290.71
59_E64_A0.6260.71
107_V113_L0.6210.70
53_I76_E0.6200.70
27_G47_E0.6180.70
113_L141_V0.6170.69
8_M12_A0.6170.69
56_Y75_T0.6130.69
50_L79_G0.6130.69
190_L193_G0.6110.69
15_E177_V0.6100.69
72_E134_N0.6100.69
105_M118_I0.6090.68
26_I103_G0.6080.68
49_G128_G0.6080.68
147_N152_S0.6080.68
18_D37_P0.6070.68
126_M130_M0.6070.68
119_P125_G0.6040.68
12_A143_M0.6000.67
21_N43_M0.5970.67
196_I199_V0.5920.66
21_N97_I0.5900.66
152_S155_K0.5850.65
44_L55_P0.5850.65
26_I71_K0.5850.65
100_A132_L0.5840.65
176_A190_L0.5810.65
14_Q17_K0.5780.64
131_D135_G0.5760.64
134_N164_G0.5760.64
112_D166_K0.5740.64
64_A73_T0.5740.64
46_S88_S0.5740.64
97_I102_L0.5730.64
125_G172_I0.5710.64
64_A68_N0.5710.64
13_V95_G0.5700.63
58_L64_A0.5700.63
125_G140_V0.5690.63
113_L168_V0.5680.63
4_A174_D0.5670.63
176_A207_F0.5670.63
48_N85_S0.5660.63
12_A134_N0.5650.63
14_Q200_Y0.5640.63
21_N51_L0.5620.62
32_V36_I0.5610.62
30_T70_G0.5580.62
94_G135_G0.5540.61
145_H178_F0.5530.61
77_V80_A0.5530.61
27_G52_G0.5520.61
71_K75_T0.5500.61
8_M174_D0.5470.60
7_R174_D0.5450.60
99_L134_N0.5450.60
107_V185_M0.5430.60
74_I82_Y0.5420.60
17_K40_V0.5420.60
34_N56_Y0.5410.59
57_P71_K0.5400.59
14_Q41_H0.5400.59
85_S119_P0.5370.59
130_M135_G0.5370.59
176_A191_Q0.5370.59
178_F208_A0.5370.59
14_Q59_E0.5370.59
47_E129_A0.5360.59
111_G141_V0.5360.59
20_M140_V0.5330.58
51_L81_S0.5330.58
194_V202_K0.5330.58
63_D66_L0.5310.58
110_Q154_V0.5280.58
92_I97_I0.5270.57
47_E127_G0.5260.57
160_L169_H0.5260.57
56_Y124_K0.5250.57
50_L72_E0.5250.57
48_N103_G0.5250.57
68_N74_I0.5230.57
8_M96_H0.5220.57
40_V43_M0.5200.56
107_V153_K0.5200.56
113_L133_V0.5190.56
9_V35_E0.5190.56
154_V164_G0.5180.56
28_M187_L0.5180.56
7_R190_L0.5160.56
126_M160_L0.5160.56
13_V35_E0.5160.56
121_K124_K0.5160.56
110_Q183_G0.5140.56
110_Q186_T0.5130.55
95_G102_L0.5120.55
53_I74_I0.5110.55
51_L91_M0.5100.55
6_K38_D0.5100.55
9_V101_I0.5050.54
38_D151_E0.5040.54
126_M133_V0.5040.54
206_D209_V0.5030.54
6_K14_Q0.5020.54
7_R193_G0.5020.54
100_A136_A0.5020.54
122_M126_M0.5020.54
197_E206_D0.5000.54
111_G184_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiB 1 0.9491 100 0.298 Contact Map
3k6mA 2 0.9907 100 0.323 Contact Map
4kgbA 2 0.9722 100 0.329 Contact Map
2ahuA 3 0.9167 100 0.345 Contact Map
1xr4A 2 0.9907 100 0.445 Contact Map
2hj0A 2 0.9861 100 0.466 Contact Map
3rrlB 1 0.9583 100 0.499 Contact Map
3gk7A 2 0.9815 100 0.5 Contact Map
3d3uA 1 0.8843 100 0.521 Contact Map
2oasA 3 0.9537 100 0.531 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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