SCOB - BACSU - GREMLIN Contacts

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SCOB - Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit B

UniProt:	P42316	Sequences: MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVMLQSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAILGGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSLPLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	216 (207)
Sequences:	3148 (1441)
Seq/√Len:	100.1

ECOLI - ATOA YDIF
BACSU - SCOB YODR
HALSA - Q9HHP2
SULSO - Q97Z51

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
108_S	112_D	4.073	1.00
147_N	151_E	3.569	1.00
197_E	201_E	3.268	1.00
178_F	207_F	3.221	1.00
84_D	87_E	3.200	1.00
156_K	204_E	3.097	1.00
170_R	179_D	3.033	1.00
181_V	184_R	2.879	1.00
190_L	199_V	2.638	1.00
181_V	186_T	2.576	1.00
109_E	156_K	2.563	1.00
179_D	188_T	2.562	1.00
190_L	196_I	2.532	1.00
175_L	202_K	2.411	1.00
187_L	209_V	2.390	1.00
154_V	185_M	2.376	1.00
76_E	80_A	2.374	1.00
180_F	185_M	2.374	1.00
196_I	209_V	2.336	1.00
11_R	189_E	2.317	1.00
198_E	202_K	2.287	1.00
58_L	61_T	2.234	1.00
17_K	20_M	2.111	1.00
50_L	76_E	2.065	1.00
12_A	142_I	2.036	1.00
56_Y	72_E	1.895	1.00
109_E	206_D	1.893	1.00
110_Q	157_T	1.889	1.00
76_E	82_Y	1.879	1.00
195_T	198_E	1.820	1.00
187_L	196_I	1.808	1.00
186_T	210_S	1.796	1.00
12_A	101_I	1.761	1.00
8_M	142_I	1.751	1.00
198_E	201_E	1.749	1.00
175_L	194_V	1.735	1.00
45_Q	92_I	1.713	1.00
171_L	180_F	1.711	1.00
158_C	162_L	1.710	1.00
196_I	200_Y	1.708	1.00
200_Y	207_F	1.706	1.00
186_T	208_A	1.696	1.00
20_M	99_L	1.696	1.00
32_V	101_I	1.657	1.00
12_A	172_I	1.654	1.00
191_Q	194_V	1.640	1.00
184_R	208_A	1.623	1.00
6_K	35_E	1.617	1.00
152_S	204_E	1.560	1.00
188_T	210_S	1.558	1.00
145_H	203_T	1.541	1.00
16_I	32_V	1.506	1.00
58_L	62_E	1.496	1.00
156_K	206_D	1.492	1.00
93_R	131_D	1.486	1.00
200_Y	206_D	1.475	1.00
106_E	156_K	1.441	1.00
104_G	143_M	1.431	1.00
106_E	159_S	1.422	1.00
154_V	171_L	1.416	1.00
170_R	188_T	1.387	0.99
138_R	168_V	1.371	0.99
106_E	152_S	1.341	0.99
4_A	7_R	1.309	0.99
15_E	172_I	1.308	0.99
15_E	170_R	1.290	0.99
171_L	185_M	1.289	0.99
98_D	137_K	1.284	0.99
203_T	207_F	1.272	0.99
183_G	208_A	1.263	0.99
18_D	40_V	1.228	0.99
16_I	22_V	1.225	0.99
106_E	160_L	1.216	0.99
50_L	53_I	1.211	0.99
176_A	199_V	1.204	0.99
146_V	202_K	1.196	0.98
197_E	200_Y	1.194	0.98
179_D	186_T	1.191	0.98
99_L	140_V	1.188	0.98
140_V	172_I	1.170	0.98
46_S	50_L	1.141	0.98
190_L	194_V	1.112	0.98
5_R	31_L	1.101	0.97
106_E	155_K	1.086	0.97
109_E	153_K	1.085	0.97
104_G	113_L	1.084	0.97
28_M	142_I	1.074	0.97
138_R	170_R	1.068	0.97
146_V	174_D	1.050	0.97
177_V	189_E	1.045	0.96
99_L	138_R	1.041	0.96
178_F	200_Y	1.036	0.96
18_D	41_H	1.031	0.96
187_L	199_V	1.026	0.96
51_L	83_F	1.018	0.96
180_F	184_R	1.006	0.96
194_V	198_E	0.999	0.95
68_N	72_E	0.998	0.95
153_K	204_E	0.979	0.95
59_E	62_E	0.977	0.95
7_R	10_K	0.977	0.95
5_R	144_E	0.973	0.95
33_A	36_I	0.970	0.95
116_W	119_P	0.960	0.94
91_M	97_I	0.951	0.94
142_I	172_I	0.948	0.94
140_V	170_R	0.948	0.94
36_I	44_L	0.946	0.94
187_L	207_F	0.941	0.94
110_Q	166_K	0.936	0.94
175_L	198_E	0.935	0.94
54_G	75_T	0.928	0.93
16_I	42_V	0.926	0.93
5_R	28_M	0.926	0.93
11_R	177_V	0.916	0.93
55_P	77_V	0.909	0.93
101_I	142_I	0.908	0.92
18_D	39_G	0.905	0.92
9_V	32_V	0.898	0.92
185_M	205_A	0.898	0.92
156_K	205_A	0.893	0.92
37_P	40_V	0.890	0.92
16_I	101_I	0.881	0.91
133_V	164_G	0.872	0.91
57_P	75_T	0.865	0.91
29_P	103_G	0.856	0.90
54_G	57_P	0.854	0.90
183_G	210_S	0.847	0.90
155_K	159_S	0.847	0.90
146_V	149_H	0.843	0.89
145_H	175_L	0.841	0.89
117_M	123_V	0.839	0.89
15_E	138_R	0.838	0.89
26_I	48_N	0.834	0.89
7_R	192_D	0.832	0.89
196_I	207_F	0.831	0.89
33_A	56_Y	0.827	0.89
16_I	99_L	0.823	0.88
12_A	32_V	0.819	0.88
181_V	208_A	0.809	0.87
178_F	209_V	0.805	0.87
29_P	48_N	0.801	0.87
101_I	172_I	0.800	0.87
104_G	107_V	0.792	0.86
83_F	88_S	0.789	0.86
118_I	121_K	0.787	0.86
109_E	205_A	0.786	0.86
183_G	186_T	0.785	0.86
168_V	179_D	0.784	0.86
194_V	199_V	0.777	0.85
50_L	82_Y	0.774	0.85
21_N	91_M	0.772	0.85
11_R	15_E	0.761	0.84
200_Y	208_A	0.752	0.83
10_K	14_Q	0.752	0.83
149_H	152_S	0.750	0.83
73_T	124_K	0.750	0.83
10_K	35_E	0.749	0.83
105_M	119_P	0.748	0.83
162_L	165_Q	0.746	0.83
200_Y	209_V	0.745	0.83
28_M	144_E	0.743	0.83
12_A	140_V	0.742	0.82
164_G	167_V	0.742	0.82
175_L	203_T	0.739	0.82
6_K	31_L	0.734	0.82
133_V	167_V	0.726	0.81
175_L	199_V	0.724	0.81
6_K	10_K	0.718	0.80
146_V	152_S	0.717	0.80
171_L	178_F	0.705	0.79
156_K	159_S	0.699	0.79
15_E	140_V	0.698	0.78
106_E	147_N	0.697	0.78
185_M	207_F	0.695	0.78
28_M	31_L	0.694	0.78
155_K	204_E	0.691	0.78
138_R	169_H	0.691	0.78
178_F	185_M	0.689	0.78
190_L	195_T	0.681	0.77
152_S	205_A	0.681	0.77
108_S	157_T	0.680	0.77
50_L	80_A	0.677	0.76
50_L	74_I	0.673	0.76
181_V	210_S	0.664	0.75
122_M	160_L	0.662	0.75
7_R	191_Q	0.659	0.74
47_E	89_F	0.651	0.73
191_Q	199_V	0.649	0.73
9_V	28_M	0.649	0.73
36_I	40_V	0.647	0.73
20_M	138_R	0.645	0.73
175_L	191_Q	0.642	0.72
199_V	202_K	0.639	0.72
176_A	188_T	0.637	0.72
22_V	42_V	0.636	0.72
11_R	14_Q	0.636	0.72
118_I	160_L	0.634	0.72
49_G	127_G	0.631	0.71
107_V	151_E	0.629	0.71
56_Y	73_T	0.629	0.71
26_I	30_T	0.629	0.71
59_E	64_A	0.626	0.71
107_V	113_L	0.621	0.70
53_I	76_E	0.620	0.70
27_G	47_E	0.618	0.70
113_L	141_V	0.617	0.69
8_M	12_A	0.617	0.69
56_Y	75_T	0.613	0.69
50_L	79_G	0.613	0.69
190_L	193_G	0.611	0.69
15_E	177_V	0.610	0.69
72_E	134_N	0.610	0.69
105_M	118_I	0.609	0.68
26_I	103_G	0.608	0.68
49_G	128_G	0.608	0.68
147_N	152_S	0.608	0.68
18_D	37_P	0.607	0.68
126_M	130_M	0.607	0.68
119_P	125_G	0.604	0.68
12_A	143_M	0.600	0.67
21_N	43_M	0.597	0.67
196_I	199_V	0.592	0.66
21_N	97_I	0.590	0.66
152_S	155_K	0.585	0.65
44_L	55_P	0.585	0.65
26_I	71_K	0.585	0.65
100_A	132_L	0.584	0.65
176_A	190_L	0.581	0.65
14_Q	17_K	0.578	0.64
131_D	135_G	0.576	0.64
134_N	164_G	0.576	0.64
112_D	166_K	0.574	0.64
64_A	73_T	0.574	0.64
46_S	88_S	0.574	0.64
97_I	102_L	0.573	0.64
125_G	172_I	0.571	0.64
64_A	68_N	0.571	0.64
13_V	95_G	0.570	0.63
58_L	64_A	0.570	0.63
125_G	140_V	0.569	0.63
113_L	168_V	0.568	0.63
4_A	174_D	0.567	0.63
176_A	207_F	0.567	0.63
48_N	85_S	0.566	0.63
12_A	134_N	0.565	0.63
14_Q	200_Y	0.564	0.63
21_N	51_L	0.562	0.62
32_V	36_I	0.561	0.62
30_T	70_G	0.558	0.62
94_G	135_G	0.554	0.61
145_H	178_F	0.553	0.61
77_V	80_A	0.553	0.61
27_G	52_G	0.552	0.61
71_K	75_T	0.550	0.61
8_M	174_D	0.547	0.60
7_R	174_D	0.545	0.60
99_L	134_N	0.545	0.60
107_V	185_M	0.543	0.60
74_I	82_Y	0.542	0.60
17_K	40_V	0.542	0.60
34_N	56_Y	0.541	0.59
57_P	71_K	0.540	0.59
14_Q	41_H	0.540	0.59
85_S	119_P	0.537	0.59
130_M	135_G	0.537	0.59
176_A	191_Q	0.537	0.59
178_F	208_A	0.537	0.59
14_Q	59_E	0.537	0.59
47_E	129_A	0.536	0.59
111_G	141_V	0.536	0.59
20_M	140_V	0.533	0.58
51_L	81_S	0.533	0.58
194_V	202_K	0.533	0.58
63_D	66_L	0.531	0.58
110_Q	154_V	0.528	0.58
92_I	97_I	0.527	0.57
47_E	127_G	0.526	0.57
160_L	169_H	0.526	0.57
56_Y	124_K	0.525	0.57
50_L	72_E	0.525	0.57
48_N	103_G	0.525	0.57
68_N	74_I	0.523	0.57
8_M	96_H	0.522	0.57
40_V	43_M	0.520	0.56
107_V	153_K	0.520	0.56
113_L	133_V	0.519	0.56
9_V	35_E	0.519	0.56
154_V	164_G	0.518	0.56
28_M	187_L	0.518	0.56
7_R	190_L	0.516	0.56
126_M	160_L	0.516	0.56
13_V	35_E	0.516	0.56
121_K	124_K	0.516	0.56
110_Q	183_G	0.514	0.56
110_Q	186_T	0.513	0.55
95_G	102_L	0.512	0.55
53_I	74_I	0.511	0.55
51_L	91_M	0.510	0.55
6_K	38_D	0.510	0.55
9_V	101_I	0.505	0.54
38_D	151_E	0.504	0.54
126_M	133_V	0.504	0.54
206_D	209_V	0.503	0.54
6_K	14_Q	0.502	0.54
7_R	193_G	0.502	0.54
100_A	136_A	0.502	0.54
122_M	126_M	0.502	0.54
197_E	206_D	0.500	0.54
111_G	184_R	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1poiB	1	0.9491	100	0.298	Contact Map
3k6mA	2	0.9907	100	0.323	Contact Map
4kgbA	2	0.9722	100	0.329	Contact Map
2ahuA	3	0.9167	100	0.345	Contact Map
1xr4A	2	0.9907	100	0.445	Contact Map
2hj0A	2	0.9861	100	0.466	Contact Map
3rrlB	1	0.9583	100	0.499	Contact Map
3gk7A	2	0.9815	100	0.5	Contact Map
3d3uA	1	0.8843	100	0.521	Contact Map
2oasA	3	0.9537	100	0.531	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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