GREMLIN Database
SCOA - Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A
UniProt: P42315 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (221)
Sequences: 3539 (1761)
Seq/√Len: 118.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_T194_E3.4331.00
120_A139_R3.3041.00
156_A165_L3.2801.00
16_H19_D3.0951.00
135_T140_T2.9271.00
165_L187_A2.6611.00
17_D45_K2.6501.00
167_F205_T2.6281.00
158_K191_E2.6101.00
46_D71_K2.5931.00
198_L203_I2.3801.00
83_I86_R2.3741.00
137_G145_R2.3401.00
9_K41_D2.3051.00
71_K94_E2.2831.00
86_R90_S2.2321.00
22_I149_G2.2231.00
15_I39_I2.0991.00
7_S10_E2.0841.00
133_H140_T2.0761.00
152_A182_G2.0381.00
5_L212_H1.9891.00
38_S41_D1.9831.00
68_K87_Q1.9611.00
72_K94_E1.9261.00
48_T74_I1.9051.00
159_A189_A1.8691.00
110_G148_T1.8611.00
22_I107_I1.8551.00
35_L153_I1.8281.00
37_L63_L1.7971.00
87_Q92_E1.7731.00
157_W168_R1.7541.00
148_T183_K1.7531.00
159_A187_A1.7181.00
162_M195_A1.7141.00
184_I212_H1.6801.00
126_S129_E1.6701.00
17_D43_G1.6501.00
68_K92_E1.6501.00
40_R69_Q1.6241.00
116_G143_L1.6201.00
14_L212_H1.6091.00
161_T195_A1.6081.00
50_V147_I1.6061.00
199_D202_H1.5841.00
123_V140_T1.5381.00
64_L69_Q1.5211.00
18_G46_D1.5131.00
22_I178_A1.5041.00
10_E13_K1.4971.00
19_D151_V1.4731.00
118_Y134_K1.4651.00
158_K166_I1.4601.00
39_I153_I1.4561.00
130_G133_H1.4271.00
48_T72_K1.4271.00
58_D66_A1.4231.00
109_A117_F1.4131.00
160_D164_N1.4001.00
159_A192_I1.3951.00
96_E106_R1.3771.00
23_A153_I1.3511.00
132_E137_G1.3401.00
179_A185_T1.3221.00
115_P136_F1.3051.00
151_V184_I1.3031.00
15_I19_D1.2821.00
128_A133_H1.2801.00
17_D44_V1.2710.99
67_N92_E1.2680.99
2_G161_T1.2650.99
135_T138_G1.2640.99
50_V149_G1.2630.99
12_A38_S1.2570.99
20_T50_V1.2520.99
31_I36_I1.2230.99
158_K193_V1.2170.99
40_R66_A1.2120.99
8_S38_S1.1980.99
9_K38_S1.1900.99
194_E197_E1.1840.99
102_T119_T1.1790.99
72_K96_E1.1720.99
38_S42_Q1.1710.99
48_T71_K1.1700.99
107_I178_A1.1640.99
105_E108_R1.1380.99
114_I117_F1.1310.99
34_Q188_E1.1240.99
4_V192_I1.1180.99
98_V106_R1.1090.99
216_G219_Q1.1040.99
23_A36_I1.1030.99
43_G69_Q1.1030.99
12_A15_I1.0970.98
115_P146_G1.0920.98
49_V70_I1.0850.98
65_L87_Q1.0830.98
169_K201_D1.0800.98
156_A189_A1.0770.98
154_V187_A1.0730.98
15_I151_V1.0710.98
154_V178_A1.0560.98
186_I214_V1.0490.98
16_H151_V1.0490.98
40_R67_N1.0420.98
11_A186_I1.0400.98
106_R146_G1.0350.98
11_A214_V1.0290.98
40_R63_L1.0160.98
192_I215_L1.0140.97
34_Q216_G1.0090.97
14_L184_I1.0020.97
37_L41_D0.9990.97
169_K190_E0.9980.97
159_A165_L0.9910.97
109_A114_I0.9880.97
5_L10_E0.9880.97
180_M209_Y0.9750.97
107_I181_A0.9740.97
12_A42_Q0.9730.97
153_I186_I0.9710.97
54_C84_F0.9680.97
191_E215_L0.9680.97
165_L189_A0.9610.97
154_V179_A0.9570.96
157_W190_E0.9550.96
5_L14_L0.9540.96
159_A213_V0.9530.96
187_A205_T0.9430.96
19_D150_D0.9420.96
106_R145_R0.9410.96
161_T197_E0.9380.96
44_V69_Q0.9340.96
14_L19_D0.9300.96
219_Q222_R0.9300.96
22_I147_I0.9230.96
130_G140_T0.9150.95
5_L12_A0.9150.95
155_K216_G0.9150.95
54_C73_M0.9080.95
133_H142_V0.9060.95
75_A78_V0.9040.95
189_A192_I0.8960.95
158_K168_R0.8950.95
15_I186_I0.8940.95
184_I187_A0.8910.95
172_R204_H0.8910.95
118_Y143_L0.8880.95
118_Y136_F0.8830.94
186_I212_H0.8800.94
66_A83_I0.8770.94
166_I202_H0.8690.94
83_I87_Q0.8610.94
15_I153_I0.8600.94
77_Y80_E0.8580.94
178_A182_G0.8510.93
14_L151_V0.8500.93
21_L153_I0.8410.93
88_F95_V0.8400.93
123_V142_V0.8390.93
22_I50_V0.8290.92
165_L205_T0.8290.92
136_F143_L0.8220.92
116_G145_R0.8210.92
218_S221_K0.8180.92
108_R112_A0.8140.92
167_F176_P0.8130.92
17_D46_D0.8130.92
185_T211_Q0.8130.92
65_L70_I0.8100.91
116_G134_K0.8070.91
172_R201_D0.8020.91
13_K42_Q0.8000.91
24_G175_N0.7920.91
105_E114_I0.7900.90
59_W222_R0.7880.90
20_T149_G0.7860.90
193_V197_E0.7780.90
128_A142_V0.7750.90
152_A178_A0.7710.89
110_G147_I0.7700.89
166_I198_L0.7630.89
105_E117_F0.7590.89
134_K137_G0.7580.89
122_G142_V0.7560.88
169_K199_D0.7520.88
154_V205_T0.7490.88
107_I149_G0.7480.88
149_G182_G0.7460.88
78_V84_F0.7450.88
115_P141_Y0.7440.88
100_Q104_A0.7410.87
136_F145_R0.7400.87
131_K144_E0.7380.87
116_G146_G0.7320.87
34_Q37_L0.7320.87
58_D222_R0.7300.87
76_S103_L0.7280.86
64_L70_I0.7270.86
132_E135_T0.7150.85
201_D204_H0.7150.85
34_Q219_Q0.7130.85
150_D183_K0.7090.85
39_I44_V0.7070.85
193_V196_G0.7060.85
39_I69_Q0.7060.85
155_K219_Q0.7040.85
155_K188_E0.6940.84
45_K69_Q0.6930.84
176_P205_T0.6920.84
11_A42_Q0.6840.83
57_D82_K0.6820.83
11_A212_H0.6810.83
7_S11_A0.6770.82
111_G180_M0.6740.82
179_A205_T0.6730.82
12_A35_L0.6700.82
20_T48_T0.6680.81
176_P180_M0.6660.81
167_F204_H0.6640.81
191_E197_E0.6630.81
15_I44_V0.6490.79
33_E59_W0.6480.79
29_C171_A0.6460.79
166_I203_I0.6450.79
11_A15_I0.6410.79
55_G100_Q0.6390.78
51_S61_L0.6390.78
76_S100_Q0.6360.78
132_E143_L0.6330.78
35_L39_I0.6320.78
57_D62_G0.6310.78
35_L214_V0.6280.77
50_V107_I0.6220.77
12_A212_H0.6220.77
14_L186_I0.6180.76
131_K142_V0.6180.76
4_V161_T0.6150.76
177_I180_M0.6130.76
28_L56_V0.6120.75
24_G173_N0.6070.75
56_V59_W0.6070.75
27_G55_G0.6040.74
120_A141_Y0.6040.74
32_P35_L0.6040.74
4_V213_V0.6000.74
106_R147_I0.6000.74
157_W191_E0.5990.74
34_Q217_A0.5980.74
128_A140_T0.5960.73
23_A32_P0.5960.73
30_G167_F0.5930.73
137_G148_T0.5890.73
56_V62_G0.5880.72
9_K13_K0.5880.72
22_I182_G0.5870.72
23_A49_V0.5860.72
143_L146_G0.5860.72
107_I177_I0.5850.72
54_C80_E0.5850.72
169_K189_A0.5840.72
112_A180_M0.5840.72
134_K143_L0.5840.72
8_S216_G0.5840.72
106_R144_E0.5840.72
100_Q175_N0.5820.72
166_I204_H0.5790.71
2_G5_L0.5760.71
23_A51_S0.5760.71
219_Q223_I0.5710.70
157_W166_I0.5700.70
172_R176_P0.5690.70
162_M207_G0.5690.70
59_W63_L0.5680.70
2_G213_V0.5670.70
123_V133_H0.5640.69
16_H44_V0.5600.69
67_N90_S0.5600.69
86_R89_L0.5590.69
87_Q90_S0.5590.69
22_I181_A0.5590.69
114_I118_Y0.5530.68
62_G78_V0.5510.68
166_I199_D0.5500.67
184_I211_Q0.5470.67
110_G149_G0.5470.67
73_M84_F0.5450.67
58_D62_G0.5410.66
155_K189_A0.5400.66
53_N61_L0.5390.66
85_E89_L0.5390.66
220_E223_I0.5380.66
217_A220_E0.5360.65
27_G80_E0.5340.65
39_I64_L0.5330.65
87_Q93_L0.5320.65
49_V54_C0.5300.65
105_E112_A0.5300.65
38_S44_V0.5280.64
44_V47_L0.5280.64
42_Q69_Q0.5270.64
110_G146_G0.5260.64
31_I190_E0.5260.64
188_E216_G0.5250.64
50_V74_I0.5230.64
24_G32_P0.5220.63
24_G174_F0.5210.63
78_V88_F0.5200.63
118_Y123_V0.5200.63
155_K190_E0.5190.63
27_G53_N0.5190.63
73_M93_L0.5170.63
28_L33_E0.5150.62
5_L184_I0.5110.62
85_E88_F0.5110.62
33_E216_G0.5110.62
123_V128_A0.5110.62
78_V81_N0.5070.61
158_K202_H0.5070.61
52_N174_F0.5050.61
74_I96_E0.5040.61
118_Y132_E0.5040.61
101_G125_T0.5040.61
53_N80_E0.5040.61
128_A131_K0.5030.61
4_V215_L0.5030.61
31_I51_S0.5030.61
71_K74_I0.5020.60
116_G136_F0.5020.60
57_D80_E0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiA 3 0.9748 100 0.238 Contact Map
3cdkA 2 0.9664 100 0.275 Contact Map
4kgbA 2 0.9832 100 0.286 Contact Map
3rrlA 2 0.9622 100 0.298 Contact Map
1k6dA 2 0.916 100 0.3 Contact Map
3k6mA 2 0.979 100 0.3 Contact Map
2ahuA 3 0.9916 100 0.327 Contact Map
2hj0A 2 0.8319 100 0.55 Contact Map
1xr4A 2 0.8277 100 0.554 Contact Map
3qliA 2 0.8319 100 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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