GREMLIN Database
YXJC - Uncharacterized transporter YxjC
UniProt: P42314 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (429)
Sequences: 3480 (2173)
Seq/√Len: 104.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_L302_T4.2471.00
50_I345_A4.1231.00
88_T239_H3.9711.00
9_A339_F3.6391.00
9_A34_A3.6141.00
341_G345_A3.5741.00
239_H243_F3.3191.00
440_T443_Q3.2321.00
12_L33_F3.1791.00
200_S204_K3.0831.00
350_H354_S2.8501.00
172_F414_I2.8471.00
465_I469_T2.8171.00
368_A456_T2.8111.00
193_A458_A2.7691.00
53_E57_G2.6631.00
194_G198_L2.5941.00
42_H47_F2.5821.00
238_R241_L2.5711.00
372_T420_G2.5461.00
185_M189_I2.5291.00
281_L285_S2.5251.00
78_M318_G2.5011.00
100_L195_M2.4991.00
461_A465_I2.4861.00
88_T91_R2.4001.00
195_M198_L2.3981.00
11_G15_F2.3841.00
302_T306_F2.3781.00
88_T92_L2.3251.00
367_G414_I2.2841.00
15_F19_R2.2491.00
199_E203_K2.2301.00
376_G421_M2.2221.00
12_L30_C2.2001.00
54_K341_G2.1721.00
5_I37_L2.1601.00
197_Y201_R2.0891.00
416_M459_V2.0811.00
42_H46_F2.0511.00
301_I305_L2.0471.00
95_A133_E2.0231.00
252_V298_I2.0071.00
155_D419_G2.0061.00
206_Q209_G1.9871.00
321_E324_G1.9861.00
421_M449_F1.9611.00
71_I319_L1.9541.00
305_L310_S1.9461.00
183_G186_G1.9271.00
186_G466_Y1.9251.00
81_L242_A1.9221.00
147_L194_G1.9151.00
450_A454_I1.8901.00
457_A461_A1.8831.00
396_Y410_M1.8801.00
166_V385_M1.8241.00
74_K78_M1.8191.00
179_A411_H1.7751.00
237_I242_A1.7691.00
186_G189_I1.7511.00
198_L202_R1.7421.00
404_N407_P1.7381.00
434_L444_S1.6821.00
59_I334_G1.6731.00
51_F338_G1.6521.00
183_G189_I1.6461.00
32_L294_I1.6461.00
442_R446_R1.6371.00
184_L188_V1.6131.00
50_I341_G1.6051.00
195_M199_E1.5941.00
249_V253_N1.5911.00
103_V191_L1.5841.00
142_P437_T1.5601.00
110_T153_T1.5551.00
21_F26_F1.5461.00
200_S203_K1.5451.00
201_R205_A1.5121.00
34_A339_F1.5051.00
333_T427_N1.5041.00
420_G456_T1.4941.00
38_T42_H1.4931.00
460_F464_A1.4881.00
197_Y450_A1.4761.00
42_H45_P1.4751.00
187_A190_V1.4741.00
135_N208_S1.4651.00
12_L16_T1.4641.00
256_F260_L1.4561.00
368_A460_F1.4531.00
376_G420_G1.4521.00
153_T160_T1.4471.00
240_A244_V1.4421.00
55_M63_F1.4401.00
365_V460_F1.4361.00
84_S88_T1.4341.00
403_Y407_P1.4261.00
186_G462_V1.4211.00
393_S397_L1.4111.00
9_A33_F1.4031.00
197_Y200_S1.3931.00
36_L43_V1.3921.00
75_V303_T1.3881.00
64_P68_L1.3851.00
45_P49_S1.3831.00
106_G123_V1.3691.00
120_V436_V1.3671.00
171_F389_L1.3651.00
326_A330_S1.3571.00
13_L30_C1.3500.99
187_A191_L1.3490.99
49_S53_E1.3450.99
203_K207_A1.3430.99
245_P306_F1.3430.99
280_R283_I1.3430.99
253_N256_F1.3410.99
241_L306_F1.3410.99
35_V342_I1.3390.99
454_I458_A1.3270.99
420_G453_L1.3260.99
253_N257_T1.3210.99
81_L307_D1.3160.99
84_S236_P1.3140.99
372_T376_G1.3110.99
340_G344_A1.3040.99
317_E321_E1.2970.99
196_L199_E1.2960.99
33_F37_L1.2810.99
182_L186_G1.2760.99
181_W185_M1.2710.99
196_L200_S1.2710.99
35_V47_F1.2660.99
242_A245_P1.2630.99
303_T307_D1.2620.99
245_P253_N1.2600.99
182_L412_R1.2520.99
198_L203_K1.2500.99
41_S346_L1.2450.99
422_D448_I1.2430.99
87_K91_R1.2430.99
84_S239_H1.2420.99
193_A196_L1.2410.99
422_D426_H1.2400.99
166_V171_F1.2270.99
179_A408_E1.2260.99
282_D285_S1.2120.99
195_M202_R1.2090.99
83_A234_K1.2080.99
181_W184_L1.2050.99
71_I300_I1.2040.99
30_C33_F1.2020.99
354_S357_S1.2020.99
259_Y286_A1.2000.99
83_A87_K1.1930.99
282_D286_A1.1910.99
296_L303_T1.1900.99
76_V81_L1.1850.99
182_L185_M1.1850.99
41_S50_I1.1730.99
205_A209_G1.1710.99
279_G283_I1.1700.99
119_V149_A1.1670.98
208_S212_Y1.1670.98
341_G344_A1.1670.98
85_I242_A1.1660.98
250_G253_N1.1600.98
46_F49_S1.1590.98
174_T179_A1.1560.98
313_A317_E1.1560.98
182_L189_I1.1550.98
194_G200_S1.1520.98
274_G280_R1.1520.98
192_A196_L1.1470.98
197_Y454_I1.1460.98
260_L287_A1.1400.98
421_M445_Y1.1310.98
257_T260_L1.1300.98
180_P184_L1.1290.98
412_R463_I1.1290.98
105_M109_L1.1230.98
201_R204_K1.1220.98
87_K236_P1.1220.98
459_V463_I1.1170.98
375_A426_H1.1080.98
182_L408_E1.1070.98
198_L201_R1.1060.98
193_A454_I1.1060.98
38_T346_L1.0940.98
409_V467_S1.0890.98
79_A303_T1.0850.98
38_T41_S1.0840.98
118_V428_G1.0820.98
147_L451_I1.0760.97
195_M200_S1.0750.97
242_A253_N1.0700.97
183_G187_A1.0700.97
150_F452_T1.0690.97
52_M61_L1.0690.97
167_I171_F1.0690.97
408_E411_H1.0630.97
452_T455_K1.0600.97
199_E202_R1.0590.97
464_A468_L1.0570.97
464_A469_T1.0470.97
16_T21_F1.0450.97
186_G190_V1.0430.97
151_T455_K1.0420.97
209_G212_Y1.0310.97
283_I287_A1.0270.97
156_A459_V1.0270.97
273_I283_I1.0270.97
244_V248_L1.0250.97
167_I179_A1.0220.97
87_K133_E1.0170.96
202_R205_A1.0140.96
351_K355_G1.0080.96
109_L123_V1.0020.96
443_Q446_R0.9920.96
248_L252_V0.9910.96
180_P183_G0.9910.96
465_I468_L0.9900.96
163_I167_I0.9890.96
281_L284_S0.9860.96
6_I10_L0.9850.96
5_I38_T0.9830.96
384_G426_H0.9820.96
462_V465_I0.9800.96
439_L443_Q0.9800.96
48_S294_I0.9780.96
378_T384_G0.9770.95
118_V433_L0.9720.95
110_T160_T0.9680.95
273_I286_A0.9670.95
7_L11_G0.9630.95
46_F50_I0.9620.95
174_T411_H0.9610.95
175_D178_A0.9600.95
372_T456_T0.9590.95
210_E213_G0.9570.95
383_G387_I0.9550.95
190_V458_A0.9520.95
190_V462_V0.9490.95
3_L7_L0.9450.95
186_G412_R0.9360.94
94_G101_A0.9360.94
85_I243_F0.9300.94
13_L26_F0.9270.94
408_E412_R0.9260.94
58_F337_Y0.9250.94
284_S287_A0.9240.94
279_G284_S0.9240.94
422_D452_T0.9230.94
164_Q167_I0.9180.94
351_K354_S0.9180.94
207_A210_E0.9160.94
214_G217_S0.9150.94
451_I455_K0.9140.94
450_A455_K0.9120.93
398_Q403_Y0.9120.93
241_L244_V0.9120.93
160_T333_T0.9110.93
154_M160_T0.9110.93
194_G197_Y0.9090.93
154_M382_S0.9080.93
274_G279_G0.9060.93
198_L209_G0.9050.93
198_L205_A0.9040.93
273_I280_R0.9030.93
464_A467_S0.9000.93
184_L187_A0.8980.93
92_L96_K0.8970.93
303_T311_V0.8900.93
248_L299_G0.8870.93
196_L204_K0.8870.93
381_A418_S0.8840.92
409_V463_I0.8840.92
423_T452_T0.8780.92
89_I93_V0.8780.92
466_Y469_T0.8750.92
200_S206_Q0.8750.92
89_I104_L0.8710.92
444_S448_I0.8700.92
207_A443_Q0.8690.92
45_P284_S0.8690.92
151_T187_A0.8650.92
314_Q317_E0.8620.91
283_I286_A0.8590.91
56_A60_K0.8560.91
445_Y449_F0.8540.91
418_S427_N0.8540.91
332_N386_G0.8530.91
36_L47_F0.8490.91
55_M64_P0.8490.91
409_V466_Y0.8480.91
167_I173_K0.8480.91
174_T189_I0.8480.91
200_S205_A0.8480.91
194_G206_Q0.8470.91
364_L405_I0.8380.90
203_K206_Q0.8380.90
35_V48_S0.8330.90
274_G283_I0.8330.90
107_A153_T0.8310.90
5_I33_F0.8280.90
352_L377_I0.8270.90
406_P467_S0.8260.90
246_L253_N0.8240.89
9_A38_T0.8230.89
421_M453_L0.8230.89
252_V255_Y0.8220.89
211_G215_F0.8210.89
462_V466_Y0.8190.89
145_I148_G0.8190.89
307_D311_V0.8170.89
123_V149_A0.8150.89
207_A439_L0.8130.89
259_Y283_I0.8100.89
381_A427_N0.8100.89
365_V369_V0.8090.89
67_L331_M0.8080.89
203_K209_G0.8070.88
195_M204_K0.8070.88
100_L192_A0.8070.88
449_F456_T0.8040.88
239_H253_N0.8040.88
458_A461_A0.8020.88
375_A381_A0.7990.88
273_I279_G0.7980.88
14_M30_C0.7970.88
140_L144_T0.7950.88
249_V252_V0.7950.88
34_A348_G0.7940.88
424_L445_Y0.7930.88
64_P293_E0.7880.87
441_H445_Y0.7870.87
48_S52_M0.7870.87
179_A186_G0.7860.87
198_L207_A0.7860.87
84_S242_A0.7860.87
460_F466_Y0.7810.87
394_E398_Q0.7770.87
241_L302_T0.7770.87
366_N396_Y0.7760.86
53_E341_G0.7750.86
282_D465_I0.7750.86
120_V124_Y0.7740.86
197_Y202_R0.7720.86
447_D450_A0.7720.86
384_G422_D0.7710.86
26_F30_C0.7680.86
304_I319_L0.7680.86
258_I261_P0.7660.86
304_I315_L0.7660.86
72_F300_I0.7650.86
110_T119_V0.7620.85
257_T261_P0.7580.85
367_G371_T0.7550.85
88_T243_F0.7550.85
147_L198_L0.7540.85
202_R209_G0.7530.85
188_V192_A0.7510.85
178_A408_E0.7510.85
8_L37_L0.7500.85
449_F453_L0.7500.85
213_G216_D0.7480.84
107_A148_G0.7470.84
5_I30_C0.7450.84
249_V254_K0.7430.84
189_I193_A0.7390.84
189_I462_V0.7390.84
153_T157_L0.7370.84
426_H448_I0.7370.84
296_L300_I0.7360.83
295_A303_T0.7300.83
106_G153_T0.7280.83
295_A298_I0.7230.82
397_L410_M0.7220.82
252_V256_F0.7210.82
143_G198_L0.7200.82
463_I467_S0.7170.82
51_F335_A0.7160.82
41_S47_F0.7160.82
375_A422_D0.7130.81
385_M388_A0.7130.81
179_A183_G0.7120.81
214_G218_Q0.7110.81
182_L405_I0.7110.81
194_G209_G0.7070.81
191_L195_M0.7070.81
244_V247_I0.7060.81
198_L204_K0.7050.81
192_A306_F0.7050.81
102_I106_G0.7010.80
319_L322_G0.6990.80
280_R284_S0.6950.80
162_Q336_E0.6950.80
68_L297_V0.6950.80
422_D428_G0.6930.80
102_I141_I0.6930.80
206_Q210_E0.6920.80
409_V469_T0.6890.79
5_I34_A0.6890.79
172_F410_M0.6880.79
171_F390_S0.6860.79
153_T163_I0.6850.79
156_A416_M0.6850.79
46_F173_K0.6830.79
171_F174_T0.6800.78
249_V256_F0.6780.78
397_L407_P0.6770.78
374_L378_T0.6770.78
207_A213_G0.6760.78
150_F374_L0.6750.78
186_G416_M0.6740.78
28_P68_L0.6740.78
186_G463_I0.6730.78
163_I166_V0.6690.77
237_I252_V0.6690.77
329_A436_V0.6690.77
70_A194_G0.6690.77
5_I9_A0.6680.77
166_V173_K0.6680.77
385_M418_S0.6650.77
191_L194_G0.6640.77
273_I462_V0.6630.77
9_A370_T0.6610.76
84_S238_R0.6580.76
90_V93_V0.6570.76
179_A182_L0.6560.76
238_R242_A0.6550.76
21_F347_P0.6540.76
233_D236_P0.6540.76
234_K237_I0.6530.75
185_M313_A0.6520.75
381_A452_T0.6520.75
94_G97_R0.6510.75
378_T422_D0.6510.75
47_F342_I0.6510.75
292_V296_L0.6510.75
216_D220_A0.6500.75
376_G449_F0.6490.75
116_L146_A0.6480.75
202_R206_Q0.6470.75
238_R255_Y0.6460.75
25_L71_I0.6450.75
256_F261_P0.6440.74
67_L334_G0.6440.74
167_I418_S0.6390.74
76_V172_F0.6390.74
244_V302_T0.6370.74
11_G310_S0.6370.74
116_L160_T0.6350.73
211_G214_G0.6330.73
127_A145_I0.6330.73
368_A420_G0.6330.73
213_G217_S0.6330.73
416_M463_I0.6320.73
106_G119_V0.6320.73
137_P205_A0.6310.73
365_V464_A0.6300.73
90_V334_G0.6300.73
150_F419_G0.6290.73
83_A105_M0.6280.73
138_K142_P0.6270.73
374_L388_A0.6270.73
180_P189_I0.6260.72
167_I170_S0.6250.72
22_S328_L0.6250.72
154_M158_P0.6250.72
185_M462_V0.6250.72
363_P410_M0.6240.72
294_I298_I0.6230.72
14_M18_Y0.6230.72
196_L202_R0.6220.72
328_L332_N0.6200.72
309_R312_F0.6200.72
246_L249_V0.6190.72
381_A419_G0.6180.71
403_Y406_P0.6180.71
27_A339_F0.6120.71
256_F287_A0.6110.71
372_T452_T0.6090.70
16_T29_I0.6090.70
144_T242_A0.6080.70
66_F432_T0.6070.70
55_M331_M0.6060.70
165_N171_F0.6040.70
82_A88_T0.6020.69
154_M161_P0.6020.69
196_L205_A0.6020.69
62_Y333_T0.6020.69
61_L427_N0.6020.69
335_A338_G0.6010.69
90_V300_I0.6010.69
364_L410_M0.6010.69
43_V285_S0.6010.69
99_I140_L0.5980.69
164_Q175_D0.5970.69
458_A462_V0.5960.69
156_A412_R0.5960.69
220_A251_A0.5960.69
115_S382_S0.5940.68
8_L12_L0.5940.68
235_S251_A0.5930.68
370_T388_A0.5930.68
79_A100_L0.5930.68
454_I457_A0.5900.68
375_A384_G0.5890.68
160_T382_S0.5880.68
209_G213_G0.5870.68
216_D219_N0.5870.68
143_G444_S0.5850.67
194_G199_E0.5840.67
307_D310_S0.5830.67
117_F154_M0.5820.67
145_I149_A0.5810.67
72_F299_G0.5810.67
183_G190_V0.5800.67
376_G445_Y0.5790.67
256_F290_W0.5790.67
256_F259_Y0.5790.67
205_A210_E0.5770.66
355_G359_T0.5750.66
140_L151_T0.5740.66
375_A448_I0.5730.66
82_A158_P0.5730.66
115_S329_A0.5710.65
188_V219_N0.5710.65
159_G337_Y0.5700.65
371_T392_M0.5690.65
461_A464_A0.5690.65
190_V194_G0.5690.65
257_T427_N0.5690.65
303_T306_F0.5670.65
273_I282_D0.5660.65
92_L102_I0.5650.65
196_L203_K0.5620.64
96_K309_R0.5620.64
182_L187_A0.5610.64
55_M59_I0.5610.64
448_I452_T0.5600.64
20_G132_Q0.5590.64
146_A433_L0.5580.64
191_L202_R0.5580.64
68_L325_G0.5580.64
204_K207_A0.5570.64
114_V333_T0.5570.64
378_T426_H0.5560.63
300_I303_T0.5560.63
199_E204_K0.5550.63
22_S323_I0.5550.63
202_R207_A0.5550.63
236_P242_A0.5550.63
75_V79_A0.5550.63
195_M203_K0.5540.63
120_V420_G0.5540.63
137_P140_L0.5530.63
52_M60_K0.5530.63
363_P403_Y0.5530.63
65_V145_I0.5530.63
336_E431_I0.5520.63
371_T414_I0.5510.63
71_I355_G0.5510.63
117_F158_P0.5500.63
12_L29_I0.5500.63
76_V307_D0.5480.62
136_I141_I0.5470.62
213_G219_N0.5470.62
110_T148_G0.5460.62
178_A406_P0.5460.62
93_V101_A0.5460.62
396_Y413_V0.5460.62
444_S452_T0.5450.62
296_L307_D0.5450.62
107_A114_V0.5440.62
146_A340_G0.5440.62
364_L409_V0.5440.62
140_L202_R0.5430.62
201_R208_S0.5430.62
234_K242_A0.5420.61
214_G220_A0.5420.61
83_A236_P0.5420.61
127_A141_I0.5400.61
356_I370_T0.5390.61
100_L104_L0.5390.61
56_A177_Y0.5390.61
367_G410_M0.5390.61
206_Q212_Y0.5380.61
114_V427_N0.5380.61
274_G286_A0.5360.61
173_K354_S0.5360.61
178_A181_W0.5350.60
89_I237_I0.5350.60
38_T47_F0.5330.60
91_R203_K0.5330.60
150_F381_A0.5330.60
59_I373_A0.5320.60
72_F114_V0.5300.60
251_A358_H0.5290.60
237_I250_G0.5280.59
115_S120_V0.5280.59
350_H357_S0.5280.59
4_I157_L0.5260.59
74_K321_E0.5250.59
240_A243_F0.5250.59
96_K241_L0.5240.59
24_I34_A0.5220.59
131_F136_I0.5210.58
180_P190_V0.5190.58
189_I192_A0.5180.58
101_A105_M0.5170.58
27_A349_F0.5160.58
7_L461_A0.5160.58
78_M317_E0.5160.58
213_G218_Q0.5160.58
422_D425_P0.5140.57
170_S174_T0.5140.57
242_A249_V0.5130.57
27_A336_E0.5130.57
89_I101_A0.5120.57
47_F50_I0.5120.57
74_K77_E0.5110.57
174_T180_P0.5110.57
93_V104_L0.5110.57
28_P51_F0.5100.57
317_E320_N0.5090.57
190_V455_K0.5090.57
63_F164_Q0.5090.57
49_S251_A0.5080.57
16_T26_F0.5080.57
155_D381_A0.5080.57
53_E350_H0.5070.56
117_F382_S0.5070.56
22_S320_N0.5060.56
50_I343_I0.5060.56
141_I213_G0.5050.56
143_G451_I0.5040.56
100_L164_Q0.5020.56
326_A333_T0.5020.56
116_L340_G0.5010.56
190_V459_V0.5010.56
251_A462_V0.5000.55
59_I72_F0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9301 100 0.724 Contact Map
4r0cA 3 0.9089 100 0.731 Contact Map
4f35D 2 0.8411 100 0.761 Contact Map
3qnqA 2 0.4343 77.4 0.961 Contact Map
4pypA 1 0.3898 50.5 0.967 Contact Map
3giaA 1 0.3856 45.5 0.968 Contact Map
3l1lA 2 0.3835 43.7 0.969 Contact Map
4zw9A 1 0.4216 41.8 0.969 Contact Map
2onkC 2 0.4004 32.2 0.971 Contact Map
4djkA 2 0.4025 26.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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