GREMLIN Database
NUPG - Purine nucleoside transport protein NupG
UniProt: P42312 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (393)
Sequences: 1648 (938)
Seq/√Len: 47.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_C268_G4.9701.00
300_D331_P4.4761.00
298_V301_A4.2571.00
365_E368_T3.9181.00
267_N280_Q3.8751.00
280_Q322_D3.7221.00
97_I252_I3.6851.00
23_Q26_K3.6421.00
322_D325_N3.5781.00
167_T205_L3.2731.00
304_V338_A3.2571.00
22_P376_K3.1971.00
304_V334_T2.9871.00
162_N372_R2.9421.00
12_V293_L2.8631.00
20_C379_V2.8401.00
153_I160_L2.8381.00
77_A257_I2.7111.00
10_L387_L2.6821.00
294_L386_L2.6801.00
115_W119_K2.6151.00
246_M250_I2.5951.00
22_P212_N2.5581.00
375_W379_V2.5241.00
203_N384_V2.4891.00
106_I234_F2.4061.00
18_F24_K2.4041.00
35_L206_I2.3551.00
157_L362_L2.3361.00
57_G61_D2.3111.00
158_T364_G2.2951.00
242_M258_G2.2581.00
310_M322_D2.2491.00
17_V210_L2.2201.00
348_F375_W2.1511.00
109_Y231_K2.1391.00
323_L333_H2.1371.00
106_I238_I2.0341.00
66_L103_F2.0290.99
22_P162_N2.0070.99
243_L251_V1.9980.99
72_D75_A1.9760.99
288_S305_A1.9720.99
140_Q152_V1.9590.99
17_V207_I1.9390.99
110_F234_F1.9210.99
192_Y340_T1.8950.99
294_L390_A1.8660.99
346_A385_S1.8620.99
71_S92_S1.8470.99
238_I262_L1.8410.99
248_M251_V1.8230.99
200_N388_S1.8120.99
211_L380_S1.8010.99
134_E209_N1.7930.99
340_T388_S1.7790.99
7_L11_I1.7690.99
51_V55_A1.7610.99
162_N368_T1.7580.99
130_L135_S1.7290.98
281_T285_Y1.7180.98
312_L382_I1.7110.98
211_L379_V1.6950.98
44_W395_F1.6850.98
161_S214_V1.6740.98
146_N350_T1.6430.98
45_F49_T1.6400.98
5_L292_F1.6380.98
123_V127_A1.6350.98
147_T248_M1.6170.97
247_N250_I1.6130.97
200_N203_N1.6110.97
119_K122_W1.6000.97
279_I283_F1.5960.97
32_I206_I1.5740.97
20_C211_L1.5730.97
17_V383_A1.5680.97
33_I37_V1.5640.97
277_L282_I1.5590.97
163_N214_V1.5550.97
121_G132_K1.5440.97
94_L253_L1.5440.97
100_I144_L1.5120.96
18_F27_I1.4950.96
146_N354_I1.4730.96
111_G114_P1.4650.95
115_W118_D1.4630.95
70_A74_I1.4620.95
23_Q215_H1.4310.95
288_S298_V1.4300.95
64_T68_A1.4220.95
55_A58_K1.4210.95
165_L368_T1.4200.95
4_L8_V1.4050.94
166_L380_S1.4000.94
249_V253_L1.3970.94
313_A348_F1.3920.94
292_F298_V1.3920.94
261_A349_S1.3910.94
8_V292_F1.3820.94
185_L190_A1.3790.94
346_A382_I1.3770.94
173_M354_I1.3770.94
105_D109_Y1.3680.93
234_F238_I1.3620.93
251_V255_M1.3530.93
246_M254_A1.3500.93
265_A269_I1.3350.92
72_D264_S1.3330.92
70_A261_A1.3310.92
157_L361_I1.3310.92
248_M252_I1.3310.92
375_W378_L1.3250.92
74_I91_F1.3210.92
28_K31_P1.3170.92
149_A171_M1.3070.92
147_T251_V1.3020.91
15_A19_L1.2850.91
146_N349_S1.2840.91
27_I210_L1.2790.91
65_W68_A1.2780.91
336_A396_V1.2750.91
78_F90_F1.2600.90
299_H303_Y1.2530.90
236_S366_K1.2500.90
285_Y302_M1.2490.90
147_T357_T1.2430.89
102_T238_I1.2420.89
119_K123_V1.2400.89
65_W69_C1.2300.89
89_F349_S1.2120.88
279_I313_A1.2120.88
236_S240_N1.2050.88
333_H337_V1.1880.87
266_V279_I1.1780.87
167_T171_M1.1760.87
237_T241_S1.1700.86
392_V395_F1.1640.86
288_S302_M1.1640.86
49_T52_G1.1620.86
102_T242_M1.1420.85
140_Q144_L1.1420.85
378_L382_I1.1400.85
161_S216_V1.1390.85
137_F149_A1.1380.85
291_A308_M1.1380.85
96_P179_S1.1310.84
280_Q310_M1.1250.84
258_G352_G1.1230.84
300_D330_L1.1210.84
161_S164_R1.1170.84
323_L338_A1.1130.83
150_L172_S1.1070.83
183_S317_F1.1020.83
385_S388_S1.1020.83
80_S84_N1.0850.82
61_D64_T1.0840.82
38_L127_A1.0840.82
189_P327_L1.0810.82
298_V305_A1.0730.81
14_M32_I1.0680.81
45_F51_V1.0660.81
315_N349_S1.0580.80
19_L24_K1.0520.80
307_L326_N1.0510.80
200_N340_T1.0460.79
269_I272_V1.0420.79
314_T318_V1.0420.79
146_N353_M1.0350.79
384_V388_S1.0340.79
120_I142_M1.0330.79
358_Y370_I1.0330.79
42_I203_N1.0300.78
179_S248_M1.0290.78
146_N312_L1.0290.78
44_W48_G1.0290.78
263_T314_T1.0270.78
320_M343_T1.0260.78
277_L281_T1.0260.78
40_L391_I1.0200.78
14_M210_L1.0170.78
278_T281_T1.0150.77
137_F171_M1.0110.77
161_S215_H1.0080.77
306_Q310_M1.0050.77
187_M321_L1.0040.77
348_F378_L1.0020.76
112_I332_P0.9990.76
80_S88_D0.9970.76
351_V354_I0.9930.76
187_M351_V0.9910.76
251_V357_T0.9900.76
296_L304_V0.9890.76
16_V290_F0.9870.75
366_K381_G0.9860.75
62_F65_W0.9840.75
207_I380_S0.9830.75
43_T334_T0.9810.75
117_I156_Q0.9750.74
43_T305_A0.9690.74
59_I62_F0.9680.74
67_I182_G0.9620.73
16_V361_I0.9610.73
98_I245_G0.9570.73
378_L381_G0.9550.73
28_K33_I0.9520.73
74_I261_A0.9500.73
55_A59_I0.9470.72
21_S210_L0.9460.72
157_L168_F0.9460.72
152_V252_I0.9450.72
270_L277_L0.9440.72
13_I387_L0.9440.72
124_I128_S0.9410.72
181_I193_V0.9370.71
141_M175_S0.9310.71
311_K317_F0.9260.71
13_I207_I0.9250.70
81_V88_D0.9230.70
130_L205_L0.9200.70
18_F210_L0.9200.70
327_L335_V0.9190.70
35_L128_S0.9190.70
86_T92_S0.9160.70
171_M201_C0.9130.69
40_L395_F0.9110.69
326_N329_S0.9020.69
30_R34_T0.9020.69
351_V378_L0.8990.68
144_L152_V0.8980.68
197_I200_N0.8970.68
180_I349_S0.8960.68
139_I183_S0.8960.68
6_N333_H0.8890.67
330_L335_V0.8880.67
16_V379_V0.8870.67
68_A71_S0.8870.67
43_T326_N0.8860.67
5_L8_V0.8850.67
117_I176_I0.8850.67
167_T208_A0.8850.67
83_A88_D0.8840.67
113_L155_Q0.8840.67
255_M348_F0.8830.67
280_Q325_N0.8820.67
173_M381_G0.8790.67
162_N212_N0.8760.66
284_A306_Q0.8740.66
256_V260_V0.8620.65
108_T155_Q0.8620.65
76_F89_F0.8590.65
351_V374_V0.8570.65
93_A249_V0.8540.64
104_F144_L0.8510.64
82_M85_E0.8500.64
110_F113_L0.8480.64
351_V370_I0.8470.64
37_V293_L0.8450.63
233_D277_L0.8440.63
70_A96_P0.8430.63
106_I262_L0.8420.63
206_I385_S0.8420.63
49_T53_S0.8410.63
162_N373_N0.8390.63
34_T128_S0.8360.63
138_S205_L0.8220.61
8_V154_R0.8200.61
141_M181_I0.8190.61
257_I272_V0.8180.61
263_T306_Q0.8140.61
34_T37_V0.8120.60
170_L286_L0.8090.60
340_T392_V0.8080.60
54_W57_G0.8050.60
91_F95_L0.8050.60
200_N385_S0.8050.60
294_L337_V0.8020.59
239_S243_L0.8020.59
337_V376_K0.7960.59
175_S189_P0.7940.59
6_N194_F0.7930.59
146_N249_V0.7920.58
35_L48_G0.7920.58
299_H331_P0.7910.58
113_L188_V0.7890.58
10_L388_S0.7880.58
121_G135_S0.7870.58
80_S83_A0.7820.57
210_L293_L0.7820.57
128_S168_F0.7800.57
121_G124_I0.7790.57
193_V209_N0.7770.57
59_I194_F0.7760.57
27_I59_I0.7740.57
203_N388_S0.7740.57
181_I185_L0.7720.56
42_I104_F0.7710.56
39_E203_N0.7700.56
264_S268_G0.7680.56
271_G298_V0.7640.56
41_L44_W0.7640.56
181_I197_I0.7560.55
347_N350_T0.7560.55
249_V305_A0.7560.55
133_L160_L0.7520.54
332_P335_V0.7510.54
90_F253_L0.7510.54
303_Y326_N0.7500.54
160_L168_F0.7470.54
113_L117_I0.7440.54
176_I180_I0.7430.54
58_K62_F0.7410.53
14_M394_L0.7410.53
353_M356_G0.7400.53
232_K372_R0.7380.53
104_F113_L0.7380.53
104_F175_S0.7350.53
15_A18_F0.7350.53
334_T338_A0.7330.53
244_V247_N0.7330.53
163_N201_C0.7330.53
156_Q381_G0.7310.52
112_I286_L0.7310.52
332_P336_A0.7310.52
12_V15_A0.7290.52
219_D223_I0.7280.52
163_N209_N0.7280.52
133_L149_A0.7260.52
71_S75_A0.7260.52
137_F168_F0.7250.52
100_I259_Y0.7200.51
147_T180_I0.7200.51
303_Y330_L0.7190.51
10_L203_N0.7180.51
367_S372_R0.7170.51
188_V342_L0.7170.51
53_S57_G0.7150.51
103_F254_A0.7140.51
171_M333_H0.7140.51
312_L346_A0.7130.51
13_I294_L0.7110.50
141_M171_M0.7110.50
340_T385_S0.7100.50
290_F386_L0.7090.50
352_G385_S0.7090.50
78_F95_L0.7090.50
214_V218_E0.7070.50
25_K126_K0.7070.50
93_A183_S0.7060.50
28_K128_S0.7060.50
72_D267_N0.7030.50
194_F198_P0.7030.50
284_A305_A0.7020.50
105_D231_K0.7010.49
159_V280_Q0.7000.49
38_L243_L0.6990.49
69_C265_A0.6990.49
82_M91_F0.6980.49
28_K129_R0.6980.49
337_V387_L0.6960.49
77_A256_V0.6930.49
134_E167_T0.6910.48
139_I142_M0.6890.48
34_T154_R0.6890.48
192_Y388_S0.6860.48
60_G260_V0.6820.48
165_L365_E0.6820.48
137_F204_A0.6790.47
207_I352_G0.6780.47
7_L367_S0.6780.47
255_M353_M0.6780.47
43_T298_V0.6770.47
212_N299_H0.6740.47
176_I287_F0.6730.47
75_A80_S0.6730.47
14_M36_I0.6690.46
124_I378_L0.6680.46
18_F22_P0.6660.46
315_N318_V0.6660.46
262_L327_L0.6650.46
138_S315_N0.6640.46
104_F308_M0.6620.46
7_L394_L0.6610.45
315_N319_A0.6580.45
357_T370_I0.6580.45
382_I385_S0.6580.45
337_V382_I0.6550.45
133_L136_F0.6550.45
43_T336_A0.6550.45
84_N92_S0.6550.45
157_L325_N0.6540.45
52_G134_E0.6530.45
45_F281_T0.6510.44
177_S310_M0.6460.44
307_L319_A0.6440.44
362_L368_T0.6440.44
386_L389_A0.6440.44
302_M305_A0.6440.44
62_F106_I0.6430.44
45_F55_A0.6420.44
352_G374_V0.6370.43
290_F293_L0.6370.43
29_W144_L0.6350.43
81_V91_F0.6350.43
162_N365_E0.6350.43
131_P218_E0.6350.43
177_S180_I0.6350.43
146_N239_S0.6340.43
26_K340_T0.6330.43
170_L344_S0.6330.43
282_I286_L0.6330.43
121_G160_L0.6290.42
93_A317_F0.6280.42
354_I358_Y0.6280.42
64_T189_P0.6270.42
246_M253_L0.6270.42
141_M201_C0.6260.42
300_D334_T0.6250.42
296_L334_T0.6230.42
101_V175_S0.6220.42
253_L256_V0.6220.42
36_I391_I0.6210.42
231_K240_N0.6190.41
111_G115_W0.6190.41
103_F262_L0.6190.41
122_W127_A0.6180.41
45_F337_V0.6180.41
41_L129_R0.6170.41
8_V12_V0.6160.41
316_E319_A0.6160.41
315_N347_N0.6160.41
35_L139_I0.6160.41
113_L200_N0.6150.41
218_E221_D0.6150.41
157_L270_L0.6100.40
296_L338_A0.6090.40
111_G255_M0.6080.40
53_S191_T0.6080.40
249_V252_I0.6080.40
334_T339_T0.6080.40
65_W268_G0.6070.40
108_T114_P0.6040.40
14_M27_I0.6030.40
94_L249_V0.6010.40
99_F134_E0.6010.40
141_M149_A0.6000.39
217_P221_D0.5990.39
160_L392_V0.5980.39
267_N278_T0.5970.39
151_A248_M0.5950.39
8_V293_L0.5950.39
169_G354_I0.5950.39
157_L269_I0.5940.39
169_G178_G0.5930.39
58_K61_D0.5920.39
154_R296_L0.5920.39
135_S145_G0.5910.39
40_L44_W0.5900.39
390_A393_G0.5890.38
62_F66_L0.5890.38
4_L122_W0.5890.38
18_F392_V0.5870.38
51_V54_W0.5860.38
325_N329_S0.5830.38
391_I394_L0.5820.38
131_P164_R0.5820.38
30_R129_R0.5820.38
252_I261_A0.5820.38
192_Y203_N0.5820.38
56_I121_G0.5810.38
251_V356_G0.5790.38
96_P201_C0.5790.38
311_K347_N0.5760.37
42_I45_F0.5740.37
355_Y391_I0.5740.37
100_I151_A0.5730.37
14_M206_I0.5730.37
43_T381_G0.5720.37
138_S200_N0.5710.37
14_M361_I0.5710.37
6_N272_V0.5690.37
79_P88_D0.5690.37
74_I390_A0.5690.37
19_L250_I0.5680.36
128_S171_M0.5680.36
77_A100_I0.5650.36
212_N373_N0.5650.36
269_I303_Y0.5630.36
14_M29_W0.5610.36
117_I188_V0.5610.36
173_M377_L0.5600.36
112_I115_W0.5600.36
115_W389_A0.5590.36
139_I171_M0.5590.36
82_M86_T0.5570.35
147_T255_M0.5570.35
38_L128_S0.5560.35
332_P395_F0.5560.35
10_L277_L0.5520.35
194_F337_V0.5520.35
245_G249_V0.5520.35
54_W98_I0.5520.35
237_T309_G0.5520.35
207_I355_Y0.5520.35
243_L250_I0.5510.35
183_S190_A0.5510.35
266_V356_G0.5510.35
41_L45_F0.5500.35
346_A350_T0.5500.35
192_Y336_A0.5500.35
297_P303_Y0.5490.35
240_N366_K0.5480.35
101_V151_A0.5470.35
141_M172_S0.5470.35
310_M315_N0.5470.35
182_G186_S0.5470.35
266_V328_K0.5460.34
175_S333_H0.5460.34
136_F152_V0.5460.34
349_S353_M0.5440.34
70_A207_I0.5440.34
144_L357_T0.5430.34
382_I386_L0.5420.34
130_L163_N0.5420.34
6_N394_L0.5400.34
188_V343_T0.5400.34
140_Q200_N0.5390.34
4_L238_I0.5390.34
15_A210_L0.5380.34
206_I374_V0.5370.34
350_T353_M0.5360.34
97_I317_F0.5350.33
248_M357_T0.5350.33
142_M201_C0.5350.33
77_A253_L0.5330.33
106_I254_A0.5330.33
54_W58_K0.5320.33
252_I371_G0.5320.33
108_T113_L0.5300.33
321_L324_K0.5280.33
235_F348_F0.5280.33
106_I110_F0.5260.33
74_I195_T0.5260.33
4_L215_H0.5260.33
152_V204_A0.5260.33
100_I312_L0.5250.33
5_L9_G0.5250.33
49_T211_L0.5240.33
144_L149_A0.5240.33
94_L101_V0.5230.32
64_T348_F0.5220.32
155_Q363_D0.5210.32
164_R279_I0.5210.32
351_V376_K0.5210.32
179_S351_V0.5180.32
112_I367_S0.5180.32
105_D236_S0.5160.32
65_W112_I0.5160.32
359_N371_G0.5160.32
283_F313_A0.5160.32
26_K215_H0.5150.32
96_P182_G0.5140.32
131_P320_M0.5140.32
161_S221_D0.5130.32
136_F141_M0.5130.32
85_E88_D0.5120.31
349_S372_R0.5120.31
70_A92_S0.5110.31
97_I177_S0.5110.31
29_W33_I0.5110.31
266_V270_L0.5110.31
238_I352_G0.5100.31
87_V92_S0.5100.31
37_V41_L0.5080.31
149_A357_T0.5080.31
166_L170_L0.5070.31
255_M382_I0.5070.31
146_N305_A0.5060.31
160_L197_I0.5060.31
282_I305_A0.5050.31
80_S86_T0.5030.31
23_Q306_Q0.5030.31
71_S165_L0.5030.31
141_M150_L0.5030.31
97_I107_L0.5020.31
209_N214_V0.5020.31
244_V252_I0.5020.31
136_F144_L0.5010.31
290_F372_R0.5000.30
180_I353_M0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9622 100 0.119 Contact Map
2cfqA 1 0.8816 37.2 0.977 Contact Map
2mofA 1 0.0806 23.9 0.979 Contact Map
4ikvA 1 0.4257 12.5 0.981 Contact Map
4f35D 2 0.8892 11.3 0.982 Contact Map
4j05A 3 0.3678 9.5 0.982 Contact Map
4oh3A 2 0.4156 5.3 0.984 Contact Map
4zw9A 1 0.3879 5.2 0.984 Contact Map
2kncB 1 0.0806 4.2 0.985 Contact Map
4o6yA 2 0.461 3.9 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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