GREMLIN Database
YXIS - Uncharacterized protein YxiS
UniProt: P42310 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 96 (91)
Sequences: 108 (88)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_N51_K4.7471.00
68_D94_R3.7500.97
4_K8_E2.5040.81
61_H64_E2.3750.77
11_E55_D2.3670.77
22_A57_V2.3050.75
90_A93_G2.1890.71
8_E11_E2.1090.68
20_V73_A2.0990.67
91_I94_R1.8660.58
53_M87_L1.8390.57
35_L42_Q1.7470.53
7_T11_E1.6080.47
71_V76_E1.5780.45
68_D91_I1.5610.45
13_D59_P1.5510.44
13_D78_F1.5110.42
48_S52_T1.5060.42
42_Q92_S1.4980.42
12_R15_N1.4900.41
19_L58_V1.4870.41
26_V59_P1.4750.41
76_E88_H1.4750.41
56_L70_T1.4460.40
8_E94_R1.4340.39
70_T77_M1.2410.31
29_D37_A1.2180.31
16_M58_V1.2040.30
19_L22_A1.1940.30
38_K65_H1.1870.29
38_K90_A1.1410.28
38_K45_L1.1290.27
48_S77_M1.0740.25
26_V53_M1.0670.25
67_P81_T1.0470.25
6_L10_Y1.0470.25
55_D67_P1.0460.25
64_E76_E1.0210.24
69_Q81_T1.0180.24
53_M65_H1.0070.23
19_L57_V0.9900.23
15_N52_T0.9880.23
78_F87_L0.9820.22
38_K59_P0.9790.22
5_Q92_S0.9690.22
11_E93_G0.9460.21
15_N20_V0.9410.21
3_E69_Q0.9400.21
10_Y85_Q0.9330.21
50_K69_Q0.9320.21
72_I91_I0.9260.21
73_A76_E0.9240.21
65_H89_E0.9140.20
50_K67_P0.9020.20
7_T85_Q0.8960.20
28_H33_M0.8960.20
71_V90_A0.8930.20
38_K89_E0.8810.20
21_F84_A0.8780.19
29_D32_P0.8770.19
24_W41_P0.8770.19
24_W43_Q0.8770.19
13_D38_K0.8750.19
46_N49_L0.8740.19
4_K81_T0.8730.19
73_A82_D0.8640.19
22_A59_P0.8570.19
37_A66_I0.8530.19
55_D77_M0.8290.18
12_R51_K0.8130.18
16_M60_K0.8090.18
5_Q53_M0.8090.18
45_L53_M0.8060.18
6_L44_K0.8040.18
38_K86_A0.7900.17
47_E51_K0.7880.17
15_N33_M0.7870.17
15_N48_S0.7790.17
22_A26_V0.7760.17
22_A58_V0.7720.17
8_E78_F0.7670.17
70_T74_V0.7640.17
51_K94_R0.7630.16
16_M89_E0.7610.16
34_E52_T0.7460.16
52_T85_Q0.7440.16
9_A12_R0.7430.16
86_A89_E0.7420.16
9_A66_I0.7390.16
10_Y49_L0.7300.16
23_Q62_E0.7140.15
56_L59_P0.7130.15
6_L35_L0.7010.15
26_V51_K0.6910.15
55_D65_H0.6890.15
6_L11_E0.6850.15
10_Y65_H0.6810.15
9_A37_A0.6800.15
4_K37_A0.6750.14
22_A94_R0.6670.14
71_V92_S0.6660.14
3_E44_K0.6580.14
26_V61_H0.6330.14
72_I87_L0.6230.13
72_I85_Q0.6220.13
47_E93_G0.6200.13
12_R37_A0.6170.13
35_L86_A0.6100.13
5_Q37_A0.6070.13
19_L88_H0.5950.13
5_Q69_Q0.5890.13
18_I91_I0.5870.13
26_V64_E0.5820.13
23_Q27_N0.5790.13
6_L51_K0.5710.12
68_D76_E0.5710.12
34_E38_K0.5670.12
9_A53_M0.5670.12
72_I76_E0.5530.12
13_D77_M0.5430.12
16_M61_H0.5420.12
11_E42_Q0.5410.12
78_F81_T0.5390.12
6_L88_H0.5380.12
85_Q90_A0.5370.12
26_V34_E0.5370.12
59_P89_E0.5330.12
56_L76_E0.5320.12
8_E18_I0.5310.12
8_E47_E0.5280.12
26_V57_V0.5180.11
5_Q77_M0.5050.11
33_M37_A0.5040.11
29_D93_G0.5030.11
56_L69_Q0.5030.11
58_V63_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nvpD 1 0.5312 6.4 0.952 Contact Map
2lekA 1 0.4375 6.1 0.952 Contact Map
2jesA 5 0.875 6.1 0.952 Contact Map
1u1jA 1 0.5208 5.8 0.953 Contact Map
1tkeA 1 0.4583 5.5 0.953 Contact Map
5a2tA 12 0.7917 5.5 0.954 Contact Map
4pbyC 1 0 5.3 0.954 Contact Map
1nh2D 1 0.5521 5.3 0.954 Contact Map
4lqeA 3 0.5 4.7 0.955 Contact Map
1k7jA 1 0.6354 4.5 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0054 seconds.