GREMLIN Database
CITN - Citrate transporter
UniProt: P42308 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (424)
Sequences: 642 (408)
Seq/√Len: 19.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_F262_V11.5401.00
273_R276_A5.6251.00
69_Y234_T4.5581.00
223_R226_L4.0681.00
237_L255_A3.9121.00
258_V262_V3.7871.00
5_L39_S3.7041.00
102_A142_I3.6211.00
49_M293_I3.4831.00
266_N269_E3.3251.00
183_A417_A3.1590.99
69_Y237_L3.1000.99
98_A142_I3.0620.99
7_F307_M3.0160.99
36_A45_L3.0090.99
330_V343_F2.9230.99
102_A188_V2.8910.99
73_M234_T2.7500.99
15_Y19_S2.7270.98
41_F48_M2.6600.98
6_G307_M2.6540.98
31_V34_V2.6320.98
223_R264_Y2.6260.98
85_K88_S2.6220.98
130_K136_R2.5820.98
237_L251_L2.5690.98
182_I186_L2.5600.98
399_H403_T2.4540.97
340_N376_H2.3760.96
60_G289_F2.3550.96
187_W410_T2.2510.95
101_T129_Y2.2500.95
51_Q300_G2.2500.95
72_I256_F2.2490.95
82_L231_L2.2030.94
97_I132_L2.1600.94
103_V189_I2.1370.93
49_M250_V2.1300.93
86_I100_G2.1260.93
78_L231_L2.1080.93
29_I253_M2.0850.92
73_M78_L2.0610.92
99_V193_Y2.0540.92
141_G403_T2.0480.92
412_I416_I2.0370.91
3_A310_S2.0360.91
64_L285_V2.0040.91
382_V385_T1.9920.90
76_S264_Y1.9840.90
16_L31_V1.9250.89
339_S342_A1.8940.88
145_L407_A1.8740.87
98_A134_M1.8600.87
46_G247_P1.8550.87
199_E202_R1.8190.86
118_Y384_S1.7950.85
99_V189_I1.7510.84
63_L284_V1.7460.83
5_L35_F1.7340.83
33_I254_T1.7310.83
75_D277_H1.7020.82
9_M35_F1.6920.81
221_L224_P1.6880.81
66_A114_G1.6800.81
104_L125_M1.6730.81
335_T376_H1.6640.80
64_L281_A1.6590.80
223_R273_R1.6560.80
135_N138_V1.6500.80
20_N398_D1.6450.79
3_A6_G1.6410.79
161_R341_D1.6390.79
151_N159_T1.6230.78
302_K305_D1.5970.77
95_L200_R1.5860.77
239_A243_T1.5840.77
163_L170_T1.5810.77
53_V82_L1.5740.76
287_M383_P1.5550.75
417_A421_I1.5490.75
69_Y229_F1.5290.74
224_P273_R1.5220.74
140_A392_A1.5210.74
106_M185_I1.5080.73
37_L42_G1.4920.72
338_M376_H1.4820.72
371_L415_T1.4750.71
162_V366_G1.4740.71
169_D244_S1.4700.71
2_L306_A1.4550.70
4_I8_V1.4540.70
335_T374_P1.4370.69
406_W409_G1.4290.69
371_L418_A1.4260.69
348_L365_I1.4260.69
75_D276_A1.4220.68
394_V399_H1.4210.68
3_A307_M1.4200.68
232_L420_L1.4190.68
221_L264_Y1.4160.68
21_R314_L1.4110.68
51_Q54_T1.4060.68
34_V239_A1.4050.67
335_T382_V1.3890.67
9_M350_I1.3780.66
75_D273_R1.3700.65
149_V188_V1.3540.65
177_L371_L1.3510.64
26_I260_L1.3450.64
398_D401_K1.3360.63
105_T121_T1.3230.63
307_M338_M1.3180.62
90_V100_G1.3100.62
226_L229_F1.3090.62
396_F399_H1.3040.62
5_L278_A1.3020.61
229_F258_V1.2800.60
151_N158_P1.2750.60
392_A399_H1.2730.60
335_T340_N1.2670.59
310_S366_G1.2660.59
14_M340_N1.2550.58
343_F369_S1.2550.58
62_M237_L1.2520.58
383_P421_I1.2500.58
377_L382_V1.2430.58
138_V402_F1.2410.58
9_M336_F1.2340.57
73_M259_A1.2330.57
348_L369_S1.2320.57
183_A315_I1.2320.57
186_L235_V1.2260.57
187_W191_V1.2210.56
340_N377_L1.2190.56
118_Y377_L1.2160.56
320_G358_Y1.2130.56
369_S388_L1.2130.56
88_S107_T1.2020.55
180_A421_I1.1970.55
232_L236_A1.1930.55
87_L190_A1.1880.54
5_L49_M1.1810.54
109_S147_S1.1800.54
375_V382_V1.1670.53
141_G402_F1.1620.53
78_L234_T1.1420.51
113_D287_M1.1380.51
105_T146_G1.1340.51
291_A342_A1.1290.50
305_D309_H1.1200.50
156_G159_T1.1180.50
113_D123_A1.1120.49
113_D116_T1.1110.49
105_T221_L1.1110.49
144_M399_H1.1020.49
169_D322_H1.0990.49
128_L238_M1.0910.48
129_Y140_A1.0890.48
408_V411_T1.0880.48
163_L168_L1.0870.48
382_V386_Y1.0850.48
331_S343_F1.0820.47
45_L393_G1.0800.47
338_M377_L1.0720.47
135_N402_F1.0710.47
216_P269_E1.0660.46
24_A67_I1.0660.46
140_A399_H1.0630.46
226_L262_V1.0600.46
118_Y147_S1.0600.46
115_T336_F1.0600.46
340_N375_V1.0540.46
182_I420_L1.0540.46
234_T237_L1.0520.45
47_E51_Q1.0480.45
119_M123_A1.0480.45
164_A319_M1.0460.45
178_I182_I1.0440.45
93_D200_R1.0440.45
148_G414_M1.0430.45
338_M374_P1.0370.45
63_L287_M1.0360.44
14_M376_H1.0350.44
76_S97_I1.0310.44
389_V396_F1.0290.44
378_L405_K1.0250.44
99_V103_V1.0220.44
162_V348_L1.0170.43
174_F181_M1.0130.43
173_V366_G1.0090.43
366_G369_S1.0080.43
131_R354_A1.0070.43
62_M151_N0.9950.42
177_L345_F0.9950.42
204_G207_S0.9890.41
150_M393_G0.9890.41
60_G136_R0.9890.41
60_G164_A0.9870.41
98_A138_V0.9850.41
108_I113_D0.9840.41
130_K133_G0.9830.41
141_G399_H0.9770.41
82_L338_M0.9770.41
233_L259_A0.9730.41
160_A386_Y0.9720.40
88_S242_I0.9720.40
187_W409_G0.9690.40
71_G105_T0.9660.40
389_V394_V0.9630.40
186_L190_A0.9620.40
115_T288_V0.9620.40
34_V232_L0.9580.40
377_L384_S0.9560.39
314_L350_I0.9540.39
22_L27_A0.9500.39
376_H382_V0.9490.39
86_I133_G0.9460.39
115_T159_T0.9430.39
328_A415_T0.9380.38
103_V208_I0.9380.38
135_N198_K0.9360.38
177_L370_L0.9360.38
369_S374_P0.9340.38
4_I51_Q0.9340.38
21_R133_G0.9330.38
60_G385_T0.9300.38
189_I416_I0.9290.38
235_V416_I0.9220.37
335_T375_V0.9220.37
231_L318_A0.9150.37
34_V37_L0.9150.37
229_F233_L0.9140.37
374_P382_V0.9120.37
340_N386_Y0.9060.36
373_Q388_L0.9060.36
310_S328_A0.9030.36
254_T258_V0.9020.36
13_F113_D0.8990.36
194_I198_K0.8950.36
69_Y78_L0.8950.36
158_P199_E0.8950.36
336_F382_V0.8940.36
176_P367_R0.8940.36
36_A41_F0.8930.36
14_M338_M0.8930.36
338_M375_V0.8930.36
96_K388_L0.8910.36
131_R375_V0.8910.36
29_I360_I0.8870.35
17_I90_V0.8860.35
11_I15_Y0.8840.35
105_T143_A0.8810.35
340_N382_V0.8810.35
221_L225_A0.8800.35
140_A388_L0.8780.35
4_I186_L0.8750.35
402_F405_K0.8750.35
63_L288_V0.8720.34
225_A329_I0.8720.34
236_A240_A0.8720.34
148_G399_H0.8700.34
335_T373_Q0.8660.34
74_I113_D0.8640.34
347_V354_A0.8560.33
260_L297_I0.8540.33
142_I188_V0.8520.33
80_D350_I0.8510.33
120_I361_D0.8510.33
186_L225_A0.8500.33
9_M382_V0.8500.33
1_M255_A0.8450.33
18_M99_V0.8440.33
118_Y376_H0.8440.33
268_K274_I0.8440.33
378_L406_W0.8430.33
190_A194_I0.8390.33
41_F44_D0.8380.32
224_P264_Y0.8360.32
30_V257_A0.8360.32
103_V420_L0.8330.32
180_A423_I0.8320.32
257_A298_L0.8260.32
415_T424_I0.8230.32
351_I365_I0.8200.31
324_P343_F0.8190.31
115_T151_N0.8180.31
221_L226_L0.8170.31
38_I208_I0.8160.31
273_R278_A0.8160.31
105_T125_M0.8150.31
397_G401_K0.8130.31
226_L418_A0.8110.31
69_Y258_V0.8090.31
71_G90_V0.8070.31
325_L424_I0.8060.31
131_R419_L0.8030.31
240_A245_L0.8030.31
69_Y138_V0.8020.30
332_M408_V0.8000.30
336_F340_N0.7990.30
186_L232_L0.7940.30
256_F260_L0.7930.30
139_L275_S0.7920.30
109_S336_F0.7890.30
90_V339_S0.7880.30
8_V173_V0.7840.29
367_R423_I0.7830.29
190_A198_K0.7830.29
8_V35_F0.7820.29
208_I235_V0.7810.29
197_K201_K0.7780.29
84_A245_L0.7760.29
69_Y262_V0.7750.29
3_A9_M0.7740.29
164_A201_K0.7720.29
168_L274_I0.7720.29
186_L268_K0.7700.29
62_M128_L0.7700.29
206_I209_D0.7700.29
298_L392_A0.7700.29
335_T338_M0.7690.29
5_L9_M0.7650.28
6_G111_D0.7650.28
3_A128_L0.7640.28
320_G355_A0.7620.28
30_V99_V0.7600.28
106_M146_G0.7590.28
71_G276_A0.7580.28
109_S152_I0.7560.28
315_I360_I0.7560.28
71_G195_L0.7540.28
142_I195_L0.7540.28
118_Y399_H0.7530.28
97_I314_L0.7520.28
63_L109_S0.7510.28
19_S27_A0.7510.28
175_T178_I0.7480.28
91_K119_M0.7470.28
18_M318_A0.7430.27
5_L59_T0.7420.27
408_V412_I0.7420.27
183_A243_T0.7370.27
118_Y375_V0.7360.27
21_R58_P0.7330.27
91_K409_G0.7310.27
163_L173_V0.7300.27
335_T339_S0.7290.27
264_Y354_A0.7290.27
102_A106_M0.7230.26
83_I411_T0.7220.26
107_T282_L0.7210.26
374_P396_F0.7190.26
137_L394_V0.7170.26
24_A253_M0.7110.26
109_S340_N0.7100.26
315_I326_I0.7090.26
12_V34_V0.7060.25
246_L412_I0.7050.25
293_I297_I0.7050.25
63_L387_L0.7030.25
152_I327_T0.7030.25
134_M145_L0.7020.25
69_Y179_P0.7010.25
74_I116_T0.7010.25
34_V212_P0.7010.25
186_L308_A0.7010.25
287_M400_Q0.7000.25
265_P301_T0.6990.25
1_M173_V0.6960.25
277_H350_I0.6960.25
14_M377_L0.6950.25
343_F351_I0.6940.25
378_L400_Q0.6940.25
16_L195_L0.6920.25
42_G142_I0.6920.25
14_M151_N0.6920.25
373_Q376_H0.6910.25
80_D298_L0.6910.25
5_L38_I0.6900.25
93_D96_K0.6890.25
246_L254_T0.6880.25
377_L385_T0.6880.25
11_I317_D0.6870.25
386_Y396_F0.6870.25
355_A365_I0.6850.24
23_S289_F0.6850.24
67_I281_A0.6850.24
11_I98_A0.6840.24
335_T377_L0.6840.24
15_Y31_V0.6810.24
227_Q231_L0.6790.24
418_A424_I0.6780.24
167_K235_V0.6760.24
264_Y273_R0.6750.24
80_D222_K0.6740.24
143_A147_S0.6730.24
280_N334_F0.6720.24
60_G403_T0.6720.24
28_L344_Y0.6710.24
28_L335_T0.6710.24
288_V339_S0.6690.24
67_I334_F0.6670.24
385_T403_T0.6670.24
94_P388_L0.6670.24
98_A398_D0.6640.23
31_V55_D0.6630.23
59_T304_V0.6630.23
24_A267_V0.6620.23
288_V331_S0.6620.23
232_L269_E0.6620.23
23_S313_S0.6620.23
184_G414_M0.6610.23
346_G373_Q0.6600.23
83_I160_A0.6600.23
315_I320_G0.6600.23
175_T193_Y0.6570.23
14_M375_V0.6560.23
253_M298_L0.6480.23
67_I81_P0.6480.23
214_S313_S0.6470.23
395_S398_D0.6470.23
273_R294_F0.6470.23
14_M59_T0.6460.23
91_K201_K0.6430.23
69_Y73_M0.6430.23
9_M338_M0.6420.22
88_S232_L0.6420.22
105_T399_H0.6410.22
164_A274_I0.6400.22
377_L383_P0.6390.22
218_A412_I0.6380.22
178_I218_A0.6370.22
18_M48_M0.6340.22
162_V289_F0.6340.22
269_E272_K0.6330.22
19_S28_L0.6330.22
348_L387_L0.6320.22
257_A261_M0.6310.22
66_A285_V0.6280.22
62_M386_Y0.6280.22
339_S375_V0.6250.22
72_I387_L0.6250.22
319_M322_H0.6250.22
30_V417_A0.6230.22
20_N395_S0.6210.22
40_G83_I0.6200.21
336_F339_S0.6180.21
197_K289_F0.6170.21
1_M28_L0.6160.21
216_P219_A0.6150.21
13_F327_T0.6150.21
197_K206_I0.6140.21
89_F401_K0.6140.21
269_E293_I0.6140.21
336_F408_V0.6130.21
34_V43_K0.6120.21
196_G202_R0.6110.21
147_S377_L0.6100.21
31_V182_I0.6100.21
171_S244_S0.6090.21
62_M382_V0.6080.21
193_Y197_K0.6080.21
160_A298_L0.6070.21
248_L298_L0.6060.21
166_L366_G0.6050.21
71_G278_A0.6030.21
198_K254_T0.6030.21
370_L386_Y0.6030.21
115_T391_M0.6020.21
68_L264_Y0.6000.21
71_G121_T0.5990.21
164_A350_I0.5980.21
140_A394_V0.5960.20
235_V239_A0.5960.20
212_P235_V0.5950.20
61_I83_I0.5950.20
102_A220_P0.5950.20
24_A386_Y0.5930.20
37_L47_E0.5920.20
128_L282_L0.5920.20
386_Y411_T0.5920.20
91_K120_I0.5910.20
72_I282_L0.5910.20
24_A69_Y0.5890.20
83_I402_F0.5880.20
287_M339_S0.5870.20
287_M345_F0.5860.20
45_L352_A0.5850.20
328_A378_L0.5850.20
94_P376_H0.5850.20
12_V329_I0.5840.20
267_V386_Y0.5840.20
71_G116_T0.5830.20
59_T164_A0.5830.20
323_L410_T0.5820.20
32_P303_M0.5820.20
232_L337_F0.5810.20
132_L393_G0.5810.20
291_A372_G0.5810.20
153_I279_G0.5810.20
232_L235_V0.5800.20
10_M250_V0.5790.20
216_P305_D0.5770.20
395_S401_K0.5740.20
295_T338_M0.5730.20
34_V213_S0.5720.19
101_T413_V0.5710.19
68_L400_Q0.5710.19
232_L416_I0.5710.19
89_F100_G0.5700.19
44_D319_M0.5700.19
45_L247_P0.5700.19
350_I413_V0.5680.19
157_G199_E0.5670.19
253_M387_L0.5670.19
99_V314_L0.5660.19
84_A416_I0.5660.19
343_F348_L0.5660.19
59_T394_V0.5650.19
281_A354_A0.5640.19
285_V383_P0.5640.19
7_F179_P0.5640.19
312_V360_I0.5640.19
103_V412_I0.5640.19
170_T305_D0.5640.19
226_L264_Y0.5640.19
291_A382_V0.5630.19
7_F334_F0.5630.19
2_L210_H0.5610.19
15_Y37_L0.5610.19
61_I79_F0.5610.19
281_A297_I0.5600.19
118_Y338_M0.5590.19
302_K322_H0.5590.19
21_R82_L0.5590.19
182_I201_K0.5580.19
11_I29_I0.5570.19
12_V31_V0.5570.19
173_V185_I0.5570.19
285_V294_F0.5570.19
178_I363_A0.5560.19
344_Y397_G0.5560.19
23_S167_K0.5560.19
105_T289_F0.5560.19
118_Y144_M0.5550.19
187_W413_V0.5540.19
332_M412_I0.5530.19
69_Y248_L0.5530.19
29_I53_V0.5530.19
229_F261_M0.5510.19
274_I287_M0.5500.19
113_D284_V0.5490.19
172_E362_A0.5490.19
153_I170_T0.5490.19
329_I416_I0.5490.19
33_I250_V0.5470.18
45_L129_Y0.5470.18
25_L286_S0.5470.18
256_F423_I0.5460.18
94_P140_A0.5460.18
115_T284_V0.5450.18
254_T313_S0.5440.18
55_D424_I0.5430.18
69_Y240_A0.5430.18
385_T396_F0.5420.18
93_D388_L0.5410.18
143_A288_V0.5410.18
138_V264_Y0.5400.18
123_A284_V0.5400.18
311_L416_I0.5390.18
356_S412_I0.5390.18
82_L164_A0.5390.18
322_H326_I0.5380.18
307_M394_V0.5360.18
138_V142_I0.5350.18
104_L116_T0.5350.18
147_S344_Y0.5340.18
231_L235_V0.5340.18
306_A310_S0.5340.18
294_F386_Y0.5330.18
18_M50_I0.5330.18
128_L369_S0.5320.18
304_V394_V0.5320.18
222_K306_A0.5310.18
28_L104_L0.5310.18
108_I251_L0.5300.18
87_L128_L0.5270.18
165_S275_S0.5260.18
156_G415_T0.5260.18
99_V258_V0.5260.18
121_T273_R0.5250.18
3_A288_V0.5250.18
4_I214_S0.5250.18
14_M17_I0.5250.18
197_K314_L0.5240.18
383_P391_M0.5240.18
12_V317_D0.5230.18
149_V410_T0.5230.18
152_I391_M0.5230.18
130_K393_G0.5220.18
339_S376_H0.5220.18
235_V272_K0.5210.17
288_V378_L0.5210.17
29_I393_G0.5200.17
42_G72_I0.5190.17
262_V272_K0.5180.17
60_G150_M0.5170.17
30_V325_L0.5170.17
94_P369_S0.5170.17
330_V417_A0.5160.17
36_A40_G0.5160.17
141_G298_L0.5160.17
47_E401_K0.5160.17
223_R276_A0.5160.17
76_S366_G0.5150.17
24_A327_T0.5120.17
103_V416_I0.5120.17
83_I326_I0.5120.17
121_T412_I0.5100.17
142_I324_P0.5090.17
378_L385_T0.5090.17
343_F371_L0.5080.17
291_A339_S0.5080.17
340_N374_P0.5070.17
374_P411_T0.5070.17
83_I143_A0.5060.17
284_V339_S0.5050.17
3_A49_M0.5050.17
179_P234_T0.5050.17
312_V350_I0.5050.17
148_G338_M0.5040.17
109_S113_D0.5040.17
147_S340_N0.5030.17
103_V272_K0.5030.17
220_P236_A0.5010.17
42_G167_K0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.9718 100 0.798 Contact Map
4f35D 2 0.9202 100 0.816 Contact Map
4r1iA 2 0.9742 100 0.819 Contact Map
2a65A 2 0.4695 86.7 0.97 Contact Map
4dx5A 3 0.3803 76.2 0.973 Contact Map
3zuxA 1 0.385 58.1 0.976 Contact Map
3w9iA 3 0.3615 54.3 0.977 Contact Map
3aqpA 1 0.3498 43.8 0.978 Contact Map
4k0jA 3 0.3357 41.4 0.979 Contact Map
4pd6A 3 0.77 37.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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