GREMLIN Database
YXIO - Uncharacterized MFS-type transporter YxiO
UniProt: P42306 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (388)
Sequences: 9520 (6881)
Seq/√Len: 349.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_S204_H3.6711.00
78_E84_F3.5551.00
325_L329_I3.5401.00
63_I119_I3.2011.00
91_A120_G3.0511.00
300_G351_K3.0221.00
310_I337_S2.9631.00
226_G230_K2.9261.00
51_A385_Q2.6771.00
317_Y330_L2.6551.00
394_V397_L2.5641.00
294_L298_F2.4611.00
393_A397_L2.4481.00
391_S397_L2.4391.00
81_K134_D2.3951.00
93_V195_G2.3801.00
95_S120_G2.3271.00
305_Y409_A2.3251.00
293_K296_E2.3201.00
269_G272_S2.3191.00
67_L122_S2.3141.00
406_V410_F2.2931.00
230_K234_Q2.2821.00
319_Y395_F2.2791.00
80_C83_K2.2711.00
294_L303_M2.2531.00
136_T144_V2.2461.00
71_L123_G2.2451.00
95_S116_V2.2291.00
98_M113_F2.2241.00
75_A81_K2.2211.00
236_R240_L2.1971.00
312_M398_I2.1921.00
52_Y107_W2.1751.00
227_Q230_K2.1741.00
287_F336_T2.1621.00
8_Q208_R2.1291.00
264_S270_S2.1171.00
390_S394_V2.0551.00
108_L112_L2.0351.00
240_L410_F2.0331.00
390_S397_L1.9811.00
71_L74_I1.9591.00
188_F192_A1.9571.00
247_F403_I1.9561.00
199_I203_K1.9071.00
378_L382_V1.9071.00
314_V337_S1.8981.00
314_V330_L1.8821.00
58_A378_L1.8741.00
88_F123_G1.8711.00
324_T328_W1.8701.00
312_M405_I1.8661.00
391_S394_V1.8631.00
13_V151_L1.8571.00
305_Y405_I1.8551.00
299_T302_T1.8521.00
290_I293_K1.8481.00
9_E140_R1.8421.00
95_S113_F1.7731.00
142_N296_E1.7591.00
109_L113_F1.7421.00
71_L122_S1.7391.00
88_F120_G1.7361.00
382_V386_L1.7281.00
293_K297_R1.7281.00
302_T306_V1.7061.00
108_L111_L1.7001.00
137_P140_R1.6951.00
86_G202_I1.6931.00
224_R227_Q1.6731.00
221_S224_R1.6601.00
301_K305_Y1.6491.00
403_I407_I1.6371.00
298_F303_M1.6361.00
223_K226_G1.6291.00
55_Y382_V1.6141.00
224_R228_T1.5981.00
97_A188_F1.5901.00
228_T232_I1.5701.00
88_F124_A1.5691.00
298_F302_T1.5581.00
183_S187_F1.5411.00
97_A191_A1.5391.00
237_A412_P1.5331.00
390_S393_A1.5071.00
67_L119_I1.4861.00
56_T111_L1.4791.00
396_S400_L1.4541.00
181_A185_L1.4531.00
55_Y59_I1.4531.00
68_G122_S1.4351.00
299_T303_M1.4341.00
16_D20_S1.4161.00
9_E143_L1.3961.00
223_K227_Q1.3861.00
136_T140_R1.3651.00
37_S389_K1.3611.00
407_I410_F1.3571.00
261_S265_D1.3501.00
180_S184_Q1.3351.00
33_L36_K1.3351.00
22_Y117_S1.3321.00
307_G340_G1.3321.00
178_S181_A1.3231.00
305_Y309_V1.3111.00
163_S190_T1.3021.00
239_F243_L1.2961.00
107_W111_L1.2951.00
397_L401_F1.2851.00
50_T385_Q1.2711.00
79_G83_K1.2641.00
225_L228_T1.2621.00
323_T326_D1.2521.00
298_F306_V1.2491.00
192_A196_L1.2431.00
54_G58_A1.2421.00
272_S324_T1.2421.00
251_G401_F1.2391.00
391_S395_F1.2361.00
74_I84_F1.2331.00
72_G359_N1.2241.00
165_A169_L1.2241.00
394_V398_I1.2231.00
139_K296_E1.2221.00
141_M351_K1.2191.00
398_I402_V1.2141.00
54_G381_A1.2131.00
357_H360_E1.2091.00
70_I74_I1.2081.00
260_T264_S1.2061.00
279_V332_M1.2041.00
51_A55_Y1.2031.00
200_P204_H1.2021.00
244_A408_L1.1961.00
383_T387_T1.1931.00
391_S398_I1.1881.00
402_V406_V1.1841.00
226_G229_M1.1831.00
76_D359_N1.1811.00
87_F91_A1.1741.00
32_P35_Y1.1741.00
143_L296_E1.1601.00
35_Y38_A1.1581.00
196_L200_P1.1571.00
60_S118_A1.1511.00
141_M350_A1.1511.00
184_Q188_F1.1501.00
82_K86_G1.1491.00
61_T64_L1.1461.00
283_V332_M1.1461.00
33_L37_S1.1441.00
75_A359_N1.1431.00
51_A54_G1.1411.00
82_K207_Q1.1381.00
94_A98_M1.1321.00
32_P381_A1.1301.00
75_A134_D1.1231.00
181_A184_Q1.1161.00
49_S52_Y1.1161.00
68_G370_K1.1121.00
143_L147_R1.1091.00
304_L408_L1.1051.00
397_L411_V1.1031.00
265_D389_K1.1011.00
63_I67_L1.0971.00
243_L407_I1.0901.00
228_T231_R1.0881.00
222_F225_L1.0861.00
37_S264_S1.0851.00
185_L188_F1.0811.00
312_M402_V1.0721.00
30_V34_F1.0711.00
221_S228_T1.0711.00
17_W155_G1.0711.00
395_F399_I1.0651.00
52_Y111_L1.0631.00
195_G199_I1.0571.00
64_L68_G1.0531.00
381_A385_Q1.0521.00
350_A362_F1.0501.00
112_L116_V1.0501.00
309_V313_I1.0501.00
246_F372_A1.0481.00
95_S117_S1.0361.00
89_V93_V1.0331.00
302_T305_Y1.0321.00
83_K87_F1.0241.00
101_F188_F1.0221.00
230_K233_R1.0201.00
131_F205_V1.0161.00
109_L112_L1.0141.00
34_F39_A1.0131.00
20_S23_S1.0121.00
82_K205_V1.0101.00
31_F34_F1.0101.00
97_A101_F1.0071.00
339_G343_A1.0071.00
163_S186_S1.0051.00
17_W197_F1.0031.00
237_A240_L0.9991.00
317_Y326_D0.9991.00
185_L189_I0.9951.00
268_I272_S0.9941.00
11_S200_P0.9941.00
24_I156_S0.9911.00
309_V405_I0.9871.00
36_K39_A0.9841.00
95_S98_M0.9831.00
72_G76_D0.9821.00
258_M263_G0.9811.00
292_G296_E0.9811.00
258_M261_S0.9771.00
279_V283_V0.9771.00
17_W154_I0.9731.00
247_F400_L0.9691.00
291_Y340_G0.9691.00
397_L400_L0.9621.00
241_F348_Y0.9591.00
103_P106_H0.9571.00
357_H361_F0.9571.00
135_V144_V0.9551.00
20_S24_I0.9541.00
219_I223_K0.9491.00
309_V312_M0.9471.00
287_F290_I0.9471.00
325_L328_W0.9401.00
406_V409_A0.9381.00
401_F404_G0.9371.00
145_S346_R0.9361.00
85_F201_M0.9231.00
15_Y128_Y0.9221.00
36_K40_A0.9211.00
35_Y110_L0.9201.00
36_K53_L0.9201.00
146_A150_G0.9191.00
34_F38_A0.9171.00
353_V358_A0.9151.00
13_V147_R0.9111.00
142_N295_A0.9101.00
17_W21_A0.9091.00
90_S94_A0.9071.00
379_L382_V0.9061.00
392_T397_L0.9061.00
152_G156_S0.9041.00
279_V328_W0.9041.00
268_I271_S0.9011.00
393_A396_S0.9001.00
392_T396_S0.8971.00
303_M306_V0.8961.00
59_I115_T0.8921.00
22_Y25_V0.8901.00
55_Y58_A0.8901.00
35_Y113_F0.8891.00
229_M233_R0.8891.00
201_M205_V0.8841.00
257_T261_S0.8821.00
231_R234_Q0.8791.00
220_N223_K0.8771.00
49_S385_Q0.8771.00
202_I205_V0.8731.00
29_A33_L0.8721.00
78_E83_K0.8681.00
182_A185_L0.8681.00
223_K228_T0.8651.00
235_Y361_F0.8611.00
16_D19_N0.8541.00
98_M109_L0.8531.00
111_L115_T0.8531.00
88_F91_A0.8521.00
397_L404_G0.8501.00
280_T335_A0.8501.00
73_T77_Y0.8491.00
218_V222_F0.8481.00
326_D329_I0.8471.00
32_P53_L0.8451.00
233_R239_F0.8421.00
99_L113_F0.8341.00
177_V180_S0.8341.00
9_E144_V0.8341.00
313_I317_Y0.8301.00
328_W332_M0.8281.00
393_A404_G0.8271.00
392_T395_F0.8271.00
133_V358_A0.8241.00
68_G126_V0.8241.00
276_I331_A0.8231.00
58_A377_P0.8211.00
37_S40_A0.8171.00
244_A407_I0.8151.00
11_S14_L0.8151.00
206_H209_Y0.8111.00
398_I405_I0.8091.00
113_F116_V0.8081.00
221_S225_L0.8071.00
71_L127_F0.8061.00
31_F36_K0.8061.00
287_F339_G0.8051.00
58_A62_F0.8041.00
289_I293_K0.8021.00
390_S398_I0.7991.00
187_F190_T0.7981.00
35_Y40_A0.7971.00
75_A123_G0.7961.00
19_N125_N0.7961.00
273_L277_L0.7951.00
237_A355_K0.7941.00
275_I328_W0.7881.00
10_N14_L0.7881.00
97_A184_Q0.7881.00
75_A127_F0.7861.00
65_A367_I0.7851.00
291_Y343_A0.7831.00
29_A35_Y0.7831.00
52_Y55_Y0.7821.00
219_I222_F0.7771.00
400_L404_G0.7771.00
301_K413_E0.7751.00
40_A49_S0.7751.00
139_K143_L0.7741.00
168_L271_S0.7721.00
194_W198_T0.7711.00
304_L307_G0.7701.00
314_V317_Y0.7681.00
19_N23_S0.7651.00
329_I333_L0.7641.00
36_K261_S0.7641.00
249_I252_V0.7621.00
390_S395_F0.7621.00
374_I378_L0.7591.00
203_K206_H0.7561.00
275_I279_V0.7551.00
60_S63_I0.7541.00
20_S152_G0.7541.00
149_F342_Q0.7521.00
128_Y131_F0.7511.00
307_G310_I0.7511.00
395_F398_I0.7501.00
228_T360_E0.7501.00
132_L362_F0.7491.00
308_I404_G0.7481.00
295_A344_L0.7451.00
67_L71_L0.7441.00
282_V286_P0.7411.00
247_F407_I0.7411.00
236_R239_F0.7381.00
248_Y345_S0.7381.00
277_L281_Q0.7381.00
35_Y39_A0.7371.00
366_N372_A0.7341.00
114_Y118_A0.7341.00
16_D128_Y0.7320.99
98_M101_F0.7320.99
33_L38_A0.7300.99
170_A182_A0.7290.99
14_L197_F0.7290.99
34_F40_A0.7260.99
129_D362_F0.7260.99
61_T377_P0.7250.99
125_N129_D0.7250.99
14_L18_A0.7240.99
225_L229_M0.7220.99
192_A195_G0.7210.99
315_C319_Y0.7210.99
165_A168_L0.7200.99
258_M265_D0.7200.99
252_V341_I0.7190.99
133_V350_A0.7180.99
79_G207_Q0.7140.99
223_K231_R0.7110.99
147_R151_L0.7100.99
392_T398_I0.7090.99
104_S108_L0.7070.99
110_L113_F0.7050.99
32_P40_A0.7050.99
222_F229_M0.7020.99
57_I61_T0.7020.99
208_R211_I0.7000.99
245_Y345_S0.6990.99
122_S125_N0.6960.99
348_Y411_V0.6880.99
17_W20_S0.6880.99
142_N347_S0.6830.99
312_M401_F0.6790.99
191_A195_G0.6790.99
307_G341_I0.6780.99
382_V385_Q0.6780.99
197_F200_P0.6770.99
177_V182_A0.6760.99
306_V309_V0.6760.99
241_F352_L0.6750.99
346_R362_F0.6740.99
398_I401_F0.6740.99
23_S26_V0.6720.99
49_S265_D0.6710.99
399_I403_I0.6700.99
391_S396_S0.6690.99
146_A292_G0.6690.99
257_T260_T0.6680.99
249_I369_G0.6680.99
393_A401_F0.6640.99
112_L115_T0.6640.99
90_S93_V0.6640.99
317_Y320_F0.6620.99
321_M330_L0.6610.99
187_F191_A0.6610.99
200_P203_K0.6610.99
92_G121_F0.6600.99
315_C318_A0.6600.99
307_G311_Y0.6590.99
88_F127_F0.6570.99
222_F228_T0.6570.99
286_P290_I0.6560.99
121_F125_N0.6550.99
66_M70_I0.6550.99
101_F184_Q0.6540.99
274_L278_F0.6500.99
29_A32_P0.6470.99
9_E147_R0.6460.99
161_I278_F0.6450.99
161_I164_I0.6450.99
387_T392_T0.6430.99
16_D148_G0.6430.99
341_I344_L0.6420.99
52_Y56_T0.6410.99
120_G123_G0.6400.99
74_I78_E0.6370.99
164_I168_L0.6350.99
18_A22_Y0.6310.98
300_G347_S0.6280.98
308_I405_I0.6280.98
96_T117_S0.6270.98
159_P163_S0.6270.98
177_V181_A0.6270.98
82_K131_F0.6270.98
151_L155_G0.6260.98
235_Y238_L0.6260.98
312_M315_C0.6240.98
164_I167_I0.6230.98
65_A69_P0.6200.98
111_L114_Y0.6190.98
56_T59_I0.6180.98
50_T53_L0.6180.98
21_A30_V0.6170.98
226_G232_I0.6160.98
231_R235_Y0.6160.98
209_Y212_K0.6160.98
262_Y266_L0.6140.98
65_A370_K0.6140.98
409_A412_P0.6130.98
220_N229_M0.6120.98
409_A413_E0.6110.98
245_Y369_G0.6100.98
263_G276_I0.6090.98
182_A186_S0.6070.98
64_L122_S0.6070.98
136_T141_M0.6030.98
189_I193_W0.6020.98
179_V182_A0.6000.98
272_S275_I0.6000.98
330_L337_S0.5990.98
305_Y308_I0.5990.98
84_F127_F0.5980.98
210_Y214_E0.5970.98
54_G57_I0.5960.98
166_V170_A0.5940.98
238_L361_F0.5930.98
319_Y398_I0.5930.98
202_I207_Q0.5930.98
14_L200_P0.5910.98
335_A345_S0.5870.98
394_V401_F0.5860.98
408_L411_V0.5850.98
53_L57_I0.5810.97
251_G404_G0.5800.97
16_D125_N0.5790.97
283_V287_F0.5780.97
314_V318_A0.5780.97
394_V411_V0.5780.97
390_S404_G0.5780.97
84_F88_F0.5780.97
304_L311_Y0.5770.97
259_S263_G0.5760.97
100_A184_Q0.5750.97
106_H114_Y0.5740.97
250_D376_G0.5740.97
186_S190_T0.5730.97
286_P289_I0.5720.97
67_L70_I0.5720.97
391_S404_G0.5720.97
8_Q11_S0.5700.97
272_S328_W0.5700.97
235_Y352_L0.5670.97
307_G337_S0.5640.97
33_L264_S0.5630.97
93_V97_A0.5610.97
224_R231_R0.5600.97
178_S182_A0.5590.97
88_F92_G0.5580.97
16_D152_G0.5570.97
89_V92_G0.5570.97
80_C207_Q0.5570.97
132_L145_S0.5570.97
133_V145_S0.5560.97
57_I60_S0.5560.97
34_F37_S0.5540.97
10_N13_V0.5530.97
272_S279_V0.5530.97
157_T285_A0.5520.97
32_P36_K0.5520.97
64_L370_K0.5520.97
148_G346_R0.5510.96
150_G289_I0.5500.96
148_G152_G0.5500.96
353_V361_F0.5500.96
61_T68_G0.5490.96
63_I115_T0.5480.96
58_A61_T0.5480.96
87_F123_G0.5470.96
14_L151_L0.5460.96
343_A347_S0.5450.96
82_K206_H0.5430.96
194_W197_F0.5430.96
311_Y315_C0.5430.96
222_F232_I0.5420.96
149_F153_Y0.5410.96
241_F365_Y0.5410.96
271_S275_I0.5410.96
18_A196_L0.5400.96
204_H207_Q0.5400.96
147_R150_G0.5400.96
30_V35_Y0.5390.96
89_V124_A0.5390.96
25_V159_P0.5390.96
391_S399_I0.5380.96
85_F131_F0.5370.96
23_S27_T0.5360.96
405_I409_A0.5350.96
153_Y288_S0.5350.96
80_C134_D0.5340.96
92_G96_T0.5340.96
55_Y385_Q0.5330.96
54_G382_V0.5330.96
222_F227_Q0.5320.96
326_D330_L0.5310.96
142_N292_G0.5310.96
229_M232_I0.5300.96
347_S350_A0.5290.96
310_I314_V0.5280.96
50_T381_A0.5260.95
295_A347_S0.5240.95
129_D153_Y0.5230.95
19_N198_T0.5230.95
128_Y148_G0.5230.95
393_A405_I0.5230.95
312_M316_V0.5230.95
300_G344_L0.5220.95
240_L412_P0.5220.95
314_V333_L0.5210.95
253_G257_T0.5200.95
58_A382_V0.5190.95
303_M344_L0.5170.95
61_T118_A0.5150.95
68_G125_N0.5120.95
102_I109_L0.5120.95
130_A133_V0.5110.95
396_S404_G0.5110.95
30_V40_A0.5110.95
350_A354_P0.5090.95
156_S160_F0.5080.95
106_H109_L0.5070.94
59_I63_I0.5040.94
95_S99_L0.5030.94
106_H110_L0.5030.94
252_V342_Q0.5030.94
291_Y339_G0.5030.94
336_T340_G0.5030.94
30_V33_L0.5020.94
397_L408_L0.5020.94
102_I110_L0.5010.94
186_S189_I0.5000.94
18_A197_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 0.965 100 0.399 Contact Map
2cfqA 1 0.9439 100 0.424 Contact Map
3wdoA 1 0.9299 100 0.435 Contact Map
1pw4A 1 0.9276 100 0.444 Contact Map
4j05A 3 0.9089 100 0.463 Contact Map
3o7qA 1 0.9182 100 0.478 Contact Map
4w6vA 1 0.9042 100 0.481 Contact Map
4pypA 1 0.9136 100 0.489 Contact Map
2gfpA 2 0.8668 100 0.495 Contact Map
4xnjA 1 0.9042 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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