GREMLIN Database
DBPA - ATP-dependent RNA helicase DbpA
UniProt: P42305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (376)
Sequences: 26530 (14015)
Seq/√Len: 722.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_G90_I5.1321.00
60_L73_A3.9641.00
36_A179_M3.5281.00
77_T86_V3.4811.00
28_V44_V3.2531.00
126_G131_V3.2401.00
19_G96_F3.1741.00
268_D291_Y3.0421.00
40_K201_E2.8891.00
250_K273_G2.8851.00
134_H139_T2.8651.00
247_C253_V2.8151.00
285_E290_E2.7611.00
284_N288_R2.6891.00
257_T267_C2.6531.00
232_K263_L2.4871.00
87_K101_A2.4331.00
87_K91_T2.3971.00
268_D285_E2.3351.00
281_D285_E2.3211.00
22_Y54_A2.2921.00
328_T340_A2.2911.00
247_C256_L2.2881.00
317_L342_S2.2441.00
162_I166_E2.2421.00
265_Y293_Y2.2301.00
254_N269_K2.2181.00
216_E339_K2.1331.00
247_C295_V2.0231.00
102_T121_S2.0131.00
72_Q146_S2.0061.00
87_K103_A1.9811.00
257_T269_K1.9801.00
19_G95_R1.9721.00
252_H316_D1.9591.00
56_F149_V1.9521.00
89_D92_N1.9491.00
308_N336_N1.9451.00
253_V271_H1.9351.00
266_P292_R1.9281.00
190_E202_H1.9181.00
162_I165_V1.9081.00
47_Q50_S1.9071.00
60_L149_V1.8681.00
268_D282_V1.8671.00
260_L295_V1.8481.00
280_F284_N1.8341.00
257_T261_D1.8321.00
300_A304_I1.8201.00
311_L341_I1.8081.00
136_E167_A1.8011.00
63_L147_Y1.7941.00
241_D310_S1.7881.00
217_H328_T1.7791.00
20_L92_N1.7741.00
155_E158_N1.7651.00
311_L339_K1.7441.00
296_A300_A1.7231.00
72_Q122_H1.7201.00
36_A42_L1.7101.00
236_M263_L1.7021.00
70_K144_R1.6731.00
90_I123_I1.6591.00
217_H324_Y1.6461.00
109_S112_K1.6431.00
190_E194_R1.6391.00
73_A147_Y1.6361.00
218_A339_K1.6331.00
163_E166_E1.6251.00
84_V280_F1.6191.00
228_F259_E1.6171.00
166_E195_Q1.6111.00
90_I101_A1.6101.00
76_L131_V1.6071.00
60_L147_Y1.6041.00
314_N328_T1.5871.00
243_C313_I1.5821.00
230_L233_D1.5811.00
37_L62_E1.5761.00
243_C311_L1.5611.00
253_V269_K1.5491.00
314_N342_S1.5481.00
163_E167_A1.5451.00
56_F181_F1.5411.00
35_A201_E1.5381.00
35_A38_E1.5241.00
44_V181_F1.5191.00
135_I171_H1.5171.00
111_D115_A1.5151.00
132_L167_A1.4941.00
153_A180_L1.4811.00
231_L313_I1.4711.00
164_Q167_A1.4691.00
224_E252_H1.4601.00
352_L356_E1.4511.00
249_T252_H1.4241.00
318_P324_Y1.4091.00
259_E263_L1.4071.00
240_P243_C1.4071.00
154_D302_R1.4031.00
231_L315_Y1.4011.00
245_I293_Y1.3981.00
274_M282_V1.3851.00
77_T83_A1.3791.00
161_F165_V1.3691.00
215_I332_G1.3671.00
212_T215_I1.3591.00
242_S308_N1.3431.00
102_T124_V1.3381.00
83_A103_A1.3291.00
88_E92_N1.3191.00
115_A119_Q1.3151.00
148_L169_I1.3131.00
227_K316_D1.3091.00
167_A171_H1.3081.00
114_K139_T1.3071.00
74_L145_L1.3061.00
214_N337_K1.3011.00
238_E339_K1.2961.00
121_S124_V1.2891.00
257_T295_V1.2841.00
234_V341_I1.2781.00
56_F86_V1.2761.00
32_V55_S1.2671.00
261_D267_C1.2621.00
90_I125_V1.2451.00
236_M265_Y1.2401.00
285_E291_Y1.2361.00
256_L295_V1.2341.00
148_L178_T1.2321.00
243_C293_Y1.2271.00
223_R226_N1.2231.00
102_T116_E1.2211.00
63_L146_S1.2191.00
54_A58_I1.2181.00
275_I278_D1.2141.00
62_E66_W1.2141.00
234_V237_T1.2051.00
39_R63_L1.1941.00
228_F263_L1.1851.00
254_N271_H1.1831.00
252_H255_Q1.1781.00
34_P38_E1.1751.00
45_K204_E1.1731.00
256_L315_Y1.1721.00
76_L126_G1.1651.00
126_G140_L1.1601.00
189_I192_L1.1551.00
61_C94_G1.1531.00
166_E170_K1.1501.00
18_E23_T1.1461.00
314_N327_R1.1451.00
284_N287_K1.1351.00
110_F137_K1.1311.00
232_K236_M1.1281.00
36_A59_P1.1221.00
39_R177_T1.1151.00
320_E323_S1.1011.00
282_V291_Y1.1011.00
353_A356_E1.0981.00
270_I300_A1.0951.00
84_V88_E1.0951.00
88_E91_T1.0851.00
161_F166_E1.0751.00
186_P189_I1.0751.00
234_V313_I1.0741.00
356_E362_E1.0731.00
189_I193_S1.0641.00
232_K259_E1.0641.00
35_A203_I1.0591.00
253_V257_T1.0521.00
111_D114_K1.0491.00
169_I172_L1.0481.00
246_F327_R1.0471.00
360_G363_I1.0471.00
100_K122_H1.0421.00
110_F114_K1.0421.00
278_D282_V1.0391.00
253_V295_V1.0391.00
87_K125_V1.0381.00
187_Q191_K1.0341.00
27_K31_S1.0331.00
115_A118_K1.0311.00
278_D281_D1.0251.00
234_V238_E1.0211.00
274_M278_D1.0191.00
133_D137_K1.0151.00
192_L196_Y1.0131.00
380_E383_A1.0111.00
167_A170_K1.0101.00
407_Y411_G1.0061.00
132_L164_Q1.0031.00
60_L75_I1.0031.00
238_E241_D1.0031.00
43_V185_L0.9951.00
149_V179_M0.9911.00
373_E377_K0.9901.00
73_A149_V0.9901.00
132_L136_E0.9881.00
231_L245_I0.9851.00
379_P383_A0.9831.00
41_D200_P0.9771.00
228_F315_Y0.9751.00
60_L90_I0.9711.00
94_G97_K0.9631.00
190_E193_S0.9611.00
226_N229_S0.9601.00
349_K353_A0.9591.00
64_A73_A0.9571.00
312_V331_T0.9561.00
258_D261_D0.9531.00
64_A99_I0.9481.00
405_K409_N0.9411.00
83_A125_V0.9361.00
75_I90_I0.9311.00
105_F108_S0.9311.00
65_N97_K0.9281.00
27_K30_Q0.9251.00
230_L234_V0.9241.00
283_M306_I0.9241.00
381_F384_K0.9191.00
366_I370_S0.9151.00
114_K118_K0.9121.00
281_D284_N0.9111.00
233_D237_T0.9101.00
244_I296_A0.9091.00
41_D198_Q0.9041.00
348_E351_F0.9021.00
408_F411_G0.9021.00
351_F354_D0.9011.00
242_S289_G0.8991.00
235_L243_C0.8951.00
286_F294_L0.8921.00
33_I58_I0.8891.00
374_V378_K0.8881.00
41_D180_L0.8881.00
229_S232_K0.8871.00
405_K408_F0.8821.00
234_V311_L0.8791.00
73_A123_I0.8771.00
112_K115_A0.8771.00
373_E376_R0.8741.00
35_A42_L0.8721.00
41_D197_M0.8721.00
94_G101_A0.8701.00
224_E345_T0.8641.00
219_V344_V0.8641.00
188_D191_K0.8611.00
110_F113_Q0.8581.00
65_N72_Q0.8561.00
43_V193_S0.8551.00
65_N68_E0.8531.00
158_N162_I0.8531.00
228_F232_K0.8501.00
258_D262_D0.8491.00
24_E30_Q0.8471.00
82_L303_G0.8471.00
220_I230_L0.8451.00
63_L177_T0.8451.00
319_L351_F0.8441.00
233_D236_M0.8421.00
146_S176_R0.8411.00
230_L343_F0.8381.00
216_E364_Q0.8361.00
228_F256_L0.8321.00
354_D358_Y0.8271.00
108_S113_Q0.8251.00
85_Q305_D0.8221.00
244_I294_L0.8211.00
255_Q259_E0.8181.00
82_L85_Q0.8181.00
31_S35_A0.8161.00
113_Q116_E0.8161.00
238_E311_L0.8141.00
242_S310_S0.8121.00
283_M286_F0.8101.00
41_D178_T0.8051.00
154_D326_H0.8041.00
147_Y177_T0.7961.00
228_F255_Q0.7941.00
318_P327_R0.7941.00
113_Q117_L0.7931.00
355_I359_I0.7931.00
53_T86_V0.7931.00
54_A93_I0.7921.00
407_Y410_G0.7901.00
251_E255_Q0.7901.00
229_S233_D0.7891.00
55_S59_P0.7891.00
405_K410_G0.7881.00
314_N318_P0.7881.00
114_K134_H0.7881.00
254_N258_D0.7841.00
64_A122_H0.7821.00
216_E337_K0.7741.00
135_I142_L0.7731.00
354_D357_E0.7721.00
298_D327_R0.7721.00
32_V36_A0.7721.00
242_S309_I0.7651.00
158_N161_F0.7641.00
271_H274_M0.7631.00
188_D192_L0.7621.00
142_L145_L0.7611.00
363_I367_E0.7591.00
67_D146_S0.7571.00
101_A104_V0.7571.00
356_E359_I0.7531.00
45_K185_L0.7521.00
200_P203_I0.7501.00
71_P145_L0.7501.00
192_L195_Q0.7491.00
191_K194_R0.7471.00
89_D93_I0.7411.00
301_A323_S0.7411.00
112_K116_E0.7381.00
234_V343_F0.7361.00
232_K265_Y0.7341.00
367_E370_S0.7341.00
197_M200_P0.7311.00
202_H205_V0.7301.00
276_Q280_F0.7281.00
298_D323_S0.7271.00
173_P176_R0.7251.00
58_I61_C0.7231.00
366_I371_Q0.7221.00
48_T183_A0.7201.00
248_R319_L0.7181.00
280_F283_M0.7181.00
104_V113_Q0.7151.00
348_E352_L0.7151.00
32_V44_V0.7151.00
375_A378_K0.7151.00
134_H138_G0.7151.00
352_L363_I0.7141.00
61_C97_K0.7051.00
40_K199_N0.7051.00
46_S50_S0.7041.00
302_R326_H0.7021.00
350_R354_D0.7021.00
58_I62_E0.7011.00
268_D294_L0.6991.00
33_I37_L0.6981.00
364_Q367_E0.6961.00
282_V294_L0.6961.00
222_V230_L0.6941.00
57_G61_C0.6931.00
289_G292_R0.6921.00
165_V168_I0.6911.00
110_F134_H0.6891.00
406_L409_N0.6881.00
307_E336_N0.6881.00
231_L256_L0.6871.00
211_T214_N0.6861.00
183_A329_G0.6851.00
76_L156_M0.6841.00
214_N332_G0.6811.00
379_P382_L0.6791.00
245_I315_Y0.6781.00
372_E376_R0.6781.00
57_G94_G0.6771.00
352_L355_I0.6771.00
35_A40_K0.6761.00
147_Y179_M0.6751.00
31_S205_V0.6751.00
34_P37_L0.6741.00
399_L407_Y0.6731.00
235_L265_Y0.6721.00
211_T217_H0.6721.00
56_F77_T0.6721.00
31_S203_I0.6691.00
377_K380_E0.6691.00
270_I299_V0.6691.00
113_Q134_H0.6691.00
367_E371_Q0.6671.00
227_K234_V0.6661.00
347_F350_R0.6641.00
381_F385_L0.6631.00
130_R133_D0.6631.00
221_Q365_K0.6611.00
309_I331_T0.6601.00
406_L410_G0.6591.00
91_T101_A0.6591.00
79_T302_R0.6571.00
192_L197_M0.6561.00
373_E378_K0.6561.00
345_T348_E0.6551.00
368_A371_Q0.6531.00
211_T215_I0.6521.00
193_S197_M0.6521.00
44_V179_M0.6511.00
89_D94_G0.6501.00
259_E262_D0.6471.00
399_L405_K0.6451.00
379_P385_L0.6451.00
71_P124_V0.6451.00
374_V377_K0.6431.00
242_S292_R0.6431.00
92_N95_R0.6421.00
344_V352_L0.6421.00
314_N340_A0.6411.00
47_Q207_A0.6401.00
380_E384_K0.6391.00
279_R286_F0.6361.00
161_F164_Q0.6351.00
245_I313_I0.6341.00
106_G110_F0.6331.00
359_I362_E0.6331.00
56_F59_P0.6311.00
172_L176_R0.6301.00
218_A221_Q0.6281.00
54_A89_D0.6271.00
159_M163_E0.6271.00
31_S201_E0.6251.00
132_L135_I0.6241.00
277_E281_D0.6221.00
193_S196_Y0.6211.00
361_F365_K0.6211.00
66_W72_Q0.6201.00
370_S373_E0.6201.00
310_S336_N0.6201.00
223_R227_K0.6191.00
358_Y361_F0.6161.00
283_M287_K0.6141.00
191_K195_Q0.6111.00
244_I309_I0.6111.00
377_K381_F0.6091.00
84_V105_F0.6091.00
321_K358_Y0.6071.00
218_A366_I0.6071.00
182_S185_L0.6071.00
74_L172_L0.6051.00
105_F109_S0.6051.00
378_K384_K0.6051.00
165_V169_I0.6041.00
240_P311_L0.5981.00
162_I169_I0.5981.00
372_E375_A0.5981.00
27_K46_S0.5971.00
251_E254_N0.5971.00
169_I176_R0.5961.00
116_E119_Q0.5961.00
26_T334_A0.5951.00
61_C70_K0.5941.00
235_L260_L0.5921.00
317_L355_I0.5921.00
242_S286_F0.5911.00
245_I256_L0.5911.00
224_E228_F0.5891.00
330_R333_R0.5891.00
254_N274_M0.5891.00
282_V286_F0.5881.00
405_K411_G0.5881.00
267_C295_V0.5851.00
161_F168_I0.5841.00
71_P144_R0.5831.00
264_G267_C0.5831.00
338_G341_I0.5831.00
48_T329_G0.5811.00
149_V181_F0.5801.00
204_E207_A0.5801.00
22_Y93_I0.5791.00
68_E122_H0.5791.00
33_I36_A0.5781.00
229_S263_L0.5781.00
240_P292_R0.5771.00
71_P146_S0.5761.00
80_R107_K0.5751.00
25_P58_I0.5741.00
240_P310_S0.5731.00
106_G114_K0.5721.00
269_K274_M0.5721.00
378_K381_F0.5711.00
89_D305_D0.5701.00
76_L150_I0.5701.00
162_I172_L0.5691.00
164_Q168_I0.5691.00
248_R252_H0.5681.00
58_I93_I0.5671.00
229_S259_E0.5671.00
45_K202_H0.5661.00
356_E365_K0.5651.00
356_E360_G0.5651.00
86_V89_D0.5631.00
65_N122_H0.5571.00
124_V140_L0.5561.00
251_E273_G0.5541.00
168_I172_L0.5541.00
106_G113_Q0.5541.00
350_R356_E0.5531.00
110_F139_T0.5531.00
136_E164_Q0.5521.00
60_L123_I0.5521.00
248_R316_D0.5521.00
64_A72_Q0.5521.00
28_V46_S0.5511.00
47_Q206_K0.5511.00
101_A125_V0.5501.00
406_L411_G0.5501.00
235_L238_E0.5481.00
180_L193_S0.5471.00
81_E85_Q0.5451.00
399_L410_G0.5451.00
376_R383_A0.5431.00
43_V180_L0.5421.00
126_G130_R0.5421.00
244_I312_V0.5411.00
291_Y294_L0.5411.00
361_F364_Q0.5401.00
158_N163_E0.5381.00
378_K382_L0.5371.00
221_Q344_V0.5371.00
380_E385_L0.5351.00
163_E170_K0.5351.00
186_P193_S0.5351.00
28_V32_V0.5351.00
247_C315_Y0.5341.00
84_V103_A0.5331.00
80_R276_Q0.5321.00
226_N371_Q0.5301.00
90_I94_G0.5301.00
30_Q34_P0.5291.00
270_I296_A0.5281.00
91_T95_R0.5281.00
86_V125_V0.5271.00
69_N122_H0.5271.00
221_Q349_K0.5261.00
317_L344_V0.5251.00
70_K122_H0.5251.00
210_L213_R0.5231.00
111_D118_K0.5231.00
108_S112_K0.5231.00
161_F169_I0.5221.00
218_A341_I0.5201.00
266_P291_Y0.5201.00
29_Q32_V0.5201.00
235_L245_I0.5191.00
349_K352_L0.5191.00
243_C247_C0.5161.00
18_E21_G0.5151.00
42_L179_M0.5151.00
363_I368_A0.5141.00
250_K271_H0.5141.00
92_N96_F0.5131.00
48_T332_G0.5131.00
372_E378_K0.5131.00
77_T127_T0.5121.00
165_V172_L0.5111.00
328_T342_S0.5101.00
227_K231_L0.5091.00
241_D337_K0.5081.00
376_R380_E0.5071.00
377_K383_A0.5060.99
282_V285_E0.5060.99
374_V379_P0.5060.99
148_L176_R0.5050.99
107_K113_Q0.5030.99
64_A68_E0.5030.99
286_F309_I0.5020.99
98_R101_A0.5020.99
104_V134_H0.5020.99
57_G101_A0.5010.99
266_P285_E0.5000.99
399_L406_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.7829 100 0.285 Contact Map
4nhoA 1 0.7704 100 0.291 Contact Map
4c9bA 1 0.7766 100 0.292 Contact Map
4d25A 1 0.7745 100 0.297 Contact Map
3eiqA 1 0.737 100 0.298 Contact Map
2db3A 1 0.7724 100 0.298 Contact Map
4ljyA 1 0.8079 100 0.301 Contact Map
1s2mA 1 0.7871 100 0.303 Contact Map
4ct4B 1 0.7808 100 0.305 Contact Map
3fmpB 1 0.4238 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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