GREMLIN Database
YXIM - Uncharacterized esterase YxiM
UniProt: P42304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (333)
Sequences: 273 (210)
Seq/√Len: 11.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_A327_L5.8671.00
243_I285_A5.5391.00
250_M288_I4.9911.00
249_F280_V4.7071.00
280_V285_A4.3691.00
270_K318_A3.9470.99
289_L316_I3.7020.99
291_T327_L3.6650.99
293_Q334_S3.1760.96
181_Y285_A3.1280.96
210_I217_V3.0250.95
118_V324_K2.8780.94
180_I210_I2.7600.92
185_D252_Q2.7300.92
191_Y223_G2.6300.90
250_M326_Y2.5850.90
206_L252_Q2.5770.89
258_T309_N2.5490.89
289_L327_L2.5410.89
344_E347_L2.4930.88
250_M374_L2.4430.87
108_V283_K2.4120.86
181_Y243_I2.3540.84
51_D57_K2.3210.84
335_S339_T2.2730.82
255_I295_R2.2630.82
53_Y98_D2.2580.82
228_R272_V2.1640.79
34_D41_E2.0690.76
289_L329_D2.0160.74
189_C222_S2.0020.73
34_D43_G1.9770.72
200_A363_A1.9580.71
273_M319_L1.9430.71
183_G230_F1.9150.70
296_A355_T1.8720.68
35_F47_V1.8510.67
274_R281_K1.8440.67
184_G253_L1.8140.65
201_G254_G1.8120.65
109_T135_E1.8090.65
305_H339_T1.8080.65
183_G239_I1.7900.64
210_I215_F1.7420.62
149_L185_D1.7170.61
206_L366_L1.6980.60
258_T292_P1.6940.60
225_Q233_D1.6670.58
244_K301_S1.6530.58
120_A138_F1.6530.58
277_I323_E1.6160.56
270_K322_E1.6160.56
185_D189_C1.6000.55
338_F366_L1.5990.55
34_D38_G1.5970.55
276_M322_E1.5940.55
265_S276_M1.5900.55
278_R323_E1.5750.54
235_Q358_P1.5600.53
274_R322_E1.5570.53
259_N309_N1.5510.53
226_I292_P1.5500.53
319_L323_E1.5330.52
231_R341_I1.5330.52
273_M325_T1.5310.52
222_S258_T1.5210.51
179_T375_K1.5160.51
191_Y199_Q1.5090.51
111_G131_G1.5020.50
184_G269_F1.4960.50
292_P334_S1.4870.50
255_I356_L1.4740.49
214_T239_I1.4670.49
307_S331_N1.4630.48
183_G287_V1.4600.48
274_R278_R1.4280.47
185_D206_L1.4090.46
189_C199_Q1.4040.46
204_Q295_R1.3920.45
34_D46_G1.3830.45
334_S366_L1.3750.44
267_A334_S1.3710.44
34_D44_Y1.3710.44
365_A368_R1.3510.43
245_P322_E1.3460.43
124_F208_H1.3390.42
188_V221_A1.3330.42
340_S377_Q1.3270.42
152_T157_G1.3250.42
235_Q253_L1.3160.41
288_I306_S1.3140.41
298_D306_S1.3120.41
162_L165_L1.3000.41
243_I249_F1.2930.40
273_M316_I1.2910.40
253_L315_S1.2870.40
199_Q351_M1.2870.40
231_R265_S1.2850.40
53_Y58_G1.2760.39
198_K358_P1.2730.39
180_I377_Q1.2710.39
206_L217_V1.2660.39
100_P311_W1.2590.39
236_L240_L1.2550.38
181_Y239_I1.2410.38
103_L179_T1.2380.38
269_F329_D1.2370.38
111_G296_A1.2230.37
52_R56_S1.2180.37
287_V329_D1.2120.36
190_N259_N1.2030.36
221_A230_F1.1990.36
43_G47_V1.1990.36
255_I269_F1.1870.35
223_G259_N1.1840.35
53_Y60_G1.1830.35
327_L337_Y1.1770.35
183_G249_F1.1750.35
292_P309_N1.1660.34
56_S180_I1.1650.34
279_Q282_A1.1600.34
189_C258_T1.1590.34
298_D308_V1.1580.34
319_L325_T1.1580.34
47_V51_D1.1520.34
206_L210_I1.1500.34
116_A243_I1.1480.34
291_T379_I1.1460.33
120_A200_A1.1450.33
274_R323_E1.1430.33
316_I377_Q1.1350.33
334_S350_Y1.1250.33
180_I374_L1.1240.33
122_G151_V1.1230.32
280_V289_L1.1200.32
314_A318_A1.1160.32
200_A205_M1.1150.32
94_T201_G1.1130.32
99_L144_D1.1090.32
225_Q276_M1.1010.32
307_S328_I1.1000.31
44_Y47_V1.0820.31
253_L358_P1.0770.31
293_Q366_L1.0770.31
258_T331_N1.0630.30
151_V162_L1.0600.30
33_F43_G1.0500.29
181_Y346_T1.0450.29
205_M361_A1.0410.29
159_A197_S1.0330.29
237_E322_E1.0290.29
98_D146_Q1.0290.29
299_F320_A1.0240.28
209_Y363_A1.0230.28
239_I318_A1.0210.28
286_D326_Y1.0200.28
255_I259_N1.0190.28
185_D289_L1.0170.28
190_N281_K1.0120.28
267_A322_E1.0110.28
35_F95_F1.0060.28
331_N335_S1.0060.28
172_D190_N1.0040.28
216_Q301_S0.9960.27
337_Y341_I0.9920.27
346_T351_M0.9910.27
53_Y167_I0.9700.26
283_K348_G0.9670.26
215_F235_Q0.9650.26
45_I182_V0.9640.26
209_Y364_D0.9530.26
333_L369_L0.9470.25
190_N199_Q0.9420.25
198_K235_Q0.9250.25
300_T304_I0.9200.24
162_L166_K0.9190.24
252_Q334_S0.9190.24
299_F327_L0.9170.24
190_N339_T0.9160.24
130_T211_D0.9150.24
106_V118_V0.9110.24
337_Y349_L0.9040.24
44_Y56_S0.9030.24
262_H283_K0.9020.24
266_E311_W0.9020.24
102_G184_G0.9000.24
185_D329_D0.8980.24
85_L108_V0.8970.24
137_T379_I0.8960.24
184_G188_V0.8950.23
45_I207_P0.8890.23
294_G309_N0.8890.23
209_Y368_R0.8880.23
186_S256_N0.8820.23
39_S47_V0.8810.23
191_Y341_I0.8770.23
206_L319_L0.8760.23
244_K283_K0.8690.23
41_E46_G0.8650.22
53_Y285_A0.8650.22
189_C358_P0.8630.22
121_E295_R0.8620.22
251_L287_V0.8610.22
251_L268_E0.8580.22
110_L179_T0.8560.22
206_L250_M0.8530.22
217_V353_G0.8530.22
149_L323_E0.8520.22
35_F219_N0.8520.22
137_T283_K0.8420.22
123_V250_M0.8380.22
41_E48_R0.8370.22
216_Q269_F0.8370.22
185_D217_V0.8350.21
288_I376_R0.8330.21
270_K314_A0.8250.21
179_T368_R0.8220.21
251_L283_K0.8140.21
157_G165_L0.8140.21
231_R272_V0.8110.21
61_F374_L0.8110.21
49_A288_I0.8080.21
180_I215_F0.8060.20
302_E306_S0.8050.20
201_G238_A0.8000.20
102_G204_Q0.7990.20
180_I345_R0.7980.20
129_M132_D0.7950.20
326_Y370_A0.7950.20
185_D360_R0.7930.20
228_R280_V0.7920.20
274_R292_P0.7910.20
44_Y66_N0.7900.20
180_I206_L0.7890.20
158_T365_A0.7880.20
89_T217_V0.7880.20
180_I217_V0.7870.20
157_G369_L0.7860.20
334_S346_T0.7860.20
252_Q293_Q0.7850.20
152_T156_A0.7820.20
235_Q338_F0.7760.20
262_H267_A0.7760.20
153_E156_A0.7760.20
37_S69_D0.7730.19
226_I268_E0.7720.19
39_S46_G0.7720.19
201_G341_I0.7660.19
268_E322_E0.7650.19
217_V378_G0.7630.19
372_Q376_R0.7590.19
41_E50_S0.7580.19
285_A337_Y0.7580.19
268_E318_A0.7580.19
190_N223_G0.7560.19
42_P48_R0.7550.19
46_G57_K0.7510.19
269_F295_R0.7500.19
53_Y59_Y0.7500.19
145_G151_V0.7490.19
184_G259_N0.7440.19
199_Q363_A0.7430.19
102_G250_M0.7420.19
332_V335_S0.7420.19
205_M209_Y0.7420.19
168_K180_I0.7380.18
307_S319_L0.7380.18
94_T227_A0.7330.18
248_Y327_L0.7320.18
263_K268_E0.7320.18
202_W257_D0.7300.18
256_N357_H0.7290.18
186_S357_H0.7290.18
228_R232_N0.7280.18
36_G99_L0.7270.18
91_S147_L0.7260.18
41_E49_A0.7240.18
268_E307_S0.7240.18
270_K327_L0.7220.18
143_T190_N0.7220.18
224_G269_F0.7190.18
107_K208_H0.7190.18
130_T147_L0.7190.18
346_T349_L0.7190.18
277_I289_L0.7180.18
235_Q360_R0.7170.18
39_S42_P0.7150.18
183_G227_A0.7140.18
207_P299_F0.7130.18
54_D301_S0.7110.18
191_Y259_N0.7090.18
186_S257_D0.7080.18
289_L350_Y0.7060.17
36_G41_E0.7060.17
236_L276_M0.7050.17
236_L316_I0.7040.17
101_N136_D0.7040.17
271_E323_E0.7030.17
132_D281_K0.7020.17
171_S377_Q0.7010.17
243_I251_L0.7010.17
165_L225_Q0.6990.17
111_G116_A0.6990.17
97_V100_P0.6960.17
237_E244_K0.6950.17
48_R55_R0.6930.17
116_A308_V0.6920.17
79_S82_V0.6870.17
319_L331_N0.6860.17
126_V378_G0.6860.17
288_I374_L0.6840.17
195_N294_G0.6830.17
152_T238_A0.6810.17
224_G295_R0.6800.17
201_G252_Q0.6800.17
315_S366_L0.6790.17
316_I358_P0.6780.17
106_V138_F0.6740.17
196_S207_P0.6720.17
142_V226_I0.6710.16
154_G265_S0.6690.16
56_S70_V0.6690.16
256_N354_D0.6680.16
186_S354_D0.6680.16
67_M70_V0.6660.16
146_Q167_I0.6660.16
235_Q356_L0.6650.16
345_R348_G0.6640.16
187_T342_G0.6640.16
229_G310_R0.6640.16
33_F60_G0.6600.16
98_D201_G0.6580.16
132_D176_T0.6560.16
288_I329_D0.6560.16
147_L370_A0.6560.16
182_V277_I0.6560.16
229_G233_D0.6540.16
122_G150_L0.6530.16
189_C259_N0.6530.16
33_F95_F0.6510.16
268_E366_L0.6500.16
269_F316_I0.6490.16
198_K308_V0.6470.16
189_C351_M0.6460.16
251_L329_D0.6460.16
120_A140_I0.6450.16
123_V136_D0.6430.16
232_N260_P0.6380.16
271_E275_D0.6370.16
103_L141_P0.6370.16
182_V212_K0.6360.16
178_R209_Y0.6350.16
189_C223_G0.6350.16
214_T251_L0.6350.16
183_G374_L0.6300.15
47_V95_F0.6300.15
56_S370_A0.6270.15
227_A269_F0.6270.15
116_A128_N0.6270.15
37_S55_R0.6260.15
106_V190_N0.6250.15
136_D249_F0.6250.15
228_R251_L0.6220.15
249_F289_L0.6170.15
112_N270_K0.6160.15
227_A276_M0.6140.15
205_M364_D0.6140.15
170_L239_I0.6120.15
180_I303_G0.6120.15
228_R270_K0.6110.15
245_P282_A0.6070.15
221_A296_A0.6070.15
227_A293_Q0.6040.15
41_E56_S0.6040.15
177_N258_T0.6040.15
142_V262_H0.6030.15
210_I374_L0.6020.15
230_F315_S0.6010.15
62_Q150_L0.6010.15
230_F362_G0.6000.15
237_E276_M0.5990.15
312_Y371_V0.5990.15
315_S328_I0.5980.15
153_E157_G0.5960.15
105_E173_Q0.5960.15
39_S340_S0.5950.15
240_L283_K0.5950.15
348_G351_M0.5940.15
262_H272_V0.5930.14
198_K226_I0.5930.14
201_G227_A0.5880.14
117_S251_L0.5870.14
226_I309_N0.5860.14
289_L331_N0.5860.14
202_W252_Q0.5860.14
205_M366_L0.5850.14
34_D51_D0.5840.14
197_S360_R0.5830.14
181_Y276_M0.5830.14
142_V269_F0.5780.14
231_R289_L0.5770.14
115_R251_L0.5770.14
42_P52_R0.5760.14
39_S48_R0.5760.14
199_Q223_G0.5740.14
269_F367_A0.5720.14
104_Y186_S0.5720.14
104_Y256_N0.5720.14
239_I320_A0.5710.14
307_S377_Q0.5710.14
209_Y236_L0.5700.14
288_I302_E0.5690.14
179_T323_E0.5680.14
292_P377_Q0.5680.14
67_M146_Q0.5670.14
128_N133_G0.5670.14
201_G265_S0.5650.14
62_Q96_N0.5640.14
36_G211_D0.5630.14
374_L378_G0.5630.14
269_F312_Y0.5620.14
225_Q339_T0.5610.14
181_Y299_F0.5610.14
204_Q255_I0.5600.14
201_G293_Q0.5600.14
54_D57_K0.5600.14
54_D328_I0.5580.14
305_H335_S0.5580.14
322_E327_L0.5580.14
94_T238_A0.5580.14
259_N265_S0.5570.14
168_K344_E0.5570.14
307_S335_S0.5570.14
299_F303_G0.5560.14
55_R64_P0.5560.14
259_N295_R0.5560.14
305_H308_V0.5540.14
263_K309_N0.5540.14
166_K206_L0.5530.14
306_S376_R0.5520.14
257_D357_H0.5510.13
226_I338_F0.5510.13
309_N316_I0.5500.13
304_I311_W0.5490.13
222_S225_Q0.5490.13
351_M358_P0.5490.13
43_G46_G0.5470.13
184_G235_Q0.5470.13
45_I51_D0.5470.13
267_A318_A0.5460.13
129_M251_L0.5460.13
245_P283_K0.5450.13
162_L225_Q0.5450.13
121_E160_F0.5440.13
152_T201_G0.5430.13
252_Q346_T0.5430.13
198_K287_V0.5430.13
251_L286_D0.5420.13
138_F332_V0.5400.13
226_I251_L0.5400.13
200_A301_S0.5390.13
228_R263_K0.5390.13
39_S336_A0.5390.13
181_Y210_I0.5390.13
274_R370_A0.5390.13
269_F356_L0.5360.13
183_G233_D0.5350.13
186_S247_D0.5340.13
247_D256_N0.5340.13
35_F43_G0.5320.13
157_G238_A0.5310.13
182_V254_G0.5310.13
149_L266_E0.5310.13
228_R262_H0.5290.13
331_N377_Q0.5250.13
320_A333_L0.5240.13
50_S69_D0.5200.13
38_G43_G0.5190.13
49_A54_D0.5170.13
338_F343_P0.5150.13
122_G149_L0.5140.13
107_K137_T0.5130.13
241_K327_L0.5120.13
157_G349_L0.5110.13
56_S352_D0.5110.13
225_Q350_Y0.5100.13
190_N222_S0.5100.13
330_L354_D0.5090.13
188_V373_E0.5090.13
139_Q332_V0.5090.13
354_D357_H0.5080.13
308_V358_P0.5070.13
251_L289_L0.5070.13
342_G354_D0.5060.12
141_P162_L0.5060.12
235_Q259_N0.5060.12
270_K331_N0.5050.12
45_I57_K0.5040.12
167_I310_R0.5020.12
112_N133_G0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o14A 1 0.9267 100 0.514 Contact Map
1k7cA 1 0.5157 100 0.772 Contact Map
4q7qA 1 0.5209 99.9 0.818 Contact Map
3rjtA 2 0.5131 99.9 0.818 Contact Map
4tx1A 5 0.4895 99.9 0.82 Contact Map
4jhlA 5 0.5236 99.9 0.82 Contact Map
3milA 2 0.5157 99.9 0.821 Contact Map
2q0qA 5 0.4895 99.9 0.824 Contact Map
1yzfA 1 0.4948 99.9 0.824 Contact Map
4q9aA 2 0.5236 99.9 0.825 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.