GREMLIN Database
YXII - Uncharacterized protein YxiI
UniProt: P42301 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 162 (146)
Sequences: 104 (76)
Seq/√Len: 6.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_V137_K3.1230.82
44_D70_L2.6590.70
36_P141_T2.5090.66
87_D90_H2.5010.65
34_I132_L2.2940.58
32_H137_K2.2660.57
36_P40_Y2.1260.52
109_W112_P2.0980.51
111_V139_A2.0840.51
119_Y135_P1.9820.47
45_I140_I1.9350.45
93_Y109_W1.8070.41
25_W134_D1.7860.40
87_D116_N1.7500.39
13_D114_F1.7110.37
69_I73_F1.7010.37
16_W86_L1.6880.37
111_V122_F1.6580.36
27_P119_Y1.6410.35
19_V123_F1.6230.35
117_G135_P1.5770.33
119_Y134_D1.5770.33
115_P133_G1.5300.32
105_E112_P1.5290.31
119_Y136_W1.4700.30
86_L115_P1.4700.30
42_V143_F1.4640.29
145_E153_N1.4450.29
27_P136_W1.4370.29
40_Y141_T1.4200.28
123_F134_D1.4180.28
118_D136_W1.4140.28
70_L111_V1.4140.28
87_D117_G1.4080.28
42_V63_S1.3960.27
78_G81_D1.3940.27
90_H119_Y1.3870.27
71_K151_I1.3830.27
16_W133_G1.3600.26
27_P135_P1.3590.26
64_D132_L1.3410.26
27_P120_Y1.3320.26
40_Y140_I1.3210.25
12_Q17_S1.3200.25
118_D144_G1.3120.25
137_K141_T1.3030.25
43_F142_V1.2900.25
28_G134_D1.2830.24
126_D142_V1.2760.24
93_Y112_P1.2690.24
12_Q15_I1.2590.24
96_S99_Q1.2530.24
96_S155_P1.2530.24
95_F109_W1.2470.23
16_W115_P1.2420.23
115_P118_D1.2410.23
137_K143_F1.2370.23
15_I85_A1.2310.23
73_F116_N1.2150.23
49_M116_N1.2120.22
25_W136_W1.2110.22
39_P77_T1.2070.22
16_W89_Q1.2070.22
69_I151_I1.2030.22
82_V94_T1.1850.22
32_H40_Y1.1830.22
72_A128_S1.1730.22
90_H134_D1.1670.21
93_Y145_E1.1610.21
32_H134_D1.1560.21
23_I137_K1.1510.21
19_V23_I1.1410.21
64_D67_T1.1220.20
123_F145_E1.1150.20
124_H129_W1.1090.20
46_S114_F1.0970.20
92_G96_S1.0890.20
81_D97_P1.0810.19
17_S27_P1.0770.19
66_E152_D1.0640.19
117_G136_W1.0640.19
20_N92_G1.0610.19
16_W130_G1.0590.19
25_W32_H1.0580.19
13_D21_K1.0450.19
67_T99_Q1.0420.18
98_H113_V1.0410.18
23_I134_D1.0400.18
93_Y111_V1.0390.18
69_I150_A1.0360.18
84_Y152_D1.0260.18
108_E112_P1.0100.18
104_D107_G1.0050.18
11_K121_F1.0040.18
98_H150_A0.9900.17
136_W144_G0.9630.17
44_D111_V0.9440.16
83_M124_H0.9240.16
76_G84_Y0.9220.16
26_K84_Y0.9080.16
95_F122_F0.9020.16
39_P146_E0.9010.16
130_G143_F0.8900.15
20_N28_G0.8850.15
86_L133_G0.8730.15
83_M99_Q0.8700.15
85_A122_F0.8700.15
32_H69_I0.8650.15
105_E111_V0.8590.15
107_G139_A0.8570.15
32_H37_P0.8550.15
80_N107_G0.8540.15
41_R95_F0.8530.15
122_F153_N0.8310.14
41_R148_L0.8210.14
82_V125_Q0.8190.14
36_P131_L0.8140.14
131_L140_I0.8130.14
108_E116_N0.8090.14
97_P147_L0.8090.14
72_A110_P0.8070.14
81_D105_E0.8050.14
88_W120_Y0.7990.14
113_V131_L0.7980.14
108_E129_W0.7940.14
97_P144_G0.7920.14
26_K138_C0.7910.14
36_P42_V0.7900.14
33_H129_W0.7880.14
73_F77_T0.7860.14
23_I143_F0.7860.14
18_E59_S0.7840.13
87_D118_D0.7840.13
59_S102_P0.7740.13
73_F150_A0.7640.13
43_F72_A0.7610.13
9_Q15_I0.7600.13
38_D105_E0.7540.13
45_I131_L0.7420.13
90_H120_Y0.7410.13
61_V114_F0.7400.13
15_I84_Y0.7390.13
19_V50_S0.7310.13
118_D135_P0.7160.12
7_L15_I0.7150.12
36_P140_I0.7150.12
71_K155_P0.7120.12
74_Q143_F0.6970.12
89_Q116_N0.6950.12
40_Y132_L0.6930.12
13_D92_G0.6910.12
95_F150_A0.6840.12
33_H120_Y0.6820.12
118_D133_G0.6790.12
25_W135_P0.6780.12
19_V34_I0.6770.12
87_D115_P0.6700.12
151_I156_P0.6670.12
134_D137_K0.6630.12
52_K65_L0.6620.12
31_C137_K0.6610.12
32_H42_V0.6600.12
44_D113_V0.6600.12
64_D152_D0.6580.11
23_I130_G0.6560.11
77_T98_H0.6510.11
71_K74_Q0.6500.11
33_H40_Y0.6460.11
67_T71_K0.6410.11
49_M114_F0.6350.11
43_F68_S0.6310.11
87_D91_D0.6250.11
43_F151_I0.6230.11
27_P134_D0.6230.11
37_P133_G0.6200.11
7_L10_T0.6190.11
90_H135_P0.6130.11
127_F131_L0.6120.11
25_W120_Y0.6000.11
33_H137_K0.5990.11
39_P82_V0.5970.11
70_L109_W0.5960.11
8_S78_G0.5940.11
151_I155_P0.5910.11
86_L118_D0.5890.11
93_Y139_A0.5860.10
123_F127_F0.5840.10
10_T17_S0.5840.10
18_E98_H0.5820.10
73_F83_M0.5800.10
68_S73_F0.5790.10
31_C46_S0.5750.10
77_T123_F0.5690.10
32_H45_I0.5680.10
62_L138_C0.5650.10
43_F129_W0.5620.10
31_C92_G0.5610.10
70_L112_P0.5580.10
70_L148_L0.5580.10
62_L112_P0.5550.10
22_I116_N0.5520.10
92_G127_F0.5410.10
7_L44_D0.5400.10
105_E109_W0.5380.10
81_D129_W0.5360.10
105_E108_E0.5320.10
63_S127_F0.5320.10
39_P96_S0.5320.10
48_A83_M0.5290.10
97_P130_G0.5210.10
124_H128_S0.5190.10
65_L143_F0.5180.10
42_V141_T0.5160.10
6_A10_T0.5080.09
85_A127_F0.5060.09
92_G155_P0.5040.09
69_I84_Y0.5010.09
22_I50_S0.5000.09
70_L80_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wasA 4 0.6296 18.3 0.956 Contact Map
1kxgA 5 0.5432 16.3 0.957 Contact Map
3kf3A 2 0.4568 10.1 0.961 Contact Map
4j27A 1 0.8272 8.8 0.962 Contact Map
2yonA 1 0.1481 5.5 0.965 Contact Map
2l1nA 1 0.5185 4.7 0.966 Contact Map
4r1dB 1 0.179 4.6 0.966 Contact Map
3kalA 2 0.7037 4.3 0.967 Contact Map
3ugfA 2 0.4568 3.5 0.968 Contact Map
2zc0A 4 0.4198 3.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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