GREMLIN Database
YXIE - Universal stress protein YxiE
UniProt: P42297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (132)
Sequences: 20003 (15984)
Seq/√Len: 1391.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_S92_I3.1561.00
6_L111_V2.7221.00
99_A135_K2.7081.00
4_K34_S2.6851.00
21_A145_L2.5721.00
32_E90_E2.4931.00
4_K32_E2.4231.00
113_L145_L2.3571.00
92_I105_H2.3231.00
116_V136_V2.0151.00
96_G101_E2.0121.00
34_S90_E1.9841.00
34_S111_V1.9321.00
114_I142_C1.8921.00
79_K91_T1.8401.00
94_A101_E1.8371.00
134_H138_Q1.8031.00
34_S105_H1.7721.00
106_A114_I1.7641.00
20_D81_K1.7291.00
36_L105_H1.6991.00
7_V22_A1.6931.00
8_A116_V1.6591.00
38_V101_E1.6491.00
8_A102_I1.5641.00
101_E104_N1.5091.00
107_K141_T1.4391.00
114_I140_S1.4291.00
25_L29_Q1.4161.00
31_A112_S1.4081.00
37_H71_G1.3991.00
135_K139_L1.3831.00
32_E88_Q1.3731.00
22_A26_A1.3691.00
68_K72_L1.3681.00
7_V19_L1.3321.00
94_A105_H1.3031.00
103_L139_L1.3011.00
106_A141_T1.2991.00
71_G75_L1.2551.00
72_L76_E1.2381.00
114_I136_V1.2321.00
98_P132_V1.2061.00
16_A81_K1.1781.00
36_L94_A1.1761.00
4_K112_S1.1601.00
140_S144_V1.1531.00
105_H111_V1.1051.00
38_V98_P1.0931.00
27_K85_K1.0881.00
64_R68_K1.0841.00
124_L128_M1.0701.00
16_A77_N1.0651.00
106_A142_C1.0651.00
76_E79_K1.0571.00
15_S18_A1.0501.00
74_I78_A1.0441.00
118_S146_I1.0401.00
78_A82_A1.0391.00
69_K73_K1.0381.00
106_A111_V1.0371.00
74_I77_N1.0311.00
103_L106_A1.0221.00
67_V70_E1.0211.00
126_E134_H1.0191.00
5_M113_L1.0161.00
4_K111_V1.0051.00
59_F62_E1.0021.00
21_A25_L1.0021.00
65_N69_K0.9941.00
11_G37_H0.9751.00
116_V133_S0.9661.00
24_H28_E0.9541.00
36_L102_I0.9521.00
137_S146_I0.9441.00
123_G126_E0.9431.00
19_L35_I0.9421.00
29_Q112_S0.9291.00
67_V71_G0.9281.00
70_E74_I0.9281.00
75_L91_T0.9261.00
39_G95_N0.9251.00
19_L78_A0.9161.00
72_L91_T0.9101.00
22_A115_V0.9031.00
35_I89_A0.9001.00
21_A24_H0.8981.00
81_K84_E0.8941.00
39_G93_Y0.8791.00
71_G74_I0.8771.00
12_S15_S0.8721.00
9_I35_I0.8681.00
23_V82_A0.8651.00
61_D65_N0.8631.00
76_E80_E0.8631.00
133_S146_I0.8421.00
103_L136_V0.8421.00
26_A33_L0.8381.00
23_V87_V0.8351.00
21_A143_P0.8311.00
22_A33_L0.8311.00
70_E73_K0.8291.00
97_E100_H0.8271.00
121_I125_K0.8241.00
118_S133_S0.8201.00
16_A20_D0.8161.00
62_E65_N0.8131.00
6_L36_L0.8111.00
103_L140_S0.8101.00
8_A117_G0.8081.00
78_A81_K0.8021.00
77_N81_K0.8001.00
17_K20_D0.7991.00
71_G93_Y0.7911.00
6_L105_H0.7901.00
26_A29_Q0.7841.00
27_K86_G0.7761.00
7_V33_L0.7751.00
23_V85_K0.7691.00
9_I19_L0.7681.00
19_L23_V0.7651.00
96_G104_N0.7631.00
115_V145_L0.7561.00
82_A89_A0.7531.00
77_N80_E0.7501.00
9_I18_A0.7421.00
66_E70_E0.7361.00
6_L114_I0.7361.00
21_A147_V0.7291.00
102_I136_V0.7271.00
9_I78_A0.7251.00
9_I16_A0.7131.00
25_L28_E0.7131.00
99_A132_V0.7131.00
38_V96_G0.7121.00
66_E69_K0.7091.00
76_E91_T0.7091.00
123_G127_M0.7021.00
39_G71_G0.7011.00
110_G142_C0.6991.00
101_E105_H0.6981.00
5_M115_V0.6931.00
12_S120_G0.6921.00
22_A31_A0.6871.00
61_D64_R0.6841.00
124_L127_M0.6821.00
75_L79_K0.6731.00
79_K89_A0.6711.00
24_H27_K0.6691.00
26_A31_A0.6641.00
116_V146_I0.6631.00
73_K77_N0.6621.00
69_K72_L0.6601.00
9_I15_S0.6571.00
120_G129_L0.6491.00
35_I78_A0.6461.00
65_N68_K0.6461.00
129_L133_S0.6451.00
35_I82_A0.6421.00
23_V27_K0.6401.00
14_M17_K0.6381.00
60_I64_R0.6351.00
82_A85_K0.6341.00
99_A103_L0.6331.00
80_E84_E0.6181.00
73_K76_E0.6151.00
60_I63_I0.6141.00
99_A136_V0.6131.00
7_V18_A0.6091.00
64_R95_N0.6051.00
16_A74_I0.6021.00
5_M26_A0.6011.00
62_E66_E0.5961.00
18_A115_V0.5911.00
100_H104_N0.5831.00
37_H74_I0.5821.00
16_A78_A0.5801.00
137_S144_V0.5801.00
115_V147_V0.5791.00
92_I95_N0.5791.00
36_L101_E0.5761.00
13_D16_A0.5761.00
118_S128_M0.5751.00
25_L145_L0.5631.00
11_G74_I0.5621.00
25_L115_V0.5611.00
107_K142_C0.5581.00
35_I91_T0.5571.00
11_G78_A0.5531.00
103_L135_K0.5521.00
99_A139_L0.5421.00
25_L31_A0.5291.00
117_G147_V0.5231.00
8_A98_P0.5231.00
81_K85_K0.5211.00
23_V81_K0.5161.00
111_V114_I0.5051.00
71_G82_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mjhA 2 0.9392 99.9 0.127 Contact Map
5ahwA 4 0.9595 99.9 0.139 Contact Map
3s3tA 4 0.9527 99.9 0.139 Contact Map
2dumA 2 0.9324 99.9 0.141 Contact Map
3hgmA 2 0.973 99.9 0.142 Contact Map
2gm3A 2 0.8649 99.9 0.143 Contact Map
4wnyA 2 0.8514 99.9 0.149 Contact Map
3fg9A 3 0.9324 99.9 0.177 Contact Map
3tnjA 2 0.8446 99.9 0.178 Contact Map
3loqA 1 0.9122 99.9 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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