GREMLIN Database
EABN2 - Extracellular endo-alpha-(1->5)-L-arabinanase 2
UniProt: P42293 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (359)
Sequences: 1838 (1382)
Seq/√Len: 72.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_K197_E8.0211.00
47_T59_K7.4901.00
236_Y260_K6.3121.00
62_D65_Q5.7941.00
111_K134_D5.5521.00
133_A139_P5.1661.00
178_K230_Y3.9831.00
231_N234_T3.8211.00
262_P266_Y3.6221.00
46_G61_N3.4261.00
47_T61_N3.3781.00
321_A352_L3.1401.00
236_Y258_R3.1161.00
197_E206_L2.9151.00
324_D329_R2.8241.00
258_R359_W2.7661.00
51_F104_V2.6901.00
228_V266_Y2.6901.00
111_K132_V2.6651.00
199_N203_G2.6361.00
175_F179_D2.4201.00
51_F140_Y2.3641.00
59_K137_E2.3521.00
403_I407_K2.3141.00
72_S114_M2.3121.00
49_Y137_E2.2861.00
195_I263_D2.2461.00
59_K67_Q2.1331.00
55_L114_M2.1181.00
234_T358_G2.0411.00
396_D399_Q1.9921.00
329_R351_Q1.9881.00
43_E46_G1.9871.00
48_F324_D1.9781.00
261_K266_Y1.9651.00
199_N204_F1.9481.00
354_M360_P1.9431.00
175_F228_V1.9311.00
59_K69_L1.9161.00
323_Y328_G1.9001.00
240_Y256_V1.8781.00
44_T112_Y1.8661.00
36_V58_A1.8501.00
133_A138_G1.8361.00
51_F136_I1.8191.00
73_V99_L1.8181.00
104_V114_M1.8151.00
21_P25_Y1.8111.00
213_K263_D1.7921.00
400_T403_I1.7541.00
183_W263_D1.7481.00
394_S397_I1.7081.00
22_N26_A1.7071.00
260_K267_Y1.7061.00
406_N410_T1.6721.00
178_K235_Q1.6551.00
353_F356_K1.6381.00
324_D327_T1.6381.00
395_A399_Q1.6371.00
199_N202_T1.6250.99
42_I112_Y1.6220.99
259_S265_P1.6040.99
394_S399_Q1.6030.99
41_I333_I1.5950.99
195_I262_P1.5860.99
60_S63_L1.5840.99
31_F333_I1.5710.99
176_F182_L1.5600.99
185_V228_V1.5430.99
395_A401_I1.5250.99
432_A437_N1.4950.99
432_A435_K1.4880.99
130_V203_G1.4770.99
259_S263_D1.4740.99
135_N140_Y1.4580.99
323_Y330_S1.4290.99
259_S266_Y1.4240.99
193_I241_L1.4130.99
70_T139_P1.4020.98
401_I407_K1.4000.98
196_L205_P1.3970.98
229_L321_A1.3810.98
175_F237_Y1.3730.98
99_L116_Y1.3720.98
215_L218_G1.3700.98
186_Y196_L1.3500.98
399_Q403_I1.3490.98
195_I228_V1.3420.98
106_Q110_G1.3410.98
115_Y202_T1.3330.98
181_K206_L1.3250.98
21_P24_V1.3230.98
177_D230_Y1.3190.98
117_N128_M1.3170.98
316_P336_T1.3150.98
258_R267_Y1.3130.98
213_K216_L1.3100.98
195_I215_L1.2890.97
43_E325_E1.2840.97
396_D403_I1.2810.97
438_G443_Q1.2710.97
55_L116_Y1.2640.97
395_A403_I1.2590.97
435_K438_G1.2530.97
431_L436_Y1.2520.97
401_I404_Q1.2500.97
332_L362_A1.2400.97
230_Y237_Y1.2340.97
334_F350_H1.2300.96
177_D237_Y1.2300.96
207_P212_G1.2240.96
72_S131_A1.2240.96
256_V360_P1.2240.96
236_Y359_W1.2210.96
19_T22_N1.2210.96
117_N172_P1.2110.96
198_M203_G1.2060.96
46_G112_Y1.2010.96
238_Y256_V1.2000.96
56_A71_T1.1980.96
435_K439_V1.1900.96
231_N358_G1.1830.96
352_L362_A1.1790.96
52_G225_G1.1670.95
17_A20_L1.1550.95
223_I241_L1.1320.94
132_V143_K1.1280.94
259_S264_G1.1280.94
243_Y255_R1.1240.94
407_K410_T1.1180.94
150_G169_V1.1140.94
425_N429_I1.1000.93
195_I266_Y1.0820.93
397_I402_N1.0750.93
331_Y351_Q1.0710.93
51_F72_S1.0630.92
258_R354_M1.0470.92
109_D180_G1.0450.92
55_L131_A1.0440.92
37_H345_H1.0410.91
438_G444_W1.0390.91
114_M131_A1.0290.91
185_V226_P1.0250.91
116_Y129_G1.0230.91
40_S318_H1.0190.91
212_G216_L1.0140.90
231_N354_M1.0120.90
103_D173_H1.0020.90
236_Y259_S1.0020.90
394_S403_I0.9940.89
22_N25_Y0.9940.89
107_L182_L0.9910.89
36_V52_G0.9860.89
94_A97_D0.9830.89
105_T176_F0.9820.89
179_D230_Y0.9820.89
397_I401_I0.9800.89
102_A114_M0.9740.88
62_D66_W0.9730.88
187_G190_S0.9710.88
335_H338_F0.9690.88
55_L99_L0.9680.88
373_K384_Y0.9660.88
399_Q407_K0.9650.88
430_T433_G0.9620.88
68_Q71_T0.9590.88
227_Y320_S0.9540.87
55_L102_A0.9510.87
235_Q260_K0.9510.87
27_Q331_Y0.9490.87
115_Y184_M0.9480.87
399_Q404_Q0.9400.87
135_N139_P0.9350.86
211_Y215_L0.9340.86
52_G58_A0.9330.86
26_A29_P0.9270.86
33_E346_E0.9210.86
188_S194_F0.9180.85
38_D101_A0.9140.85
443_Q446_S0.9100.85
145_I148_K0.9100.85
256_V321_A0.9070.85
173_H185_V0.9070.85
403_I411_I0.9070.85
44_T106_Q0.9000.84
240_Y254_I0.9000.84
216_L219_N0.8960.84
170_V226_P0.8910.84
252_Y317_G0.8900.84
170_V244_G0.8890.83
39_P50_V0.8860.83
18_F22_N0.8860.83
18_F24_V0.8820.83
18_F21_P0.8800.83
445_D448_R0.8780.83
402_N407_K0.8780.83
262_P265_P0.8750.82
118_A126_S0.8740.82
230_Y235_Q0.8680.82
386_L389_H0.8660.82
395_A407_K0.8630.82
331_Y349_V0.8580.81
215_L219_N0.8570.81
69_L137_E0.8530.81
435_K441_L0.8480.80
66_W237_Y0.8470.80
436_Y440_F0.8460.80
231_N330_S0.8440.80
429_I438_G0.8420.80
20_L24_V0.8400.80
226_P239_L0.8320.79
105_T174_T0.8280.79
431_L438_G0.8260.79
399_Q402_N0.8260.79
57_S104_V0.8230.78
185_V266_Y0.8220.78
433_G436_Y0.8190.78
373_K377_Q0.8180.78
423_G446_S0.8160.78
196_L207_P0.8150.78
397_I400_T0.8140.78
317_G324_D0.8140.78
191_G220_H0.8130.78
275_L362_A0.8120.78
228_V262_P0.8120.78
386_L390_G0.8110.77
187_G191_G0.8100.77
51_F102_A0.8050.77
109_D204_F0.8020.77
427_A440_F0.8010.77
38_D318_H0.8000.76
372_L375_V0.7980.76
395_A400_T0.7970.76
43_E322_Y0.7970.76
358_G361_V0.7960.76
38_D345_H0.7950.76
226_P241_L0.7950.76
18_F25_Y0.7950.76
371_T374_E0.7940.76
44_T47_T0.7930.76
63_L320_S0.7920.76
174_T198_M0.7900.76
236_Y267_Y0.7890.75
53_S245_G0.7860.75
70_T74_S0.7850.75
254_I257_A0.7840.75
53_S252_Y0.7810.75
213_K217_G0.7800.75
57_S72_S0.7800.75
396_D407_K0.7780.74
325_E329_R0.7780.74
107_L113_Y0.7740.74
198_M201_K0.7710.74
417_G421_K0.7700.74
394_S401_I0.7630.73
17_A21_P0.7590.73
71_T74_S0.7590.73
339_P342_G0.7590.73
231_N323_Y0.7540.72
241_L257_A0.7540.72
113_Y130_V0.7540.72
317_G335_H0.7530.72
170_V252_Y0.7510.72
48_F60_S0.7500.72
46_G325_E0.7490.72
405_L410_T0.7490.72
254_I319_N0.7480.72
31_F41_I0.7470.71
43_E324_D0.7370.70
193_I226_P0.7350.70
421_K424_K0.7340.70
411_I431_L0.7330.70
242_S317_G0.7330.70
40_S227_Y0.7320.70
43_E323_Y0.7310.70
254_I332_L0.7260.69
432_A438_G0.7250.69
246_L252_Y0.7250.69
118_A127_A0.7210.69
423_G427_A0.7210.69
374_E392_D0.7190.69
324_D328_G0.7190.69
323_Y329_R0.7180.68
407_K414_E0.7150.68
38_D53_S0.7150.68
131_A143_K0.7120.68
189_Y194_F0.7120.68
60_S225_G0.7110.68
238_Y258_R0.7090.67
315_S337_R0.7070.67
380_I384_Y0.7070.67
27_Q64_M0.7060.67
436_Y442_R0.7050.67
434_K437_N0.7040.67
375_V384_Y0.7040.67
273_P276_D0.7010.67
131_A140_Y0.7000.66
434_K441_L0.6920.66
425_N440_F0.6920.66
397_I405_L0.6890.65
409_H412_S0.6880.65
416_T420_R0.6870.65
59_K68_Q0.6850.65
17_A22_N0.6850.65
136_I140_Y0.6830.65
106_Q112_Y0.6820.64
90_T93_W0.6820.64
101_A318_H0.6820.64
230_Y234_T0.6820.64
30_I345_H0.6800.64
378_K412_S0.6800.64
133_A137_E0.6800.64
133_A140_Y0.6800.64
427_A431_L0.6780.64
398_K402_N0.6770.64
403_I406_N0.6760.64
261_K265_P0.6760.64
259_S267_Y0.6750.64
334_F348_R0.6750.64
148_K169_V0.6750.64
146_F149_S0.6740.64
135_N138_G0.6740.64
89_E92_E0.6730.63
216_L257_A0.6730.63
242_S252_Y0.6720.63
335_H346_E0.6720.63
442_R448_R0.6710.63
51_F114_M0.6710.63
149_S169_V0.6710.63
214_K217_G0.6710.63
377_Q382_G0.6710.63
231_N236_Y0.6690.63
57_S110_G0.6680.63
32_K104_V0.6670.63
424_K427_A0.6670.63
433_G437_N0.6670.63
403_I409_H0.6660.63
394_S398_K0.6650.62
183_W197_E0.6640.62
116_Y142_N0.6640.62
197_E207_P0.6630.62
365_Y369_G0.6620.62
115_Y172_P0.6620.62
242_S254_I0.6610.62
425_N442_R0.6590.62
252_Y335_H0.6570.62
193_I223_I0.6560.61
372_L434_K0.6560.61
117_N170_V0.6550.61
144_G203_G0.6540.61
352_L360_P0.6530.61
364_P367_Y0.6510.61
73_V131_A0.6500.61
374_E378_K0.6470.60
401_I410_T0.6470.60
41_I320_S0.6460.60
321_A330_S0.6430.60
243_Y246_L0.6410.60
313_Y336_T0.6400.60
45_N59_K0.6390.59
53_S315_S0.6390.59
112_Y135_N0.6390.59
313_Y317_G0.6380.59
42_I135_N0.6370.59
377_Q392_D0.6350.59
318_H335_H0.6340.59
45_N141_K0.6340.59
414_E417_G0.6340.59
429_I433_G0.6340.59
115_Y128_M0.6330.59
363_A368_A0.6310.58
404_Q407_K0.6300.58
55_L170_V0.6300.58
133_A141_K0.6300.58
48_F61_N0.6290.58
433_G439_V0.6280.58
42_I136_I0.6280.58
401_I405_L0.6270.58
66_W264_G0.6260.58
336_T348_R0.6260.58
399_Q416_T0.6250.58
220_H223_I0.6240.58
60_S66_W0.6240.58
174_T184_M0.6230.57
275_L278_R0.6230.57
70_T137_E0.6220.57
410_T429_I0.6200.57
97_D119_C0.6180.57
128_M184_M0.6170.57
22_N28_K0.6170.57
324_D331_Y0.6160.57
174_T182_L0.6150.57
51_F57_S0.6150.57
438_G441_L0.6150.57
59_K136_I0.6150.57
181_K260_K0.6150.57
330_S360_P0.6140.56
199_N206_L0.6140.56
413_G417_G0.6140.56
50_V347_V0.6130.56
396_D409_H0.6120.56
437_N442_R0.6110.56
99_L102_A0.6100.56
399_Q406_N0.6100.56
142_N145_I0.6090.56
193_I266_Y0.6090.56
132_V203_G0.6090.56
252_Y318_H0.6090.56
173_H227_Y0.6080.56
36_V40_S0.6080.56
417_G420_R0.6070.56
55_L73_V0.6050.55
423_G429_I0.6040.55
425_N428_D0.6030.55
101_A172_P0.6020.55
225_G319_N0.6010.55
185_V195_I0.6000.55
128_M170_V0.5990.55
330_S354_M0.5980.54
182_L198_M0.5980.54
89_E94_A0.5960.54
400_T404_Q0.5960.54
316_P350_H0.5950.54
21_P26_A0.5940.54
93_W97_D0.5930.54
109_D113_Y0.5920.54
441_L445_D0.5900.53
396_D402_N0.5900.53
399_Q410_T0.5900.53
134_D393_I0.5890.53
27_Q30_I0.5880.53
49_Y59_K0.5880.53
119_C128_M0.5870.53
442_R445_D0.5860.53
110_G179_D0.5850.53
256_V274_M0.5840.53
413_G418_T0.5840.53
53_S101_A0.5840.53
400_T407_K0.5830.53
267_Y359_W0.5820.52
390_G393_I0.5820.52
20_L23_S0.5820.52
375_V381_T0.5810.52
313_Y348_R0.5810.52
91_F94_A0.5800.52
49_Y138_G0.5790.52
367_Y370_E0.5790.52
399_Q409_H0.5780.52
256_V269_A0.5750.52
53_S317_G0.5730.51
244_G317_G0.5720.51
101_A345_H0.5700.51
19_T26_A0.5690.51
440_F445_D0.5690.51
226_P244_G0.5690.51
135_N376_K0.5680.51
357_D425_N0.5640.50
19_T24_V0.5620.50
48_F325_E0.5620.50
436_Y444_W0.5620.50
44_T136_I0.5610.50
443_Q447_V0.5610.50
396_D401_I0.5580.49
433_G440_F0.5580.49
331_Y399_Q0.5570.49
231_N321_A0.5570.49
99_L114_M0.5560.49
102_A106_Q0.5520.49
53_S345_H0.5510.49
113_Y132_V0.5510.49
329_R371_T0.5500.48
115_Y174_T0.5500.48
90_T95_Q0.5480.48
338_F348_R0.5460.48
433_G442_R0.5440.48
379_D387_I0.5420.48
42_I51_F0.5420.48
39_P101_A0.5410.47
100_W254_I0.5370.47
187_G194_F0.5370.47
317_G320_S0.5360.47
398_K408_N0.5360.47
371_T378_K0.5350.47
52_G316_P0.5340.47
375_V380_I0.5340.47
439_V444_W0.5340.47
238_Y359_W0.5330.46
29_P34_V0.5320.46
377_Q405_L0.5300.46
103_D185_V0.5290.46
38_D100_W0.5290.46
34_V140_Y0.5290.46
198_M206_L0.5290.46
434_K444_W0.5290.46
398_K401_I0.5270.46
148_K194_F0.5240.45
37_H52_G0.5240.45
215_L220_H0.5230.45
440_F444_W0.5230.45
396_D416_T0.5220.45
271_G410_T0.5220.45
196_L212_G0.5220.45
412_S433_G0.5210.45
392_D395_A0.5210.45
407_K412_S0.5210.45
58_A68_Q0.5210.45
412_S435_K0.5200.45
245_G317_G0.5190.45
99_L226_P0.5190.45
426_T441_L0.5180.45
53_S246_L0.5180.45
54_H71_T0.5180.45
66_W177_D0.5170.44
245_G252_Y0.5140.44
440_F448_R0.5110.44
130_V144_G0.5100.44
226_P240_Y0.5100.44
191_G222_R0.5100.44
239_L257_A0.5090.43
63_L349_V0.5080.43
380_I386_L0.5080.43
35_S335_H0.5080.43
373_K376_K0.5070.43
102_A117_N0.5070.43
115_Y335_H0.5060.43
36_V50_V0.5060.43
56_A68_Q0.5060.43
429_I436_Y0.5050.43
376_K426_T0.5050.43
242_S319_N0.5040.43
365_Y368_A0.5040.43
400_T411_I0.5030.43
109_D234_T0.5020.43
116_Y131_A0.5020.43
375_V390_G0.5020.43
18_F23_S0.5010.42
379_D393_I0.5000.42
396_D400_T0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x8sA 1 0.936 100 0.271 Contact Map
4kc7A 1 0.9211 100 0.3 Contact Map
4kcaA 2 0.9744 100 0.33 Contact Map
1yrzA 1 0.8081 100 0.427 Contact Map
3c2uA 3 0.8081 100 0.428 Contact Map
1yifA 3 0.806 100 0.43 Contact Map
2exhA 3 0.806 100 0.432 Contact Map
3zxkA 1 0.7825 100 0.46 Contact Map
1gyhA 1 0.6354 100 0.492 Contact Map
4kcbA 1 0.6205 100 0.493 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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