GREMLIN Database
YCBU - Uncharacterized aminotransferase YcbU
UniProt: P42253 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (327)
Sequences: 34842 (23960)
Seq/√Len: 1325.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_A178_L3.4141.00
291_D357_R3.3751.00
100_H124_S3.3111.00
295_Y360_I3.2981.00
291_D353_K3.2551.00
153_H185_S2.9631.00
163_D166_A2.8281.00
64_E271_S2.7451.00
139_E170_I2.7161.00
192_D195_E2.5731.00
105_D127_P2.5581.00
139_E173_R2.5171.00
100_H122_T2.5061.00
182_A201_L2.4461.00
171_S176_S2.3721.00
268_A271_S2.3711.00
203_A217_F2.3451.00
100_H143_S2.3151.00
291_D295_Y2.2911.00
137_Q140_T2.2571.00
259_A262_S2.2491.00
149_T171_S2.2401.00
332_K365_A2.1401.00
295_Y357_R2.1201.00
358_H362_E2.0501.00
332_K362_E2.0021.00
168_A172_Q2.0021.00
137_Q141_H1.9811.00
70_G192_D1.9711.00
302_Q318_R1.9531.00
284_H288_I1.9511.00
100_H146_T1.9401.00
31_E35_R1.9321.00
124_S141_H1.9031.00
38_Q42_D1.9021.00
295_Y298_E1.8771.00
134_P137_Q1.8281.00
80_P84_D1.8251.00
34_S38_Q1.8221.00
151_V167_I1.8111.00
345_L359_A1.8081.00
100_H145_E1.7731.00
287_T353_K1.7711.00
64_E267_A1.7711.00
127_P137_Q1.7471.00
328_L366_K1.7351.00
165_K195_E1.7291.00
171_S178_L1.7261.00
169_E173_R1.7231.00
67_K274_N1.7131.00
165_K169_E1.7101.00
170_I174_K1.6931.00
128_S132_V1.6621.00
302_Q320_E1.6411.00
39_D43_S1.6171.00
180_V198_V1.6051.00
135_L170_I1.6041.00
304_A318_R1.5861.00
172_Q197_G1.5801.00
99_K147_V1.5781.00
86_L110_A1.5761.00
328_L332_K1.5611.00
64_E274_N1.5551.00
166_A169_E1.5451.00
89_V200_M1.5371.00
292_A347_P1.5341.00
35_R39_D1.5261.00
327_G331_K1.5141.00
75_E222_K1.5081.00
79_V85_A1.4951.00
286_K290_A1.4771.00
139_E174_K1.4751.00
290_A294_Q1.4551.00
31_E42_D1.4531.00
135_L166_A1.4531.00
151_V178_L1.4481.00
198_V201_L1.4451.00
60_F64_E1.4371.00
142_I170_I1.4191.00
172_Q199_D1.4171.00
295_Y364_A1.4171.00
82_V183_Y1.4161.00
34_S42_D1.4141.00
170_I173_R1.4131.00
283_D287_T1.4121.00
279_S283_D1.4021.00
293_V315_V1.3851.00
36_A268_A1.3741.00
289_C293_V1.3701.00
282_R286_K1.3681.00
35_R38_Q1.3671.00
148_L179_F1.3661.00
353_K357_R1.3611.00
60_F267_A1.3591.00
93_L177_L1.3441.00
65_F217_F1.3321.00
293_V297_A1.3301.00
205_T266_A1.3291.00
37_I265_A1.3261.00
328_L331_K1.3231.00
63_N67_K1.3141.00
352_T355_E1.3001.00
72_E222_K1.2931.00
86_L179_F1.2931.00
36_A39_D1.2911.00
139_E143_S1.2881.00
292_A356_M1.2841.00
105_D125_V1.2831.00
91_S233_S1.2641.00
117_A233_S1.2631.00
63_N66_A1.2631.00
44_L53_E1.2571.00
164_I180_V1.2561.00
362_E365_A1.2551.00
168_A197_G1.2521.00
169_E197_G1.2481.00
126_I141_H1.2481.00
212_I265_A1.2381.00
358_H361_D1.2241.00
200_M220_V1.2101.00
61_A267_A1.2091.00
179_F202_A1.2011.00
30_A272_L1.1981.00
103_Y115_W1.1981.00
154_V311_Q1.1951.00
334_V358_H1.1941.00
143_S174_K1.1901.00
32_P272_L1.1811.00
99_K145_E1.1701.00
64_E67_K1.1701.00
277_G280_H1.1631.00
136_E139_E1.1631.00
267_A271_S1.1591.00
136_E140_T1.1561.00
112_P125_V1.1541.00
284_H287_T1.1501.00
102_V146_T1.1491.00
297_A307_Q1.1341.00
324_E328_L1.1341.00
102_V141_H1.1331.00
113_H116_Q1.1241.00
360_I364_A1.1161.00
103_Y125_V1.1071.00
135_L139_E1.1021.00
298_E364_A1.0931.00
186_A203_A1.0841.00
294_Q297_A1.0841.00
151_V164_I1.0821.00
85_A202_A1.0821.00
154_V185_S1.0811.00
210_L348_H1.0791.00
143_S146_T1.0771.00
139_E166_A1.0711.00
138_Y149_T1.0691.00
288_I356_M1.0681.00
56_E60_F1.0641.00
138_Y167_I1.0601.00
336_C343_I1.0601.00
96_F99_K1.0591.00
63_N73_P1.0581.00
288_I353_K1.0561.00
149_T176_S1.0511.00
191_I195_E1.0501.00
161_V189_I1.0481.00
95_A98_K1.0481.00
68_L186_A1.0421.00
74_D222_K1.0381.00
98_K147_V1.0371.00
354_E357_R1.0301.00
57_K264_Y1.0261.00
209_L266_A1.0261.00
311_Q314_M1.0181.00
153_H201_L1.0131.00
294_Q298_E1.0101.00
323_S327_G1.0031.00
357_R361_D1.0011.00
326_A338_P0.9991.00
271_S275_H0.9911.00
361_D365_A0.9811.00
34_S41_Y0.9801.00
95_A99_K0.9781.00
70_G194_K0.9771.00
111_V150_C0.9721.00
192_D196_W0.9701.00
130_D306_A0.9661.00
106_M162_Q0.9631.00
280_H284_H0.9551.00
334_V359_A0.9511.00
326_A330_K0.9491.00
91_S117_A0.9421.00
295_Y361_D0.9401.00
277_G281_I0.9391.00
313_G316_A0.9381.00
76_V219_Y0.9381.00
271_S274_N0.9361.00
150_C179_F0.9351.00
185_S201_L0.9341.00
101_V115_W0.9331.00
354_E358_H0.9311.00
291_D356_M0.9241.00
293_V303_L0.9211.00
193_V219_Y0.9191.00
280_H283_D0.9181.00
153_H196_W0.9181.00
300_G320_E0.9151.00
289_C315_V0.9131.00
177_L200_M0.9131.00
58_T263_V0.9121.00
329_L336_C0.9121.00
190_P193_V0.9111.00
268_A272_L0.9101.00
199_D221_R0.9061.00
66_A71_A0.9041.00
153_H164_I0.9021.00
72_E75_E0.9021.00
94_T121_Y0.9021.00
142_I174_K0.9011.00
32_P35_R0.9011.00
190_P279_S0.9011.00
324_E327_G0.8981.00
122_T143_S0.8981.00
44_L47_K0.8971.00
172_Q178_L0.8951.00
292_A359_A0.8921.00
177_L224_L0.8891.00
171_S175_G0.8841.00
90_A115_W0.8841.00
47_K50_N0.8841.00
347_P356_M0.8811.00
281_I285_V0.8761.00
334_V362_E0.8751.00
68_L270_L0.8751.00
128_S134_P0.8731.00
61_A64_E0.8691.00
336_C345_L0.8651.00
317_I345_L0.8611.00
325_T366_K0.8601.00
142_I146_T0.8591.00
154_V312_P0.8581.00
193_V196_W0.8481.00
326_A336_C0.8471.00
311_Q315_V0.8451.00
179_F200_M0.8431.00
190_P194_K0.8421.00
200_M224_L0.8401.00
69_I203_A0.8401.00
112_P116_Q0.8381.00
351_N355_E0.8311.00
351_N356_M0.8291.00
281_I349_F0.8251.00
135_L138_Y0.8181.00
348_H351_N0.8151.00
296_A317_I0.8151.00
93_L200_M0.8131.00
37_I41_Y0.8121.00
152_P156_Y0.8071.00
327_G330_K0.8061.00
31_E34_S0.8051.00
191_I194_K0.8001.00
229_K233_S0.7941.00
205_T215_V0.7911.00
221_R224_L0.7881.00
69_I219_Y0.7851.00
234_A238_R0.7851.00
142_I176_S0.7841.00
292_A315_V0.7801.00
89_V179_F0.7751.00
72_E194_K0.7741.00
215_V262_S0.7701.00
53_E56_E0.7691.00
287_T291_D0.7661.00
235_W238_R0.7651.00
104_T107_D0.7631.00
149_T167_I0.7621.00
60_F271_S0.7591.00
234_A237_G0.7561.00
171_S174_K0.7511.00
46_Y50_N0.7491.00
281_I284_H0.7481.00
304_A316_A0.7471.00
65_F270_L0.7411.00
168_A196_W0.7411.00
292_A345_L0.7401.00
190_P195_E0.7351.00
127_P141_H0.7331.00
115_W123_V0.7321.00
211_G215_V0.7311.00
292_A296_A0.7301.00
103_Y123_V0.7301.00
59_E63_N0.7291.00
197_G221_R0.7281.00
60_F63_N0.7261.00
101_V148_L0.7231.00
325_T363_I0.7201.00
109_P113_H0.7201.00
267_A270_L0.7171.00
57_K60_F0.7171.00
43_S47_K0.7151.00
30_A33_V0.7141.00
108_F156_Y0.7131.00
132_V309_G0.7131.00
276_I280_H0.7131.00
64_E68_L0.7111.00
209_L270_L0.7101.00
141_H144_D0.7091.00
124_S146_T0.7081.00
87_V91_S0.7021.00
45_L48_G0.6971.00
116_Q125_V0.6971.00
44_L48_G0.6951.00
236_F239_E0.6931.00
177_L199_D0.6921.00
165_K196_W0.6881.00
91_S231_K0.6871.00
166_A170_I0.6871.00
205_T211_G0.6871.00
132_V162_Q0.6861.00
182_A185_S0.6851.00
124_S143_S0.6821.00
210_L349_F0.6821.00
224_L227_A0.6811.00
191_I196_W0.6771.00
169_E172_Q0.6761.00
315_V318_R0.6761.00
222_K226_D0.6761.00
153_H180_V0.6761.00
359_A363_I0.6751.00
71_A219_Y0.6751.00
77_A88_S0.6741.00
111_V115_W0.6741.00
45_L49_T0.6721.00
140_T144_D0.6691.00
39_D42_D0.6661.00
186_A209_L0.6641.00
182_A186_A0.6641.00
330_K335_I0.6631.00
61_A263_V0.6621.00
86_L202_A0.6591.00
215_V263_V0.6581.00
296_A363_I0.6571.00
297_A306_A0.6551.00
291_D294_Q0.6531.00
361_D364_A0.6521.00
126_I137_Q0.6521.00
32_P268_A0.6521.00
39_D44_L0.6521.00
248_K251_R0.6501.00
185_S189_I0.6501.00
103_Y107_D0.6491.00
153_H191_I0.6421.00
114_V118_H0.6411.00
71_A75_E0.6411.00
32_P275_H0.6401.00
67_K70_G0.6391.00
293_V307_Q0.6391.00
68_L274_N0.6381.00
167_I178_L0.6341.00
55_I59_E0.6331.00
211_G214_G0.6331.00
284_H353_K0.6321.00
288_I347_P0.6261.00
95_A121_Y0.6261.00
222_K225_A0.6261.00
288_I292_A0.6251.00
292_A360_I0.6241.00
115_W150_C0.6231.00
138_Y142_I0.6221.00
190_P196_W0.6211.00
291_D360_I0.6181.00
250_A253_F0.6181.00
45_L50_N0.6171.00
283_D286_K0.6171.00
357_R360_I0.6171.00
168_A198_V0.6171.00
235_W239_E0.6161.00
233_S236_F0.6141.00
82_V202_A0.6141.00
186_A270_L0.6141.00
59_E62_R0.6111.00
310_I314_M0.6101.00
190_P282_R0.6091.00
164_I178_L0.6061.00
168_A171_S0.6051.00
33_V269_A0.6031.00
75_E223_E0.6031.00
279_S282_R0.6011.00
249_V252_R0.6011.00
296_A301_L0.5981.00
128_S131_G0.5971.00
65_F78_I0.5961.00
102_V124_S0.5961.00
75_E221_R0.5951.00
249_V253_F0.5941.00
64_E270_L0.5931.00
301_L319_D0.5911.00
356_M360_I0.5911.00
232_A237_G0.5911.00
287_T290_A0.5901.00
278_V282_R0.5891.00
104_T151_V0.5891.00
46_Y49_T0.5881.00
165_K191_I0.5861.00
165_K197_G0.5851.00
312_P315_V0.5831.00
102_V126_I0.5831.00
296_A360_I0.5821.00
40_Y57_K0.5811.00
118_H121_Y0.5801.00
285_V313_G0.5781.00
44_L49_T0.5771.00
89_V218_L0.5771.00
312_P316_A0.5771.00
168_A180_V0.5761.00
314_M318_R0.5761.00
82_V86_L0.5741.00
103_Y150_C0.5731.00
319_D325_T0.5711.00
41_Y261_I0.5711.00
31_E38_Q0.5711.00
79_V88_S0.5701.00
58_T260_F0.5681.00
153_H161_V0.5671.00
232_A235_W0.5671.00
138_Y170_I0.5661.00
292_A295_Y0.5631.00
152_P155_H0.5621.00
52_K55_I0.5621.00
84_D87_V0.5601.00
89_V93_L0.5591.00
122_T145_E0.5541.00
136_E166_A0.5531.00
66_A73_P0.5511.00
205_T217_F0.5511.00
37_I261_I0.5501.00
265_A269_A0.5501.00
162_Q167_I0.5501.00
152_P162_Q0.5501.00
84_D232_A0.5501.00
314_M317_I0.5481.00
306_A309_G0.5471.00
71_A201_L0.5441.00
69_I193_V0.5431.00
186_A191_I0.5431.00
177_L223_E0.5381.00
231_K235_W0.5381.00
90_A94_T0.5361.00
359_A362_E0.5351.00
126_I133_L0.5341.00
325_T329_L0.5341.00
333_K337_A0.5331.00
272_L275_H0.5311.00
130_D307_Q0.5291.00
293_V311_Q0.5291.00
228_L232_A0.5281.00
75_E194_K0.5281.00
295_Y356_M0.5261.00
318_R321_R0.5261.00
201_L219_Y0.5241.00
32_P36_A0.5241.00
69_I186_A0.5241.00
288_I351_N0.5221.00
42_D47_K0.5221.00
272_L276_I0.5201.00
40_Y264_Y0.5201.00
183_Y204_G0.5191.00
87_V117_A0.5191.00
299_K364_A0.5191.00
135_L167_I0.5181.00
310_I313_G0.5171.00
35_R42_D0.5151.00
336_C359_A0.5141.00
36_A40_Y0.5141.00
299_K302_Q0.5131.00
314_M320_E0.5131.00
30_A349_F0.5121.00
113_H117_A0.5121.00
316_A320_E0.5111.00
290_A293_V0.5101.00
146_T176_S0.5101.00
264_Y267_A0.5091.00
205_T209_L0.5091.00
42_D45_L0.5081.00
148_L177_L0.5081.00
311_Q316_A0.5081.00
170_I176_S0.5071.00
312_P317_I0.5071.00
40_Y261_I0.5061.00
107_D112_P0.5051.00
91_S118_H0.5001.00
293_V310_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e9kA 2 0.9946 100 0.338 Contact Map
1qz9A 2 0.9838 100 0.371 Contact Map
1eluA 2 0.9649 100 0.374 Contact Map
1kmjA 2 0.9892 100 0.376 Contact Map
1t3iA 2 0.9892 100 0.387 Contact Map
4lw2A 2 0.9892 100 0.391 Contact Map
4w91A 2 0.9919 100 0.393 Contact Map
4q75A 2 0.9946 100 0.396 Contact Map
3caiA 2 0.9514 100 0.4 Contact Map
3a9zA 2 0.9162 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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