GREMLIN Database
TATCD - Sec-independent protein translocase protein TatCd
UniProt: P42252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (230)
Sequences: 3371 (2146)
Seq/√Len: 141.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_T226_S4.3491.00
186_R220_E4.1251.00
25_A79_V3.9041.00
17_R21_V3.7081.00
183_A227_A3.6741.00
21_V79_V3.3261.00
82_Y86_R3.0481.00
194_I212_M2.9821.00
14_E18_R2.7141.00
179_P230_Y2.7131.00
30_L72_A2.5961.00
51_K139_E2.1471.00
189_S219_F2.1121.00
22_T80_A2.0691.00
31_I35_L2.0021.00
40_I71_C1.9791.00
171_L176_I1.9691.00
168_V182_L1.9661.00
33_A71_C1.9611.00
179_P226_S1.9431.00
20_I24_A1.9361.00
178_N181_R1.9361.00
55_L143_T1.9311.00
190_Y216_L1.9311.00
134_S140_T1.8821.00
72_A76_S1.8811.00
116_S120_F1.8771.00
21_V83_Q1.8501.00
219_F223_V1.8451.00
92_L96_E1.8261.00
104_I108_F1.7841.00
29_F72_A1.7801.00
59_E143_T1.7741.00
53_A141_M1.7681.00
26_F69_G1.7531.00
111_F159_G1.7391.00
188_L192_L1.7261.00
36_F39_D1.7251.00
7_H10_G1.7181.00
107_L163_E1.7081.00
183_A186_R1.6811.00
19_I23_L1.6761.00
56_G59_E1.6491.00
194_I208_D1.6431.00
193_L215_L1.6401.00
177_L182_L1.6361.00
18_R83_Q1.6021.00
181_R185_A1.5851.00
185_A188_L1.5821.00
76_S80_A1.5721.00
18_R86_R1.5541.00
29_F75_A1.5411.00
112_L116_S1.5251.00
205_F208_D1.5161.00
89_A97_R1.4971.00
196_V200_I1.4861.00
180_Y184_K1.4811.00
172_T179_P1.4801.00
203_P208_D1.4621.00
57_P127_L1.4601.00
229_V233_R1.4591.00
183_A220_E1.4231.00
179_P183_A1.4221.00
22_T76_S1.4211.00
179_P227_A1.4041.00
21_V24_A1.4011.00
6_T10_G1.3831.00
57_P60_I1.3611.00
32_T35_L1.3291.00
191_F195_V1.3111.00
54_V60_I1.3111.00
57_P150_F1.2951.00
29_F76_S1.2811.00
169_M229_V1.2761.00
43_W120_F1.2711.00
25_A76_S1.2711.00
26_F76_S1.2681.00
123_F151_M1.2671.00
198_I208_D1.2641.00
143_T146_R1.2581.00
77_I81_A1.2351.00
173_R229_V1.2241.00
109_A113_A1.2151.00
131_T140_T1.2111.00
200_I211_V1.1941.00
168_V226_S1.1911.00
64_Y133_L1.1871.00
224_T228_F1.1771.00
26_F80_A1.1671.00
55_L141_M1.1651.00
56_G146_R1.1590.99
115_I155_S1.1580.99
32_T36_F1.1350.99
180_Y183_A1.1250.99
13_E17_R1.1230.99
28_L32_T1.1230.99
220_E224_T1.1100.99
87_F90_P1.1080.99
47_D147_Y1.1050.99
58_S130_L1.1010.99
91_A96_E1.0910.99
168_V222_S1.0910.99
54_V138_F1.0900.99
209_F213_I1.0860.99
193_L216_L1.0750.99
126_V207_S1.0750.99
22_T25_A1.0520.99
182_L219_F1.0500.99
34_F64_Y1.0430.99
24_A27_F1.0410.99
94_K98_K1.0400.99
231_K234_M1.0180.99
83_Q86_R1.0130.99
14_E83_Q1.0070.99
37_V64_Y1.0050.99
21_V82_Y1.0000.98
11_H96_E0.9940.98
138_F144_A0.9860.98
185_A189_S0.9840.98
33_A75_A0.9730.98
164_M193_L0.9690.98
73_I80_A0.9620.98
24_A28_L0.9580.98
54_V144_A0.9580.98
115_I159_G0.9580.98
73_I77_I0.9570.98
123_F127_L0.9380.98
23_L27_F0.9360.98
57_P142_F0.9330.98
164_M222_S0.9320.98
87_F91_A0.9320.98
27_F31_I0.9300.98
179_P223_V0.9300.98
127_L150_F0.9290.98
183_A223_V0.9150.97
34_F65_M0.9070.97
126_V130_L0.9060.97
130_L164_M0.8990.97
38_Q42_D0.8990.97
201_T211_V0.8950.97
187_K208_D0.8830.97
11_H87_F0.8750.96
157_P200_I0.8740.96
54_V59_E0.8710.96
190_Y220_E0.8700.96
42_D45_I0.8680.96
190_Y212_M0.8640.96
197_S200_I0.8570.96
11_H14_E0.8550.96
208_D212_M0.8530.96
18_R91_A0.8450.96
186_R190_Y0.8420.96
114_G159_G0.8420.96
198_I201_T0.8410.96
56_G145_D0.8380.95
85_W122_L0.8360.95
197_S201_T0.8340.95
182_L223_V0.8250.95
26_F73_I0.8250.95
11_H15_L0.8230.95
11_H90_P0.8220.95
193_L197_S0.8110.95
177_L181_R0.8110.95
54_V140_T0.8090.95
29_F33_A0.8080.95
178_N234_M0.8070.94
192_L195_V0.8060.94
125_I128_S0.8010.94
164_M215_L0.8000.94
100_T104_I0.7990.94
226_S230_Y0.7960.94
87_F96_E0.7930.94
107_L166_L0.7910.94
125_I210_L0.7890.94
161_L215_L0.7890.94
186_R224_T0.7850.94
101_L105_P0.7820.93
8_L17_R0.7770.93
74_A115_I0.7750.93
187_K190_Y0.7720.93
66_M149_R0.7690.93
54_V134_S0.7690.93
224_T227_A0.7650.93
77_I80_A0.7630.93
19_I22_T0.7620.93
131_T142_F0.7530.92
16_R20_I0.7500.92
85_W100_T0.7470.92
201_T208_D0.7460.92
38_Q64_Y0.7450.92
134_S138_F0.7450.92
30_L69_G0.7390.91
201_T204_D0.7380.91
89_A93_T0.7340.91
180_Y227_A0.7340.91
34_F68_S0.7320.91
60_I133_L0.7310.91
61_L133_L0.7290.91
25_A80_A0.7240.91
108_F112_L0.7150.90
41_Y45_I0.7140.90
77_I108_F0.7110.90
100_T108_F0.7080.90
14_E87_F0.7000.89
194_I216_L0.7000.89
87_F92_L0.6990.89
198_I205_F0.6960.89
128_S132_H0.6930.89
93_T96_E0.6900.88
42_D46_R0.6870.88
174_L177_L0.6770.87
51_K141_M0.6750.87
149_R153_N0.6740.87
35_L68_S0.6730.87
197_S212_M0.6730.87
11_H91_A0.6720.87
190_Y194_I0.6710.87
122_L158_F0.6670.87
99_V102_M0.6650.87
168_V177_L0.6650.87
90_P147_Y0.6620.86
33_A72_A0.6610.86
117_F222_S0.6610.86
79_V83_Q0.6560.86
21_V25_A0.6550.86
62_W66_M0.6500.85
154_L158_F0.6500.85
48_L142_F0.6480.85
41_Y67_L0.6470.85
203_P207_S0.6450.85
44_L151_M0.6440.85
158_F203_P0.6430.85
33_A36_F0.6400.84
55_L59_E0.6390.84
113_A116_S0.6390.84
204_D208_D0.6380.84
43_W47_D0.6310.84
35_L39_D0.6260.83
9_I12_L0.6260.83
169_M225_L0.6260.83
102_M105_P0.6230.83
140_T143_T0.6220.83
59_E63_V0.6180.82
99_V170_F0.6180.82
73_I156_L0.6150.82
144_A166_L0.6120.82
110_L218_L0.6110.82
73_I107_L0.6110.82
60_I140_T0.6090.81
29_F32_T0.6090.81
88_V100_T0.6090.81
216_L220_E0.6040.81
213_I217_V0.6040.81
44_L89_A0.6040.81
161_L211_V0.6020.81
36_F40_I0.6020.81
34_F38_Q0.6010.80
8_L13_E0.6010.80
6_T67_L0.6000.80
204_D207_S0.5980.80
47_D57_P0.5970.80
199_L205_F0.5960.80
48_L117_F0.5930.80
118_G123_F0.5920.79
68_S71_C0.5890.79
207_S211_V0.5860.79
111_F114_G0.5850.79
81_A107_L0.5840.79
134_S137_H0.5820.78
220_E223_V0.5800.78
63_V144_A0.5790.78
118_G154_L0.5770.78
33_A68_S0.5760.78
59_E142_F0.5740.77
18_R90_P0.5740.77
126_V187_K0.5740.77
41_Y138_F0.5730.77
111_F163_E0.5710.77
81_A112_L0.5710.77
90_P96_E0.5700.77
118_G158_F0.5690.77
64_Y138_F0.5670.77
81_A85_W0.5650.76
153_N207_S0.5630.76
72_A99_V0.5630.76
60_I138_F0.5610.76
70_I152_V0.5600.76
39_D42_D0.5560.75
153_N156_L0.5560.75
52_L68_S0.5520.75
184_K191_F0.5510.75
28_L31_I0.5490.74
209_F212_M0.5480.74
197_S215_L0.5470.74
106_G166_L0.5440.74
148_F224_T0.5430.73
69_G73_I0.5430.73
172_T230_Y0.5430.73
70_I74_A0.5420.73
14_E91_A0.5410.73
58_S62_W0.5410.73
125_I208_D0.5400.73
107_L158_F0.5400.73
16_R204_D0.5400.73
39_D43_W0.5400.73
22_T72_A0.5400.73
11_H18_R0.5400.73
107_L155_S0.5400.73
45_I48_L0.5380.73
162_F218_L0.5370.73
127_L133_L0.5350.72
131_T134_S0.5350.72
198_I202_P0.5330.72
36_F42_D0.5330.72
223_V226_S0.5320.72
179_P186_R0.5320.72
201_T207_S0.5300.72
228_F232_K0.5280.71
129_F203_P0.5260.71
194_I209_F0.5260.71
34_F60_I0.5250.71
8_L70_I0.5240.71
203_P209_F0.5230.71
66_M70_I0.5220.71
74_A156_L0.5210.70
6_T9_I0.5210.70
201_T205_F0.5210.70
48_L52_L0.5190.70
78_P114_G0.5180.70
173_R225_L0.5160.70
44_L168_V0.5160.70
122_L183_A0.5150.70
114_G162_F0.5140.69
83_Q90_P0.5130.69
97_R101_L0.5120.69
32_T75_A0.5110.69
100_T150_F0.5090.69
33_A40_I0.5080.68
9_I13_E0.5060.68
200_I208_D0.5060.68
190_Y193_L0.5060.68
46_R120_F0.5060.68
63_V67_L0.5050.68
186_R223_V0.5040.68
14_E86_R0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.9008 100 0.075 Contact Map
4b4aA 1 0.9008 100 0.083 Contact Map
4xnjA 1 0.7934 11.9 0.96 Contact Map
2kluA 1 0.1736 11.4 0.96 Contact Map
2rddB 1 0.1364 9.6 0.961 Contact Map
2m7xA 1 0.124 9.4 0.962 Contact Map
2l2tA 2 0.1653 8.3 0.962 Contact Map
2l0eA 1 0.1281 7.6 0.963 Contact Map
3rkoM 1 0.624 6.7 0.964 Contact Map
4p02A 1 0.2231 6.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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