PPBD - BACSU - GREMLIN Contacts

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PPBD - Alkaline phosphatase D

UniProt:	P42251	Sequences: MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLTIAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPVKWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKTKTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYVSKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANKIPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDTRQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAKWNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFEKTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQWKADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSHNKAHEKQMIKKRAKITN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	583 (495)
Sequences:	1758 (1268)
Seq/√Len:	57.0

BACSU - PPBD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
422_I	430_V	3.992	1.00
79_V	160_T	3.813	1.00
320_H	373_N	3.482	1.00
367_E	414_Q	3.458	1.00
105_E	147_R	3.378	1.00
112_F	147_R	3.369	1.00
371_F	421_F	3.345	1.00
178_A	194_M	3.339	1.00
367_E	417_R	3.267	1.00
160_T	259_P	3.205	1.00
273_Y	295_Y	3.004	1.00
81_L	135_A	3.002	1.00
175_F	201_L	2.984	1.00
177_F	205_L	2.962	1.00
511_D	530_S	2.920	1.00
78_S	134_E	2.888	1.00
331_V	385_A	2.866	1.00
192_K	250_N	2.853	1.00
108_K	114_K	2.852	1.00
343_N	351_S	2.826	1.00
105_E	112_F	2.802	1.00
174_T	502_T	2.746	1.00
105_E	118_K	2.720	1.00
177_F	499_V	2.705	1.00
322_T	328_S	2.685	1.00
104_W	119_G	2.673	1.00
261_V	321_F	2.553	1.00
339_D	359_R	2.431	1.00
123_A	127_L	2.431	1.00
261_V	331_V	2.380	1.00
231_E	290_R	2.349	1.00
371_F	417_R	2.320	1.00
201_L	261_V	2.318	1.00
298_Y	304_L	2.283	1.00
108_K	139_E	2.267	1.00
75_L	134_E	2.254	1.00
391_A	443_S	2.229	1.00
134_E	305_R	2.189	1.00
139_E	144_Y	2.189	1.00
380_H	535_K	2.171	1.00
143_V	159_K	2.133	1.00
254_A	260_W	2.117	1.00
238_Y	290_R	2.115	1.00
173_M	327_A	2.108	1.00
107_A	112_F	2.107	1.00
246_R	255_H	2.106	1.00
503_V	508_W	2.102	1.00
209_I	232_I	2.083	1.00
516_P	524_A	2.080	1.00
128_A	301_H	2.080	1.00
407_S	437_V	2.077	1.00
420_N	424_S	2.058	1.00
191_Y	204_H	2.051	1.00
176_A	194_M	2.045	1.00
516_P	523_A	2.040	1.00
461_F	533_Y	2.038	1.00
167_G	325_N	2.034	1.00
208_Y	255_H	2.022	1.00
445_L	458_G	2.015	1.00
242_H	246_R	1.970	1.00
430_V	458_G	1.951	1.00
29_F	33_A	1.929	1.00
364_K	368_Q	1.928	1.00
24_F	29_F	1.926	1.00
73_D	319_R	1.897	1.00
178_A	466_I	1.892	1.00
390_F	445_L	1.871	1.00
262_V	302_M	1.862	1.00
107_A	111_H	1.836	0.99
75_L	78_S	1.830	0.99
182_Q	185_H	1.827	0.99
499_V	510_A	1.812	0.99
375_G	425_K	1.809	0.99
431_V	508_W	1.794	0.99
342_A	359_R	1.763	0.99
172_Q	502_T	1.763	0.99
101_P	120_T	1.758	0.99
329_F	385_A	1.753	0.99
230_A	237_D	1.752	0.99
440_S	464_T	1.741	0.99
330_N	373_N	1.735	0.99
389_F	437_V	1.728	0.99
190_A	466_I	1.727	0.99
110_E	145_Y	1.700	0.99
235_L	297_A	1.699	0.99
99_A	125_P	1.697	0.99
368_Q	372_N	1.693	0.99
253_A	256_A	1.683	0.99
383_V	508_W	1.683	0.99
327_A	503_V	1.681	0.99
404_S	407_S	1.667	0.99
143_V	161_K	1.663	0.99
451_K	454_S	1.653	0.99
181_Q	188_Y	1.625	0.99
78_S	135_A	1.623	0.99
263_T	331_V	1.622	0.99
371_F	418_V	1.620	0.99
334_T	387_Q	1.615	0.99
149_K	154_L	1.614	0.99
169_N	325_N	1.604	0.99
491_F	528_R	1.601	0.99
375_G	421_F	1.601	0.99
513_R	527_T	1.598	0.99
428_N	535_K	1.597	0.99
361_L	388_I	1.585	0.98
444_N	490_Q	1.577	0.98
105_E	149_K	1.574	0.98
123_A	131_V	1.553	0.98
192_K	196_K	1.552	0.98
461_F	499_V	1.528	0.98
391_A	445_L	1.526	0.98
108_K	142_K	1.526	0.98
102_V	131_V	1.524	0.98
443_S	489_I	1.517	0.98
403_Y	406_D	1.514	0.98
71_S	259_P	1.511	0.98
389_F	407_S	1.501	0.98
390_F	432_V	1.496	0.98
243_A	301_H	1.495	0.98
386_Q	434_T	1.481	0.98
390_F	419_I	1.476	0.97
127_L	296_Q	1.470	0.97
67_L	301_H	1.456	0.97
361_L	414_Q	1.454	0.97
269_V	287_F	1.448	0.97
446_H	456_I	1.448	0.97
490_Q	493_N	1.446	0.97
234_T	237_D	1.446	0.97
271_N	278_P	1.434	0.97
355_R	412_P	1.434	0.97
253_A	257_A	1.427	0.97
514_V	528_R	1.426	0.97
264_W	273_Y	1.421	0.97
269_V	294_A	1.417	0.97
534_Q	537_Q	1.396	0.96
103_K	120_T	1.390	0.96
509_K	530_S	1.376	0.96
203_F	433_L	1.372	0.96
419_I	445_L	1.368	0.96
181_Q	191_Y	1.364	0.96
178_A	204_H	1.363	0.96
422_I	458_G	1.357	0.96
416_E	420_N	1.356	0.96
325_N	505_P	1.348	0.96
239_R	300_E	1.336	0.95
79_V	259_P	1.335	0.95
38_G	41_L	1.314	0.95
42_G	45_I	1.313	0.95
382_N	427_L	1.308	0.95
69_V	155_S	1.308	0.95
367_E	371_F	1.302	0.95
437_V	462_V	1.297	0.95
174_T	500_R	1.290	0.94
28_K	31_Q	1.286	0.94
71_S	160_T	1.279	0.94
75_L	305_R	1.277	0.94
328_S	379_A	1.274	0.94
104_W	133_V	1.270	0.94
423_K	447_V	1.263	0.94
446_H	449_F	1.261	0.94
103_K	149_K	1.254	0.94
73_D	305_R	1.249	0.93
193_H	197_E	1.236	0.93
183_Y	247_S	1.229	0.93
280_K	285_E	1.228	0.93
107_A	115_I	1.227	0.93
442_A	512_Y	1.227	0.93
163_L	321_F	1.220	0.93
417_R	421_F	1.218	0.93
201_L	501_C	1.213	0.92
140_P	144_Y	1.213	0.92
112_F	157_V	1.208	0.92
421_F	427_L	1.201	0.92
363_G	366_Q	1.200	0.92
507_Q	532_V	1.200	0.92
193_H	196_K	1.199	0.92
488_H	491_F	1.189	0.92
362_L	414_Q	1.189	0.92
264_W	295_Y	1.188	0.92
165_A	168_A	1.183	0.91
250_N	521_P	1.182	0.91
330_N	370_L	1.181	0.91
480_D	484_K	1.177	0.91
388_I	434_T	1.176	0.91
327_A	433_L	1.173	0.91
66_T	86_A	1.172	0.91
199_L	258_F	1.172	0.91
29_F	32_G	1.172	0.91
192_K	195_A	1.167	0.91
286_A	289_L	1.160	0.91
480_D	483_L	1.159	0.91
187_Y	250_N	1.158	0.91
412_P	416_E	1.154	0.90
440_S	514_V	1.149	0.90
434_T	462_V	1.149	0.90
121_E	133_V	1.145	0.90
461_F	508_W	1.144	0.90
289_L	293_A	1.141	0.90
35_K	39_L	1.139	0.90
226_T	244_Q	1.134	0.90
440_S	463_G	1.134	0.90
414_Q	417_R	1.121	0.89
402_I	406_D	1.115	0.89
392_K	488_H	1.113	0.89
402_I	408_W	1.111	0.89
333_D	337_Y	1.110	0.89
228_N	241_R	1.107	0.89
197_E	500_R	1.104	0.88
231_E	279_E	1.103	0.88
173_M	323_Y	1.097	0.88
71_S	146_Y	1.095	0.88
470_G	496_R	1.091	0.88
233_I	237_D	1.090	0.88
392_K	450_E	1.084	0.87
230_A	233_I	1.082	0.87
202_V	258_F	1.082	0.87
334_T	362_L	1.079	0.87
134_E	306_I	1.072	0.87
109_D	113_R	1.071	0.87
81_L	160_T	1.066	0.87
277_I	280_K	1.065	0.87
108_K	116_V	1.062	0.86
80_V	134_E	1.061	0.86
237_D	241_R	1.059	0.86
232_I	237_D	1.057	0.86
175_F	503_V	1.051	0.86
444_N	449_F	1.047	0.86
175_F	501_C	1.041	0.85
405_M	408_W	1.037	0.85
117_R	135_A	1.032	0.85
43_L	46_A	1.031	0.85
276_K	288_V	1.030	0.85
516_P	526_S	1.025	0.84
328_S	382_N	1.018	0.84
339_D	360_T	1.017	0.84
173_M	201_L	1.013	0.84
212_Y	232_I	1.012	0.84
197_E	498_Y	1.007	0.83
404_S	408_W	1.007	0.83
254_A	262_V	1.005	0.83
374_L	422_I	1.002	0.83
527_T	530_S	1.000	0.83
403_Y	408_W	0.995	0.83
446_H	488_H	0.988	0.82
402_I	407_S	0.986	0.82
194_M	202_V	0.985	0.82
322_T	378_T	0.975	0.81
270_E	280_K	0.972	0.81
263_T	337_Y	0.969	0.81
179_S	463_G	0.966	0.81
370_L	384_L	0.962	0.80
225_R	229_S	0.961	0.80
392_K	409_D	0.958	0.80
100_V	150_T	0.958	0.80
214_P	244_Q	0.957	0.80
225_R	244_Q	0.955	0.80
318_Y	337_Y	0.954	0.80
517_F	520_E	0.953	0.80
109_D	115_I	0.950	0.79
174_T	198_K	0.950	0.79
212_Y	279_E	0.946	0.79
429_N	535_K	0.944	0.79
78_S	136_D	0.942	0.79
482_I	489_I	0.940	0.79
106_V	135_A	0.937	0.79
383_V	503_V	0.937	0.79
334_T	386_Q	0.933	0.78
456_I	459_A	0.933	0.78
102_V	121_E	0.931	0.78
212_Y	217_Y	0.930	0.78
228_N	240_N	0.927	0.78
389_F	462_V	0.927	0.78
39_L	43_L	0.926	0.78
194_M	254_A	0.925	0.78
191_Y	466_I	0.924	0.78
271_N	279_E	0.924	0.78
220_K	223_N	0.919	0.77
424_S	427_L	0.918	0.77
180_C	183_Y	0.917	0.77
104_W	135_A	0.915	0.77
393_W	489_I	0.914	0.77
502_T	507_Q	0.913	0.77
112_F	145_Y	0.912	0.77
448_D	451_K	0.912	0.77
447_V	455_K	0.911	0.77
101_P	122_M	0.911	0.77
384_L	432_V	0.910	0.76
36_I	40_S	0.908	0.76
517_F	523_A	0.906	0.76
390_F	418_V	0.905	0.76
420_N	447_V	0.903	0.76
431_V	461_F	0.902	0.76
179_S	205_L	0.902	0.76
124_K	127_L	0.902	0.76
270_E	279_E	0.901	0.76
393_W	404_S	0.898	0.76
229_S	244_Q	0.892	0.75
464_T	514_V	0.891	0.75
141_N	168_A	0.891	0.75
272_N	341_Q	0.887	0.75
459_A	533_Y	0.882	0.74
216_E	219_S	0.882	0.74
273_Y	276_K	0.878	0.74
40_S	43_L	0.877	0.74
149_K	152_H	0.873	0.73
87_P	100_V	0.871	0.73
383_V	501_C	0.869	0.73
278_P	281_G	0.869	0.73
203_F	385_A	0.867	0.73
189_T	523_A	0.865	0.73
227_H	240_N	0.863	0.73
407_S	439_A	0.862	0.73
341_Q	411_Y	0.859	0.72
68_G	256_A	0.858	0.72
421_F	425_K	0.856	0.72
264_W	317_L	0.855	0.72
330_N	382_N	0.853	0.72
469_G	518_V	0.850	0.71
354_S	412_P	0.850	0.71
182_Q	215_N	0.849	0.71
173_M	326_L	0.849	0.71
101_P	123_A	0.848	0.71
377_S	382_N	0.846	0.71
193_H	498_Y	0.846	0.71
201_L	329_F	0.845	0.71
41_L	45_I	0.842	0.71
338_R	388_I	0.839	0.70
69_V	146_Y	0.837	0.70
489_I	493_N	0.837	0.70
114_K	118_K	0.833	0.70
431_V	503_V	0.828	0.69
67_L	86_A	0.827	0.69
188_Y	467_T	0.827	0.69
81_L	106_V	0.826	0.69
304_L	317_L	0.823	0.69
27_R	30_I	0.818	0.68
77_D	140_P	0.816	0.68
41_L	44_T	0.815	0.68
189_T	517_F	0.813	0.68
107_A	145_Y	0.812	0.68
39_L	44_T	0.811	0.68
452_T	455_K	0.811	0.68
404_S	409_D	0.808	0.68
29_F	36_I	0.807	0.67
231_E	284_V	0.807	0.67
81_L	142_K	0.806	0.67
163_L	323_Y	0.805	0.67
414_Q	418_V	0.804	0.67
463_G	499_V	0.804	0.67
35_K	38_G	0.803	0.67
221_T	224_V	0.803	0.67
270_E	277_I	0.802	0.67
109_D	112_F	0.801	0.67
204_H	298_Y	0.801	0.67
177_F	433_L	0.795	0.66
515_M	518_V	0.795	0.66
402_I	405_M	0.794	0.66
502_T	511_D	0.790	0.66
419_I	422_I	0.789	0.66
392_K	446_H	0.788	0.66
69_V	156_P	0.787	0.65
339_D	342_A	0.786	0.65
203_F	329_F	0.786	0.65
205_L	385_A	0.784	0.65
194_M	258_F	0.783	0.65
81_L	104_W	0.780	0.65
143_V	258_F	0.780	0.65
382_N	430_V	0.778	0.65
305_R	319_R	0.776	0.64
208_Y	251_L	0.776	0.64
413_A	417_R	0.776	0.64
277_I	340_D	0.776	0.64
317_L	331_V	0.774	0.64
437_V	441_W	0.774	0.64
406_D	409_D	0.774	0.64
177_F	463_G	0.773	0.64
228_N	244_Q	0.771	0.64
108_K	247_S	0.769	0.64
66_T	85_L	0.764	0.63
334_T	361_L	0.764	0.63
393_W	437_V	0.763	0.63
31_Q	45_I	0.760	0.63
181_Q	204_H	0.757	0.62
429_N	536_D	0.757	0.62
57_A	424_S	0.757	0.62
34_G	37_A	0.756	0.62
387_Q	432_V	0.755	0.62
208_Y	246_R	0.755	0.62
320_H	330_N	0.754	0.62
178_A	202_V	0.754	0.62
338_R	342_A	0.754	0.62
434_T	437_V	0.752	0.62
491_F	514_V	0.749	0.62
374_L	421_F	0.747	0.61
187_Y	521_P	0.746	0.61
432_V	445_L	0.743	0.61
76_S	166_P	0.742	0.61
220_K	224_V	0.740	0.61
442_A	459_A	0.739	0.61
113_R	118_K	0.737	0.60
67_L	243_A	0.736	0.60
84_R	128_A	0.736	0.60
209_I	242_H	0.735	0.60
392_K	449_F	0.734	0.60
274_A	339_D	0.733	0.60
83_T	148_F	0.732	0.60
197_E	513_R	0.731	0.60
79_V	106_V	0.731	0.60
112_F	154_L	0.728	0.59
176_A	500_R	0.727	0.59
389_F	434_T	0.727	0.59
386_Q	432_V	0.727	0.59
132_H	301_H	0.727	0.59
419_I	430_V	0.726	0.59
81_L	119_G	0.726	0.59
165_A	170_V	0.725	0.59
482_I	485_E	0.725	0.59
116_V	144_Y	0.724	0.59
78_S	81_L	0.724	0.59
419_I	447_V	0.723	0.59
109_D	114_K	0.723	0.59
37_A	40_S	0.722	0.59
191_Y	194_M	0.721	0.59
382_N	422_I	0.720	0.59
274_A	277_I	0.720	0.59
245_Y	251_L	0.720	0.59
107_A	114_K	0.714	0.58
65_F	83_T	0.713	0.58
170_V	505_P	0.712	0.58
264_W	315_M	0.710	0.58
203_F	357_P	0.709	0.57
489_I	492_F	0.708	0.57
317_L	333_D	0.705	0.57
482_I	486_N	0.704	0.57
263_T	317_L	0.703	0.57
374_L	427_L	0.702	0.57
500_R	511_D	0.700	0.56
190_A	515_M	0.700	0.56
26_R	30_I	0.700	0.56
99_A	124_K	0.699	0.56
332_L	384_L	0.699	0.56
77_D	136_D	0.699	0.56
272_N	278_P	0.698	0.56
266_D	406_D	0.697	0.56
493_N	528_R	0.696	0.56
298_Y	302_M	0.695	0.56
106_V	144_Y	0.695	0.56
299_Y	306_I	0.695	0.56
77_D	198_K	0.694	0.56
62_S	88_D	0.693	0.56
470_G	518_V	0.693	0.56
74_P	261_V	0.693	0.56
325_N	380_H	0.693	0.56
161_K	200_D	0.692	0.56
501_C	508_W	0.692	0.56
182_Q	188_Y	0.691	0.55
267_H	436_D	0.691	0.55
65_F	71_S	0.690	0.55
73_D	134_E	0.686	0.55
219_S	225_R	0.685	0.55
225_R	241_R	0.682	0.55
245_Y	298_Y	0.681	0.54
170_V	325_N	0.679	0.54
126_S	296_Q	0.679	0.54
386_Q	496_R	0.674	0.54
193_H	523_A	0.673	0.54
213_G	216_E	0.672	0.53
99_A	126_S	0.671	0.53
32_G	35_K	0.671	0.53
64_P	153_E	0.670	0.53
242_H	255_H	0.670	0.53
107_A	116_V	0.667	0.53
362_L	367_E	0.664	0.53
36_I	41_L	0.663	0.52
333_D	379_A	0.661	0.52
234_T	521_P	0.658	0.52
495_Y	514_V	0.658	0.52
396_G	485_E	0.658	0.52
212_Y	280_K	0.658	0.52
449_F	454_S	0.657	0.52
272_N	404_S	0.657	0.52
298_Y	317_L	0.657	0.52
102_V	148_F	0.656	0.52
67_L	132_H	0.656	0.52
419_I	458_G	0.655	0.52
368_Q	373_N	0.655	0.52
323_Y	329_F	0.655	0.52
179_S	188_Y	0.655	0.52
167_G	322_T	0.653	0.51
139_E	142_K	0.652	0.51
278_P	282_Q	0.652	0.51
67_L	128_A	0.651	0.51
265_D	438_H	0.651	0.51
204_H	270_E	0.650	0.51
279_E	340_D	0.650	0.51
246_R	320_H	0.648	0.51
65_F	148_F	0.647	0.51
411_Y	415_R	0.647	0.51
173_M	503_V	0.647	0.51
193_H	463_G	0.646	0.51
356_N	359_R	0.645	0.50
194_M	466_I	0.645	0.50
30_I	33_A	0.645	0.50
266_D	335_R	0.645	0.50
382_N	429_N	0.644	0.50
204_H	245_Y	0.643	0.50
209_I	241_R	0.643	0.50
488_H	493_N	0.642	0.50
442_A	463_G	0.642	0.50
254_A	258_F	0.642	0.50
28_K	32_G	0.641	0.50
188_Y	441_W	0.640	0.50
176_A	202_V	0.640	0.50
78_S	160_T	0.639	0.50
533_Y	537_Q	0.637	0.50
276_K	279_E	0.635	0.49
338_R	341_Q	0.634	0.49
24_F	356_N	0.633	0.49
156_P	256_A	0.632	0.49
67_L	85_L	0.630	0.49
33_A	317_L	0.630	0.49
409_D	488_H	0.630	0.49
184_E	227_H	0.629	0.49
495_Y	528_R	0.628	0.49
204_H	260_W	0.627	0.49
106_V	117_R	0.627	0.49
397_T	400_S	0.627	0.49
517_F	524_A	0.626	0.48
81_L	488_H	0.626	0.48
360_T	363_G	0.624	0.48
513_R	525_I	0.622	0.48
334_T	388_I	0.622	0.48
443_S	458_G	0.621	0.48
486_N	490_Q	0.621	0.48
65_F	69_V	0.621	0.48
371_F	375_G	0.620	0.48
228_N	232_I	0.619	0.48
330_N	386_Q	0.619	0.48
146_Y	158_G	0.619	0.48
63_Y	153_E	0.618	0.48
512_Y	516_P	0.618	0.48
503_V	507_Q	0.618	0.48
174_T	199_L	0.618	0.48
306_I	317_L	0.617	0.47
176_A	199_L	0.616	0.47
240_N	243_A	0.616	0.47
384_L	430_V	0.614	0.47
26_R	29_F	0.614	0.47
330_N	374_L	0.613	0.47
202_V	419_I	0.613	0.47
279_E	285_E	0.613	0.47
277_I	287_F	0.613	0.47
419_I	457_F	0.611	0.47
79_V	134_E	0.611	0.47
465_S	496_R	0.611	0.47
138_L	144_Y	0.611	0.47
446_H	454_S	0.609	0.47
134_E	309_L	0.609	0.47
30_I	34_G	0.609	0.47
179_S	437_V	0.608	0.46
486_N	489_I	0.607	0.46
115_I	118_K	0.606	0.46
282_Q	285_E	0.602	0.46
371_F	424_S	0.602	0.46
394_N	398_S	0.602	0.46
486_N	493_N	0.601	0.46
232_I	298_Y	0.600	0.46
389_F	404_S	0.598	0.45
356_N	360_T	0.596	0.45
184_E	225_R	0.596	0.45
246_R	302_M	0.594	0.45
99_A	123_A	0.592	0.45
36_I	44_T	0.590	0.44
181_Q	467_T	0.589	0.44
222_G	225_R	0.589	0.44
246_R	251_L	0.587	0.44
440_S	512_Y	0.585	0.44
486_N	491_F	0.585	0.44
64_P	85_L	0.584	0.44
78_S	137_G	0.584	0.44
71_S	82_W	0.583	0.44
208_Y	302_M	0.582	0.44
484_K	491_F	0.579	0.43
39_L	46_A	0.579	0.43
466_I	491_F	0.578	0.43
482_I	492_F	0.577	0.43
177_F	180_C	0.576	0.43
180_C	207_D	0.576	0.43
86_A	89_P	0.576	0.43
319_R	331_V	0.575	0.43
115_I	283_S	0.575	0.43
39_L	42_G	0.574	0.43
386_Q	393_W	0.574	0.43
172_Q	487_P	0.574	0.43
65_F	74_P	0.574	0.43
72_G	132_H	0.573	0.43
394_N	399_A	0.573	0.43
188_Y	251_L	0.572	0.43
474_D	493_N	0.570	0.42
296_Q	299_Y	0.569	0.42
387_Q	390_F	0.567	0.42
185_H	217_Y	0.567	0.42
441_W	489_I	0.567	0.42
238_Y	407_S	0.567	0.42
242_H	501_C	0.566	0.42
272_N	472_G	0.566	0.42
292_A	315_M	0.566	0.42
74_P	79_V	0.565	0.42
473_A	496_R	0.565	0.42
89_P	317_L	0.564	0.42
295_Y	336_Q	0.563	0.42
161_K	165_A	0.562	0.41
168_A	325_N	0.562	0.41
422_I	425_K	0.562	0.41
423_K	455_K	0.562	0.41
188_Y	212_Y	0.562	0.41
272_N	434_T	0.561	0.41
248_D	264_W	0.561	0.41
141_N	161_K	0.561	0.41
500_R	513_R	0.561	0.41
75_L	79_V	0.560	0.41
485_E	491_F	0.560	0.41
202_V	260_W	0.559	0.41
208_Y	298_Y	0.559	0.41
280_K	284_V	0.559	0.41
207_D	265_D	0.558	0.41
533_Y	536_D	0.558	0.41
365_E	368_Q	0.558	0.41
185_H	470_G	0.558	0.41
127_L	130_S	0.557	0.41
77_D	137_G	0.557	0.41
479_T	483_L	0.556	0.41
31_Q	40_S	0.556	0.41
180_C	435_G	0.556	0.41
183_Y	258_F	0.556	0.41
396_G	402_I	0.556	0.41
194_M	500_R	0.555	0.41
234_T	293_A	0.555	0.41
447_V	454_S	0.554	0.41
318_Y	365_E	0.554	0.41
269_V	336_Q	0.553	0.41
228_N	285_E	0.552	0.40
440_S	499_V	0.551	0.40
67_L	84_R	0.550	0.40
387_Q	496_R	0.550	0.40
202_V	254_A	0.550	0.40
131_V	148_F	0.550	0.40
256_A	259_P	0.549	0.40
226_T	229_S	0.549	0.40
33_A	40_S	0.549	0.40
259_P	262_V	0.548	0.40
191_Y	251_L	0.548	0.40
175_F	203_F	0.548	0.40
76_S	163_L	0.547	0.40
38_G	42_G	0.547	0.40
419_I	449_F	0.546	0.40
292_A	296_Q	0.545	0.40
263_T	385_A	0.545	0.40
166_P	325_N	0.544	0.40
318_Y	333_D	0.543	0.39
193_H	515_M	0.543	0.39
482_I	493_N	0.542	0.39
182_Q	226_T	0.541	0.39
240_N	244_Q	0.541	0.39
423_K	457_F	0.540	0.39
380_H	505_P	0.540	0.39
135_A	516_P	0.540	0.39
107_A	141_N	0.539	0.39
439_A	489_I	0.539	0.39
440_S	528_R	0.538	0.39
327_A	383_V	0.538	0.39
471_N	519_T	0.537	0.39
188_Y	271_N	0.537	0.39
229_S	240_N	0.536	0.39
264_W	377_S	0.536	0.39
474_D	528_R	0.536	0.39
461_F	512_Y	0.535	0.39
69_V	83_T	0.535	0.39
359_R	413_A	0.534	0.39
332_L	386_Q	0.534	0.39
298_Y	433_L	0.534	0.39
365_E	484_K	0.533	0.38
299_Y	463_G	0.529	0.38
390_F	422_I	0.529	0.38
132_H	306_I	0.528	0.38
201_L	327_A	0.528	0.38
208_Y	241_R	0.527	0.38
385_A	508_W	0.527	0.38
107_A	147_R	0.526	0.38
132_H	304_L	0.525	0.38
177_F	501_C	0.525	0.38
394_N	483_L	0.523	0.37
412_P	415_R	0.523	0.37
148_F	155_S	0.523	0.37
238_Y	294_A	0.522	0.37
233_I	270_E	0.522	0.37
72_G	82_W	0.521	0.37
80_V	256_A	0.521	0.37
483_L	486_N	0.521	0.37
308_S	315_M	0.519	0.37
246_R	468_S	0.519	0.37
178_A	254_A	0.518	0.37
79_V	261_V	0.518	0.37
219_S	226_T	0.517	0.37
85_L	100_V	0.517	0.37
439_A	472_G	0.516	0.37
71_S	83_T	0.515	0.37
336_Q	361_L	0.514	0.36
314_D	337_Y	0.514	0.36
219_S	224_V	0.514	0.36
198_K	257_A	0.514	0.36
25_D	42_G	0.513	0.36
191_Y	462_V	0.513	0.36
231_E	238_Y	0.513	0.36
499_V	512_Y	0.513	0.36
237_D	240_N	0.511	0.36
342_A	405_M	0.510	0.36
208_Y	497_G	0.510	0.36
24_F	32_G	0.509	0.36
23_T	33_A	0.509	0.36
498_Y	513_R	0.508	0.36
214_P	218_V	0.508	0.36
291_R	336_Q	0.508	0.36
108_K	145_Y	0.507	0.36
191_Y	441_W	0.506	0.36
469_G	472_G	0.505	0.36
318_Y	363_G	0.505	0.36
54_V	157_V	0.505	0.36
35_K	43_L	0.504	0.35
479_T	492_F	0.504	0.35
73_D	321_F	0.504	0.35
65_F	406_D	0.504	0.35
195_A	257_A	0.503	0.35
320_H	328_S	0.502	0.35
483_L	490_Q	0.502	0.35
119_G	133_V	0.502	0.35
59_N	125_P	0.501	0.35
236_Q	240_N	0.501	0.35
242_H	302_M	0.501	0.35
291_R	315_M	0.501	0.35
255_H	260_W	0.500	0.35
85_L	102_V	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yeqA	2	0.8954	100	0.355	Contact Map
1xzwA	2	0.6947	100	0.776	Contact Map
2qfpA	2	0.6913	100	0.777	Contact Map
3zk4A	5	0.7719	100	0.792	Contact Map
1uteA	1	0.482	99.9	0.881	Contact Map
3tghA	1	0.5197	99.6	0.908	Contact Map
3ib7A	2	0.4717	99.3	0.926	Contact Map
3d03A	5	0.4425	99.2	0.929	Contact Map
2nxfA	1	0.4528	99.1	0.93	Contact Map
2xmoA	1	0.554	98.7	0.94	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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