GREMLIN Database
CWLJ - Cell wall hydrolase CwlJ
UniProt: P42249 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (139)
Sequences: 333 (156)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_R91_E5.0311.00
12_D81_R4.3631.00
78_D82_A3.6410.99
52_R56_Q2.9220.96
53_T56_Q2.8610.96
11_V88_I2.8170.95
4_V38_I2.7140.94
103_F110_P2.6260.93
44_N52_R2.5580.92
67_V70_G2.5540.92
119_V129_Q2.4440.90
114_Y128_Y2.3660.89
33_V37_G2.2390.86
10_D54_I2.2120.85
37_G57_M2.2120.85
17_L61_P2.2080.85
112_Q117_P2.2040.85
28_Q32_L2.0410.80
14_M37_G2.0360.80
8_S85_R2.0280.79
11_V85_R1.8910.74
9_A12_D1.8870.74
18_L38_I1.8710.74
104_R124_S1.8340.72
25_E36_V1.7970.70
3_V42_R1.6420.63
86_R93_R1.5740.60
32_L97_K1.5550.59
13_L55_R1.4930.56
27_K79_S1.4560.54
9_A81_R1.4350.53
65_E102_Y1.3930.50
43_A137_N1.3200.46
3_V90_G1.3190.46
25_E114_Y1.3170.46
11_V81_R1.3160.46
17_L63_A1.3060.46
44_N56_Q1.3040.46
19_R77_R1.2870.45
44_N50_G1.2650.44
13_L58_I1.2550.43
98_F129_Q1.2230.41
33_V87_S1.2100.41
37_G87_S1.1900.40
8_S89_N1.1420.37
118_F128_Y1.1270.37
45_C135_C1.1230.36
18_L80_E1.1220.36
104_R139_Y1.1210.36
5_R82_A1.1030.35
8_S12_D1.0860.35
4_V136_E1.0800.34
28_Q94_W1.0650.34
9_A104_R1.0640.34
8_S78_D1.0630.34
25_E124_S1.0610.33
119_V128_Y1.0570.33
31_L35_N1.0470.33
99_S131_T1.0440.33
102_Y118_F1.0400.32
2_A90_G1.0280.32
23_E71_Y1.0270.32
28_Q93_R1.0220.32
99_S129_Q1.0200.32
31_L83_L1.0130.31
5_R8_S0.9820.30
23_E77_R0.9790.30
6_A27_K0.9760.30
86_R90_G0.9710.29
24_G67_V0.9680.29
33_V97_K0.9600.29
115_N123_K0.9550.29
24_G137_N0.9550.29
99_S112_Q0.9510.28
17_L37_G0.9500.28
43_A58_I0.9370.28
131_T134_T0.9310.28
62_H102_Y0.9190.27
38_I136_E0.8800.26
7_T12_D0.8640.25
99_S110_P0.8640.25
128_Y134_T0.8580.25
99_S107_G0.8540.24
113_W116_Q0.8510.24
94_W137_N0.8460.24
22_A33_V0.8430.24
7_T55_R0.8370.24
6_A119_V0.8360.24
32_L96_A0.8340.24
18_L102_Y0.8300.24
19_R45_C0.8270.23
97_K128_Y0.8220.23
7_T99_S0.8200.23
14_M61_P0.8130.23
51_L58_I0.8040.23
33_V42_R0.8030.23
120_A123_K0.7970.22
5_R50_G0.7900.22
65_E92_R0.7900.22
48_F101_W0.7890.22
82_A128_Y0.7880.22
10_D55_R0.7780.22
59_Y132_A0.7770.22
8_S104_R0.7740.21
95_P120_A0.7720.21
76_A81_R0.7610.21
5_R27_K0.7610.21
6_A11_V0.7600.21
8_S11_V0.7600.21
78_D111_A0.7530.21
98_F117_P0.7520.21
90_G127_F0.7410.20
4_V18_L0.7350.20
87_S93_R0.7190.20
93_R137_N0.7180.20
3_V121_R0.7080.19
113_W135_C0.7070.19
26_G30_M0.7020.19
17_L102_Y0.6990.19
117_P129_Q0.6950.19
7_T50_G0.6790.18
51_L57_M0.6710.18
32_L94_W0.6620.18
54_I92_R0.6620.18
48_F95_P0.6600.18
92_R103_F0.6500.17
59_Y101_W0.6490.17
43_A52_R0.6470.17
10_D112_Q0.6430.17
4_V51_L0.6400.17
23_E65_E0.6380.17
19_R23_E0.6370.17
70_G73_Y0.6350.17
4_V106_Q0.6340.17
4_V119_V0.6310.17
41_L48_F0.6300.17
35_N83_L0.6290.17
35_N95_P0.6280.17
85_R89_N0.6270.17
43_A50_G0.6270.17
78_D81_R0.6270.17
45_C95_P0.6250.17
5_R132_A0.6240.17
47_D77_R0.6210.17
14_M87_S0.6170.16
90_G121_R0.6150.16
23_E66_A0.6120.16
112_Q115_N0.6060.16
28_Q31_L0.6040.16
14_M17_L0.6020.16
62_H118_F0.6010.16
33_V115_N0.6000.16
41_L101_W0.5990.16
6_A55_R0.5980.16
53_T128_Y0.5960.16
46_S63_A0.5960.16
69_H138_V0.5950.16
43_A56_Q0.5890.16
65_E103_F0.5830.15
5_R137_N0.5810.15
8_S55_R0.5780.15
62_H127_F0.5780.15
19_R74_Q0.5770.15
104_R136_E0.5770.15
72_F123_K0.5770.15
53_T75_R0.5760.15
14_M57_M0.5740.15
53_T112_Q0.5720.15
43_A78_D0.5700.15
98_F139_Y0.5690.15
107_G110_P0.5660.15
54_I58_I0.5660.15
12_D76_A0.5660.15
8_S58_I0.5650.15
19_R72_F0.5630.15
112_Q118_F0.5610.15
66_A71_Y0.5500.15
5_R25_E0.5460.14
6_A87_S0.5450.14
117_P128_Y0.5400.14
70_G137_N0.5350.14
23_E74_Q0.5350.14
24_G88_I0.5340.14
119_V133_E0.5290.14
88_I106_Q0.5290.14
63_A102_Y0.5260.14
67_V99_S0.5240.14
28_Q122_F0.5240.14
118_F129_Q0.5240.14
27_K80_E0.5220.14
10_D75_R0.5210.14
95_P123_K0.5200.14
7_T87_S0.5180.14
49_K115_N0.5180.14
53_T137_N0.5170.14
10_D110_P0.5150.14
86_R98_F0.5150.14
61_P90_G0.5140.14
3_V57_M0.5130.14
68_T122_F0.5120.14
46_S118_F0.5120.14
17_L95_P0.5110.14
4_V102_Y0.5100.14
55_R114_Y0.5080.14
24_G76_A0.5060.13
66_A69_H0.5030.13
8_S114_Y0.5020.13
24_G41_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f55A 1 0.8592 100 0.574 Contact Map
4fetB 1 0.8451 100 0.609 Contact Map
4iiwA 4 0.5282 15.7 0.961 Contact Map
4grcA 2 0.5211 13.5 0.962 Contact Map
4gt2B 2 0.5704 11.1 0.964 Contact Map
4g09A 2 0.338 10.2 0.964 Contact Map
2ofkA 1 0.2958 6.3 0.968 Contact Map
3r64A 4 0.4718 6 0.968 Contact Map
2r1fA 4 0.5423 5.6 0.968 Contact Map
2lydA 1 0.5563 4.2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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