GREMLIN Database
YCBN - Uncharacterized ABC transporter ATP-binding protein YcbN
UniProt: P42246 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (240)
Sequences: 77872 (47974)
Seq/√Len: 3096.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E202_T3.7051.00
33_Y204_G3.1791.00
78_N152_D3.1641.00
18_E21_S3.0951.00
6_Q26_H3.0671.00
9_G22_N2.8921.00
8_N60_E2.7971.00
34_G200_A2.7791.00
13_T18_E2.7661.00
202_T214_E2.6911.00
60_E67_K2.5851.00
6_Q62_I2.5381.00
28_K31_E2.5261.00
12_K49_M2.4361.00
11_T58_S2.3871.00
216_S219_D2.3501.00
64_L152_D2.3301.00
215_V219_D2.3231.00
11_T18_E2.3011.00
204_G211_L2.2071.00
21_S210_R2.1981.00
119_M182_Y2.1411.00
11_T22_N2.1211.00
125_I128_K2.1181.00
8_N62_I2.0591.00
7_T10_L2.0251.00
29_K152_D1.9591.00
204_G214_E1.9461.00
177_V181_E1.9031.00
94_A133_F1.8861.00
112_A150_K1.8251.00
47_M189_S1.8091.00
128_K132_T1.8091.00
14_Y19_V1.7431.00
115_E119_M1.7221.00
14_Y45_T1.7021.00
47_M155_I1.6691.00
112_A115_E1.6611.00
197_E218_E1.6571.00
95_E99_D1.6301.00
176_Q198_Q1.6251.00
64_L78_N1.6191.00
190_S196_I1.6121.00
150_K184_M1.6031.00
118_D123_K1.5881.00
12_K54_V1.5871.00
12_K57_T1.5681.00
95_E127_K1.5651.00
99_D113_I1.5121.00
110_K114_Q1.5081.00
215_V220_V1.5081.00
9_G24_S1.5001.00
123_K126_D1.4931.00
11_T21_S1.4921.00
67_K70_H1.4921.00
13_T57_T1.4861.00
178_L184_M1.4741.00
119_M181_E1.4711.00
25_M204_G1.4381.00
114_Q118_D1.4111.00
7_T25_M1.3881.00
33_Y214_E1.3701.00
31_E201_D1.3681.00
10_L56_P1.3611.00
150_K182_Y1.3471.00
116_V148_L1.3461.00
119_M177_V1.3271.00
62_I67_K1.3201.00
93_T96_E1.3121.00
219_D223_Q1.3001.00
23_V46_I1.2931.00
27_I33_Y1.2841.00
28_K202_T1.2811.00
34_G196_I1.2811.00
99_D110_K1.2771.00
156_L186_L1.2671.00
92_L96_E1.2591.00
4_I64_L1.2271.00
25_M46_I1.2261.00
112_A116_V1.2201.00
7_T50_L1.2191.00
32_I179_S1.2191.00
66_N71_T1.2181.00
98_L117_L1.2071.00
8_N26_H1.1761.00
95_E110_K1.1761.00
172_R195_E1.1611.00
93_T127_K1.1531.00
84_E135_L1.1361.00
116_V120_V1.1291.00
33_Y202_T1.1281.00
49_M56_P1.1171.00
95_E113_I1.1171.00
111_K115_E1.1161.00
116_V144_A1.1131.00
224_N228_I1.1131.00
207_R212_L1.1121.00
114_Q126_D1.1071.00
51_T81_S1.1001.00
29_K64_L1.0991.00
8_N24_S1.0931.00
52_S55_K1.0911.00
35_F187_L1.0811.00
35_F46_I1.0771.00
117_L126_D1.0721.00
20_V49_M1.0541.00
48_K54_V1.0531.00
229_E232_T1.0411.00
97_N145_R1.0401.00
229_E233_P1.0261.00
32_I186_L1.0221.00
218_E222_G1.0201.00
179_S186_L1.0121.00
114_Q122_L1.0101.00
226_E230_L1.0011.00
82_M156_L0.9931.00
105_M149_T0.9911.00
96_E99_D0.9901.00
174_L177_V0.9851.00
176_Q179_S0.9841.00
169_K173_Q0.9831.00
213_E223_Q0.9831.00
163_L171_I0.9821.00
226_E229_E0.9821.00
120_V144_A0.9701.00
130_V141_L0.9671.00
219_D222_G0.9641.00
110_K113_I0.9561.00
203_I217_M0.9531.00
175_F186_L0.9481.00
32_I200_A0.9471.00
168_I195_E0.9451.00
99_D103_E0.9431.00
98_L148_L0.9411.00
115_E118_D0.9411.00
133_F141_L0.9401.00
95_E126_D0.9361.00
93_T129_P0.9341.00
121_N170_K0.9331.00
7_T46_I0.9311.00
154_L184_M0.9301.00
168_I192_L0.9281.00
102_C148_L0.9201.00
74_E77_G0.9171.00
87_I138_K0.9121.00
95_E114_Q0.9121.00
156_L175_F0.9091.00
9_G58_S0.9061.00
80_G146_A0.9061.00
225_T228_I0.8941.00
29_K183_G0.8831.00
228_I232_T0.8751.00
91_N131_K0.8741.00
48_K53_L0.8731.00
38_P207_R0.8701.00
80_G151_P0.8691.00
7_T61_I0.8651.00
172_R198_Q0.8611.00
129_P132_T0.8611.00
46_I206_I0.8601.00
217_M221_R0.8531.00
114_Q124_Q0.8511.00
106_G109_N0.8491.00
82_M146_A0.8451.00
154_L186_L0.8451.00
94_A141_L0.8441.00
5_V50_L0.8431.00
121_N177_V0.8421.00
173_Q176_Q0.8411.00
50_L187_L0.8401.00
66_N78_N0.8391.00
32_I188_I0.8381.00
35_F204_G0.8381.00
51_T155_I0.8381.00
122_L126_D0.8371.00
32_I176_Q0.8311.00
101_H145_R0.8301.00
71_T74_E0.8301.00
179_S201_D0.8291.00
126_D133_F0.8271.00
49_M54_V0.8261.00
75_V79_I0.8261.00
197_E221_R0.8251.00
158_E191_H0.8221.00
228_I231_V0.8171.00
56_P69_T0.8101.00
224_N227_Y0.8091.00
12_K45_T0.8011.00
88_F138_K0.7981.00
36_L196_I0.7941.00
102_C106_G0.7931.00
93_T97_N0.7891.00
10_L49_M0.7881.00
82_M143_I0.7871.00
41_A206_I0.7861.00
207_R230_L0.7831.00
97_N130_V0.7801.00
116_V119_M0.7801.00
133_F137_M0.7771.00
22_N58_S0.7721.00
113_I116_V0.7711.00
13_T21_S0.7701.00
176_Q199_I0.7651.00
170_K173_Q0.7641.00
91_N96_E0.7631.00
92_L97_N0.7601.00
160_V171_I0.7581.00
213_E220_V0.7571.00
27_I185_T0.7551.00
227_Y230_L0.7541.00
237_R240_F0.7521.00
49_M61_I0.7511.00
23_V211_L0.7501.00
227_Y231_V0.7461.00
155_I187_L0.7461.00
118_D124_Q0.7391.00
20_V23_V0.7391.00
28_K185_T0.7381.00
121_N124_Q0.7381.00
22_N210_R0.7331.00
5_V153_L0.7281.00
211_L214_E0.7271.00
27_I153_L0.7221.00
224_N229_E0.7211.00
67_K71_T0.7171.00
92_L100_L0.7171.00
33_Y187_L0.7151.00
66_N74_E0.7131.00
111_K114_Q0.7051.00
20_V46_I0.7041.00
12_K20_V0.6991.00
4_I29_K0.6971.00
217_M227_Y0.6951.00
102_C109_N0.6911.00
13_T19_V0.6841.00
152_D184_M0.6831.00
205_V220_V0.6811.00
32_I199_I0.6801.00
98_L113_I0.6791.00
197_E217_M0.6781.00
116_V147_I0.6771.00
64_L153_L0.6771.00
200_A203_I0.6761.00
173_Q177_V0.6731.00
60_E69_T0.6701.00
212_L225_T0.6671.00
27_I187_L0.6661.00
102_C108_H0.6631.00
55_K69_T0.6621.00
14_Y54_V0.6611.00
230_L234_N0.6591.00
173_Q198_Q0.6581.00
117_L122_L0.6571.00
79_I153_L0.6571.00
19_V45_T0.6571.00
36_L205_V0.6541.00
188_I200_A0.6541.00
122_L125_I0.6501.00
105_M108_H0.6501.00
153_L185_T0.6491.00
207_R210_R0.6451.00
9_G12_K0.6371.00
86_P142_G0.6361.00
195_E199_I0.6351.00
193_L221_R0.6291.00
190_S195_E0.6291.00
188_I199_I0.6281.00
5_V63_I0.6281.00
62_I65_G0.6261.00
26_H214_E0.6221.00
49_M57_T0.6191.00
13_T16_G0.6181.00
102_C105_M0.6171.00
18_E22_N0.6141.00
13_T58_S0.6111.00
74_E78_N0.6061.00
90_E131_K0.6001.00
239_C242_L0.5981.00
36_L193_L0.5961.00
200_A217_M0.5951.00
102_C107_Y0.5941.00
143_I171_I0.5931.00
110_K127_K0.5931.00
160_V195_E0.5911.00
80_G149_T0.5901.00
105_M109_N0.5871.00
227_Y233_P0.5851.00
89_Y92_L0.5841.00
194_G198_Q0.5831.00
63_I78_N0.5811.00
118_D121_N0.5801.00
118_D126_D0.5791.00
135_L140_R0.5771.00
213_E224_N0.5761.00
235_Q239_C0.5741.00
68_F75_V0.5741.00
85_Y138_K0.5731.00
101_H104_Y0.5721.00
32_I201_D0.5711.00
50_L61_I0.5691.00
175_F188_I0.5691.00
90_E138_K0.5681.00
167_G170_K0.5671.00
220_V228_I0.5661.00
115_E150_K0.5651.00
71_T75_V0.5641.00
44_T48_K0.5631.00
100_L104_Y0.5601.00
4_I63_I0.5601.00
235_Q238_A0.5601.00
4_I28_K0.5591.00
4_I185_T0.5571.00
60_E70_H0.5571.00
153_L187_L0.5561.00
177_V182_Y0.5541.00
134_S137_M0.5541.00
179_S182_Y0.5541.00
53_L83_I0.5531.00
241_V244_K0.5521.00
111_K118_D0.5521.00
66_N75_V0.5521.00
63_I75_V0.5501.00
51_T79_I0.5441.00
215_V221_R0.5441.00
196_I200_A0.5431.00
4_I153_L0.5411.00
139_Q162_G0.5381.00
230_L233_P0.5371.00
240_F243_E0.5351.00
213_E228_I0.5351.00
12_K15_Q0.5341.00
112_A119_M0.5341.00
82_M142_G0.5331.00
117_L120_V0.5331.00
114_Q123_K0.5321.00
101_H149_T0.5321.00
10_L61_I0.5301.00
233_P236_T0.5291.00
48_K81_S0.5291.00
77_G106_G0.5251.00
208_D230_L0.5221.00
64_L68_F0.5191.00
121_N126_D0.5191.00
39_N158_E0.5171.00
73_Y77_G0.5151.00
231_V234_N0.5151.00
196_I203_I0.5141.00
89_Y97_N0.5131.00
101_H105_M0.5131.00
39_N167_G0.5121.00
83_I86_P0.5101.00
218_E221_R0.5091.00
127_K130_V0.5091.00
225_T229_E0.5091.00
52_S69_T0.5091.00
202_T216_S0.5091.00
192_L195_E0.5031.00
130_V138_K0.5011.00
11_T57_T0.5001.00
172_R199_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9023 100 0.124 Contact Map
3tuiC 2 0.9935 100 0.182 Contact Map
4u00A 1 0.7622 100 0.197 Contact Map
4rvcA 4 0.772 100 0.201 Contact Map
2oljA 2 0.7622 100 0.204 Contact Map
3d31A 2 0.9772 100 0.208 Contact Map
3fvqA 2 0.9935 100 0.21 Contact Map
1v43A 2 0.9479 100 0.211 Contact Map
4mkiB 2 0.8795 100 0.212 Contact Map
2it1A 1 0.9837 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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