GREMLIN Database
YCBL - Uncharacterized transcriptional regulatory protein YcbL
UniProt: P42244 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (199)
Sequences: 74740 (53091)
Seq/√Len: 3763.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_S26_H3.7801.00
10_S28_F3.3081.00
14_D26_H3.2231.00
3_V33_G2.7331.00
34_I62_I2.7151.00
31_E53_K2.6261.00
25_V42_Y2.6151.00
30_G54_L2.4541.00
54_L62_I2.4201.00
29_D53_K2.4151.00
38_Q66_K2.4091.00
16_Y101_M2.1351.00
14_D18_T2.0861.00
20_E105_T2.0751.00
27_A36_L2.0201.00
50_M77_K1.9231.00
83_K103_E1.9031.00
28_F32_E1.8931.00
190_N193_N1.8721.00
47_L59_F1.8651.00
155_T158_Q1.8181.00
25_V36_L1.8131.00
60_L71_V1.7861.00
29_D32_E1.7801.00
73_M86_G1.7561.00
36_L40_G1.7231.00
62_I66_K1.6941.00
173_K193_N1.6861.00
64_R92_D1.6811.00
80_D100_S1.6671.00
54_L58_D1.6311.00
162_L179_S1.6211.00
73_M91_A1.6101.00
161_C165_S1.5971.00
25_V40_G1.5941.00
30_G59_F1.5681.00
93_D107_R1.5621.00
36_L39_Q1.5471.00
130_R135_A1.5311.00
55_N58_D1.5191.00
17_L108_V1.5171.00
77_K82_D1.5011.00
61_K89_F1.4671.00
195_H198_R1.4661.00
37_F63_I1.4651.00
171_F179_S1.4651.00
62_I65_E1.4641.00
133_Q146_N1.4491.00
45_V69_I1.4231.00
31_E54_L1.4141.00
58_D61_K1.4041.00
172_T175_Q1.3971.00
60_L73_M1.3961.00
44_L108_V1.3911.00
34_I59_F1.3701.00
7_H28_F1.3651.00
72_L111_A1.3601.00
36_L42_Y1.2961.00
49_I57_M1.2961.00
128_V135_A1.2881.00
92_D114_R1.2751.00
4_E10_S1.2701.00
156_E202_K1.2581.00
47_L60_L1.2521.00
34_I54_L1.2481.00
35_R39_Q1.2471.00
162_L166_N1.2441.00
22_F109_K1.2381.00
5_D48_D1.2131.00
92_D111_A1.2111.00
32_E36_L1.2101.00
3_V51_L1.1981.00
32_E35_R1.1911.00
57_M86_G1.1901.00
49_I73_M1.1861.00
27_A33_G1.1781.00
79_G82_D1.1691.00
105_T109_K1.1571.00
175_Q179_S1.1551.00
80_D84_A1.1541.00
137_D140_N1.1391.00
31_E35_R1.1391.00
21_G109_K1.1371.00
57_M85_L1.1361.00
135_A144_L1.1241.00
20_E109_K1.1131.00
88_G109_K1.1101.00
157_W161_C1.1081.00
44_L112_I1.1031.00
85_L89_F1.0951.00
142_S149_P1.0951.00
174_E189_Q1.0771.00
162_L171_F1.0731.00
194_V197_R1.0641.00
106_A110_A1.0611.00
191_I195_H1.0481.00
81_V85_L1.0461.00
103_E106_A1.0371.00
34_I38_Q1.0361.00
84_A88_G1.0311.00
190_N194_V1.0241.00
27_A32_E1.0141.00
158_Q161_C1.0121.00
33_G59_F1.0101.00
138_I161_C1.0051.00
61_K85_L1.0051.00
11_E26_H0.9861.00
83_K96_A0.9821.00
33_G37_F0.9811.00
47_L71_V0.9711.00
57_M89_F0.9711.00
136_I164_A0.9661.00
144_L149_P0.9661.00
13_V74_I0.9631.00
206_D209_S0.9631.00
14_D24_I0.9511.00
154_S158_Q0.9491.00
3_V27_A0.9481.00
130_R133_Q0.9461.00
49_I55_N0.9451.00
7_H11_E0.9411.00
8_S12_M0.9371.00
45_V63_I0.9351.00
60_L89_F0.9291.00
111_A114_R0.9231.00
1_M27_A0.9201.00
58_D62_I0.9121.00
3_V45_V0.9071.00
2_L13_V0.9041.00
196_M200_R0.9021.00
206_D210_P0.8991.00
136_I157_W0.8981.00
46_L104_L0.8861.00
2_L24_I0.8851.00
171_F175_Q0.8821.00
47_L73_M0.8821.00
60_L91_A0.8811.00
22_F105_T0.8801.00
80_D83_K0.8791.00
35_R38_Q0.8721.00
189_Q193_N0.8671.00
11_E14_D0.8661.00
78_D96_A0.8651.00
190_N197_R0.8611.00
7_H10_S0.8601.00
85_L88_G0.8581.00
15_H19_K0.8531.00
51_L59_F0.8501.00
45_V71_V0.8501.00
128_V137_D0.8441.00
162_L176_I0.8321.00
205_D211_Q0.8311.00
198_R201_E0.8261.00
103_E107_R0.8221.00
70_P92_D0.8201.00
197_R201_E0.8191.00
49_I77_K0.8171.00
72_L107_R0.8131.00
101_M105_T0.8091.00
194_V198_R0.8041.00
141_V158_Q0.8021.00
49_I82_D0.8001.00
54_L59_F0.7971.00
59_F63_I0.7961.00
37_F69_I0.7931.00
84_A102_I0.7861.00
74_I99_F0.7811.00
153_T202_K0.7791.00
13_V104_L0.7781.00
173_K189_Q0.7731.00
46_L74_I0.7731.00
61_K65_E0.7671.00
9_I99_F0.7601.00
110_A113_R0.7601.00
82_D85_L0.7581.00
50_M76_A0.7521.00
100_S103_E0.7501.00
81_V102_I0.7491.00
37_F42_Y0.7481.00
110_A115_A0.7431.00
87_L107_R0.7411.00
159_L163_F0.7411.00
174_E178_R0.7401.00
63_I67_S0.7361.00
205_D215_T0.7321.00
162_L165_S0.7261.00
112_I115_A0.7211.00
11_E15_H0.7211.00
30_G34_I0.7201.00
34_I37_F0.7101.00
175_Q178_R0.7101.00
133_Q145_K0.7051.00
144_L147_G0.7021.00
30_G53_K0.7011.00
115_A119_S0.6981.00
200_R205_D0.6911.00
1_M42_Y0.6891.00
41_S67_S0.6871.00
12_M16_Y0.6831.00
86_G91_A0.6791.00
134_L145_K0.6791.00
37_F45_V0.6771.00
70_P112_I0.6751.00
72_L93_D0.6751.00
10_S14_D0.6741.00
38_Q62_I0.6741.00
88_G106_A0.6731.00
18_T24_I0.6691.00
102_I106_A0.6681.00
99_F104_L0.6681.00
46_L108_V0.6671.00
3_V59_F0.6671.00
2_L14_D0.6661.00
129_I133_Q0.6631.00
141_V157_W0.6591.00
129_I138_I0.6571.00
204_E211_Q0.6551.00
2_L26_H0.6541.00
165_S179_S0.6521.00
16_Y105_T0.6481.00
63_I71_V0.6471.00
17_L22_F0.6471.00
165_S171_F0.6431.00
193_N196_M0.6421.00
34_I66_K0.6411.00
204_E210_P0.6401.00
68_N117_Q0.6321.00
30_G51_L0.6301.00
4_E51_L0.6291.00
188_D191_I0.6271.00
46_L72_L0.6261.00
80_D102_I0.6211.00
131_I135_A0.6211.00
107_R111_A0.6211.00
1_M33_G0.6191.00
187_D192_I0.6191.00
37_F67_S0.6181.00
83_K100_S0.6181.00
68_N118_Y0.6141.00
136_I161_C0.6131.00
57_M82_D0.6131.00
211_Q215_T0.6121.00
211_Q214_K0.6111.00
158_Q162_L0.6111.00
206_D211_Q0.6051.00
145_K204_E0.6041.00
16_Y20_E0.6021.00
49_I86_G0.6001.00
129_I164_A0.5971.00
64_R70_P0.5941.00
93_D110_A0.5921.00
155_T195_H0.5911.00
210_P213_I0.5911.00
133_Q137_D0.5901.00
64_R69_I0.5871.00
6_D76_A0.5841.00
163_F196_M0.5831.00
75_S83_K0.5791.00
48_D97_K0.5761.00
106_A109_K0.5741.00
145_K206_D0.5711.00
60_L64_R0.5701.00
22_F112_I0.5691.00
6_D9_I0.5671.00
99_F103_E0.5671.00
145_K148_E0.5641.00
32_E53_K0.5621.00
137_D142_S0.5581.00
70_P114_R0.5571.00
81_V84_A0.5551.00
18_T23_G0.5521.00
47_L51_L0.5471.00
9_I12_M0.5451.00
166_N179_S0.5401.00
138_I165_S0.5401.00
37_F66_K0.5391.00
37_F59_F0.5381.00
109_K113_R0.5321.00
145_K205_D0.5311.00
12_M15_H0.5301.00
44_L111_A0.5291.00
63_I69_I0.5281.00
29_D51_L0.5271.00
38_Q67_S0.5231.00
131_I164_A0.5191.00
84_A87_L0.5191.00
136_I143_V0.5181.00
78_D98_P0.5171.00
130_R134_L0.5141.00
131_I134_L0.5101.00
114_R118_Y0.5101.00
70_P115_A0.5091.00
3_V47_L0.5081.00
15_H18_T0.5081.00
153_T156_E0.5081.00
33_G45_V0.5061.00
75_S97_K0.5041.00
160_L163_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gwrA 1 0.9646 100 0.161 Contact Map
2oqrA 2 0.9823 100 0.176 Contact Map
4b09A 2 0.9115 100 0.178 Contact Map
3r0jA 2 0.9513 100 0.178 Contact Map
1ys7A 2 0.9779 100 0.182 Contact Map
4kfcA 2 0.9735 100 0.185 Contact Map
1kgsA 1 0.9469 100 0.205 Contact Map
1p2fA 1 0.9336 100 0.228 Contact Map
2hqrA 2 0.9381 100 0.23 Contact Map
3q9sA 1 0.9115 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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