GREMLIN Database
YCBK - Uncharacterized transporter YcbK
UniProt: P42243 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (276)
Sequences: 38730 (28075)
Seq/√Len: 1689.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_G168_I3.5681.00
18_F250_E2.8591.00
107_V165_A2.8361.00
250_E254_R2.7171.00
275_G281_E2.6611.00
48_L207_M2.4611.00
55_V200_T2.4571.00
32_W235_V2.4251.00
98_I167_F2.4061.00
138_A297_V2.3741.00
250_E253_K2.2711.00
118_F172_S2.2391.00
95_L170_L2.2371.00
129_K183_G2.1951.00
95_L167_F2.1591.00
34_K281_E2.1121.00
109_R271_T2.0901.00
122_F180_V2.0591.00
74_K77_D2.0151.00
53_L237_A1.9911.00
19_L251_G1.9891.00
227_L231_G1.9831.00
27_A270_L1.9791.00
33_I97_F1.9541.00
52_L203_G1.9171.00
124_A131_S1.9141.00
59_W196_A1.8481.00
91_L174_V1.8391.00
123_T129_K1.8201.00
120_F139_V1.8171.00
114_S118_F1.7761.00
166_V170_L1.7681.00
132_S135_D1.7611.00
103_V165_A1.7471.00
119_V261_A1.7461.00
226_P229_M1.6851.00
27_A274_Y1.6841.00
77_D188_Q1.6811.00
102_H163_I1.6781.00
204_A208_L1.6751.00
103_V164_G1.6571.00
28_S235_V1.6331.00
256_G259_R1.6321.00
237_A242_V1.6171.00
190_G193_R1.6061.00
299_T303_Y1.5971.00
95_L174_V1.5851.00
55_V203_G1.5821.00
60_L63_L1.5771.00
142_V265_M1.5761.00
118_F176_A1.5711.00
24_V270_L1.5341.00
25_C239_V1.5241.00
208_L211_G1.5201.00
284_G287_Q1.5091.00
98_I102_H1.4881.00
138_A301_M1.4381.00
108_E168_I1.4381.00
162_M165_A1.4261.00
41_A229_M1.4161.00
76_G80_K1.4141.00
122_F126_R1.4101.00
182_S249_L1.4051.00
118_F173_A1.4041.00
61_I65_Y1.4031.00
22_G251_G1.3861.00
59_W63_L1.3851.00
48_L203_G1.3821.00
39_M229_M1.3811.00
285_L289_I1.3641.00
76_G79_W1.3471.00
36_A46_V1.3381.00
98_I101_N1.3151.00
79_W83_G1.3051.00
105_A275_G1.3051.00
106_M272_I1.2991.00
103_V107_V1.2971.00
75_K79_W1.2921.00
54_A199_M1.2921.00
56_P60_L1.2831.00
138_A300_G1.2801.00
123_T127_D1.2771.00
288_V292_G1.2761.00
133_I137_F1.2751.00
274_Y278_F1.2741.00
31_I274_Y1.2681.00
18_F247_L1.2671.00
145_G290_G1.2601.00
35_W232_L1.2601.00
60_L64_I1.2601.00
148_L293_G1.2581.00
142_V297_V1.2581.00
26_F244_P1.2481.00
176_A180_V1.2441.00
57_L242_V1.2421.00
102_H167_F1.2371.00
80_K181_L1.2341.00
75_K78_L1.2321.00
270_L274_Y1.2301.00
104_S107_V1.2291.00
292_G296_F1.2231.00
136_L140_L1.2221.00
148_L286_I1.2201.00
46_V236_I1.2191.00
16_T263_I1.2091.00
227_L230_Y1.2091.00
184_H188_Q1.2001.00
283_L288_V1.1881.00
231_G235_V1.1761.00
134_Q300_G1.1711.00
162_M166_V1.1681.00
266_A270_L1.1671.00
140_L144_F1.1601.00
183_G256_G1.1481.00
77_D80_K1.1461.00
205_A208_L1.1281.00
110_I291_C1.1251.00
39_M226_P1.1251.00
163_I167_F1.1251.00
42_E45_A1.1241.00
149_A290_G1.1191.00
228_S231_G1.1131.00
34_K38_Q1.1101.00
100_L108_E1.1061.00
17_I21_I1.0991.00
122_F177_G1.0971.00
44_D209_Y1.0971.00
228_S232_L1.0951.00
184_H187_H1.0871.00
102_H161_N1.0831.00
183_G187_H1.0791.00
145_G294_V1.0721.00
119_V257_A1.0711.00
48_L52_L1.0691.00
82_C201_A1.0671.00
48_L210_T1.0661.00
32_W232_L1.0621.00
252_I260_A1.0551.00
86_V205_A1.0521.00
124_A130_M1.0511.00
133_I136_L1.0471.00
90_F205_A1.0451.00
21_I247_L1.0441.00
50_R241_T1.0431.00
102_H164_G1.0391.00
83_G181_L1.0331.00
22_G26_F1.0321.00
127_D180_V1.0311.00
90_F206_M1.0221.00
96_D100_L1.0211.00
103_V168_I1.0211.00
129_K135_D1.0181.00
55_V196_A1.0181.00
163_I166_V1.0151.00
47_L97_F1.0131.00
183_G257_A1.0071.00
119_V179_L1.0031.00
80_K84_A1.0031.00
25_C247_L1.0021.00
28_S274_Y1.0011.00
15_G251_G1.0001.00
22_G247_L1.0001.00
122_F176_A1.0001.00
79_W82_C0.9981.00
231_G234_A0.9941.00
105_A279_L0.9921.00
209_Y213_K0.9891.00
114_S146_L0.9891.00
82_C85_G0.9851.00
26_F248_M0.9851.00
111_L172_S0.9821.00
120_F131_S0.9811.00
67_P190_G0.9781.00
131_S136_L0.9701.00
239_V243_I0.9641.00
36_A229_M0.9631.00
235_V239_V0.9591.00
151_G284_G0.9441.00
111_L165_A0.9431.00
234_A237_A0.9411.00
125_C128_R0.9371.00
33_I100_L0.9351.00
36_A232_L0.9301.00
285_L288_V0.9291.00
122_F173_A0.9241.00
51_Q202_A0.9221.00
132_S136_L0.9201.00
252_I256_G0.9201.00
63_L66_R0.9171.00
15_G254_R0.9161.00
141_A297_V0.9141.00
63_L67_P0.9131.00
122_F125_C0.9121.00
172_S176_A0.9061.00
111_L168_I0.9041.00
31_I278_F0.9011.00
43_P47_L0.8971.00
77_D189_I0.8961.00
23_T27_A0.8951.00
44_D94_L0.8941.00
147_F151_G0.8901.00
164_G168_I0.8881.00
105_A281_E0.8861.00
45_A210_T0.8831.00
88_C178_Y0.8821.00
230_Y234_A0.8801.00
80_K185_L0.8791.00
119_V176_A0.8781.00
52_L207_M0.8781.00
134_Q303_Y0.8781.00
130_M134_Q0.8741.00
83_G86_V0.8661.00
89_F178_Y0.8631.00
255_I260_A0.8631.00
85_G201_A0.8581.00
67_P70_P0.8541.00
256_G260_A0.8531.00
23_T270_L0.8511.00
208_L212_I0.8491.00
88_C177_G0.8431.00
78_L201_A0.8401.00
57_L238_V0.8361.00
110_I147_F0.8261.00
80_K184_H0.8231.00
255_I259_R0.8211.00
31_I275_G0.8181.00
33_I37_Y0.8161.00
251_G260_A0.8131.00
276_A283_L0.8131.00
159_Q162_M0.8111.00
161_N165_A0.8071.00
269_I291_C0.8031.00
226_P230_Y0.8011.00
94_L98_I0.7981.00
272_I283_L0.7901.00
211_G214_S0.7901.00
20_L270_L0.7851.00
144_F148_L0.7821.00
146_L150_L0.7801.00
130_M133_I0.7801.00
59_W200_T0.7791.00
291_C295_F0.7741.00
286_I289_I0.7701.00
148_L289_I0.7701.00
144_F293_G0.7681.00
200_T204_A0.7661.00
233_F237_A0.7641.00
57_L60_L0.7631.00
201_A204_A0.7611.00
90_F94_L0.7611.00
177_G181_L0.7531.00
49_Y53_L0.7511.00
47_L206_M0.7501.00
19_L263_I0.7491.00
203_G207_M0.7491.00
81_A85_G0.7481.00
66_R69_M0.7451.00
121_G125_C0.7431.00
225_Y229_M0.7431.00
297_V301_M0.7381.00
266_A269_I0.7381.00
78_L82_C0.7371.00
145_G297_V0.7361.00
225_Y230_Y0.7361.00
168_I172_S0.7351.00
55_V59_W0.7341.00
272_I291_C0.7311.00
137_F141_A0.7291.00
63_L68_P0.7261.00
209_Y212_I0.7221.00
92_S174_V0.7221.00
151_G154_N0.7221.00
212_I215_A0.7181.00
189_I194_L0.7181.00
289_I293_G0.7161.00
82_C86_V0.7151.00
243_I247_L0.7151.00
119_V180_V0.7051.00
197_Y201_A0.7041.00
91_L95_L0.7041.00
117_L142_V0.7001.00
62_F66_R0.6981.00
70_P73_K0.6971.00
124_A128_R0.6961.00
23_T266_A0.6961.00
175_Y179_L0.6941.00
19_L255_I0.6941.00
99_G164_G0.6931.00
52_L56_P0.6921.00
196_A200_T0.6911.00
120_F135_D0.6901.00
45_A49_Y0.6881.00
229_M232_L0.6861.00
114_S117_L0.6851.00
16_T259_R0.6831.00
58_F242_V0.6791.00
232_L235_V0.6771.00
31_I105_A0.6751.00
61_I192_I0.6731.00
92_S178_Y0.6721.00
118_F169_L0.6721.00
111_L169_L0.6701.00
234_A238_V0.6701.00
296_F300_G0.6701.00
213_K216_A0.6691.00
276_A282_R0.6631.00
204_A207_M0.6621.00
89_F245_F0.6611.00
103_V108_E0.6601.00
88_C174_V0.6591.00
195_N198_G0.6541.00
65_Y190_G0.6531.00
35_W279_L0.6521.00
65_Y68_P0.6511.00
80_K83_G0.6461.00
62_F196_A0.6431.00
30_S96_D0.6421.00
141_A300_G0.6421.00
57_L237_A0.6421.00
129_K258_Q0.6401.00
201_A205_A0.6401.00
283_L287_Q0.6391.00
135_D256_G0.6361.00
175_Y248_M0.6311.00
282_R286_I0.6311.00
131_S135_D0.6261.00
275_G279_L0.6251.00
64_I68_P0.6241.00
81_A189_I0.6231.00
99_G108_E0.6231.00
25_C240_T0.6211.00
210_T214_S0.6201.00
272_I276_A0.6171.00
74_K78_L0.6151.00
193_R197_Y0.6141.00
64_I67_P0.6081.00
246_V250_E0.6081.00
195_N249_L0.6071.00
61_I64_I0.6041.00
85_G90_F0.6041.00
25_C244_P0.6031.00
53_L57_L0.6001.00
120_F124_A0.5981.00
65_Y69_M0.5971.00
262_A301_M0.5931.00
113_M116_P0.5921.00
200_T203_G0.5901.00
191_G195_N0.5881.00
178_Y249_L0.5861.00
287_Q291_C0.5851.00
90_F209_Y0.5841.00
96_D108_E0.5841.00
30_S109_R0.5821.00
74_K79_W0.5791.00
114_S172_S0.5791.00
41_A46_V0.5781.00
116_P265_M0.5761.00
167_F170_L0.5741.00
202_A206_M0.5741.00
96_D171_S0.5731.00
21_I25_C0.5721.00
65_Y192_I0.5701.00
235_V238_V0.5701.00
88_C181_L0.5691.00
127_D184_H0.5681.00
211_G215_A0.5671.00
273_F277_L0.5591.00
274_Y277_L0.5581.00
54_A242_V0.5581.00
97_F101_N0.5571.00
150_L165_A0.5571.00
113_M172_S0.5571.00
77_D81_A0.5551.00
121_G139_V0.5541.00
89_F198_G0.5531.00
110_I149_A0.5511.00
78_L81_A0.5491.00
277_L280_G0.5491.00
113_M146_L0.5481.00
81_A194_L0.5471.00
197_Y200_T0.5471.00
284_G288_V0.5471.00
15_G255_I0.5461.00
298_I301_M0.5431.00
89_F202_A0.5411.00
126_R177_G0.5391.00
110_I150_L0.5351.00
179_L248_M0.5341.00
265_M298_I0.5341.00
29_K240_T0.5321.00
20_L23_T0.5321.00
23_T267_G0.5321.00
42_E214_S0.5271.00
95_L171_S0.5261.00
159_Q163_I0.5261.00
29_K97_F0.5251.00
247_L250_E0.5241.00
19_L248_M0.5231.00
160_A163_I0.5221.00
207_M211_G0.5211.00
99_G103_V0.5201.00
273_F276_A0.5201.00
276_A288_V0.5191.00
109_R113_M0.5151.00
264_S267_G0.5151.00
53_L56_P0.5141.00
127_D183_G0.5141.00
16_T20_L0.5131.00
49_Y233_F0.5121.00
173_A177_G0.5111.00
92_S96_D0.5111.00
282_R287_Q0.5091.00
56_P59_W0.5081.00
44_D213_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2468 98.7 0.77 Contact Map
3b5dA 2 0.3237 98.1 0.808 Contact Map
4tphA 2 0.8814 26.2 0.934 Contact Map
1pw4A 1 0.8526 24.8 0.934 Contact Map
2gfpA 2 0.7628 22.2 0.936 Contact Map
4he8J 1 0.5032 21.1 0.937 Contact Map
4j05A 3 0.9199 21.1 0.937 Contact Map
4pgrA 1 0.6442 18.9 0.938 Contact Map
3o7qA 1 0.7756 17 0.939 Contact Map
4pypA 1 0.9038 16.9 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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