GREMLIN Database
GUDD - Probable glucarate dehydratase
UniProt: P42238 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (359)
Sequences: 5639 (3436)
Seq/√Len: 181.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_E398_C3.9991.00
289_R318_D3.8101.00
59_N133_L3.5091.00
85_K96_T3.4011.00
52_I413_M2.8651.00
203_E236_R2.8571.00
24_K52_I2.8021.00
135_G142_V2.7451.00
251_S254_E2.7161.00
312_I344_L2.6361.00
22_E54_T2.6061.00
286_A290_R2.5981.00
55_D133_L2.4541.00
24_K54_T2.4521.00
62_V411_I2.4421.00
259_C269_A2.3801.00
259_C292_T2.3531.00
54_T60_Q2.3471.00
263_Q293_G2.3241.00
127_E330_Q2.3001.00
256_I291_A2.2961.00
59_N137_F2.2431.00
203_E207_E2.2161.00
136_K410_D2.2021.00
277_N284_V2.2001.00
55_D59_N2.1981.00
327_W335_V2.1721.00
287_E290_R2.1711.00
260_K263_Q2.1531.00
19_S56_S2.1331.00
23_M53_L2.1151.00
305_W331_G2.0951.00
283_E314_L2.0851.00
52_I60_Q2.0851.00
156_K212_Q2.0371.00
199_V236_R2.0261.00
389_K410_D2.0021.00
195_P199_V1.9651.00
273_C288_F1.9621.00
287_E291_A1.9131.00
231_T235_K1.9091.00
231_T265_V1.9071.00
309_G313_Q1.8961.00
150_K153_D1.8771.00
286_A314_L1.8421.00
206_Q240_A1.8311.00
252_L288_F1.8111.00
263_Q294_L1.7911.00
21_S56_S1.7901.00
26_I52_I1.7881.00
89_A92_A1.7801.00
194_T197_A1.7731.00
26_I420_H1.7681.00
227_I261_G1.7451.00
258_L262_K1.7101.00
389_K412_D1.7011.00
313_Q342_W1.6931.00
231_T264_D1.6911.00
29_A45_F1.6881.00
140_E144_A1.6881.00
154_E400_K1.6751.00
21_S54_T1.6551.00
200_R203_E1.6531.00
237_F242_I1.6481.00
23_M79_E1.6401.00
334_R340_H1.6361.00
214_F240_A1.6191.00
53_L130_L1.6161.00
55_D137_F1.6101.00
261_G264_D1.6091.00
395_S400_K1.6031.00
59_N136_K1.5971.00
413_M417_E1.5731.00
142_V407_L1.5591.00
50_I416_V1.5491.00
65_V125_A1.5271.00
197_A200_R1.5191.00
312_I338_M1.5151.00
234_S238_P1.5061.00
252_L287_E1.5011.00
202_A237_F1.4971.00
232_A235_K1.4881.00
85_K92_A1.4831.00
93_I97_V1.4671.00
308_M335_V1.4661.00
273_C284_V1.4521.00
50_I356_I1.4491.00
135_G145_L1.4441.00
337_Q340_H1.4431.00
86_S89_A1.4391.00
217_K247_N1.4301.00
310_H314_L1.4301.00
56_S87_I1.4291.00
91_Q334_R1.4151.00
311_A317_V1.4131.00
51_V125_A1.4121.00
390_Q404_K1.4031.00
134_L138_L1.3961.00
332_S364_V1.3891.00
57_S137_F1.3891.00
73_R76_E1.3881.00
91_Q333_V1.3611.00
222_R225_E1.3591.00
142_V329_M1.3521.00
331_G334_R1.3521.00
154_E396_S1.3481.00
256_I288_F1.3481.00
22_E79_E1.3461.00
366_A401_V1.3361.00
78_S97_V1.3301.00
228_E231_T1.3261.00
18_P56_S1.3221.00
303_T307_E1.3171.00
241_R267_A1.3111.00
85_K93_I1.3061.00
206_Q214_F1.3051.00
23_M82_V1.3021.00
323_D349_H1.2921.00
93_I96_T1.2911.00
333_V337_Q1.2811.00
244_L266_L1.2741.00
37_N42_H1.2711.00
415_Q418_K1.2661.00
310_H313_Q1.2561.00
156_K398_C1.2511.00
308_M320_P1.2501.00
257_A261_G1.2461.00
297_A321_L1.2431.00
88_G137_F1.2411.00
203_E206_Q1.2391.00
127_E131_L1.2291.00
312_I342_W1.2211.00
88_G134_L1.2101.00
243_T267_A1.2031.00
234_S239_E1.2011.00
415_Q419_A1.2001.00
196_E200_R1.2001.00
85_K89_A1.1981.00
225_E228_E1.1961.00
298_T311_A1.1921.00
411_I416_V1.1861.00
202_A214_F1.1841.00
263_Q292_T1.1811.00
78_S126_L1.1771.00
227_I265_V1.1701.00
230_V244_L1.1611.00
18_P57_S1.1581.00
97_V123_V1.1511.00
216_L233_L1.1421.00
412_D415_Q1.1381.00
228_E232_A1.1261.00
53_L82_V1.1231.00
52_I62_V1.1171.00
234_S242_I1.1171.00
88_G138_L1.1081.00
340_H369_P1.1081.00
141_P144_A1.1071.00
283_E310_H1.1071.00
143_A401_V1.1041.00
260_K293_G1.1031.00
260_K291_A1.1031.00
92_A96_T1.1021.00
199_V235_K1.1021.00
271_D321_L1.1011.00
230_V265_V1.0981.00
202_A233_L1.0961.00
360_M407_L1.0911.00
195_P232_A1.0771.00
285_M298_T1.0751.00
131_L330_Q1.0701.00
140_E145_L1.0671.00
25_V72_R1.0661.00
204_S209_Y1.0651.00
266_L294_L1.0531.00
322_A332_S1.0531.00
213_D243_T1.0491.00
224_E261_G1.0441.00
90_Y134_L1.0401.00
233_L237_F1.0341.00
414_E417_E1.0331.00
327_W332_S1.0251.00
317_V320_P1.0220.99
138_L145_L1.0210.99
25_V75_L1.0190.99
282_R311_A1.0140.99
227_I231_T1.0130.99
79_E83_V1.0070.99
252_L284_V1.0040.99
204_S207_E1.0020.99
336_A368_A0.9940.99
250_W258_L0.9890.99
150_K403_D0.9880.99
338_M342_W0.9810.99
144_A403_D0.9790.99
54_T57_S0.9780.99
199_V237_F0.9720.99
288_F296_T0.9680.99
128_A360_M0.9680.99
334_R337_Q0.9670.99
218_G246_P0.9650.99
232_A236_R0.9620.99
134_L145_L0.9590.99
230_V262_K0.9560.99
312_I320_P0.9510.99
237_F240_A0.9440.99
135_G138_L0.9440.99
70_H73_R0.9430.99
94_L97_V0.9330.99
246_P269_A0.9310.99
302_A307_E0.9300.99
139_Q405_P0.9300.99
227_I264_D0.9260.99
282_R316_A0.9260.99
216_L230_V0.9240.99
292_T296_T0.9240.99
93_I130_L0.9230.99
223_G258_L0.9220.99
143_A150_K0.9110.99
199_V233_L0.9090.99
130_L134_L0.9070.99
205_A209_Y0.9070.99
297_A319_I0.9040.99
26_I417_E0.9030.99
305_W338_M0.9010.99
304_D307_E0.8920.99
214_F237_F0.8910.99
333_V367_A0.8890.99
324_P364_V0.8890.99
72_R75_L0.8870.99
385_Q415_Q0.8870.99
243_T268_Y0.8860.99
366_A402_P0.8840.99
20_I53_L0.8840.99
309_G342_W0.8830.99
299_N323_D0.8810.98
324_P332_S0.8780.98
82_V93_I0.8770.98
320_P339_C0.8760.98
256_I287_E0.8760.98
362_T401_V0.8760.98
224_E257_A0.8750.98
359_A409_V0.8740.98
289_R315_H0.8670.98
244_L262_K0.8660.98
206_Q237_F0.8660.98
315_H344_L0.8640.98
417_E420_H0.8620.98
133_L137_F0.8610.98
136_K404_K0.8580.98
256_I260_K0.8570.98
50_I62_V0.8530.98
75_L79_E0.8530.98
199_V203_E0.8500.98
154_E395_S0.8490.98
219_G226_E0.8490.98
200_R204_S0.8460.98
199_V202_A0.8450.98
18_P137_F0.8390.98
19_S86_S0.8380.98
195_P228_E0.8380.98
413_M416_V0.8330.98
202_A236_R0.8280.98
54_T62_V0.8280.98
200_R236_R0.8270.98
203_E237_F0.8270.98
49_N72_R0.8260.98
199_V232_A0.8240.98
246_P250_W0.8180.98
198_I229_A0.8170.98
212_Q396_S0.8160.98
252_L273_C0.8130.97
89_A144_A0.8090.97
395_S398_C0.8080.97
394_I399_V0.7990.97
324_P361_F0.7970.97
250_W269_A0.7960.97
340_H370_G0.7940.97
75_L126_L0.7910.97
290_R315_H0.7790.97
321_L349_H0.7790.97
307_E310_H0.7780.97
94_L98_R0.7770.97
302_A308_M0.7770.97
285_M296_T0.7720.97
27_P47_T0.7700.96
94_L127_E0.7680.96
144_A150_K0.7660.96
393_E400_K0.7630.96
302_A311_A0.7620.96
271_D299_N0.7620.96
153_D403_D0.7590.96
224_E228_E0.7580.96
253_E257_A0.7580.96
377_T382_Q0.7570.96
159_G211_F0.7570.96
143_A403_D0.7570.96
390_Q410_D0.7560.96
132_D136_K0.7540.96
392_F399_V0.7530.96
322_A346_W0.7530.96
87_I130_L0.7510.96
202_A232_A0.7490.96
226_E250_W0.7480.96
256_I292_T0.7460.96
282_R310_H0.7420.96
206_Q236_R0.7390.96
82_V130_L0.7380.95
27_P72_R0.7380.95
400_K403_D0.7360.95
329_M364_V0.7360.95
159_G205_A0.7360.95
252_L256_I0.7350.95
81_L96_T0.7330.95
287_E315_H0.7310.95
213_D241_R0.7270.95
21_S57_S0.7270.95
259_C294_L0.7260.95
70_H75_L0.7240.95
95_Q151_Q0.7220.95
218_G262_K0.7220.95
362_T402_P0.7210.95
74_T122_A0.7200.95
63_G125_A0.7190.95
329_M333_V0.7180.95
86_S144_A0.7160.95
289_R296_T0.7140.95
227_I262_K0.7120.95
201_L204_S0.7110.94
75_L80_P0.7100.94
157_M399_V0.7090.94
135_G140_E0.7040.94
62_V413_M0.7010.94
267_A295_P0.7010.94
90_Y97_V0.6940.94
21_S55_D0.6930.94
49_N65_V0.6930.94
277_N343_G0.6930.94
273_C285_M0.6930.94
135_G405_P0.6920.94
359_A362_T0.6910.94
309_G338_M0.6900.94
379_W382_Q0.6870.93
82_V126_L0.6870.93
76_E79_E0.6840.93
133_L136_K0.6840.93
23_M126_L0.6840.93
79_E126_L0.6840.93
362_T399_V0.6810.93
134_L137_F0.6790.93
355_D388_T0.6790.93
257_A260_K0.6790.93
404_K410_D0.6760.93
87_I133_L0.6750.93
321_L348_S0.6740.93
94_L330_Q0.6740.93
143_A363_H0.6700.93
356_I409_V0.6690.93
286_A315_H0.6690.93
299_N321_L0.6680.92
18_P87_I0.6670.92
146_L329_M0.6620.92
70_H77_L0.6610.92
218_G244_L0.6600.92
98_R331_G0.6600.92
60_Q410_D0.6570.92
102_G118_T0.6560.92
308_M339_C0.6520.92
71_I74_T0.6510.91
272_P296_T0.6500.91
283_E313_Q0.6500.91
141_P363_H0.6470.91
93_I126_L0.6460.91
131_L142_V0.6460.91
233_L236_R0.6460.91
212_Q239_E0.6450.91
29_A47_T0.6440.91
308_M322_A0.6420.91
60_Q136_K0.6420.91
218_G250_W0.6400.91
76_E80_P0.6380.91
266_L269_A0.6350.90
72_R76_E0.6330.90
97_V126_L0.6320.90
71_I75_L0.6320.90
271_D301_I0.6310.90
378_H381_W0.6310.90
150_K401_V0.6310.90
329_M360_M0.6300.90
62_V136_K0.6300.90
70_H74_T0.6280.90
414_E418_K0.6280.90
359_A407_L0.6270.90
128_A356_I0.6260.90
346_W368_A0.6250.90
66_P325_H0.6230.90
269_A294_L0.6230.90
77_L80_P0.6220.90
299_N348_S0.6210.89
376_D380_I0.6150.89
225_E229_A0.6140.89
356_I411_I0.6090.89
336_A370_G0.6090.89
101_F123_V0.6080.88
73_R77_L0.6060.88
255_A273_C0.6060.88
141_P404_K0.6050.88
56_S59_N0.6040.88
196_E199_V0.6040.88
285_M288_F0.6030.88
288_F291_A0.5980.88
141_P145_L0.5970.88
78_S101_F0.5970.88
161_L164_I0.5960.87
285_M316_A0.5950.87
22_E56_S0.5950.87
18_P86_S0.5950.87
298_T317_V0.5940.87
90_Y130_L0.5940.87
152_R155_V0.5940.87
90_Y93_I0.5930.87
299_N349_H0.5920.87
138_L141_P0.5900.87
31_H419_A0.5900.87
378_H382_Q0.5890.87
65_V121_H0.5890.87
57_S87_I0.5880.87
38_L43_S0.5870.87
276_E306_R0.5870.87
223_G227_I0.5860.87
61_G129_A0.5850.87
234_S265_V0.5850.87
263_Q266_L0.5830.86
321_L347_G0.5820.86
271_D300_M0.5810.86
196_E228_E0.5810.86
97_V101_F0.5800.86
248_G275_D0.5790.86
254_E257_A0.5780.86
161_L205_A0.5770.86
381_W384_G0.5770.86
87_I137_F0.5760.86
282_R314_L0.5760.86
105_D117_R0.5750.86
268_Y299_N0.5720.85
230_V266_L0.5710.85
212_Q398_C0.5700.85
268_Y347_G0.5670.85
26_I62_V0.5670.85
146_L333_V0.5650.85
95_Q99_K0.5650.85
311_A316_A0.5650.85
345_T372_I0.5620.84
233_L242_I0.5620.84
380_I383_D0.5610.84
96_T99_K0.5600.84
195_P225_E0.5600.84
227_I230_V0.5590.84
162_F271_D0.5570.84
78_S123_V0.5560.84
138_L142_V0.5560.84
273_C298_T0.5560.84
295_P319_I0.5560.84
328_T331_G0.5550.84
130_L133_L0.5530.83
142_V333_V0.5520.83
128_A407_L0.5520.83
38_L41_A0.5520.83
35_L43_S0.5460.83
338_M341_D0.5460.83
35_L42_H0.5420.82
74_T77_L0.5410.82
32_D46_F0.5410.82
51_V126_L0.5390.82
160_Y163_Y0.5380.82
206_Q239_E0.5380.82
286_A316_A0.5360.81
28_V419_A0.5350.81
195_P202_A0.5350.81
226_E247_N0.5330.81
367_A370_G0.5320.81
56_S137_F0.5320.81
158_L375_I0.5310.81
89_A153_D0.5290.81
385_Q418_K0.5290.81
299_N322_A0.5290.81
196_E232_A0.5290.81
325_H351_N0.5280.80
385_Q419_A0.5280.80
333_V368_A0.5270.80
332_S346_W0.5260.80
103_D106_R0.5250.80
34_M201_L0.5240.80
23_M51_V0.5240.80
28_V411_I0.5230.80
348_S365_A0.5230.80
306_R310_H0.5230.80
49_N71_I0.5210.80
32_D36_L0.5210.80
296_T316_A0.5210.80
196_E417_E0.5190.79
66_P349_H0.5190.79
216_L244_L0.5190.79
39_S352_N0.5190.79
359_A363_H0.5190.79
350_S358_L0.5180.79
158_L321_L0.5180.79
218_G226_E0.5170.79
325_H357_S0.5170.79
18_P21_S0.5170.79
135_G407_L0.5170.79
98_R123_V0.5160.79
19_S83_V0.5150.79
242_I266_L0.5150.79
20_I23_M0.5140.79
255_A269_A0.5140.79
378_H383_D0.5130.79
67_G121_H0.5120.78
320_P335_V0.5120.78
142_V363_H0.5120.78
50_I411_I0.5120.78
276_E282_R0.5110.78
268_Y380_I0.5100.78
217_K226_E0.5100.78
244_L259_C0.5100.78
30_G354_F0.5090.78
234_S240_A0.5080.78
87_I90_Y0.5080.78
227_I258_L0.5070.78
131_L135_G0.5070.78
40_G46_F0.5060.78
376_D379_W0.5050.77
329_M332_S0.5030.77
39_S249_A0.5030.77
80_P126_L0.5020.77
378_H384_G0.5020.77
320_P344_L0.5010.77
81_L85_K0.5000.77
128_A142_V0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mznA 2 0.9648 100 0.274 Contact Map
3pfrA 2 0.9209 100 0.287 Contact Map
3p0wA 2 0.9253 100 0.287 Contact Map
4hyrA 4 0.9538 100 0.292 Contact Map
4g8tA 3 0.9516 100 0.302 Contact Map
3vdgA 2 0.9143 100 0.323 Contact Map
3vc5A 2 0.8989 100 0.323 Contact Map
4it1A 3 0.9187 100 0.327 Contact Map
3va8A 2 0.9121 100 0.329 Contact Map
3s5sA 2 0.778 100 0.345 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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