GREMLIN Database
ALDH1 - Probable aldehyde dehydrogenase YcbD
UniProt: P42236 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (453)
Sequences: 36535 (21845)
Seq/√Len: 1026.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_S402_D5.0211.00
243_Q247_A3.5701.00
299_S400_K3.1561.00
271_E308_K3.0961.00
302_Y400_K2.9391.00
28_K41_Y2.8281.00
359_E373_Q2.7911.00
58_N225_G2.7711.00
266_D298_Q2.7351.00
381_T384_M2.6921.00
34_D37_D2.6881.00
334_K338_D2.6161.00
346_K385_T2.5841.00
275_E312_R2.5741.00
191_K194_A2.5481.00
345_E349_Q2.5271.00
306_K398_L2.4811.00
266_D300_G2.4371.00
86_R89_E2.4011.00
84_E117_R2.3751.00
28_K38_I2.3291.00
424_T430_M2.3241.00
344_I372_V2.2241.00
58_N227_N2.2211.00
197_E203_A2.1921.00
46_T49_D2.1631.00
87_L110_A2.1421.00
88_E106_K2.1381.00
341_L345_E2.1361.00
79_T196_F2.1161.00
82_I198_E2.0761.00
404_I429_R2.0561.00
353_S379_N2.0171.00
415_K462_Q2.0111.00
341_L360_K1.9951.00
222_E244_A1.9891.00
184_E333_S1.9831.00
218_Q222_E1.9761.00
145_V482_K1.9661.00
144_R476_D1.9301.00
346_K350_E1.9291.00
310_L314_K1.9201.00
262_V277_V1.9191.00
432_S436_E1.9141.00
331_I340_C1.9141.00
89_E191_K1.9081.00
341_L372_V1.9041.00
348_K354_L1.8981.00
304_R308_K1.8911.00
75_Y201_L1.8511.00
355_L378_D1.8121.00
240_I243_Q1.8011.00
267_D429_R1.8001.00
55_T225_G1.7961.00
239_K462_Q1.7921.00
51_E219_G1.7841.00
82_I85_Q1.7681.00
296_I410_I1.7651.00
86_R198_E1.7591.00
438_D461_K1.7481.00
387_A399_I1.7291.00
144_R479_T1.7001.00
404_I432_S1.6981.00
82_I199_A1.6811.00
51_E55_T1.6721.00
298_Q401_V1.6621.00
38_I41_Y1.6391.00
93_C191_K1.6321.00
377_F386_I1.6271.00
382_S410_I1.6251.00
296_I407_A1.6231.00
313_T376_I1.6201.00
77_Y117_R1.6151.00
310_L355_L1.6141.00
193_I208_L1.6121.00
82_I195_C1.6061.00
406_E409_N1.5941.00
353_S378_D1.5891.00
102_L106_K1.5881.00
402_D406_E1.5731.00
277_V305_F1.5651.00
282_F313_T1.5641.00
302_Y306_K1.5641.00
116_L168_A1.5631.00
212_P215_V1.5631.00
307_E311_Q1.5521.00
84_E113_I1.5491.00
68_T71_E1.5481.00
61_K65_R1.5471.00
342_S385_T1.5231.00
176_T205_V1.5171.00
385_T389_E1.5161.00
308_K311_Q1.5121.00
81_D85_Q1.5081.00
334_K370_Y1.5031.00
270_L308_K1.4961.00
78_K81_D1.4871.00
51_E223_H1.4861.00
274_A308_K1.4771.00
26_M41_Y1.4691.00
295_V396_I1.4681.00
303_E400_K1.4641.00
265_A429_R1.4541.00
354_L377_F1.4531.00
37_D368_N1.4521.00
194_A198_E1.4521.00
71_E74_Q1.4511.00
36_N368_N1.4321.00
66_K436_E1.4301.00
87_L106_K1.4211.00
296_I401_V1.4201.00
276_A423_F1.4181.00
77_Y124_M1.4171.00
92_A96_R1.4041.00
67_L71_E1.4001.00
266_D429_R1.3971.00
277_V295_V1.3961.00
304_R307_E1.3961.00
312_R315_D1.3951.00
405_E436_E1.3941.00
80_A117_R1.3871.00
420_A439_A1.3871.00
88_E92_A1.3841.00
122_E125_R1.3831.00
143_T435_D1.3791.00
406_E410_I1.3771.00
297_V305_F1.3741.00
302_Y378_D1.3741.00
116_L164_I1.3691.00
317_T325_D1.3631.00
86_R191_K1.3601.00
30_E38_I1.3571.00
345_E348_K1.3561.00
152_V177_V1.3541.00
49_D52_R1.3521.00
81_D117_R1.3431.00
92_A322_L1.3371.00
340_C393_G1.3311.00
25_D44_N1.3271.00
343_Y391_I1.3201.00
242_G466_H1.3121.00
228_A253_Q1.3071.00
337_L341_L1.3021.00
265_A401_V1.3011.00
95_T105_A1.2881.00
163_P179_I1.2811.00
338_D342_S1.2801.00
350_E385_T1.2801.00
31_N34_D1.2791.00
401_V410_I1.2771.00
303_E307_E1.2701.00
61_K176_T1.2661.00
306_K310_L1.2521.00
193_I206_I1.2501.00
337_L372_V1.2441.00
265_A433_F1.2411.00
337_L360_K1.2401.00
311_Q314_K1.2361.00
314_K356_I1.2351.00
334_K337_L1.2241.00
263_I407_A1.2141.00
301_I304_R1.2091.00
80_A84_E1.2081.00
44_N212_P1.2031.00
298_Q301_I1.2011.00
298_Q403_S1.2001.00
383_E388_Q1.1941.00
408_L433_F1.1921.00
317_T327_W1.1921.00
218_Q244_A1.1881.00
403_S406_E1.1871.00
473_A476_D1.1821.00
319_G326_V1.1801.00
141_F431_L1.1751.00
54_V223_H1.1751.00
183_T213_G1.1741.00
342_S346_K1.1671.00
183_T212_P1.1651.00
90_I191_K1.1631.00
55_T59_E1.1631.00
308_K312_R1.1621.00
196_F206_I1.1611.00
472_E476_D1.1591.00
352_A377_F1.1581.00
144_R481_I1.1551.00
92_A102_L1.1531.00
67_L75_Y1.1461.00
309_L396_I1.1421.00
204_G207_N1.1421.00
382_S413_D1.1341.00
420_A442_V1.1331.00
54_V226_V1.1321.00
434_I484_V1.1271.00
305_F309_L1.1221.00
54_V225_G1.1151.00
78_K82_I1.1131.00
347_G377_F1.1071.00
95_T321_S1.1051.00
50_V216_V1.1041.00
47_A219_G1.1041.00
311_Q315_D1.1041.00
306_K378_D1.1041.00
240_I244_A1.1031.00
56_A207_N1.1011.00
237_V240_I1.1001.00
405_E432_S1.0991.00
430_M444_I1.0931.00
306_K355_L1.0931.00
79_T195_C1.0921.00
147_L228_A1.0921.00
218_Q240_I1.0901.00
219_G223_H1.0891.00
236_Q240_I1.0861.00
190_A210_T1.0851.00
458_G468_R1.0851.00
388_Q415_K1.0841.00
31_N320_D1.0801.00
27_V44_N1.0791.00
242_G252_Y1.0761.00
405_E409_N1.0741.00
362_E367_Q1.0731.00
262_V292_T1.0731.00
79_T201_L1.0721.00
77_Y121_G1.0681.00
167_M206_I1.0671.00
388_Q413_D1.0641.00
468_R480_A1.0611.00
222_E247_A1.0581.00
361_L373_Q1.0571.00
473_A481_I1.0551.00
310_L356_I1.0541.00
152_V230_T1.0521.00
269_D425_E1.0501.00
314_K373_Q1.0441.00
129_D472_E1.0421.00
404_I433_F1.0401.00
408_L436_E1.0381.00
151_G220_L1.0371.00
40_G187_V1.0361.00
79_T116_L1.0341.00
167_M177_V1.0271.00
44_N215_V1.0261.00
316_I328_M1.0211.00
263_I433_F1.0201.00
239_K249_G1.0171.00
263_I411_A1.0161.00
337_L370_Y1.0101.00
357_G375_A1.0091.00
62_T438_D1.0081.00
129_D473_A1.0061.00
350_E384_M1.0041.00
320_D323_K0.9991.00
401_V407_A0.9981.00
63_A67_L0.9981.00
158_F288_K0.9971.00
151_G226_V0.9971.00
426_N429_R0.9931.00
60_A176_T0.9931.00
259_K293_S0.9881.00
47_A215_V0.9841.00
33_A321_S0.9831.00
90_I195_C0.9831.00
73_G124_M0.9801.00
357_G373_Q0.9781.00
86_R195_C0.9771.00
269_D272_A0.9761.00
149_V176_T0.9631.00
242_G246_L0.9621.00
62_T409_N0.9611.00
36_N370_Y0.9601.00
85_Q198_E0.9581.00
190_A208_L0.9531.00
112_G164_I0.9531.00
460_M480_A0.9521.00
86_R194_A0.9511.00
58_N62_T0.9471.00
123_G172_V0.9451.00
194_A197_E0.9431.00
346_K349_Q0.9401.00
143_T484_V0.9391.00
278_I312_R0.9391.00
261_P420_A0.9381.00
340_C395_V0.9381.00
89_E92_A0.9381.00
380_V384_M0.9371.00
91_A106_K0.9331.00
421_S447_E0.9331.00
272_A276_A0.9321.00
147_L251_K0.9321.00
343_Y346_K0.9321.00
77_Y120_A0.9231.00
280_G292_T0.9221.00
31_N96_R0.9221.00
271_E304_R0.9211.00
227_N438_D0.9181.00
47_A51_E0.9161.00
281_A293_S0.9161.00
96_R322_L0.9151.00
342_S345_E0.9151.00
82_I86_R0.9051.00
409_N413_D0.9041.00
140_M455_A0.8991.00
150_V228_A0.8941.00
431_L435_D0.8941.00
74_Q78_K0.8891.00
302_Y398_L0.8891.00
303_E306_K0.8881.00
145_V435_D0.8851.00
348_K377_F0.8821.00
73_G77_Y0.8821.00
262_V423_F0.8821.00
31_N37_D0.8791.00
270_L274_A0.8791.00
338_D341_L0.8791.00
98_M185_T0.8781.00
62_T66_K0.8751.00
112_G160_V0.8741.00
239_K243_Q0.8741.00
265_A404_I0.8731.00
184_E335_N0.8721.00
100_K108_E0.8721.00
30_E370_Y0.8721.00
149_V226_V0.8711.00
50_V151_G0.8691.00
234_S237_V0.8671.00
145_V460_M0.8671.00
69_G73_G0.8661.00
166_K469_E0.8651.00
340_C391_I0.8621.00
399_I410_I0.8621.00
343_Y385_T0.8561.00
52_R56_A0.8541.00
80_A120_A0.8531.00
274_A312_R0.8521.00
242_G245_A0.8501.00
265_A424_T0.8491.00
274_A309_L0.8481.00
427_I430_M0.8471.00
83_M112_G0.8471.00
193_I197_E0.8421.00
455_A483_T0.8421.00
420_A437_I0.8401.00
251_K480_A0.8371.00
382_S399_I0.8351.00
407_A410_I0.8241.00
65_R438_D0.8211.00
48_E52_R0.8211.00
73_G120_A0.8211.00
27_V212_P0.8201.00
60_A205_V0.8181.00
169_P474_A0.8151.00
242_G249_G0.8111.00
401_V406_E0.8101.00
33_A371_Y0.8101.00
48_E51_E0.8091.00
351_G384_M0.8081.00
229_V245_A0.8051.00
173_Y479_T0.8031.00
45_S49_D0.8021.00
52_R55_T0.8011.00
274_A305_F0.8011.00
190_A194_A0.7991.00
147_L175_N0.7991.00
264_V305_F0.7991.00
56_A204_G0.7981.00
273_A277_V0.7971.00
179_I189_C0.7971.00
238_G256_M0.7951.00
352_A384_M0.7951.00
66_K435_D0.7941.00
147_L480_A0.7911.00
63_A66_K0.7911.00
422_I433_F0.7901.00
229_V241_I0.7901.00
57_A207_N0.7891.00
307_E310_L0.7871.00
408_L412_N0.7861.00
163_P167_M0.7831.00
64_W205_V0.7821.00
318_I361_L0.7811.00
77_Y81_D0.7771.00
59_E62_T0.7771.00
170_A177_V0.7741.00
45_S53_A0.7721.00
181_P210_T0.7701.00
238_G254_L0.7691.00
358_G375_A0.7671.00
221_A244_A0.7651.00
260_N293_S0.7621.00
98_M332_A0.7571.00
340_C372_V0.7571.00
344_I395_V0.7561.00
439_A442_V0.7551.00
164_I192_I0.7551.00
76_L172_V0.7501.00
103_P327_W0.7501.00
309_L376_I0.7481.00
39_V96_R0.7471.00
95_T102_L0.7461.00
84_E87_L0.7451.00
302_Y379_N0.7451.00
335_N338_D0.7451.00
221_A241_I0.7431.00
231_F237_V0.7421.00
270_L301_I0.7391.00
152_V166_K0.7381.00
70_A124_M0.7381.00
273_A305_F0.7371.00
261_P411_A0.7371.00
245_A252_Y0.7341.00
201_L206_I0.7321.00
243_Q246_L0.7311.00
151_G229_V0.7311.00
274_A278_I0.7311.00
160_V188_T0.7301.00
201_L205_V0.7301.00
91_A95_T0.7281.00
91_A102_L0.7271.00
235_N462_Q0.7261.00
362_E368_N0.7251.00
239_K247_A0.7251.00
84_E110_A0.7231.00
313_T356_I0.7221.00
96_R187_V0.7221.00
83_M113_I0.7211.00
211_G216_V0.7201.00
298_Q404_I0.7201.00
140_M483_T0.7181.00
271_E312_R0.7171.00
343_Y389_E0.7131.00
316_I327_W0.7121.00
102_L322_L0.7111.00
78_K199_A0.7071.00
163_P189_C0.7071.00
62_T65_R0.7041.00
106_K324_E0.7001.00
297_V301_I0.6991.00
184_E332_A0.6951.00
348_K359_E0.6951.00
175_N479_T0.6941.00
88_E102_L0.6941.00
378_D400_K0.6931.00
310_L313_T0.6891.00
278_I309_L0.6891.00
221_A229_V0.6891.00
265_A298_Q0.6871.00
64_W75_Y0.6871.00
323_K326_V0.6851.00
57_A176_T0.6841.00
179_I206_I0.6821.00
147_L227_N0.6821.00
50_V219_G0.6811.00
58_N61_K0.6801.00
339_N342_S0.6801.00
30_E36_N0.6781.00
154_S163_P0.6781.00
51_E225_G0.6781.00
425_E428_G0.6771.00
89_E194_A0.6751.00
333_S336_Q0.6741.00
60_A63_A0.6731.00
26_M43_Q0.6731.00
427_I431_L0.6721.00
313_T316_I0.6711.00
94_A97_E0.6691.00
285_T328_M0.6691.00
336_Q339_N0.6681.00
296_I387_A0.6641.00
251_K477_F0.6641.00
50_V54_V0.6631.00
69_G123_G0.6621.00
93_C187_V0.6611.00
244_A247_A0.6611.00
183_T339_N0.6601.00
31_N322_L0.6601.00
81_D84_E0.6601.00
382_S387_A0.6591.00
36_N334_K0.6581.00
65_R436_E0.6571.00
334_K360_K0.6561.00
296_I382_S0.6561.00
25_D215_V0.6561.00
347_G391_I0.6551.00
163_P192_I0.6541.00
267_D424_T0.6541.00
434_I444_I0.6521.00
75_Y199_A0.6511.00
403_S409_N0.6501.00
278_I316_I0.6441.00
410_I413_D0.6441.00
380_V387_A0.6421.00
151_G217_G0.6411.00
476_D479_T0.6411.00
295_V305_F0.6391.00
64_W171_L0.6391.00
372_V375_A0.6391.00
264_V273_A0.6381.00
253_Q477_F0.6371.00
272_A275_E0.6361.00
404_I408_L0.6321.00
139_L431_L0.6321.00
100_K104_E0.6311.00
56_A203_A0.6301.00
337_L361_L0.6291.00
309_L398_L0.6281.00
318_I328_M0.6271.00
90_I160_V0.6261.00
126_K479_T0.6251.00
196_F201_L0.6251.00
140_M485_F0.6241.00
438_D460_M0.6241.00
183_T240_I0.6241.00
341_L344_I0.6241.00
344_I377_F0.6231.00
65_R146_P0.6231.00
100_K158_F0.6231.00
277_V309_L0.6231.00
320_D326_V0.6221.00
270_L304_R0.6221.00
71_E75_Y0.6211.00
143_T482_K0.6211.00
65_R145_V0.6211.00
380_V386_I0.6211.00
75_Y200_G0.6201.00
356_I376_I0.6191.00
80_A113_I0.6191.00
95_T322_L0.6191.00
424_T429_R0.6191.00
335_N339_N0.6171.00
62_T436_E0.6171.00
43_Q210_T0.6171.00
178_V207_N0.6161.00
109_T113_I0.6151.00
242_G254_L0.6141.00
476_D481_I0.6141.00
215_V218_Q0.6131.00
430_M434_I0.6131.00
191_K195_C0.6121.00
267_D426_N0.6111.00
272_A425_E0.6091.00
290_T451_V0.6091.00
343_Y347_G0.6071.00
361_L367_Q0.6071.00
350_E383_E0.6071.00
166_K230_T0.6061.00
94_A105_A0.6061.00
167_M179_I0.6041.00
87_L91_A0.6041.00
69_G172_V0.6021.00
94_A188_T0.6011.00
29_V97_E0.5961.00
29_V40_G0.5931.00
219_G222_E0.5931.00
92_A95_T0.5931.00
47_A222_E0.5921.00
358_G373_Q0.5911.00
297_V302_Y0.5891.00
391_I395_V0.5891.00
331_I336_Q0.5891.00
45_S209_V0.5881.00
428_G431_L0.5871.00
53_A209_V0.5861.00
428_G432_S0.5841.00
47_A218_Q0.5821.00
280_G447_E0.5811.00
211_G217_G0.5811.00
55_T58_N0.5801.00
83_M192_I0.5791.00
126_K475_K0.5791.00
318_I327_W0.5781.00
228_A477_F0.5761.00
83_M116_L0.5761.00
408_L432_S0.5761.00
94_A108_E0.5751.00
59_E63_A0.5751.00
422_I430_M0.5751.00
262_V295_V0.5741.00
39_V187_V0.5731.00
42_V186_A0.5731.00
235_N239_K0.5721.00
354_L375_A0.5721.00
176_T207_N0.5711.00
297_V398_L0.5701.00
407_A411_A0.5701.00
150_V175_N0.5701.00
82_I200_G0.5681.00
262_V421_S0.5681.00
160_V192_I0.5681.00
382_S409_N0.5671.00
141_F484_V0.5671.00
344_I375_A0.5671.00
118_Y122_E0.5661.00
377_F380_V0.5661.00
271_E311_Q0.5641.00
422_I444_I0.5641.00
83_M160_V0.5641.00
80_A116_L0.5611.00
360_K373_Q0.5611.00
288_K291_A0.5601.00
379_N400_K0.5601.00
79_T82_I0.5601.00
281_A396_I0.5581.00
310_L376_I0.5511.00
319_G323_K0.5501.00
91_A109_T0.5501.00
341_L348_K0.5491.00
25_D46_T0.5481.00
110_A113_I0.5471.00
121_G124_M0.5461.00
260_N419_S0.5451.00
411_A437_I0.5451.00
270_L305_F0.5451.00
266_D401_V0.5441.00
149_V227_N0.5441.00
53_A207_N0.5441.00
56_A60_A0.5431.00
183_T236_Q0.5431.00
331_I372_V0.5421.00
267_D425_E0.5421.00
408_L437_I0.5421.00
173_Y475_K0.5411.00
122_E472_E0.5391.00
295_V398_L0.5391.00
268_A273_A0.5381.00
197_E204_G0.5381.00
58_N149_V0.5381.00
109_T160_V0.5381.00
270_L273_A0.5361.00
70_A74_Q0.5351.00
29_V186_A0.5351.00
119_Y169_P0.5341.00
192_I196_F0.5321.00
404_I436_E0.5311.00
442_V482_K0.5301.00
354_L357_G0.5301.00
75_Y79_T0.5301.00
317_T323_K0.5291.00
292_T421_S0.5291.00
350_E381_T0.5281.00
221_A248_R0.5281.00
57_A178_V0.5271.00
161_A165_W0.5271.00
165_W470_Q0.5241.00
74_Q77_Y0.5241.00
213_G218_Q0.5231.00
57_A149_V0.5231.00
443_R446_A0.5231.00
230_T478_F0.5221.00
98_M284_S0.5221.00
83_M90_I0.5221.00
150_V177_V0.5221.00
438_D480_A0.5201.00
42_V187_V0.5201.00
63_A176_T0.5191.00
236_Q335_N0.5191.00
282_F316_I0.5191.00
111_R161_A0.5191.00
299_S302_Y0.5171.00
152_V167_M0.5161.00
78_K200_G0.5151.00
433_F437_I0.5151.00
90_I109_T0.5151.00
274_A301_I0.5141.00
355_L379_N0.5141.00
111_R451_V0.5131.00
106_K110_A0.5131.00
386_I391_I0.5121.00
87_L113_I0.5091.00
217_G221_A0.5081.00
145_V438_D0.5081.00
348_K351_G0.5081.00
69_G127_T0.5071.00
171_L206_I0.5071.00
108_E158_F0.5061.00
44_N183_T0.5061.00
336_Q340_C0.5041.00
419_S443_R0.5041.00
466_H480_A0.5021.00
354_L358_G0.5021.00
151_G178_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yweA 5 0.9693 100 0.04 Contact Map
4o5hA 4 0.9857 100 0.04 Contact Map
4qf6A 4 0.9836 100 0.042 Contact Map
4pxlA 4 0.9754 100 0.042 Contact Map
4lihA 5 0.9795 100 0.043 Contact Map
4qtoA 4 0.9918 100 0.043 Contact Map
3ek1A 5 0.9816 100 0.044 Contact Map
2o2pA 5 0.9857 100 0.045 Contact Map
1a4sA 4 0.9898 100 0.046 Contact Map
4wj9A 4 0.9836 100 0.047 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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