GREMLIN Database
KDGD - Probable 5-dehydro-4-deoxyglucarate dehydratase
UniProt: P42235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (283)
Sequences: 10374 (6868)
Seq/√Len: 408.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_N233_L3.8031.00
35_E72_A3.2941.00
20_N24_K3.1381.00
121_Y152_R3.0871.00
266_I291_E3.0251.00
31_F72_A2.7861.00
27_E64_Q2.7331.00
27_E68_V2.6141.00
98_E132_D2.5841.00
31_F68_V2.5751.00
63_E96_L2.4971.00
225_A233_L2.4681.00
83_V94_A2.4561.00
199_Y204_F2.3741.00
94_A105_Y2.2671.00
233_L236_E2.1191.00
35_E76_K2.0631.00
125_K156_C2.0241.00
224_D228_N2.0111.00
12_L44_A1.9911.00
225_A230_N1.9911.00
129_E156_C1.9611.00
36_F40_E1.9561.00
220_R224_D1.9501.00
151_K178_T1.9481.00
117_Q149_Q1.9271.00
117_Q146_S1.9181.00
200_L226_L1.9171.00
87_L123_Y1.9031.00
64_Q67_E1.8811.00
291_E295_K1.8651.00
26_E29_A1.8621.00
43_E224_D1.8471.00
125_K129_E1.8441.00
262_A287_Y1.8231.00
35_E39_N1.8181.00
59_Q89_T1.8171.00
118_E122_Q1.8081.00
144_V171_L1.7961.00
31_F71_S1.7661.00
218_I240_H1.7581.00
121_Y125_K1.7511.00
118_E152_R1.7301.00
40_E217_H1.7211.00
34_I69_A1.6861.00
70_V79_V1.6691.00
67_E71_S1.6581.00
136_I161_G1.6521.00
30_L69_A1.6481.00
64_Q68_V1.6451.00
13_G212_S1.6161.00
128_I156_C1.6141.00
265_E273_N1.6081.00
29_A32_Q1.5951.00
122_Q125_K1.5701.00
288_Q291_E1.5661.00
150_I162_V1.5661.00
107_I127_I1.5651.00
61_E276_R1.5601.00
47_I69_A1.5281.00
68_V72_A1.5131.00
94_A131_T1.5061.00
66_V81_T1.4871.00
146_S149_Q1.4841.00
18_P30_L1.4681.00
38_L77_V1.4531.00
236_E240_H1.4491.00
30_L65_M1.4271.00
90_A127_I1.3801.00
221_M225_A1.3761.00
122_Q126_T1.3651.00
98_E131_T1.3581.00
284_K287_Y1.3561.00
288_Q292_A1.3491.00
284_K288_Q1.3421.00
16_V264_M1.3401.00
43_E220_R1.3401.00
265_E270_N1.3341.00
221_M233_L1.3311.00
251_Q289_Q1.3271.00
262_A266_I1.3251.00
96_L99_K1.3141.00
85_G90_A1.3131.00
12_L46_F1.3111.00
98_E133_L1.2951.00
59_Q92_D1.2891.00
68_V71_S1.2811.00
217_H221_M1.2711.00
270_N273_N1.2641.00
9_A227_K1.2631.00
36_F269_L1.2551.00
283_E286_H1.2541.00
174_N178_T1.2541.00
63_E92_D1.2431.00
91_L126_T1.2241.00
197_P234_V1.2201.00
292_A296_Q1.2191.00
136_I208_S1.2161.00
176_V185_W1.2121.00
53_E261_K1.2121.00
80_Y104_G1.2111.00
11_I42_L1.2081.00
63_E67_E1.2051.00
86_N89_T1.2011.00
105_Y131_T1.1961.00
226_L231_D1.1951.00
66_V97_S1.1781.00
60_K64_Q1.1761.00
59_Q96_L1.1681.00
126_T277_P1.1671.00
34_I73_A1.1481.00
38_L76_K1.1471.00
128_I158_Q1.1441.00
24_K88_S1.1401.00
48_A65_M1.1371.00
223_Y227_K1.1291.00
184_G205_H1.1241.00
126_T129_E1.1041.00
292_A295_K1.1021.00
70_V103_D1.1021.00
231_D235_K1.0971.00
67_E96_L1.0931.00
263_G294_L1.0861.00
20_N26_E1.0851.00
63_E99_K1.0821.00
73_A79_V1.0821.00
95_Q99_K1.0781.00
95_Q130_S1.0721.00
29_A271_V1.0691.00
19_F57_L1.0671.00
221_M224_D1.0661.00
28_E31_F1.0641.00
67_E100_K1.0611.00
126_T130_S1.0591.00
232_E235_K1.0531.00
262_A265_E1.0511.00
148_E178_T1.0461.00
262_A291_E1.0421.00
27_E31_F1.0421.00
152_R155_E1.0261.00
13_G37_L1.0251.00
34_I72_A1.0241.00
81_T102_A1.0161.00
80_Y136_I1.0161.00
21_T274_T1.0131.00
96_L100_K1.0111.00
118_E121_Y1.0051.00
105_Y133_L1.0041.00
118_E283_E0.9991.00
172_N199_Y0.9921.00
83_V97_S0.9901.00
282_V286_H0.9891.00
84_G108_L0.9891.00
233_L237_L0.9891.00
91_L95_Q0.9771.00
282_V290_L0.9761.00
46_F106_L0.9761.00
13_G42_L0.9761.00
9_A205_H0.9731.00
105_Y135_A0.9701.00
201_P231_D0.9681.00
189_M194_V0.9661.00
287_Y291_E0.9651.00
31_F35_E0.9651.00
11_I220_R0.9641.00
59_Q93_W0.9611.00
174_N247_D0.9581.00
153_L159_L0.9451.00
151_K179_I0.9451.00
286_H289_Q0.9441.00
121_Y149_Q0.9391.00
289_Q292_A0.9381.00
91_L130_S0.9361.00
33_N264_M0.9271.00
92_D96_L0.9261.00
139_Q144_V0.9251.00
265_E287_Y0.9211.00
235_K239_R0.9151.00
232_E236_E0.9151.00
117_Q152_R0.9141.00
128_I135_A0.9131.00
70_V102_A0.9121.00
154_T183_L0.9101.00
244_P296_Q0.9101.00
137_L150_I0.9071.00
15_P37_L0.9061.00
211_I246_N0.9041.00
23_G88_S0.9031.00
200_L223_Y0.9031.00
43_E223_Y0.9031.00
60_K92_D0.9011.00
62_Y93_W0.8981.00
19_F276_R0.8951.00
151_K155_E0.8921.00
85_G89_T0.8901.00
83_V105_Y0.8851.00
225_A237_L0.8801.00
122_Q280_G0.8801.00
109_P143_A0.8791.00
293_I296_Q0.8761.00
70_V100_K0.8761.00
38_L73_A0.8741.00
34_I68_V0.8701.00
92_D95_Q0.8691.00
120_L143_A0.8681.00
266_I295_K0.8671.00
209_S212_S0.8631.00
23_G277_P0.8591.00
222_F237_L0.8571.00
79_V102_A0.8551.00
285_D288_Q0.8501.00
196_M207_Y0.8481.00
273_N287_Y0.8471.00
95_Q98_E0.8471.00
248_I293_I0.8461.00
107_I135_A0.8431.00
47_I65_M0.8431.00
26_E270_N0.8411.00
147_V178_T0.8391.00
11_I207_Y0.8311.00
186_L206_S0.8261.00
42_L216_P0.8261.00
87_L91_L0.8251.00
201_P226_L0.8241.00
128_I159_L0.8231.00
11_I223_Y0.8211.00
29_A270_N0.8141.00
201_P235_K0.8071.00
28_E32_Q0.8061.00
285_D289_Q0.8051.00
156_C159_L0.8041.00
198_A201_P0.8021.00
32_Q269_L0.7991.00
23_G274_T0.7941.00
121_Y156_C0.7931.00
60_K63_E0.7891.00
215_I245_I0.7871.00
15_P45_I0.7821.00
66_V102_A0.7821.00
40_E216_P0.7751.00
273_N281_P0.7701.00
48_A81_T0.7701.00
147_V171_L0.7681.00
265_E271_V0.7671.00
147_V174_N0.7661.00
11_I212_S0.7641.00
243_L247_D0.7641.00
97_S102_A0.7631.00
50_G112_L0.7631.00
266_I287_Y0.7571.00
147_V151_K0.7561.00
88_S92_D0.7551.00
229_G232_E0.7511.00
66_V100_K0.7481.00
197_P226_L0.7481.00
15_P30_L0.7461.00
187_N199_Y0.7441.00
57_L65_M0.7421.00
179_I205_H0.7371.00
30_L34_I0.7351.00
215_I218_I0.7311.00
215_I242_I0.7311.00
138_Y163_K0.7281.00
101_G133_L0.7271.00
122_Q277_P0.7261.00
34_I45_I0.7191.00
44_A80_Y0.7181.00
90_A107_I0.7171.00
198_A202_I0.7051.00
221_M237_L0.7021.00
25_L30_L0.7011.00
20_N28_E0.6991.00
45_I73_A0.6981.00
238_Y243_L0.6981.00
78_P103_D0.6961.00
117_Q148_E0.6941.00
73_A76_K0.6921.00
87_L126_T0.6891.00
228_N233_L0.6861.00
109_P145_L0.6861.00
274_T281_P0.6851.00
172_N185_W0.6841.00
150_I175_L0.6821.00
155_E182_R0.6821.00
20_N274_T0.6811.00
251_Q286_H0.6791.00
38_L72_A0.6760.99
174_N177_Y0.6740.99
222_F226_L0.6740.99
83_V107_I0.6720.99
145_L150_I0.6720.99
217_H267_M0.6720.99
36_F267_M0.6690.99
258_S275_A0.6680.99
148_E174_N0.6680.99
218_I221_M0.6680.99
63_E93_W0.6660.99
170_D194_V0.6660.99
59_Q63_E0.6630.99
37_L42_L0.6600.99
173_I177_Y0.6600.99
54_F82_G0.6590.99
155_E180_G0.6560.99
48_A57_L0.6550.99
258_S282_V0.6530.99
116_E258_S0.6510.99
63_E100_K0.6500.99
73_A77_V0.6490.99
275_A279_V0.6480.99
37_L40_E0.6470.99
63_E97_S0.6460.99
125_K152_R0.6450.99
12_L80_Y0.6450.99
196_M222_F0.6440.99
271_V274_T0.6440.99
33_N37_L0.6440.99
20_N23_G0.6420.99
137_L145_L0.6400.99
144_V168_N0.6390.99
8_P104_G0.6380.99
58_S88_S0.6380.99
139_Q164_D0.6380.99
15_P69_A0.6360.99
266_I294_L0.6350.99
119_G280_G0.6340.99
289_Q293_I0.6330.99
172_N176_V0.6300.99
176_V179_I0.6270.99
288_Q295_K0.6250.99
55_Q113_V0.6250.99
173_I202_I0.6230.99
154_T179_I0.6230.99
25_L65_M0.6230.99
252_R286_H0.6210.99
67_E99_K0.6200.99
264_M267_M0.6200.99
197_P231_D0.6200.99
89_T92_D0.6180.99
176_V205_H0.6150.99
50_G138_Y0.6140.99
132_D158_Q0.6130.99
198_A238_Y0.6130.99
264_M269_L0.6110.99
66_V70_V0.6100.99
177_Y239_R0.6080.99
225_A228_N0.6080.99
293_I297_A0.6030.99
35_E38_L0.5960.99
48_A62_Y0.5950.99
263_G266_I0.5940.99
173_I238_Y0.5940.99
282_V287_Y0.5910.99
27_E72_A0.5900.99
136_I160_V0.5850.99
47_I79_V0.5800.98
25_L68_V0.5770.98
116_E119_G0.5770.98
197_P238_Y0.5770.98
179_I182_R0.5760.98
9_A43_E0.5750.98
164_D172_N0.5740.98
200_L227_K0.5680.98
253_K259_L0.5680.98
21_T271_V0.5670.98
262_A275_A0.5660.98
224_D227_K0.5650.98
145_L149_Q0.5650.98
149_Q152_R0.5650.98
275_A280_G0.5650.98
214_Y263_G0.5630.98
148_E151_K0.5600.98
41_G220_R0.5580.98
75_G103_D0.5550.98
14_F210_A0.5530.98
160_V184_G0.5490.98
161_G184_G0.5470.98
129_E158_Q0.5460.98
16_V260_I0.5440.98
226_L234_V0.5430.98
102_A133_L0.5420.98
71_S74_G0.5420.98
80_Y106_L0.5420.98
42_L220_R0.5400.98
218_I237_L0.5390.98
109_P124_A0.5380.97
19_F61_E0.5380.97
284_K291_E0.5380.97
60_K96_L0.5370.97
169_M195_T0.5360.97
46_F80_Y0.5350.97
225_A234_V0.5330.97
94_A127_I0.5310.97
214_Y260_I0.5290.97
173_I198_A0.5270.97
168_N171_L0.5270.97
14_F209_S0.5270.97
118_E280_G0.5250.97
236_E239_R0.5250.97
237_L240_H0.5230.97
81_T97_S0.5230.97
210_A260_I0.5220.97
116_E252_R0.5220.97
196_M219_S0.5220.97
196_M223_Y0.5210.97
123_Y126_T0.5200.97
177_Y244_P0.5180.97
33_N269_L0.5180.97
124_A159_L0.5170.97
14_F190_P0.5160.97
90_A94_A0.5160.97
24_K64_Q0.5150.97
48_A66_V0.5120.97
49_C138_Y0.5110.97
85_G93_W0.5110.97
185_W199_Y0.5100.97
107_I124_A0.5100.97
15_P34_I0.5080.96
161_G183_L0.5060.96
62_Y89_T0.5050.96
249_R260_I0.5050.96
91_L127_I0.5040.96
263_G290_L0.5040.96
36_F216_P0.5030.96
62_Y96_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i7wA 3 0.9286 100 0.089 Contact Map
3si9A 3 0.9383 100 0.089 Contact Map
3na8A 3 0.9286 100 0.093 Contact Map
3eb2A 3 0.9318 100 0.094 Contact Map
2ojpA 2 0.9286 100 0.094 Contact Map
3l21A 5 0.9448 100 0.095 Contact Map
4oe7A 3 0.9383 100 0.096 Contact Map
4fhaA 3 0.9578 100 0.096 Contact Map
3qzeA 2 0.9286 100 0.097 Contact Map
4pfmA 2 0.9416 100 0.097 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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