GREMLIN Database
TCYB - L-cystine transport system permease protein TcyB
UniProt: P42200 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (204)
Sequences: 38692 (24173)
Seq/√Len: 1692.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Y37_P3.6211.00
135_G145_T3.4611.00
45_F109_S3.2371.00
41_L105_V2.8681.00
141_T144_K2.7251.00
104_A176_A2.6971.00
143_Q147_F2.5331.00
144_K148_R2.4581.00
163_S221_Q2.4411.00
136_Y145_T2.4261.00
123_S157_V2.1551.00
219_L223_V2.1021.00
197_D201_V1.9811.00
131_Q153_Q1.9631.00
132_W145_T1.9581.00
53_T117_S1.9511.00
37_P101_F1.9261.00
132_W136_Y1.8741.00
132_W150_I1.8591.00
140_M144_K1.8531.00
189_Q192_G1.8461.00
34_Y37_P1.8281.00
186_R190_E1.8131.00
186_R189_Q1.8111.00
116_A165_T1.8061.00
29_S33_Y1.8051.00
187_K190_E1.8021.00
121_R125_L1.7991.00
78_T83_Q1.7801.00
56_A68_F1.7771.00
53_T113_G1.7481.00
39_T166_F1.7311.00
62_R65_R1.6701.00
142_H145_T1.6431.00
54_A120_I1.6391.00
144_K147_F1.6191.00
30_G33_Y1.6181.00
69_S121_R1.6061.00
63_P66_W1.6061.00
136_Y142_H1.5981.00
87_I107_A1.5971.00
188_A206_A1.5971.00
51_L120_I1.5931.00
223_V226_R1.5761.00
135_G140_M1.5501.00
62_R66_W1.5401.00
63_P67_V1.5381.00
105_V109_S1.5371.00
43_F166_F1.5311.00
48_I52_I1.5301.00
215_F219_L1.5121.00
45_F105_V1.4831.00
47_M162_L1.4641.00
188_A192_G1.4441.00
219_L222_H1.4351.00
141_T145_T1.4291.00
37_P41_L1.4251.00
49_L113_G1.4121.00
57_R69_S1.4091.00
142_H146_L1.3991.00
58_M125_L1.3811.00
27_I30_G1.3791.00
50_A116_A1.3161.00
201_V204_I1.2961.00
185_F188_A1.2841.00
140_M148_R1.2681.00
43_F162_L1.2661.00
135_G149_V1.2611.00
72_V117_S1.2591.00
188_A191_I1.2581.00
184_L187_K1.2561.00
129_K133_E1.2221.00
61_V66_W1.2151.00
211_W215_F1.1971.00
102_P105_V1.1951.00
183_E188_A1.1731.00
194_R197_D1.1711.00
200_L204_I1.1681.00
25_W29_S1.1601.00
99_D102_P1.1511.00
214_C218_S1.1511.00
220_V223_V1.1501.00
189_Q193_A1.1471.00
204_I207_A1.1471.00
61_V65_R1.1461.00
183_E186_R1.1421.00
95_N98_L1.1391.00
183_E187_K1.1231.00
192_G199_I1.1231.00
30_G34_Y1.1191.00
35_T170_I1.1101.00
32_I213_I1.1071.00
41_L109_S1.0981.00
61_V64_L1.0691.00
185_F189_Q1.0671.00
67_V70_V1.0621.00
34_Y181_V1.0571.00
44_I162_L1.0461.00
67_V71_Y1.0431.00
190_E194_R1.0421.00
39_T170_I1.0401.00
130_G133_E1.0261.00
101_F105_V1.0211.00
65_R69_S1.0211.00
42_S108_F1.0131.00
108_F169_L1.0121.00
223_V227_R1.0061.00
129_K132_W1.0061.00
134_A137_T0.9951.00
42_S169_L0.9921.00
42_S109_S0.9891.00
118_E121_R0.9871.00
203_Y207_A0.9831.00
26_P30_G0.9771.00
184_L188_A0.9721.00
218_S222_H0.9651.00
222_H225_E0.9561.00
49_L109_S0.9451.00
46_G112_V0.9441.00
54_A124_I0.9431.00
127_V153_Q0.9381.00
83_Q111_N0.9381.00
124_I154_A0.9331.00
190_E193_A0.9301.00
116_A120_I0.9291.00
203_Y206_A0.9251.00
126_S157_V0.9241.00
44_I48_I0.9121.00
60_K63_P0.9101.00
157_V161_P0.9091.00
64_L67_V0.9051.00
120_I158_S0.9041.00
124_I150_I0.9031.00
216_L220_V0.8971.00
116_A162_L0.8951.00
205_E209_I0.8921.00
50_A117_S0.8911.00
29_S32_I0.8871.00
185_F190_E0.8861.00
66_W70_V0.8821.00
41_L45_F0.8751.00
187_K191_I0.8721.00
57_R117_S0.8711.00
38_L176_A0.8671.00
183_E189_Q0.8641.00
119_I161_P0.8611.00
146_L150_I0.8561.00
52_I56_A0.8541.00
39_T173_T0.8531.00
84_L176_A0.8481.00
112_V165_T0.8451.00
182_A186_R0.8441.00
199_I202_I0.8431.00
120_I154_A0.8401.00
200_L203_Y0.8371.00
40_I44_I0.8261.00
55_L146_L0.8201.00
217_L221_Q0.8141.00
38_L104_A0.8121.00
50_A120_I0.8081.00
73_S118_E0.7991.00
37_P40_I0.7961.00
222_H226_R0.7931.00
55_L124_I0.7871.00
38_L101_F0.7871.00
66_W69_S0.7861.00
207_A210_Y0.7841.00
204_I208_F0.7831.00
46_G116_A0.7821.00
195_N199_I0.7811.00
58_M132_W0.7761.00
146_L151_L0.7731.00
112_V169_L0.7671.00
107_A175_L0.7641.00
80_L172_D0.7501.00
86_I90_L0.7491.00
210_Y214_C0.7451.00
188_A202_I0.7351.00
123_S158_S0.7291.00
43_F169_L0.7251.00
59_S132_W0.7251.00
186_R191_I0.7231.00
78_T111_N0.7211.00
184_L189_Q0.7201.00
51_L154_A0.7191.00
56_A59_S0.7161.00
154_A157_V0.7161.00
212_I216_L0.7141.00
68_F117_S0.7101.00
83_Q87_I0.7091.00
58_M124_I0.7081.00
34_Y101_F0.7071.00
185_F191_I0.7051.00
100_P180_L0.7051.00
150_I153_Q0.7031.00
221_Q225_E0.6991.00
183_E190_E0.6951.00
39_T43_F0.6921.00
127_V154_A0.6901.00
178_Q182_A0.6891.00
202_I206_A0.6821.00
102_P106_I0.6821.00
191_I195_N0.6811.00
43_F116_A0.6731.00
53_T68_F0.6701.00
207_A211_W0.6691.00
119_I165_T0.6691.00
132_W142_H0.6671.00
184_L190_E0.6661.00
206_A210_Y0.6661.00
140_M145_T0.6641.00
27_I187_K0.6631.00
202_I205_E0.6571.00
100_P103_S0.6501.00
54_A117_S0.6491.00
99_D103_S0.6471.00
70_V73_S0.6471.00
90_L94_F0.6421.00
113_G117_S0.6411.00
75_I110_L0.6401.00
199_I203_Y0.6401.00
183_E191_I0.6331.00
191_I194_R0.6331.00
213_I217_L0.6321.00
38_L42_S0.6321.00
220_V224_I0.6291.00
84_L107_A0.6241.00
33_Y36_I0.6211.00
41_L44_I0.6191.00
45_F48_I0.6181.00
73_S215_F0.6181.00
120_I124_I0.6171.00
80_L111_N0.6141.00
168_S172_D0.6131.00
120_I161_P0.6121.00
184_L191_I0.6111.00
71_Y75_I0.6111.00
54_A58_M0.6101.00
98_L102_P0.6101.00
215_F218_S0.6091.00
216_L219_L0.6091.00
155_F159_I0.6081.00
104_A108_F0.6061.00
56_A60_K0.6061.00
186_R192_G0.6011.00
147_F151_L0.5961.00
101_F181_V0.5941.00
104_A181_V0.5911.00
128_P131_Q0.5911.00
192_G203_Y0.5901.00
41_L101_F0.5861.00
61_V67_V0.5851.00
42_S105_V0.5841.00
49_L52_I0.5801.00
69_S73_S0.5791.00
208_F212_I0.5771.00
188_A195_N0.5771.00
87_I90_L0.5761.00
184_L192_G0.5751.00
129_K136_Y0.5751.00
51_L158_S0.5731.00
75_I114_A0.5721.00
192_G195_N0.5671.00
207_A214_C0.5661.00
147_F150_I0.5641.00
36_I40_I0.5631.00
108_F176_A0.5611.00
200_L206_A0.5561.00
30_G37_P0.5531.00
59_S63_P0.5511.00
46_G109_S0.5471.00
98_L103_S0.5461.00
204_I210_Y0.5451.00
100_P181_V0.5401.00
86_I204_I0.5401.00
38_L105_V0.5401.00
31_G187_K0.5401.00
200_L207_A0.5381.00
194_R199_I0.5371.00
37_P102_P0.5351.00
48_I51_L0.5331.00
145_T148_R0.5321.00
60_K64_L0.5321.00
84_L179_I0.5311.00
190_E195_N0.5311.00
81_L178_Q0.5301.00
55_L151_L0.5301.00
71_Y113_G0.5281.00
187_K194_R0.5271.00
131_Q149_V0.5261.00
202_I207_A0.5251.00
116_A161_P0.5241.00
151_L158_S0.5241.00
90_L93_A0.5221.00
161_P164_N0.5191.00
83_Q107_A0.5191.00
188_A193_A0.5151.00
60_K65_R0.5151.00
57_R118_E0.5141.00
87_I103_S0.5061.00
183_E192_G0.5041.00
205_E208_F0.5041.00
38_L108_F0.5011.00
43_F47_M0.5011.00
187_K192_G0.5001.00
193_A197_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9402 100 0.347 Contact Map
4ymuD 2 0.9188 100 0.361 Contact Map
3d31C 2 0.9444 100 0.362 Contact Map
3rlfF 1 0.9359 100 0.386 Contact Map
3tuiA 2 0.8932 100 0.404 Contact Map
4tquM 1 0.9615 100 0.407 Contact Map
3rlfG 1 0.9957 99.9 0.426 Contact Map
4tquN 1 0.9444 99.9 0.45 Contact Map
4mrsA 2 0.406 9.2 0.944 Contact Map
3w9iA 3 0.8034 7.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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