GREMLIN Database
TCYA - L-cystine-binding protein TcyA
UniProt: P42199 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (225)
Sequences: 20861 (14270)
Seq/√Len: 951.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V88_D3.5341.00
50_G106_F3.4361.00
156_A192_V3.3361.00
82_R247_E2.8061.00
48_T88_D2.3751.00
164_N176_G2.3701.00
115_K119_E2.3281.00
126_D246_K2.3241.00
177_V186_M2.2011.00
62_D65_T2.1581.00
115_K227_Y2.1451.00
179_G182_Q2.1151.00
48_T90_K2.1091.00
100_G106_F2.1021.00
102_N121_K2.0951.00
62_D69_T2.0871.00
164_N168_T2.0721.00
46_V86_K2.0251.00
82_R244_A2.0081.00
183_A195_T1.9961.00
123_D238_V1.9841.00
122_Y229_T1.9781.00
253_T256_K1.9781.00
230_F238_V1.9451.00
78_E81_K1.9001.00
255_S259_K1.8961.00
186_M191_R1.8691.00
197_N202_V1.8561.00
246_K250_E1.8381.00
80_A87_V1.8261.00
154_T175_E1.8221.00
49_V76_I1.7931.00
238_V242_N1.7711.00
100_G105_R1.7281.00
230_F241_V1.7231.00
146_S149_D1.7161.00
138_K190_G1.7021.00
78_E253_T1.6861.00
126_D242_N1.6831.00
145_K149_D1.6761.00
78_E248_M1.6601.00
154_T173_K1.6241.00
78_E82_R1.5841.00
235_G239_D1.5801.00
130_T225_S1.5671.00
110_A228_F1.5661.00
136_V202_V1.5461.00
231_R234_S1.4791.00
92_T100_G1.4781.00
62_D67_K1.4321.00
199_K203_L1.4301.00
39_A43_K1.4221.00
74_E260_K1.4201.00
159_L178_E1.3951.00
134_V199_K1.3841.00
49_V108_V1.3751.00
240_Q243_K1.3641.00
97_M109_V1.3591.00
153_K193_D1.3561.00
125_S242_N1.3541.00
73_V77_T1.3511.00
186_M192_V1.3501.00
82_R251_D1.3501.00
239_D243_K1.3471.00
151_K171_G1.3421.00
165_K169_N1.3381.00
61_H91_E1.3361.00
60_Y69_T1.3291.00
53_G91_E1.3261.00
123_D233_G1.3221.00
79_V244_A1.3091.00
187_I214_V1.2891.00
168_T176_G1.2851.00
139_K213_N1.2851.00
83_L244_A1.2721.00
133_A163_Y1.2681.00
244_A247_E1.2571.00
98_F122_Y1.2511.00
76_I110_A1.2351.00
140_D215_K1.2301.00
188_Q213_N1.2221.00
113_V229_T1.2161.00
85_L240_Q1.2121.00
40_S44_K1.2061.00
185_Q188_Q1.2051.00
104_K231_R1.2041.00
99_A102_N1.1931.00
155_S194_M1.1931.00
156_A177_V1.1891.00
77_T89_F1.1891.00
137_T194_M1.1851.00
135_V194_M1.1701.00
249_K254_L1.1611.00
240_Q244_A1.1561.00
39_A42_K1.1531.00
139_K215_K1.1421.00
123_D235_G1.1371.00
185_Q189_Q1.1361.00
99_A103_S1.1301.00
247_E251_D1.1251.00
235_G238_V1.1221.00
72_D128_Y1.1221.00
154_T193_D1.1201.00
244_A248_M1.1151.00
157_Q164_N1.1141.00
178_E182_Q1.0881.00
137_T217_A1.0551.00
204_N208_T1.0521.00
71_Y258_S1.0491.00
45_G85_L1.0451.00
93_Q96_S1.0381.00
69_T74_E1.0301.00
134_V216_I1.0291.00
243_K247_E1.0251.00
74_E261_W1.0211.00
123_D232_K1.0201.00
77_T81_K1.0121.00
109_V113_V1.0091.00
187_I192_V1.0071.00
75_V254_L1.0051.00
177_V183_A1.0031.00
253_T257_I1.0021.00
74_E77_T0.9991.00
76_I89_F0.9981.00
71_Y257_I0.9981.00
36_D236_E0.9971.00
187_I195_T0.9911.00
159_L176_G0.9841.00
236_E240_Q0.9811.00
158_S161_S0.9801.00
125_S241_V0.9781.00
38_W41_I0.9711.00
188_Q209_S0.9661.00
182_Q185_Q0.9651.00
92_T106_F0.9651.00
61_H66_D0.9641.00
44_K48_T0.9641.00
126_D249_K0.9631.00
108_V230_F0.9521.00
37_L40_S0.9521.00
68_L73_V0.9451.00
53_G68_L0.9451.00
71_Y262_F0.9391.00
56_E60_Y0.9351.00
49_V87_V0.9301.00
79_V241_V0.9291.00
124_F229_T0.9271.00
165_K168_T0.9271.00
181_A185_Q0.9261.00
117_D120_D0.9261.00
76_I87_V0.9211.00
108_V241_V0.9181.00
131_S200_L0.9151.00
248_M253_T0.9111.00
98_F113_V0.9081.00
156_A183_A0.8881.00
166_L169_N0.8871.00
75_V248_M0.8681.00
148_A151_K0.8661.00
180_M197_N0.8631.00
82_R253_T0.8631.00
132_R199_K0.8601.00
242_N246_K0.8601.00
67_K77_T0.8581.00
119_E232_K0.8571.00
136_V214_V0.8491.00
78_E244_A0.8461.00
254_L258_S0.8451.00
61_H68_L0.8451.00
255_S258_S0.8371.00
144_I149_D0.8291.00
47_L108_V0.8261.00
242_N245_L0.8251.00
36_D40_S0.8231.00
96_S100_G0.8231.00
41_I85_L0.8181.00
36_D39_A0.8171.00
51_T89_F0.8161.00
137_T215_K0.8121.00
256_K260_K0.8101.00
41_I44_K0.8091.00
48_T107_D0.8061.00
256_K259_K0.8011.00
76_I228_F0.7961.00
38_W42_K0.7941.00
47_L85_L0.7931.00
258_S262_F0.7921.00
108_V228_F0.7901.00
114_G224_Q0.7881.00
150_V194_M0.7861.00
76_I108_V0.7861.00
58_F129_T0.7801.00
83_L240_Q0.7781.00
247_E250_E0.7681.00
47_L80_A0.7621.00
60_Y261_W0.7551.00
102_N122_Y0.7541.00
236_E239_D0.7531.00
248_M251_D0.7521.00
82_R248_M0.7471.00
71_Y254_L0.7471.00
132_R220_T0.7451.00
175_E186_M0.7451.00
79_V83_L0.7431.00
243_K246_K0.7421.00
182_Q186_M0.7381.00
125_S228_F0.7381.00
51_T73_V0.7301.00
203_L207_K0.7291.00
109_V229_T0.7261.00
90_K105_R0.7261.00
79_V110_A0.7261.00
94_W97_M0.7221.00
135_V196_Y0.7161.00
46_V85_L0.7121.00
130_T223_P0.7111.00
204_N207_K0.7111.00
77_T87_V0.7081.00
131_S199_K0.7071.00
98_F102_N0.7031.00
246_K249_K0.7021.00
41_I45_G0.6961.00
96_S99_A0.6921.00
184_L188_Q0.6901.00
42_K45_G0.6891.00
248_M254_L0.6851.00
168_T174_V0.6841.00
248_M252_G0.6781.00
51_T111_N0.6761.00
239_D242_N0.6751.00
101_L106_F0.6741.00
35_G40_S0.6701.00
138_K213_N0.6691.00
125_S230_F0.6671.00
75_V245_L0.6651.00
101_L231_R0.6641.00
203_L216_I0.6621.00
78_E257_I0.6561.00
234_S237_V0.6541.00
115_K127_K0.6531.00
52_E94_W0.6491.00
209_S213_N0.6481.00
69_T261_W0.6461.00
102_N231_R0.6401.00
90_K106_F0.6401.00
49_V89_F0.6391.00
143_D215_K0.6381.00
101_L122_Y0.6371.00
134_V202_V0.6331.00
73_V89_F0.6311.00
118_R124_F0.6291.00
175_E192_V0.6191.00
104_K233_G0.6181.00
228_F241_V0.6171.00
123_D234_S0.6141.00
53_G61_H0.6131.00
76_I80_A0.6111.00
133_A196_Y0.6101.00
124_F227_Y0.6071.00
127_K130_T0.6001.00
202_V206_L0.5991.00
197_N201_A0.5981.00
167_A174_V0.5981.00
156_A186_M0.5951.00
125_S245_L0.5941.00
80_A85_L0.5941.00
50_G97_M0.5931.00
56_E208_T0.5921.00
151_K170_A0.5921.00
92_T97_M0.5911.00
132_R223_P0.5911.00
53_G59_T0.5901.00
252_G255_S0.5891.00
158_S180_M0.5881.00
101_L109_V0.5851.00
40_S43_K0.5841.00
52_E59_T0.5841.00
132_R222_E0.5841.00
82_R240_Q0.5831.00
248_M257_I0.5821.00
51_T68_L0.5801.00
114_G118_R0.5781.00
134_V218_F0.5781.00
143_D153_K0.5781.00
83_L237_V0.5771.00
184_L214_V0.5751.00
55_Y94_W0.5741.00
52_E158_S0.5731.00
170_A174_V0.5721.00
136_V184_L0.5691.00
74_E257_I0.5661.00
80_A83_L0.5651.00
42_K240_Q0.5601.00
188_Q214_V0.5601.00
131_S226_T0.5591.00
37_L231_R0.5571.00
177_V192_V0.5561.00
135_V150_V0.5551.00
167_A196_Y0.5531.00
140_D190_G0.5531.00
252_G256_K0.5531.00
55_Y112_Q0.5531.00
155_S167_A0.5531.00
72_D112_Q0.5521.00
59_T111_N0.5521.00
154_T192_V0.5521.00
214_V217_A0.5491.00
50_G109_V0.5491.00
162_N224_Q0.5451.00
136_V206_L0.5451.00
129_T226_T0.5441.00
35_G39_A0.5421.00
119_E123_D0.5421.00
188_Q211_N0.5371.00
44_K107_D0.5371.00
113_V122_Y0.5351.00
159_L164_N0.5351.00
125_S238_V0.5341.00
126_D245_L0.5321.00
52_E111_N0.5311.00
115_K124_F0.5301.00
79_V228_F0.5271.00
90_K100_G0.5201.00
114_G162_N0.5201.00
220_T223_P0.5181.00
157_Q167_A0.5181.00
94_W113_V0.5171.00
199_K220_T0.5161.00
175_E191_R0.5151.00
57_P60_Y0.5151.00
38_W85_L0.5071.00
65_T69_T0.5061.00
205_Y208_T0.5051.00
186_M189_Q0.5051.00
81_K253_T0.5041.00
157_Q176_G0.5031.00
157_Q174_V0.5031.00
37_L41_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ylnA 1 0.8769 100 0.262 Contact Map
1xt8A 1 0.8694 100 0.291 Contact Map
2yjpA 1 0.8582 100 0.296 Contact Map
4ohnA 1 0.8731 100 0.308 Contact Map
2ieeA 1 0.8657 100 0.318 Contact Map
1pb7A 1 0.9254 100 0.318 Contact Map
3hv1A 2 0.8918 100 0.32 Contact Map
2vhaA 2 0.8806 100 0.326 Contact Map
4powA 1 0.8321 100 0.326 Contact Map
3kbrA 4 0.8321 100 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0088 seconds.