ERA - BACSU - GREMLIN Contacts

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ERA - GTPase Era

UniProt:	P42182	Sequences: MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTRNKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYGKGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNNIETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIESIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLELWVKVQKDWRNKMSQLRDFGFKEDEY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (260)
Sequences:	7372 (5510)
Seq/√Len:	341.7

ECOLI - ERA YFJP YKFA CRFC DER MNME ENGB FEOB HFLX OBG
BACSU - ERA YPBR DER MNME ENGB HFLX
HALSA - Q9HQ88 Q9HMC2 ENGB Q9HMD6 Y1111
SULSO - Q7LXR6 HFLX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_S	169_E	3.193	1.00
92_L	122_I	3.009	1.00
149_E	167_Q	2.804	1.00
258_K	262_A	2.698	1.00
167_Q	170_A	2.658	1.00
140_E	144_R	2.603	1.00
139_D	142_R	2.440	1.00
255_E	259_R	2.415	1.00
151_V	167_Q	2.406	1.00
27_R	158_G	2.347	1.00
48_Q	59_I	2.287	1.00
200_K	263_D	2.246	1.00
177_Q	181_S	2.238	1.00
167_Q	171_Y	2.182	1.00
218_E	233_T	2.179	1.00
139_D	143_K	2.148	1.00
97_A	123_V	2.082	1.00
264_I	268_L	2.074	1.00
137_L	140_E	1.994	1.00
138_I	152_P	1.945	1.00
27_R	161_I	1.888	1.00
137_L	141_Y	1.886	1.00
13_I	25_L	1.883	1.00
122_I	153_I	1.870	1.00
13_I	92_L	1.857	1.00
24_F	94_M	1.827	1.00
98_E	128_K	1.805	1.00
24_F	28_V	1.761	1.00
125_K	128_K	1.759	1.00
135_L	139_D	1.745	1.00
197_I	232_A	1.741	1.00
257_G	261_R	1.727	1.00
265_E	271_R	1.713	1.00
140_E	143_K	1.700	1.00
12_S	88_V	1.689	1.00
187_H	191_F	1.669	1.00
162_E	166_A	1.655	1.00
195_E	198_R	1.621	1.00
261_R	265_E	1.607	1.00
120_F	171_Y	1.596	1.00
208_E	211_H	1.587	1.00
92_L	168_I	1.576	1.00
239_D	243_G	1.563	1.00
23_T	155_A	1.556	1.00
223_Q	229_H	1.552	1.00
122_I	164_L	1.550	1.00
28_V	161_I	1.545	1.00
23_T	36_M	1.544	1.00
185_T	189_E	1.533	1.00
203_H	206_R	1.532	1.00
184_V	188_P	1.522	1.00
138_I	141_Y	1.512	1.00
78_M	81_A	1.508	1.00
201_V	205_T	1.497	1.00
211_H	215_V	1.483	1.00
262_A	266_A	1.476	1.00
121_L	147_F	1.464	1.00
106_E	110_E	1.454	1.00
11_V	58_T	1.448	1.00
90_L	168_I	1.448	1.00
134_L	137_L	1.448	1.00
92_L	164_L	1.438	1.00
103_K	107_F	1.426	1.00
55_T	169_E	1.424	1.00
94_M	124_N	1.413	1.00
242_K	246_I	1.412	1.00
53_T	169_E	1.409	1.00
93_F	109_I	1.402	1.00
16_R	104_G	1.397	1.00
106_E	144_R	1.397	1.00
124_N	155_A	1.396	1.00
259_R	262_A	1.387	1.00
160_N	163_T	1.381	1.00
219_S	231_A	1.363	1.00
241_Q	244_I	1.354	1.00
201_V	213_I	1.352	1.00
228_V	270_S	1.342	1.00
193_I	220_I	1.329	1.00
129_I	134_L	1.326	1.00
190_R	193_I	1.319	1.00
136_L	139_D	1.312	1.00
82_Q	111_K	1.306	1.00
190_R	194_S	1.301	1.00
90_L	171_Y	1.288	1.00
163_T	167_Q	1.286	1.00
138_I	142_R	1.283	1.00
123_V	138_I	1.279	1.00
200_K	203_H	1.279	1.00
71_H	74_G	1.263	1.00
161_I	165_L	1.257	1.00
215_V	219_S	1.247	1.00
121_L	148_K	1.241	1.00
209_I	213_I	1.238	1.00
16_R	105_D	1.231	1.00
95_I	121_L	1.227	1.00
101_Y	106_E	1.225	1.00
217_I	232_A	1.218	1.00
110_E	114_T	1.215	1.00
240_S	244_I	1.214	1.00
189_E	196_L	1.208	1.00
251_S	255_E	1.198	1.00
51_L	165_L	1.188	1.00
109_I	113_Q	1.186	1.00
24_F	153_I	1.176	1.00
52_T	177_Q	1.173	1.00
191_F	194_S	1.170	1.00
135_L	138_I	1.166	1.00
28_V	51_L	1.162	1.00
210_P	213_I	1.160	1.00
228_V	268_L	1.154	1.00
238_R	241_Q	1.151	1.00
120_F	167_Q	1.151	1.00
90_L	120_F	1.144	1.00
123_V	152_P	1.129	1.00
25_L	60_F	1.128	1.00
204_L	259_R	1.128	1.00
246_I	250_G	1.127	1.00
119_V	148_K	1.117	1.00
252_L	255_E	1.115	1.00
141_Y	144_R	1.113	1.00
204_L	208_E	1.107	1.00
130_H	159_N	1.092	1.00
53_T	165_L	1.091	1.00
142_R	150_I	1.087	1.00
96_N	125_K	1.081	1.00
212_S	241_Q	1.077	1.00
217_I	223_Q	1.076	1.00
149_E	171_Y	1.075	1.00
76_F	80_V	1.072	1.00
68_K	104_G	1.071	1.00
193_I	197_I	1.059	1.00
222_G	270_S	1.059	1.00
110_E	113_Q	1.059	1.00
214_A	218_E	1.058	1.00
72_K	75_D	1.057	1.00
201_V	204_L	1.051	1.00
29_I	51_L	1.049	1.00
109_I	112_L	1.047	1.00
254_K	258_K	1.039	1.00
24_F	164_L	1.039	1.00
208_E	212_S	1.027	1.00
119_V	145_Y	1.024	1.00
126_I	129_I	1.024	1.00
11_V	168_I	1.021	1.00
188_P	195_E	1.017	1.00
96_N	124_N	1.011	1.00
24_F	161_I	1.007	1.00
189_E	192_I	0.994	1.00
206_R	210_P	0.991	1.00
126_I	152_P	0.989	1.00
200_K	204_L	0.987	1.00
76_F	79_K	0.987	1.00
207_E	213_I	0.982	1.00
210_P	214_A	0.980	1.00
16_R	102_G	0.977	1.00
231_A	235_V	0.966	1.00
45_N	191_F	0.964	1.00
120_F	151_V	0.960	1.00
28_V	165_L	0.959	1.00
215_V	218_E	0.958	1.00
165_L	168_I	0.957	1.00
193_I	196_L	0.956	1.00
75_D	79_K	0.952	1.00
204_L	255_E	0.946	1.00
69_P	74_G	0.943	1.00
188_P	192_I	0.940	1.00
191_F	195_E	0.938	1.00
102_G	105_D	0.937	1.00
188_P	191_F	0.933	1.00
53_T	56_S	0.931	1.00
136_L	140_E	0.930	1.00
164_L	168_I	0.929	1.00
239_D	242_K	0.929	1.00
50_V	57_Q	0.928	1.00
163_T	166_A	0.923	1.00
189_E	193_I	0.912	1.00
204_L	207_E	0.912	1.00
29_I	49_G	0.906	1.00
236_V	240_S	0.899	1.00
204_L	213_I	0.899	1.00
205_T	209_I	0.892	1.00
187_H	192_I	0.889	1.00
185_T	190_R	0.887	1.00
103_K	106_E	0.886	1.00
262_A	265_E	0.886	1.00
212_S	216_A	0.886	1.00
188_P	193_I	0.871	1.00
96_N	99_E	0.868	1.00
150_I	153_I	0.867	1.00
73_L	77_M	0.867	1.00
186_D	190_R	0.864	1.00
257_G	260_A	0.863	1.00
73_L	76_F	0.861	1.00
202_L	211_H	0.861	1.00
93_F	112_L	0.856	1.00
51_L	60_F	0.856	1.00
180_P	183_Q	0.856	1.00
122_I	151_V	0.850	1.00
74_G	77_M	0.847	1.00
207_E	210_P	0.844	1.00
166_A	169_E	0.841	1.00
134_L	141_Y	0.839	1.00
186_D	191_F	0.839	1.00
235_V	239_D	0.838	1.00
263_D	267_L	0.835	1.00
169_E	172_L	0.834	1.00
25_L	29_I	0.832	1.00
186_D	189_E	0.832	1.00
91_I	119_V	0.830	1.00
81_A	85_L	0.820	1.00
253_L	257_G	0.820	1.00
218_E	221_K	0.818	1.00
250_G	253_L	0.817	1.00
205_T	213_I	0.810	1.00
107_F	111_K	0.810	1.00
223_Q	227_S	0.809	1.00
256_V	260_A	0.802	1.00
188_P	196_L	0.800	1.00
37_S	41_Q	0.798	1.00
205_T	208_E	0.797	1.00
111_K	114_T	0.794	1.00
120_F	149_E	0.787	1.00
212_S	215_V	0.781	1.00
231_A	234_I	0.781	1.00
214_A	217_I	0.780	1.00
246_I	253_L	0.780	1.00
229_H	233_T	0.778	1.00
149_E	152_P	0.771	1.00
158_G	161_I	0.770	1.00
137_L	142_R	0.770	1.00
244_I	248_K	0.769	1.00
184_V	195_E	0.766	1.00
243_G	247_G	0.765	1.00
238_R	242_K	0.765	1.00
227_S	231_A	0.763	1.00
199_E	203_H	0.759	1.00
25_L	49_G	0.750	1.00
121_L	150_I	0.749	1.00
61_I	87_E	0.748	1.00
207_E	211_H	0.738	0.99
243_G	253_L	0.737	0.99
131_P	159_N	0.736	0.99
24_F	155_A	0.736	0.99
237_E	241_Q	0.732	0.99
38_D	203_H	0.729	0.99
52_T	57_Q	0.728	0.99
216_A	219_S	0.726	0.99
134_L	138_I	0.724	0.99
16_R	19_V	0.722	0.99
148_K	152_P	0.718	0.99
193_I	264_I	0.711	0.99
202_L	205_T	0.710	0.99
48_Q	51_L	0.710	0.99
95_I	141_Y	0.705	0.99
192_I	195_E	0.700	0.99
68_K	77_M	0.700	0.99
266_A	269_G	0.688	0.99
165_L	169_E	0.688	0.99
220_I	223_Q	0.685	0.99
219_S	223_Q	0.685	0.99
235_V	238_R	0.684	0.99
11_V	90_L	0.683	0.99
97_A	129_I	0.682	0.99
98_E	123_V	0.680	0.99
93_F	119_V	0.679	0.99
53_T	166_A	0.679	0.99
113_Q	146_P	0.677	0.99
249_K	253_L	0.677	0.99
220_I	268_L	0.677	0.99
69_P	73_L	0.673	0.99
250_G	257_G	0.672	0.99
201_V	209_I	0.672	0.99
104_G	107_F	0.671	0.99
203_H	208_E	0.669	0.99
241_Q	246_I	0.668	0.99
208_E	213_I	0.667	0.99
260_A	263_D	0.666	0.99
185_T	188_P	0.664	0.99
201_V	206_R	0.664	0.99
92_L	120_F	0.664	0.99
206_R	213_I	0.664	0.99
79_K	83_N	0.663	0.99
246_I	251_S	0.662	0.99
241_Q	245_V	0.661	0.99
12_S	91_I	0.661	0.99
19_V	105_D	0.659	0.99
232_A	236_V	0.658	0.99
107_F	110_E	0.658	0.99
166_A	170_A	0.657	0.99
171_Y	175_G	0.657	0.99
26_N	36_M	0.656	0.99
185_T	191_F	0.656	0.99
250_G	254_K	0.656	0.99
51_L	58_T	0.656	0.99
234_I	238_R	0.654	0.99
252_L	256_V	0.653	0.99
169_E	173_P	0.652	0.99
16_R	67_H	0.652	0.99
42_T	46_K	0.650	0.99
204_L	216_A	0.649	0.99
253_L	265_E	0.648	0.99
94_M	153_I	0.648	0.99
202_L	206_R	0.647	0.99
31_Q	184_V	0.645	0.99
211_H	220_I	0.643	0.99
219_S	222_G	0.638	0.98
66_I	82_Q	0.636	0.98
157_E	160_N	0.635	0.98
62_D	65_G	0.631	0.98
151_V	160_N	0.629	0.98
123_V	137_L	0.629	0.98
156_L	160_N	0.623	0.98
151_V	154_S	0.622	0.98
199_E	202_L	0.621	0.98
37_S	203_H	0.620	0.98
199_E	205_T	0.620	0.98
254_K	257_G	0.618	0.98
118_P	148_K	0.610	0.98
54_G	166_A	0.610	0.98
182_D	188_P	0.610	0.98
176_P	179_Y	0.609	0.98
101_Y	105_D	0.602	0.98
137_L	144_R	0.602	0.98
192_I	267_L	0.600	0.98
67_H	74_G	0.598	0.98
242_K	250_G	0.594	0.98
108_I	112_L	0.593	0.98
19_V	123_V	0.591	0.98
162_E	165_L	0.589	0.97
123_V	141_Y	0.586	0.97
243_G	246_I	0.585	0.97
67_H	78_M	0.583	0.97
54_G	177_Q	0.582	0.97
198_R	201_V	0.579	0.97
248_K	252_L	0.575	0.97
247_G	251_S	0.575	0.97
29_I	33_I	0.573	0.97
201_V	208_E	0.571	0.97
249_K	252_L	0.568	0.97
198_R	202_L	0.565	0.97
70_K	75_D	0.565	0.97
67_H	104_G	0.562	0.97
66_I	108_I	0.561	0.97
240_S	250_G	0.560	0.97
102_G	107_F	0.560	0.97
176_P	180_P	0.557	0.96
246_I	249_K	0.557	0.96
171_Y	174_E	0.557	0.96
184_V	189_E	0.556	0.96
152_P	155_A	0.555	0.96
227_S	230_V	0.554	0.96
25_L	34_A	0.554	0.96
14_I	91_I	0.553	0.96
17_P	43_T	0.552	0.96
260_A	265_E	0.551	0.96
19_V	96_N	0.542	0.96
79_K	82_Q	0.542	0.96
35_I	41_Q	0.541	0.96
24_F	122_I	0.541	0.96
261_R	264_I	0.540	0.96
76_F	83_N	0.538	0.96
75_D	78_M	0.538	0.96
35_I	42_T	0.537	0.96
148_K	151_V	0.536	0.96
212_S	223_Q	0.536	0.96
113_Q	144_R	0.536	0.96
58_T	165_L	0.536	0.96
61_I	88_V	0.533	0.96
36_M	39_K	0.531	0.95
253_L	261_R	0.531	0.95
213_I	216_A	0.527	0.95
217_I	221_K	0.527	0.95
192_I	196_L	0.527	0.95
246_I	254_K	0.526	0.95
258_K	261_R	0.526	0.95
105_D	108_I	0.525	0.95
258_K	271_R	0.524	0.95
182_D	195_E	0.523	0.95
194_S	197_I	0.523	0.95
188_P	194_S	0.521	0.95
134_L	144_R	0.520	0.95
18_N	41_Q	0.517	0.95
99_E	105_D	0.513	0.94
14_I	78_M	0.511	0.94
260_A	264_I	0.508	0.94
43_T	77_M	0.508	0.94
60_F	165_L	0.502	0.94
202_L	208_E	0.502	0.94
149_E	153_I	0.501	0.94
67_H	81_A	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ievA	1	0.9767	100	0.337	Contact Map
1wf3A	1	0.9701	100	0.343	Contact Map
1egaA	2	0.9668	100	0.355	Contact Map
2j69A	1	0.9834	100	0.41	Contact Map
4aurA	1	0.9867	100	0.466	Contact Map
3j8gX	1	0.8505	100	0.491	Contact Map
4dcuA	1	0.8306	100	0.494	Contact Map
1mkyA	1	0.8007	100	0.495	Contact Map
1xzpA	4	0.814	100	0.507	Contact Map
3geeA	2	0.691	100	0.507	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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