GREMLIN Database
ERA - GTPase Era
UniProt: P42182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (260)
Sequences: 7372 (5510)
Seq/√Len: 341.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_S169_E3.1931.00
92_L122_I3.0091.00
149_E167_Q2.8041.00
258_K262_A2.6981.00
167_Q170_A2.6581.00
140_E144_R2.6031.00
139_D142_R2.4401.00
255_E259_R2.4151.00
151_V167_Q2.4061.00
27_R158_G2.3471.00
48_Q59_I2.2871.00
200_K263_D2.2461.00
177_Q181_S2.2381.00
167_Q171_Y2.1821.00
218_E233_T2.1791.00
139_D143_K2.1481.00
97_A123_V2.0821.00
264_I268_L2.0741.00
137_L140_E1.9941.00
138_I152_P1.9451.00
27_R161_I1.8881.00
137_L141_Y1.8861.00
13_I25_L1.8831.00
122_I153_I1.8701.00
13_I92_L1.8571.00
24_F94_M1.8271.00
98_E128_K1.8051.00
24_F28_V1.7611.00
125_K128_K1.7591.00
135_L139_D1.7451.00
197_I232_A1.7411.00
257_G261_R1.7271.00
265_E271_R1.7131.00
140_E143_K1.7001.00
12_S88_V1.6891.00
187_H191_F1.6691.00
162_E166_A1.6551.00
195_E198_R1.6211.00
261_R265_E1.6071.00
120_F171_Y1.5961.00
208_E211_H1.5871.00
92_L168_I1.5761.00
239_D243_G1.5631.00
23_T155_A1.5561.00
223_Q229_H1.5521.00
122_I164_L1.5501.00
28_V161_I1.5451.00
23_T36_M1.5441.00
185_T189_E1.5331.00
203_H206_R1.5321.00
184_V188_P1.5221.00
138_I141_Y1.5121.00
78_M81_A1.5081.00
201_V205_T1.4971.00
211_H215_V1.4831.00
262_A266_A1.4761.00
121_L147_F1.4641.00
106_E110_E1.4541.00
11_V58_T1.4481.00
90_L168_I1.4481.00
134_L137_L1.4481.00
92_L164_L1.4381.00
103_K107_F1.4261.00
55_T169_E1.4241.00
94_M124_N1.4131.00
242_K246_I1.4121.00
53_T169_E1.4091.00
93_F109_I1.4021.00
16_R104_G1.3971.00
106_E144_R1.3971.00
124_N155_A1.3961.00
259_R262_A1.3871.00
160_N163_T1.3811.00
219_S231_A1.3631.00
241_Q244_I1.3541.00
201_V213_I1.3521.00
228_V270_S1.3421.00
193_I220_I1.3291.00
129_I134_L1.3261.00
190_R193_I1.3191.00
136_L139_D1.3121.00
82_Q111_K1.3061.00
190_R194_S1.3011.00
90_L171_Y1.2881.00
163_T167_Q1.2861.00
138_I142_R1.2831.00
123_V138_I1.2791.00
200_K203_H1.2791.00
71_H74_G1.2631.00
161_I165_L1.2571.00
215_V219_S1.2471.00
121_L148_K1.2411.00
209_I213_I1.2381.00
16_R105_D1.2311.00
95_I121_L1.2271.00
101_Y106_E1.2251.00
217_I232_A1.2181.00
110_E114_T1.2151.00
240_S244_I1.2141.00
189_E196_L1.2081.00
251_S255_E1.1981.00
51_L165_L1.1881.00
109_I113_Q1.1861.00
24_F153_I1.1761.00
52_T177_Q1.1731.00
191_F194_S1.1701.00
135_L138_I1.1661.00
28_V51_L1.1621.00
210_P213_I1.1601.00
228_V268_L1.1541.00
238_R241_Q1.1511.00
120_F167_Q1.1511.00
90_L120_F1.1441.00
123_V152_P1.1291.00
25_L60_F1.1281.00
204_L259_R1.1281.00
246_I250_G1.1271.00
119_V148_K1.1171.00
252_L255_E1.1151.00
141_Y144_R1.1131.00
204_L208_E1.1071.00
130_H159_N1.0921.00
53_T165_L1.0911.00
142_R150_I1.0871.00
96_N125_K1.0811.00
212_S241_Q1.0771.00
217_I223_Q1.0761.00
149_E171_Y1.0751.00
76_F80_V1.0721.00
68_K104_G1.0711.00
193_I197_I1.0591.00
222_G270_S1.0591.00
110_E113_Q1.0591.00
214_A218_E1.0581.00
72_K75_D1.0571.00
201_V204_L1.0511.00
29_I51_L1.0491.00
109_I112_L1.0471.00
254_K258_K1.0391.00
24_F164_L1.0391.00
208_E212_S1.0271.00
119_V145_Y1.0241.00
126_I129_I1.0241.00
11_V168_I1.0211.00
188_P195_E1.0171.00
96_N124_N1.0111.00
24_F161_I1.0071.00
189_E192_I0.9941.00
206_R210_P0.9911.00
126_I152_P0.9891.00
200_K204_L0.9871.00
76_F79_K0.9871.00
207_E213_I0.9821.00
210_P214_A0.9801.00
16_R102_G0.9771.00
231_A235_V0.9661.00
45_N191_F0.9641.00
120_F151_V0.9601.00
28_V165_L0.9591.00
215_V218_E0.9581.00
165_L168_I0.9571.00
193_I196_L0.9561.00
75_D79_K0.9521.00
204_L255_E0.9461.00
69_P74_G0.9431.00
188_P192_I0.9401.00
191_F195_E0.9381.00
102_G105_D0.9371.00
188_P191_F0.9331.00
53_T56_S0.9311.00
136_L140_E0.9301.00
164_L168_I0.9291.00
239_D242_K0.9291.00
50_V57_Q0.9281.00
163_T166_A0.9231.00
189_E193_I0.9121.00
204_L207_E0.9121.00
29_I49_G0.9061.00
236_V240_S0.8991.00
204_L213_I0.8991.00
205_T209_I0.8921.00
187_H192_I0.8891.00
185_T190_R0.8871.00
103_K106_E0.8861.00
262_A265_E0.8861.00
212_S216_A0.8861.00
188_P193_I0.8711.00
96_N99_E0.8681.00
150_I153_I0.8671.00
73_L77_M0.8671.00
186_D190_R0.8641.00
257_G260_A0.8631.00
73_L76_F0.8611.00
202_L211_H0.8611.00
93_F112_L0.8561.00
51_L60_F0.8561.00
180_P183_Q0.8561.00
122_I151_V0.8501.00
74_G77_M0.8471.00
207_E210_P0.8441.00
166_A169_E0.8411.00
134_L141_Y0.8391.00
186_D191_F0.8391.00
235_V239_D0.8381.00
263_D267_L0.8351.00
169_E172_L0.8341.00
25_L29_I0.8321.00
186_D189_E0.8321.00
91_I119_V0.8301.00
81_A85_L0.8201.00
253_L257_G0.8201.00
218_E221_K0.8181.00
250_G253_L0.8171.00
205_T213_I0.8101.00
107_F111_K0.8101.00
223_Q227_S0.8091.00
256_V260_A0.8021.00
188_P196_L0.8001.00
37_S41_Q0.7981.00
205_T208_E0.7971.00
111_K114_T0.7941.00
120_F149_E0.7871.00
212_S215_V0.7811.00
231_A234_I0.7811.00
214_A217_I0.7801.00
246_I253_L0.7801.00
229_H233_T0.7781.00
149_E152_P0.7711.00
158_G161_I0.7701.00
137_L142_R0.7701.00
244_I248_K0.7691.00
184_V195_E0.7661.00
243_G247_G0.7651.00
238_R242_K0.7651.00
227_S231_A0.7631.00
199_E203_H0.7591.00
25_L49_G0.7501.00
121_L150_I0.7491.00
61_I87_E0.7481.00
207_E211_H0.7380.99
243_G253_L0.7370.99
131_P159_N0.7360.99
24_F155_A0.7360.99
237_E241_Q0.7320.99
38_D203_H0.7290.99
52_T57_Q0.7280.99
216_A219_S0.7260.99
134_L138_I0.7240.99
16_R19_V0.7220.99
148_K152_P0.7180.99
193_I264_I0.7110.99
202_L205_T0.7100.99
48_Q51_L0.7100.99
95_I141_Y0.7050.99
192_I195_E0.7000.99
68_K77_M0.7000.99
266_A269_G0.6880.99
165_L169_E0.6880.99
220_I223_Q0.6850.99
219_S223_Q0.6850.99
235_V238_R0.6840.99
11_V90_L0.6830.99
97_A129_I0.6820.99
98_E123_V0.6800.99
93_F119_V0.6790.99
53_T166_A0.6790.99
113_Q146_P0.6770.99
249_K253_L0.6770.99
220_I268_L0.6770.99
69_P73_L0.6730.99
250_G257_G0.6720.99
201_V209_I0.6720.99
104_G107_F0.6710.99
203_H208_E0.6690.99
241_Q246_I0.6680.99
208_E213_I0.6670.99
260_A263_D0.6660.99
185_T188_P0.6640.99
201_V206_R0.6640.99
92_L120_F0.6640.99
206_R213_I0.6640.99
79_K83_N0.6630.99
246_I251_S0.6620.99
241_Q245_V0.6610.99
12_S91_I0.6610.99
19_V105_D0.6590.99
232_A236_V0.6580.99
107_F110_E0.6580.99
166_A170_A0.6570.99
171_Y175_G0.6570.99
26_N36_M0.6560.99
185_T191_F0.6560.99
250_G254_K0.6560.99
51_L58_T0.6560.99
234_I238_R0.6540.99
252_L256_V0.6530.99
169_E173_P0.6520.99
16_R67_H0.6520.99
42_T46_K0.6500.99
204_L216_A0.6490.99
253_L265_E0.6480.99
94_M153_I0.6480.99
202_L206_R0.6470.99
31_Q184_V0.6450.99
211_H220_I0.6430.99
219_S222_G0.6380.98
66_I82_Q0.6360.98
157_E160_N0.6350.98
62_D65_G0.6310.98
151_V160_N0.6290.98
123_V137_L0.6290.98
156_L160_N0.6230.98
151_V154_S0.6220.98
199_E202_L0.6210.98
37_S203_H0.6200.98
199_E205_T0.6200.98
254_K257_G0.6180.98
118_P148_K0.6100.98
54_G166_A0.6100.98
182_D188_P0.6100.98
176_P179_Y0.6090.98
101_Y105_D0.6020.98
137_L144_R0.6020.98
192_I267_L0.6000.98
67_H74_G0.5980.98
242_K250_G0.5940.98
108_I112_L0.5930.98
19_V123_V0.5910.98
162_E165_L0.5890.97
123_V141_Y0.5860.97
243_G246_I0.5850.97
67_H78_M0.5830.97
54_G177_Q0.5820.97
198_R201_V0.5790.97
248_K252_L0.5750.97
247_G251_S0.5750.97
29_I33_I0.5730.97
201_V208_E0.5710.97
249_K252_L0.5680.97
198_R202_L0.5650.97
70_K75_D0.5650.97
67_H104_G0.5620.97
66_I108_I0.5610.97
240_S250_G0.5600.97
102_G107_F0.5600.97
176_P180_P0.5570.96
246_I249_K0.5570.96
171_Y174_E0.5570.96
184_V189_E0.5560.96
152_P155_A0.5550.96
227_S230_V0.5540.96
25_L34_A0.5540.96
14_I91_I0.5530.96
17_P43_T0.5520.96
260_A265_E0.5510.96
19_V96_N0.5420.96
79_K82_Q0.5420.96
35_I41_Q0.5410.96
24_F122_I0.5410.96
261_R264_I0.5400.96
76_F83_N0.5380.96
75_D78_M0.5380.96
35_I42_T0.5370.96
148_K151_V0.5360.96
212_S223_Q0.5360.96
113_Q144_R0.5360.96
58_T165_L0.5360.96
61_I88_V0.5330.96
36_M39_K0.5310.95
253_L261_R0.5310.95
213_I216_A0.5270.95
217_I221_K0.5270.95
192_I196_L0.5270.95
246_I254_K0.5260.95
258_K261_R0.5260.95
105_D108_I0.5250.95
258_K271_R0.5240.95
182_D195_E0.5230.95
194_S197_I0.5230.95
188_P194_S0.5210.95
134_L144_R0.5200.95
18_N41_Q0.5170.95
99_E105_D0.5130.94
14_I78_M0.5110.94
260_A264_I0.5080.94
43_T77_M0.5080.94
60_F165_L0.5020.94
202_L208_E0.5020.94
149_E153_I0.5010.94
67_H81_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ievA 1 0.9767 100 0.337 Contact Map
1wf3A 1 0.9701 100 0.343 Contact Map
1egaA 2 0.9668 100 0.355 Contact Map
2j69A 1 0.9834 100 0.41 Contact Map
4aurA 1 0.9867 100 0.466 Contact Map
3j8gX 1 0.8505 100 0.491 Contact Map
4dcuA 1 0.8306 100 0.494 Contact Map
1mkyA 1 0.8007 100 0.495 Contact Map
1xzpA 4 0.814 100 0.507 Contact Map
3geeA 2 0.691 100 0.507 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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