GREMLIN Database
NARI - Nitrate reductase gamma chain
UniProt: P42177 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (219)
Sequences: 1085 (657)
Seq/√Len: 44.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_G106_I5.2691.00
97_G140_V3.3031.00
17_I194_I3.0791.00
17_I198_F2.9581.00
127_L195_L2.8841.00
5_I13_I2.8731.00
135_M189_G2.7471.00
76_A82_E2.6271.00
192_V201_L2.5641.00
81_S84_M2.5571.00
118_R126_I2.5161.00
180_L184_F2.5101.00
18_F22_H2.4751.00
112_L118_R2.4281.00
10_M191_V2.4241.00
56_G103_G2.2781.00
124_S195_L2.2311.00
16_T20_G2.2061.00
57_L100_A2.1891.00
52_L102_T2.1631.00
72_E153_D2.1411.00
6_L187_V2.1211.00
131_L195_L1.9990.99
74_V78_L1.9830.99
60_V100_A1.9520.99
88_M92_A1.8950.99
84_M88_M1.8860.99
186_I190_Y1.8780.99
90_I147_I1.8520.99
22_H205_F1.8210.99
59_C96_A1.8000.98
135_M188_I1.7860.98
60_V97_G1.7300.98
59_C92_A1.7080.98
52_L99_A1.6990.98
3_G176_E1.6610.97
15_L165_I1.6550.97
104_L133_L1.6380.97
58_L62_G1.6240.97
196_W204_V1.6080.97
112_L126_I1.6010.97
101_C133_L1.5990.97
42_E114_D1.5780.96
141_A145_L1.5370.96
91_G95_P1.5270.96
105_V109_Y1.5170.95
20_G23_I1.5160.95
108_T126_I1.5040.95
123_P127_L1.5040.95
83_H87_K1.4700.95
72_E76_A1.4630.94
17_I20_G1.4240.94
109_Y113_F1.4160.93
85_Y155_R1.3790.92
41_L128_T1.3690.92
162_F166_V1.3660.92
72_E82_E1.3520.92
64_H110_R1.3450.91
101_C137_L1.3390.91
3_G183_K1.3370.91
80_I84_M1.3180.91
195_L199_T1.2910.90
39_E43_K1.2910.90
108_T112_L1.2890.90
210_K213_T1.2880.90
100_A136_M1.2870.90
105_V133_L1.2820.89
9_I170_P1.2750.89
12_Y170_P1.2720.89
108_T131_L1.2570.88
41_L116_R1.2540.88
95_P99_A1.2400.88
114_D117_I1.2360.88
73_G76_A1.2220.87
72_E156_T1.2120.87
131_L134_F1.2000.86
36_K122_S1.1980.86
98_I102_T1.1980.86
33_W206_S1.1960.86
87_K150_K1.1880.85
154_Y179_P1.1880.85
42_E117_I1.1690.84
14_V190_Y1.1680.84
22_H196_W1.1670.84
14_V194_I1.1650.84
45_K49_G1.1640.84
45_K109_Y1.1490.83
24_Y29_D1.1320.82
131_L135_M1.1280.82
138_S184_F1.1140.81
187_V191_V1.1110.81
44_K208_P1.1030.81
200_R211_Y1.1010.81
64_H185_H1.0970.80
126_I130_L1.0820.80
42_E46_L1.0700.79
5_I84_M1.0690.79
18_F196_W1.0620.78
154_Y157_T1.0510.77
30_Q33_W1.0400.77
75_Y78_L1.0350.76
121_S129_L1.0330.76
29_D216_Y1.0270.76
87_K91_G1.0240.76
22_H202_V1.0200.75
104_L108_T1.0160.75
57_L62_G1.0140.75
72_E159_G1.0100.75
85_Y162_F1.0090.75
139_G185_H1.0080.74
131_L188_I1.0060.74
152_F182_F0.9990.74
128_T195_L0.9950.74
111_R203_H0.9930.73
26_Y82_E0.9900.73
18_F205_F0.9830.73
9_I20_G0.9810.72
108_T133_L0.9720.72
38_S41_L0.9720.72
62_G66_M0.9570.71
82_E159_G0.9570.71
118_R121_S0.9540.70
130_L134_F0.9480.70
110_R185_H0.9440.69
138_S188_I0.9430.69
142_A158_V0.9380.69
207_L210_K0.9370.69
9_I168_F0.9360.69
20_G24_Y0.9310.68
173_S176_E0.9280.68
61_V134_F0.9260.68
121_S126_I0.9190.67
108_T192_V0.9170.67
76_A153_D0.9160.67
154_Y159_G0.9150.67
215_S221_K0.9120.67
37_S41_L0.9110.67
141_A181_W0.9020.66
89_A94_L0.8940.65
62_G65_V0.8910.65
74_V77_S0.8910.65
36_K215_S0.8830.64
101_C136_M0.8770.64
106_I109_Y0.8610.62
158_V178_V0.8600.62
18_F204_V0.8540.62
63_G67_G0.8520.61
157_T160_P0.8500.61
147_I150_K0.8470.61
54_H203_H0.8450.61
4_Q9_I0.8450.61
46_L49_G0.8420.61
75_Y159_G0.8400.60
133_L137_L0.8390.60
48_A52_L0.8310.60
16_T168_F0.8310.60
113_F184_F0.8280.59
102_T123_P0.8270.59
134_F188_I0.8210.59
78_L81_S0.8200.59
210_K215_S0.8200.59
5_I9_I0.8200.59
66_M91_G0.8200.59
112_L115_K0.8130.58
83_H150_K0.8110.58
3_G193_F0.8060.57
19_I205_F0.8020.57
55_W59_C0.7980.56
202_V206_S0.7960.56
24_Y55_W0.7930.56
16_T61_V0.7920.56
84_M177_S0.7920.56
13_I106_I0.7920.56
59_C99_A0.7910.56
171_D174_L0.7890.56
52_L89_A0.7870.55
82_E156_T0.7860.55
54_H111_R0.7820.55
115_K119_K0.7780.55
113_F117_I0.7590.53
84_M92_A0.7580.53
104_L132_L0.7560.52
15_L80_I0.7520.52
29_D215_S0.7490.52
76_A96_A0.7380.51
8_G172_A0.7350.50
157_T177_S0.7280.50
23_I168_F0.7270.50
26_Y33_W0.7240.49
33_W202_V0.7140.48
146_N149_S0.7130.48
116_R120_T0.7120.48
6_L175_M0.7060.48
64_H71_P0.7060.48
152_F179_P0.7040.47
19_I23_I0.7040.47
9_I16_T0.7020.47
192_V212_L0.7010.47
118_R131_L0.7000.47
155_R219_Y0.6990.47
30_Q41_L0.6960.47
121_S194_I0.6950.47
175_M178_V0.6920.46
37_S40_L0.6920.46
49_G52_L0.6910.46
212_L215_S0.6790.45
102_T105_V0.6770.45
13_I16_T0.6750.45
51_T129_L0.6740.45
82_E151_G0.6740.45
26_Y29_D0.6710.44
104_L137_L0.6700.44
31_F216_Y0.6660.44
107_L111_R0.6650.44
164_E169_R0.6640.44
146_N165_I0.6630.43
57_L204_V0.6620.43
69_L162_F0.6570.43
124_S199_T0.6570.43
133_L207_L0.6560.43
82_E153_D0.6560.43
90_I148_D0.6540.43
99_A103_G0.6530.43
36_K39_E0.6520.42
113_F145_L0.6500.42
22_H204_V0.6490.42
213_T221_K0.6470.42
57_L61_V0.6460.42
66_M199_T0.6430.42
11_P25_R0.6370.41
53_F63_G0.6320.41
98_I184_F0.6310.40
64_H139_G0.6300.40
25_R37_S0.6280.40
61_V95_P0.6280.40
46_L51_T0.6280.40
168_F171_D0.6260.40
59_C62_G0.6260.40
41_L120_T0.6250.40
153_D164_E0.6250.40
26_Y216_Y0.6240.40
16_T98_I0.6220.40
153_D156_T0.6200.39
77_S199_T0.6200.39
164_E174_L0.6190.39
72_E75_Y0.6140.39
64_H125_D0.6120.39
97_G101_C0.6100.39
137_L169_R0.6090.38
46_L107_L0.6070.38
154_Y182_F0.6070.38
122_S130_L0.6030.38
96_A216_Y0.6010.38
26_Y210_K0.5970.37
59_C221_K0.5960.37
128_T192_V0.5950.37
15_L166_V0.5940.37
53_F71_P0.5930.37
7_W175_M0.5930.37
111_R121_S0.5900.37
32_G128_T0.5890.37
124_S127_L0.5890.37
145_L169_R0.5880.37
4_Q173_S0.5870.36
142_A179_P0.5860.36
94_L102_T0.5840.36
185_H203_H0.5840.36
38_S200_R0.5840.36
109_Y207_L0.5770.36
58_L61_V0.5740.35
162_F193_F0.5730.35
94_L151_G0.5730.35
144_F184_F0.5680.35
83_H104_L0.5680.35
69_L166_V0.5670.35
169_R176_E0.5670.35
51_T75_Y0.5650.34
43_K216_Y0.5610.34
91_G123_P0.5600.34
86_H219_Y0.5600.34
10_M194_I0.5590.34
177_S183_K0.5570.34
110_R203_H0.5540.34
191_V209_L0.5530.33
57_L90_I0.5510.33
125_D200_R0.5410.32
140_V187_V0.5390.32
46_L182_F0.5380.32
35_A41_L0.5340.32
162_F178_V0.5310.32
178_V186_I0.5310.32
148_D159_G0.5300.31
49_G104_L0.5300.31
8_G106_I0.5290.31
17_I181_W0.5290.31
123_P130_L0.5280.31
99_A147_I0.5270.31
25_R103_G0.5250.31
40_L138_S0.5250.31
7_W85_Y0.5250.31
86_H155_R0.5230.31
103_G175_M0.5230.31
21_G125_D0.5230.31
78_L95_P0.5220.31
95_P146_N0.5220.31
66_M148_D0.5220.31
16_T188_I0.5200.31
51_T55_W0.5190.31
164_E171_D0.5180.30
72_E77_S0.5160.30
67_G103_G0.5140.30
113_F179_P0.5130.30
95_P212_L0.5120.30
197_P203_H0.5120.30
10_M14_V0.5120.30
62_G95_P0.5120.30
116_R119_K0.5110.30
19_I167_L0.5110.30
124_S165_I0.5100.30
155_R163_R0.5100.30
55_W58_L0.5070.30
23_I184_F0.5060.30
65_V69_L0.5050.29
70_I163_R0.5040.29
158_V174_L0.5020.29
28_H116_R0.5010.29
131_L192_V0.5000.29
38_S111_R0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q16C 2 0.991 100 0.331 Contact Map
2wswA 3 0.87 30.6 0.952 Contact Map
2l2tA 2 0.1839 30.3 0.952 Contact Map
2kluA 1 0.2332 9.3 0.962 Contact Map
2ks1B 1 0.1839 9.2 0.962 Contact Map
2m20A 2 0.2556 5.7 0.966 Contact Map
4p6vD 1 0.4439 5 0.967 Contact Map
2l9uA 2 0.1794 4.7 0.967 Contact Map
4c7rA 3 0.8969 4.1 0.968 Contact Map
1iijA 1 0.1435 3.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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