GREMLIN Database
YXAL - Uncharacterized protein YxaL
UniProt: P42111 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (332)
Sequences: 1308 (1169)
Seq/√Len: 64.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_S195_S6.5131.00
136_G153_L5.0931.00
279_A289_Y3.7781.00
238_V248_I3.6421.00
153_L157_D3.5401.00
177_S198_D3.4051.00
272_D275_G3.4011.00
152_Y193_Y3.3991.00
153_L163_I3.1651.00
152_Y186_I3.0611.00
278_Y311_I3.0521.00
237_Y277_I2.9951.00
197_L200_Y2.8711.00
302_N319_I2.8021.00
278_Y317_I2.6041.00
239_G266_K2.5591.00
280_G306_S2.4851.00
183_E196_T2.3811.00
112_L145_L2.3711.00
177_S197_L2.3691.00
142_S154_A2.3421.00
194_F236_V2.3101.00
136_G157_D2.3061.00
358_Y368_A2.2931.00
237_Y271_I2.2801.00
42_A76_S2.2671.00
194_F230_L2.2231.00
152_Y160_I2.2151.00
221_N238_V2.2061.00
227_V239_G2.1971.00
242_N246_Y2.1771.00
43_E46_F2.1631.00
359_F369_A2.1471.00
113_H117_G2.1371.00
245_F279_A2.0581.00
95_T113_H2.0081.00
136_G155_S2.0011.00
160_I195_S1.9831.00
194_F203_A1.9611.00
112_L151_I1.9091.00
89_Q92_I1.8371.00
55_F58_G1.8161.00
152_Y184_T1.8101.00
319_I329_I1.7731.00
195_S198_D1.7681.00
195_S204_I1.7400.99
152_Y162_F1.7350.99
37_T41_A1.7280.99
177_S200_Y1.6990.99
104_I111_Y1.6980.99
84_G88_W1.6920.99
176_L195_S1.6800.99
184_T195_S1.6730.99
249_N252_T1.6730.99
85_T88_W1.6650.99
185_V194_F1.6590.99
112_L115_R1.6530.99
146_G186_I1.6200.99
42_A46_F1.6020.99
155_S159_K1.6020.99
262_S283_D1.5980.99
194_F228_P1.5860.99
155_S161_Y1.5780.99
136_G140_T1.5740.99
101_G114_S1.5300.99
42_A49_N1.5060.99
59_R66_A1.5030.99
136_G163_I1.5000.98
41_A45_V1.4710.98
320_G324_G1.4520.98
249_N291_S1.4500.98
62_V65_M1.4470.98
161_Y173_T1.4440.98
63_Q70_F1.4320.98
68_A80_G1.4300.98
361_S364_M1.4100.98
95_T117_G1.4090.98
65_M69_M1.4040.98
194_F201_V1.3990.98
38_A42_A1.3710.97
57_P64_A1.3680.97
197_L240_T1.3670.97
286_L299_F1.3620.97
283_D287_Y1.3510.97
55_F61_D1.3480.97
278_Y288_A1.3470.97
361_S369_A1.3430.97
44_T48_Q1.3350.97
44_T49_N1.3270.97
53_S64_A1.3190.97
73_S77_R1.3140.96
146_G149_G1.3130.96
204_I329_I1.3120.96
311_I317_I1.3060.96
99_G113_H1.3050.96
160_I181_S1.3040.96
177_S204_I1.3000.96
237_Y247_A1.2930.96
56_L60_Y1.2920.96
45_V49_N1.2920.96
113_H123_N1.2530.95
230_L233_N1.2450.95
203_A230_L1.2410.95
44_T47_S1.2360.95
35_Q41_A1.2330.95
75_E78_F1.2300.95
112_L143_P1.2240.95
347_T351_I1.2180.95
64_A67_P1.2150.95
47_S59_R1.2020.94
105_D109_T1.1990.94
36_P41_A1.1840.94
42_A53_S1.1830.94
41_A44_T1.1820.94
48_Q52_A1.1810.94
280_G284_G1.1730.93
286_L319_I1.1690.93
61_D64_A1.1680.93
35_Q42_A1.1630.93
72_W76_S1.1630.93
35_Q38_A1.1480.93
36_P39_A1.1430.93
42_A47_S1.1400.92
38_A54_G1.1290.92
79_A85_T1.1140.92
47_S52_A1.1110.91
103_V112_L1.1070.91
112_L122_F1.1070.91
74_R77_R1.1000.91
62_V69_M1.0990.91
55_F63_Q1.0930.91
71_N77_R1.0920.91
160_I174_V1.0910.91
157_D161_Y1.0900.91
63_Q66_A1.0880.91
196_T225_S1.0800.90
69_M72_W1.0770.90
47_S58_G1.0630.90
262_S279_A1.0600.89
57_P60_Y1.0600.89
39_A71_N1.0590.89
62_V74_R1.0540.89
58_G62_V1.0530.89
160_I184_T1.0480.89
136_G161_Y1.0470.89
176_L204_I1.0460.89
63_Q67_P1.0290.88
242_N248_I1.0250.88
47_S54_G1.0220.88
79_A86_L1.0220.88
78_F81_N1.0210.88
82_T86_L1.0190.87
45_V52_A1.0190.87
59_R63_Q1.0180.87
318_Y357_V1.0100.87
39_A42_A1.0020.87
80_G84_G0.9990.86
48_Q51_G0.9930.86
50_N53_S0.9920.86
163_I204_I0.9910.86
62_V67_P0.9860.86
187_G230_L0.9820.85
60_Y65_M0.9800.85
105_D108_G0.9790.85
68_A71_N0.9780.85
55_F66_A0.9770.85
231_A271_I0.9620.84
54_G58_G0.9610.84
69_M73_S0.9550.84
49_N58_G0.9510.84
154_A181_S0.9460.83
309_P319_I0.9450.83
45_V48_Q0.9430.83
46_F49_N0.9410.83
41_A46_F0.9390.83
52_A55_F0.9380.83
67_P76_S0.9340.82
71_N76_S0.9330.82
53_S75_E0.9330.82
51_G56_L0.9320.82
71_N74_R0.9240.82
342_D359_F0.9240.82
272_D311_I0.9220.82
84_G89_Q0.9190.81
39_A57_P0.9130.81
137_K155_S0.9110.81
54_G59_R0.9100.81
201_V238_V0.9080.81
188_S234_G0.9080.81
95_T99_G0.9060.80
52_A58_G0.9030.80
238_V246_Y0.8990.80
43_E52_A0.8970.80
97_Q110_V0.8930.79
66_A70_F0.8880.79
53_S63_Q0.8830.79
72_W75_E0.8810.79
71_N78_F0.8770.78
356_T360_G0.8750.78
52_A60_Y0.8730.78
38_A45_V0.8720.78
281_N317_I0.8700.78
47_S60_Y0.8700.78
56_L74_R0.8670.77
85_T90_N0.8650.77
318_Y328_S0.8620.77
49_N54_G0.8610.77
82_T87_K0.8580.77
70_F76_S0.8560.77
56_L62_V0.8550.76
45_V59_R0.8530.76
45_V57_P0.8510.76
60_Y63_Q0.8490.76
105_D279_A0.8480.76
35_Q39_A0.8470.76
60_Y67_P0.8470.76
56_L59_R0.8470.76
80_G83_D0.8410.75
49_N59_R0.8410.75
361_S366_V0.8390.75
42_A45_V0.8380.75
52_A57_P0.8350.75
81_N86_L0.8290.74
145_L151_I0.8270.74
195_S200_Y0.8230.74
40_Y47_S0.8230.74
59_R67_P0.8220.74
69_M74_R0.8200.73
67_P70_F0.8180.73
64_A68_A0.8080.72
52_A63_Q0.8050.72
44_T59_R0.8020.72
221_N248_I0.8010.72
147_T186_I0.7990.71
358_Y369_A0.7980.71
46_F50_N0.7980.71
79_A82_T0.7950.71
83_D86_L0.7950.71
49_N52_A0.7930.71
359_F367_Y0.7920.71
288_A311_I0.7910.71
155_S158_K0.7880.70
55_F60_Y0.7860.70
57_P61_D0.7830.70
142_S203_A0.7810.70
347_T352_D0.7800.70
198_D202_H0.7770.69
243_Y269_P0.7760.69
50_N68_A0.7750.69
63_Q69_M0.7720.69
40_Y49_N0.7700.69
56_L65_M0.7690.69
62_V66_A0.7690.69
301_L329_I0.7670.68
215_R240_T0.7660.68
153_L159_K0.7600.68
48_Q70_F0.7560.67
135_L161_Y0.7540.67
74_R78_F0.7530.67
289_Y295_L0.7530.67
69_M77_R0.7510.67
41_A50_N0.7510.67
280_G323_S0.7450.66
44_T60_Y0.7440.66
344_P363_D0.7440.66
59_R64_A0.7420.66
55_F65_M0.7410.66
59_R70_F0.7400.66
80_G85_T0.7380.65
123_N151_I0.7380.65
78_F114_S0.7350.65
120_K143_P0.7350.65
221_N242_N0.7330.65
80_G91_D0.7320.65
286_L310_A0.7310.65
345_V348_A0.7300.64
162_F331_K0.7290.64
42_A54_G0.7280.64
143_P153_L0.7280.64
56_L61_D0.7250.64
43_E47_S0.7250.64
55_F64_A0.7250.64
46_F51_G0.7240.64
88_W92_I0.7210.64
52_A56_L0.7200.63
352_D358_Y0.7190.63
85_T89_Q0.7190.63
44_T54_G0.7180.63
49_N56_L0.7150.63
269_P277_I0.7150.63
257_W260_T0.7140.63
53_S56_L0.7100.62
170_I245_F0.7090.62
82_T88_W0.7090.62
217_K269_P0.7070.62
60_Y69_M0.7060.62
177_S181_S0.7020.61
36_P44_T0.7020.61
110_V114_S0.7020.61
346_R359_F0.7020.61
36_P42_A0.7010.61
84_G91_D0.6990.61
84_G90_N0.6980.61
42_A73_S0.6930.60
278_Y286_L0.6910.60
261_T289_Y0.6900.60
195_S202_H0.6900.60
284_G328_S0.6890.60
136_G159_K0.6890.60
51_G59_R0.6880.60
48_Q55_F0.6840.59
36_P45_V0.6810.59
40_Y54_G0.6780.59
66_A72_W0.6780.59
322_G360_G0.6770.59
52_A62_V0.6770.59
60_Y72_W0.6760.59
37_T66_A0.6740.58
151_I196_T0.6720.58
135_L163_I0.6710.58
38_A41_A0.6690.58
86_L92_I0.6690.58
232_K271_I0.6680.58
122_F145_L0.6680.58
185_V229_V0.6680.58
160_I193_Y0.6670.58
117_G124_P0.6670.58
57_P62_V0.6650.57
40_Y45_V0.6630.57
159_K173_T0.6620.57
46_F60_Y0.6620.57
311_I315_G0.6610.57
101_G105_D0.6600.57
40_Y65_M0.6600.57
335_M338_S0.6590.57
54_G62_V0.6580.57
81_N85_T0.6550.56
51_G61_D0.6540.56
56_L75_E0.6540.56
162_F186_I0.6530.56
142_S155_S0.6520.56
40_Y70_F0.6520.56
72_W80_G0.6510.56
86_L89_Q0.6510.56
203_A216_W0.6510.56
35_Q44_T0.6500.56
50_N55_F0.6490.55
55_F59_R0.6480.55
100_A104_I0.6450.55
79_A87_K0.6420.55
58_G66_A0.6420.55
62_V68_A0.6400.54
198_D204_I0.6380.54
205_K211_T0.6370.54
46_F65_M0.6370.54
105_D113_H0.6350.54
310_A318_Y0.6350.54
132_T155_S0.6330.54
87_K91_D0.6310.53
330_S334_D0.6300.53
154_A195_S0.6290.53
53_S62_V0.6280.53
211_T221_N0.6270.53
69_M76_S0.6270.53
179_G189_D0.6260.53
348_A351_I0.6260.53
104_I117_G0.6250.53
73_S89_Q0.6250.53
99_G114_S0.6250.53
55_F62_V0.6240.53
144_V184_T0.6240.53
52_A64_A0.6210.52
53_S57_P0.6210.52
360_G364_M0.6190.52
220_T248_I0.6160.52
42_A50_N0.6160.52
63_Q76_S0.6150.52
133_G141_Q0.6140.51
60_Y64_A0.6140.51
106_G145_L0.6130.51
42_A68_A0.6110.51
54_G57_P0.6090.51
48_Q59_R0.6070.51
148_N181_S0.6050.50
41_A56_L0.6050.50
68_A76_S0.6040.50
95_T123_N0.6030.50
161_Y170_I0.6020.50
73_S76_S0.6020.50
99_G102_A0.6010.50
67_P71_N0.6010.50
38_A66_A0.6010.50
43_E49_N0.6000.50
76_S92_I0.6000.50
113_H118_E0.5990.50
49_N60_Y0.5990.50
220_T240_T0.5980.50
164_D205_K0.5980.50
201_V228_P0.5970.49
212_W216_W0.5960.49
321_S324_G0.5930.49
190_G202_H0.5930.49
356_T361_S0.5920.49
78_F83_D0.5920.49
40_Y46_F0.5910.49
125_D286_L0.5900.49
107_D195_S0.5890.49
85_T91_D0.5890.49
36_P59_R0.5880.48
46_F57_P0.5870.48
326_L359_F0.5870.48
355_G359_F0.5860.48
289_Y293_G0.5850.48
213_T220_T0.5830.48
147_T190_G0.5830.48
67_P73_S0.5820.48
68_A79_A0.5820.48
60_Y66_A0.5800.47
45_V56_L0.5790.47
43_E61_D0.5770.47
54_G64_A0.5770.47
240_T279_A0.5750.47
211_T288_A0.5750.47
318_Y351_I0.5730.47
59_R68_A0.5720.47
44_T50_N0.5720.47
273_K276_N0.5710.46
256_K259_R0.5700.46
104_I113_H0.5700.46
36_P40_Y0.5680.46
348_A360_G0.5670.46
57_P63_Q0.5670.46
316_N320_G0.5670.46
236_V253_G0.5670.46
48_Q62_V0.5640.46
42_A70_F0.5640.46
225_S250_S0.5630.46
162_F206_P0.5610.45
39_A56_L0.5590.45
114_S118_E0.5590.45
36_P46_F0.5580.45
45_V51_G0.5560.45
59_R74_R0.5530.44
201_V358_Y0.5490.44
215_R222_G0.5470.44
268_Y280_G0.5460.44
274_D288_A0.5460.44
228_P238_V0.5460.44
83_D90_N0.5430.43
201_V243_Y0.5420.43
89_Q96_P0.5420.43
44_T53_S0.5410.43
37_T53_S0.5410.43
181_S200_Y0.5410.43
84_G92_I0.5400.43
153_L161_Y0.5380.43
68_A72_W0.5370.43
197_L220_T0.5370.43
203_A235_T0.5360.42
49_N57_P0.5340.42
144_V152_Y0.5330.42
315_G330_S0.5330.42
120_K124_P0.5330.42
44_T51_G0.5320.42
43_E59_R0.5310.42
152_Y171_L0.5310.42
49_N55_F0.5310.42
298_T321_S0.5300.42
186_I193_Y0.5280.42
122_F164_D0.5260.41
264_A299_F0.5260.41
43_E48_Q0.5250.41
318_Y329_I0.5240.41
54_G68_A0.5230.41
37_T42_A0.5210.41
351_I354_K0.5210.41
56_L63_Q0.5200.41
359_F366_V0.5180.40
174_V186_I0.5160.40
63_Q71_N0.5160.40
154_A160_I0.5150.40
339_F346_R0.5120.40
56_L67_P0.5100.40
49_N63_Q0.5100.40
254_Q294_S0.5080.39
54_G60_Y0.5070.39
231_A273_K0.5060.39
169_E225_S0.5050.39
228_P236_V0.5040.39
45_V68_A0.5030.39
63_Q74_R0.5030.39
58_G65_M0.5030.39
44_T56_L0.5030.39
42_A48_Q0.5030.39
43_E51_G0.5020.39
40_Y58_G0.5020.39
202_H217_K0.5010.39
70_F74_R0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.7024 100 0.387 Contact Map
2ymuA 1 0.7902 100 0.41 Contact Map
4wjuA 1 0.9146 100 0.421 Contact Map
1gotB 1 0.7927 100 0.427 Contact Map
5a1uD 1 0.7951 100 0.436 Contact Map
3sfzA 1 0.9902 100 0.437 Contact Map
4lg9A 1 0.7854 100 0.44 Contact Map
4j87A 1 0.6927 100 0.441 Contact Map
4j0xA 1 0.7561 100 0.443 Contact Map
4i79A 2 0.6756 100 0.444 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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