GREMLIN Database
YXAH - Uncharacterized protein YxaH
UniProt: P42107 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 402 (358)
Sequences: 1992 (1646)
Seq/√Len: 87.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
328_L381_F6.4961.00
112_L132_A5.4801.00
326_N369_S4.9701.00
333_V361_V3.7081.00
112_L129_T3.5181.00
141_F152_W3.2751.00
108_L135_G3.2181.00
30_V70_I3.1751.00
110_A388_A3.1531.00
87_V243_A3.0781.00
378_M383_W2.9811.00
122_I331_S2.9251.00
105_V136_F2.9041.00
146_P244_K2.8771.00
336_W343_L2.8021.00
80_F242_A2.7041.00
141_F237_L2.6991.00
256_K260_R2.6111.00
150_L241_A2.5951.00
250_E253_K2.5821.00
146_P241_A2.5801.00
325_T329_M2.5661.00
144_A152_W2.4891.00
145_K148_T2.4851.00
319_V326_N2.4391.00
349_V357_I2.4321.00
84_F243_A2.4271.00
371_L375_V2.4001.00
144_A148_T2.3631.00
315_S318_A2.3601.00
147_K151_I2.2481.00
87_V240_A2.2391.00
65_I69_F2.1881.00
319_V366_M2.1651.00
146_P245_S2.1431.00
86_M104_Y2.1411.00
141_F144_A2.1381.00
267_V271_G2.0981.00
196_S199_D2.0821.00
114_F381_F2.0811.00
335_T341_Y2.0231.00
318_A370_H2.0041.00
262_W299_T1.9941.00
262_W295_F1.9821.00
262_W298_T1.9171.00
18_V300_V1.8451.00
92_R95_N1.8371.00
117_I122_I1.8071.00
255_R259_K1.7371.00
118_H331_S1.7131.00
77_L297_V1.7061.00
28_L334_C1.6901.00
261_L298_T1.6671.00
153_A238_L1.6451.00
26_G74_C1.6391.00
265_G298_T1.6301.00
241_A245_S1.6231.00
148_T151_I1.6151.00
151_I155_S1.6121.00
322_M372_W1.5961.00
25_F362_C1.5921.00
73_K273_Q1.5681.00
105_V109_M1.5641.00
325_T368_F1.5621.00
353_A356_L1.5471.00
321_R373_L1.5341.00
105_V139_L1.5301.00
114_F324_F1.5031.00
377_R383_W1.4890.99
261_L265_G1.4760.99
383_W387_S1.4730.99
76_L293_M1.4610.99
18_V317_S1.4600.99
143_K147_K1.4600.99
86_M138_L1.4340.99
73_K292_L1.4260.99
76_L289_A1.4220.99
57_E61_A1.4180.99
153_A241_A1.4160.99
322_M368_F1.4060.99
326_N365_Q1.3940.99
86_M142_R1.3850.99
29_F358_T1.3790.99
152_W237_L1.3700.99
371_L374_R1.3650.99
17_D20_R1.3590.99
166_L170_D1.3500.99
108_L132_A1.3430.99
356_L360_A1.3420.99
104_Y108_L1.3360.99
329_M368_F1.3310.99
157_Y234_S1.3290.99
322_M373_L1.3230.99
14_G317_S1.3210.99
16_L84_F1.3160.99
369_S373_L1.3150.99
295_F298_T1.3120.99
267_V295_F1.3100.99
330_Q365_Q1.2890.99
23_A26_G1.2680.98
203_Q207_D1.2670.98
370_H374_R1.2660.98
247_Y257_G1.2650.98
19_L300_V1.2530.98
336_W341_Y1.2460.98
269_G295_F1.2430.98
15_V301_V1.2430.98
110_A114_F1.2400.98
378_M387_S1.2380.98
246_R249_H1.2330.98
32_L354_G1.2310.98
266_L295_F1.2160.98
108_L136_F1.2130.98
372_W376_F1.2110.98
87_V91_E1.2050.98
255_R305_H1.2030.98
350_Y353_A1.1890.97
117_I121_L1.1880.97
24_I323_A1.1860.97
134_L233_F1.1840.97
85_G88_V1.1800.97
333_V337_I1.1790.97
59_D350_Y1.1770.97
127_I131_Y1.1760.97
272_A288_G1.1620.97
386_R390_Y1.1570.97
122_I126_D1.1560.97
16_L321_R1.1470.97
264_A267_V1.1410.97
387_S392_S1.1360.97
148_T152_W1.1310.97
90_M142_R1.1300.97
89_M103_L1.1270.97
315_S370_H1.1250.96
88_V92_R1.1200.96
364_V368_F1.1190.96
366_M370_H1.1190.96
231_P234_S1.1170.96
373_L376_F1.1150.96
57_E60_F1.1120.96
67_K71_Q1.1120.96
263_M267_V1.1110.96
76_L235_M1.1090.96
334_C361_V1.0980.96
337_I345_L1.0970.96
90_M100_F1.0960.96
110_A385_W1.0950.96
22_M300_V1.0900.96
109_M136_F1.0890.96
195_G199_D1.0850.96
77_L293_M1.0850.96
260_R264_A1.0800.96
151_I154_V1.0790.96
114_F385_W1.0780.96
27_I331_S1.0670.95
367_V371_L1.0580.95
18_V304_Y1.0520.95
369_S372_W1.0500.95
85_G390_Y1.0460.95
138_L240_A1.0440.95
136_F140_L1.0430.95
184_Q187_Q1.0420.95
73_K131_Y1.0360.94
340_H344_G1.0330.94
61_A65_I1.0210.94
128_L324_F1.0190.94
241_A244_K1.0150.94
197_L201_A1.0120.94
291_F295_F1.0120.94
87_V244_K1.0110.94
137_V140_L1.0070.94
153_A234_S1.0010.93
18_V316_F0.9990.93
62_A352_A0.9930.93
59_D352_A0.9890.93
30_V71_Q0.9880.93
299_T303_L0.9880.93
66_L70_I0.9880.93
154_V158_L0.9860.93
205_I209_L0.9840.93
101_V142_R0.9840.93
323_A326_N0.9810.93
158_L162_I0.9760.92
145_K151_I0.9720.92
84_F246_R0.9670.92
106_R110_A0.9640.92
62_A355_V0.9630.92
199_D203_Q0.9560.92
134_L229_S0.9540.92
204_R341_Y0.9520.92
123_W126_D0.9490.91
246_R250_E0.9390.91
265_G295_F0.9380.91
86_M236_F0.9370.91
345_L349_V0.9330.91
197_L341_Y0.9290.91
25_F319_V0.9250.90
114_F388_A0.9240.90
378_M386_R0.9220.90
27_I75_I0.9190.90
125_G331_S0.9170.90
208_R212_M0.9050.89
201_A205_I0.9050.89
324_F381_F0.9030.89
87_V90_M0.8990.89
298_T302_Y0.8990.89
32_L334_C0.8940.89
84_F248_L0.8900.89
273_Q288_G0.8880.88
150_L154_V0.8850.88
32_L357_I0.8850.88
337_I343_L0.8770.88
86_M90_M0.8750.88
293_M297_V0.8750.88
114_F128_L0.8740.88
84_F242_A0.8730.88
35_F38_P0.8730.88
100_F104_Y0.8730.88
19_L292_L0.8720.88
269_G292_L0.8690.87
22_M316_F0.8670.87
185_A188_A0.8650.87
323_A369_S0.8640.87
13_I249_H0.8630.87
156_L233_F0.8610.87
58_A352_A0.8610.87
120_F205_I0.8570.87
75_I289_A0.8570.87
123_W331_S0.8570.87
134_L236_F0.8540.86
118_H126_D0.8530.86
108_L112_L0.8520.86
271_G275_L0.8520.86
120_F208_R0.8490.86
80_F235_M0.8470.86
12_R17_D0.8450.86
132_A240_A0.8430.86
35_F338_F0.8420.86
371_L376_F0.8420.86
69_F296_Y0.8400.85
32_L361_V0.8370.85
190_H194_S0.8370.85
295_F299_T0.8350.85
28_L32_L0.8330.85
257_G265_G0.8330.85
109_M113_L0.8320.85
75_I79_S0.8280.85
192_Y195_G0.8280.85
376_F383_W0.8280.85
362_C366_M0.8250.84
114_F328_L0.8220.84
26_G31_N0.8170.84
13_I301_V0.8160.84
75_I231_P0.8150.84
306_K309_V0.8140.84
309_V313_L0.8140.84
152_W155_S0.8130.84
302_Y305_H0.8080.83
106_R386_R0.8060.83
92_R123_W0.8020.83
335_T339_Y0.7990.83
189_I192_Y0.7970.82
111_L376_F0.7950.82
240_A243_A0.7860.81
31_N131_Y0.7850.81
333_V365_Q0.7810.81
149_L244_K0.7790.81
266_L296_Y0.7750.81
122_I125_G0.7730.80
258_L298_T0.7720.80
269_G273_Q0.7700.80
138_L236_F0.7690.80
63_A351_P0.7650.80
92_R96_K0.7630.80
21_G25_F0.7610.79
103_L390_Y0.7580.79
155_S159_L0.7560.79
105_V140_L0.7560.79
106_R390_Y0.7530.79
200_I339_Y0.7480.78
152_W156_L0.7480.78
187_Q190_H0.7480.78
58_A62_A0.7470.78
85_G103_L0.7450.78
259_K263_M0.7440.78
152_W271_G0.7400.77
367_V370_H0.7390.77
73_K76_L0.7390.77
82_F135_G0.7370.77
81_L84_F0.7360.77
311_T315_S0.7350.77
161_S287_I0.7330.77
85_G285_L0.7320.77
138_L233_F0.7320.77
200_I204_R0.7310.77
31_N85_G0.7310.77
32_L36_S0.7310.77
354_G358_T0.7240.76
330_Q339_Y0.7230.76
28_L361_V0.7230.76
74_C296_Y0.7220.76
191_V195_G0.7220.76
29_F70_I0.7180.75
13_I16_L0.7170.75
28_L339_Y0.7160.75
28_L323_A0.7160.75
85_G89_M0.7150.75
322_M325_T0.7140.75
186_K189_I0.7120.75
73_K288_G0.7120.75
149_L241_A0.7090.74
123_W323_A0.7080.74
325_T381_F0.7070.74
78_F81_L0.7030.74
85_G240_A0.7030.74
88_V372_W0.7030.74
75_I232_Y0.7020.74
128_L328_L0.7020.74
100_F132_A0.7020.74
114_F129_T0.7010.74
150_L153_A0.6980.73
276_Y284_C0.6960.73
118_H123_W0.6930.73
82_F330_Q0.6920.73
81_L131_Y0.6900.72
187_Q191_V0.6900.72
228_A232_Y0.6890.72
192_Y339_Y0.6890.72
247_Y252_E0.6880.72
62_A350_Y0.6880.72
292_L295_F0.6850.72
84_F362_C0.6850.72
118_H328_L0.6850.72
16_L85_G0.6840.72
11_E390_Y0.6810.71
28_L358_T0.6810.71
360_A367_V0.6780.71
197_L200_I0.6770.71
103_L389_T0.6760.71
31_N358_T0.6750.71
25_F365_Q0.6740.71
322_M365_Q0.6730.70
159_L209_L0.6720.70
17_D21_G0.6720.70
86_M108_L0.6710.70
15_V19_L0.6710.70
323_A373_L0.6690.70
12_R20_R0.6690.70
139_L142_R0.6680.70
86_M240_A0.6670.70
36_S338_F0.6660.70
340_H343_L0.6660.70
310_R314_Q0.6660.70
118_H122_I0.6650.70
230_I234_S0.6640.69
200_I341_Y0.6640.69
125_G386_R0.6610.69
82_F131_Y0.6610.69
91_E95_N0.6600.69
329_M365_Q0.6580.69
54_K158_L0.6580.69
368_F372_W0.6510.68
72_T76_L0.6510.68
37_Y41_Y0.6500.68
361_V365_Q0.6480.68
256_K263_M0.6460.67
91_E243_A0.6450.67
253_K305_H0.6440.67
388_A391_L0.6440.67
20_R107_R0.6430.67
12_R16_L0.6420.67
84_F297_V0.6410.67
256_K265_G0.6410.67
386_R389_T0.6410.67
75_I330_Q0.6410.67
18_V309_V0.6400.67
158_L287_I0.6390.67
78_F107_R0.6380.66
111_L128_L0.6380.66
339_Y342_G0.6380.66
188_A203_Q0.6370.66
323_A385_W0.6340.66
31_N123_W0.6330.66
157_Y161_S0.6310.66
89_M100_F0.6300.65
311_T314_Q0.6290.65
73_K104_Y0.6280.65
164_F168_S0.6280.65
85_G386_R0.6270.65
15_V293_M0.6250.65
196_S297_V0.6240.65
198_K202_E0.6230.65
276_Y297_V0.6230.65
25_F290_P0.6220.64
19_L23_A0.6200.64
27_I78_F0.6190.64
310_R313_L0.6180.64
129_T224_N0.6160.64
19_L297_V0.6160.64
111_L385_W0.6120.63
148_T162_I0.6090.63
197_L335_T0.6090.63
159_L166_L0.6080.63
29_F316_F0.6060.62
305_H309_V0.6050.62
11_E92_R0.6020.62
106_R391_L0.6010.62
264_A360_A0.6000.62
377_R387_S0.6000.62
29_F355_V0.5980.61
31_N36_S0.5970.61
91_E97_G0.5940.61
36_S354_G0.5930.61
89_M142_R0.5920.61
358_T362_C0.5910.61
269_G288_G0.5900.60
57_E297_V0.5890.60
300_V304_Y0.5890.60
31_N106_R0.5890.60
75_I124_D0.5890.60
131_Y325_T0.5870.60
26_G322_M0.5870.60
56_S256_K0.5840.60
24_I319_V0.5840.60
134_L232_Y0.5820.59
329_M332_I0.5780.59
108_L385_W0.5760.59
335_T340_H0.5750.58
164_F366_M0.5750.58
226_F230_I0.5730.58
111_L328_L0.5730.58
171_Q263_M0.5720.58
75_I243_A0.5720.58
35_F123_W0.5710.58
108_L365_Q0.5710.58
146_P149_L0.5700.58
82_F338_F0.5690.58
21_G319_V0.5690.58
258_L262_W0.5680.58
82_F118_H0.5670.57
387_S391_L0.5650.57
24_I78_F0.5650.57
144_A241_A0.5650.57
295_F302_Y0.5650.57
93_A103_L0.5640.57
158_L371_L0.5640.57
108_L139_L0.5640.57
324_F385_W0.5630.57
275_L312_V0.5610.57
18_V22_M0.5610.57
255_R302_Y0.5590.56
322_M369_S0.5590.56
27_I289_A0.5590.56
231_P235_M0.5590.56
342_G345_L0.5580.56
64_D277_S0.5570.56
27_I82_F0.5570.56
91_E94_E0.5570.56
69_F271_G0.5570.56
379_G382_E0.5560.56
80_F85_G0.5540.56
259_K302_Y0.5540.56
84_F231_P0.5540.56
105_V108_L0.5510.55
118_H296_Y0.5510.55
268_I271_G0.5510.55
263_M302_Y0.5510.55
19_L22_M0.5500.55
167_T170_D0.5480.55
124_D341_Y0.5470.55
38_P346_Y0.5470.55
332_I381_F0.5470.55
257_G261_L0.5460.55
31_N386_R0.5420.54
294_F297_V0.5410.54
52_M55_W0.5410.54
56_S59_D0.5410.54
292_L296_Y0.5400.54
153_A332_I0.5400.54
23_A323_A0.5390.54
9_T274_V0.5390.54
118_H125_G0.5390.54
74_C289_A0.5360.53
16_L244_K0.5330.53
58_A61_A0.5330.53
93_A100_F0.5330.53
27_I118_H0.5330.53
31_N354_G0.5320.53
256_K259_K0.5320.53
142_R240_A0.5310.53
299_T302_Y0.5310.53
19_L89_M0.5300.52
34_H124_D0.5300.52
227_F230_I0.5300.52
30_V289_A0.5300.52
385_W388_A0.5290.52
251_P255_R0.5290.52
274_V277_S0.5290.52
72_T276_Y0.5280.52
125_G385_W0.5280.52
279_T332_I0.5270.52
232_Y235_M0.5270.52
23_A372_W0.5270.52
104_Y142_R0.5270.52
72_T75_I0.5270.52
112_L136_F0.5250.52
242_A247_Y0.5240.52
145_K150_L0.5230.51
123_W197_L0.5220.51
155_S263_M0.5220.51
364_V371_L0.5210.51
78_F331_S0.5200.51
385_W389_T0.5180.51
23_A111_L0.5180.51
133_L137_V0.5180.51
158_L263_M0.5170.51
235_M294_F0.5150.50
155_S269_G0.5140.50
186_K325_T0.5140.50
75_I296_Y0.5130.50
261_L294_F0.5120.50
349_V354_G0.5120.50
62_A66_L0.5120.50
117_I145_K0.5120.50
187_Q195_G0.5090.50
99_R133_L0.5080.49
120_F201_A0.5070.49
93_A321_R0.5060.49
21_G365_Q0.5050.49
276_Y316_F0.5050.49
312_V315_S0.5050.49
118_H386_R0.5050.49
100_F361_V0.5040.49
199_D202_E0.5030.49
126_D330_Q0.5020.49
75_I82_F0.5010.49
262_W265_G0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o5gB 1 0.0473 2.8 0.979 Contact Map
2gfpA 2 0.49 2.3 0.979 Contact Map
3mi9A 1 0.1318 1.8 0.981 Contact Map
3j7y3 1 0.0373 1.7 0.981 Contact Map
2m3eA 1 0.1244 1.7 0.981 Contact Map
2k1aA 1 0.1045 1.7 0.981 Contact Map
4p02A 1 0.296 1.7 0.981 Contact Map
1wazA 1 0.1144 1.6 0.981 Contact Map
4i5sA 2 0.0871 1.5 0.981 Contact Map
2eq8C 1 0.0572 1.3 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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