YXAH - BACSU - GREMLIN Contacts

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YXAH - Uncharacterized protein YxaH

UniProt:	P42107	Sequences: MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSMLGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVPLYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLFSIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGMLTYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLYSVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVCTWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLSWQPIAKKTKV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	402 (358)
Sequences:	1992 (1646)
Seq/√Len:	87.0

ECOLI - YEIB
BACSU - YXAH YRKO
HALSA - Q9HNH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
328_L	381_F	6.496	1.00
112_L	132_A	5.480	1.00
326_N	369_S	4.970	1.00
333_V	361_V	3.708	1.00
112_L	129_T	3.518	1.00
141_F	152_W	3.275	1.00
108_L	135_G	3.218	1.00
30_V	70_I	3.175	1.00
110_A	388_A	3.153	1.00
87_V	243_A	3.078	1.00
378_M	383_W	2.981	1.00
122_I	331_S	2.925	1.00
105_V	136_F	2.904	1.00
146_P	244_K	2.877	1.00
336_W	343_L	2.802	1.00
80_F	242_A	2.704	1.00
141_F	237_L	2.699	1.00
256_K	260_R	2.611	1.00
150_L	241_A	2.595	1.00
250_E	253_K	2.582	1.00
146_P	241_A	2.580	1.00
325_T	329_M	2.566	1.00
144_A	152_W	2.489	1.00
145_K	148_T	2.485	1.00
319_V	326_N	2.439	1.00
349_V	357_I	2.432	1.00
84_F	243_A	2.427	1.00
371_L	375_V	2.400	1.00
144_A	148_T	2.363	1.00
315_S	318_A	2.360	1.00
147_K	151_I	2.248	1.00
87_V	240_A	2.239	1.00
65_I	69_F	2.188	1.00
319_V	366_M	2.165	1.00
146_P	245_S	2.143	1.00
86_M	104_Y	2.141	1.00
141_F	144_A	2.138	1.00
267_V	271_G	2.098	1.00
196_S	199_D	2.082	1.00
114_F	381_F	2.081	1.00
335_T	341_Y	2.023	1.00
318_A	370_H	2.004	1.00
262_W	299_T	1.994	1.00
262_W	295_F	1.982	1.00
262_W	298_T	1.917	1.00
18_V	300_V	1.845	1.00
92_R	95_N	1.837	1.00
117_I	122_I	1.807	1.00
255_R	259_K	1.737	1.00
118_H	331_S	1.713	1.00
77_L	297_V	1.706	1.00
28_L	334_C	1.690	1.00
261_L	298_T	1.667	1.00
153_A	238_L	1.645	1.00
26_G	74_C	1.639	1.00
265_G	298_T	1.630	1.00
241_A	245_S	1.623	1.00
148_T	151_I	1.615	1.00
151_I	155_S	1.612	1.00
322_M	372_W	1.596	1.00
25_F	362_C	1.592	1.00
73_K	273_Q	1.568	1.00
105_V	109_M	1.564	1.00
325_T	368_F	1.562	1.00
353_A	356_L	1.547	1.00
321_R	373_L	1.534	1.00
105_V	139_L	1.530	1.00
114_F	324_F	1.503	1.00
377_R	383_W	1.489	0.99
261_L	265_G	1.476	0.99
383_W	387_S	1.473	0.99
76_L	293_M	1.461	0.99
18_V	317_S	1.460	0.99
143_K	147_K	1.460	0.99
86_M	138_L	1.434	0.99
73_K	292_L	1.426	0.99
76_L	289_A	1.422	0.99
57_E	61_A	1.418	0.99
153_A	241_A	1.416	0.99
322_M	368_F	1.406	0.99
326_N	365_Q	1.394	0.99
86_M	142_R	1.385	0.99
29_F	358_T	1.379	0.99
152_W	237_L	1.370	0.99
371_L	374_R	1.365	0.99
17_D	20_R	1.359	0.99
166_L	170_D	1.350	0.99
108_L	132_A	1.343	0.99
356_L	360_A	1.342	0.99
104_Y	108_L	1.336	0.99
329_M	368_F	1.331	0.99
157_Y	234_S	1.329	0.99
322_M	373_L	1.323	0.99
14_G	317_S	1.321	0.99
16_L	84_F	1.316	0.99
369_S	373_L	1.315	0.99
295_F	298_T	1.312	0.99
267_V	295_F	1.310	0.99
330_Q	365_Q	1.289	0.99
23_A	26_G	1.268	0.98
203_Q	207_D	1.267	0.98
370_H	374_R	1.266	0.98
247_Y	257_G	1.265	0.98
19_L	300_V	1.253	0.98
336_W	341_Y	1.246	0.98
269_G	295_F	1.243	0.98
15_V	301_V	1.243	0.98
110_A	114_F	1.240	0.98
378_M	387_S	1.238	0.98
246_R	249_H	1.233	0.98
32_L	354_G	1.231	0.98
266_L	295_F	1.216	0.98
108_L	136_F	1.213	0.98
372_W	376_F	1.211	0.98
87_V	91_E	1.205	0.98
255_R	305_H	1.203	0.98
350_Y	353_A	1.189	0.97
117_I	121_L	1.188	0.97
24_I	323_A	1.186	0.97
134_L	233_F	1.184	0.97
85_G	88_V	1.180	0.97
333_V	337_I	1.179	0.97
59_D	350_Y	1.177	0.97
127_I	131_Y	1.176	0.97
272_A	288_G	1.162	0.97
386_R	390_Y	1.157	0.97
122_I	126_D	1.156	0.97
16_L	321_R	1.147	0.97
264_A	267_V	1.141	0.97
387_S	392_S	1.136	0.97
148_T	152_W	1.131	0.97
90_M	142_R	1.130	0.97
89_M	103_L	1.127	0.97
315_S	370_H	1.125	0.96
88_V	92_R	1.120	0.96
364_V	368_F	1.119	0.96
366_M	370_H	1.119	0.96
231_P	234_S	1.117	0.96
373_L	376_F	1.115	0.96
57_E	60_F	1.112	0.96
67_K	71_Q	1.112	0.96
263_M	267_V	1.111	0.96
76_L	235_M	1.109	0.96
334_C	361_V	1.098	0.96
337_I	345_L	1.097	0.96
90_M	100_F	1.096	0.96
110_A	385_W	1.095	0.96
22_M	300_V	1.090	0.96
109_M	136_F	1.089	0.96
195_G	199_D	1.085	0.96
77_L	293_M	1.085	0.96
260_R	264_A	1.080	0.96
151_I	154_V	1.079	0.96
114_F	385_W	1.078	0.96
27_I	331_S	1.067	0.95
367_V	371_L	1.058	0.95
18_V	304_Y	1.052	0.95
369_S	372_W	1.050	0.95
85_G	390_Y	1.046	0.95
138_L	240_A	1.044	0.95
136_F	140_L	1.043	0.95
184_Q	187_Q	1.042	0.95
73_K	131_Y	1.036	0.94
340_H	344_G	1.033	0.94
61_A	65_I	1.021	0.94
128_L	324_F	1.019	0.94
241_A	244_K	1.015	0.94
197_L	201_A	1.012	0.94
291_F	295_F	1.012	0.94
87_V	244_K	1.011	0.94
137_V	140_L	1.007	0.94
153_A	234_S	1.001	0.93
18_V	316_F	0.999	0.93
62_A	352_A	0.993	0.93
59_D	352_A	0.989	0.93
30_V	71_Q	0.988	0.93
299_T	303_L	0.988	0.93
66_L	70_I	0.988	0.93
154_V	158_L	0.986	0.93
205_I	209_L	0.984	0.93
101_V	142_R	0.984	0.93
323_A	326_N	0.981	0.93
158_L	162_I	0.976	0.92
145_K	151_I	0.972	0.92
84_F	246_R	0.967	0.92
106_R	110_A	0.964	0.92
62_A	355_V	0.963	0.92
199_D	203_Q	0.956	0.92
134_L	229_S	0.954	0.92
204_R	341_Y	0.952	0.92
123_W	126_D	0.949	0.91
246_R	250_E	0.939	0.91
265_G	295_F	0.938	0.91
86_M	236_F	0.937	0.91
345_L	349_V	0.933	0.91
197_L	341_Y	0.929	0.91
25_F	319_V	0.925	0.90
114_F	388_A	0.924	0.90
378_M	386_R	0.922	0.90
27_I	75_I	0.919	0.90
125_G	331_S	0.917	0.90
208_R	212_M	0.905	0.89
201_A	205_I	0.905	0.89
324_F	381_F	0.903	0.89
87_V	90_M	0.899	0.89
298_T	302_Y	0.899	0.89
32_L	334_C	0.894	0.89
84_F	248_L	0.890	0.89
273_Q	288_G	0.888	0.88
150_L	154_V	0.885	0.88
32_L	357_I	0.885	0.88
337_I	343_L	0.877	0.88
86_M	90_M	0.875	0.88
293_M	297_V	0.875	0.88
114_F	128_L	0.874	0.88
84_F	242_A	0.873	0.88
35_F	38_P	0.873	0.88
100_F	104_Y	0.873	0.88
19_L	292_L	0.872	0.88
269_G	292_L	0.869	0.87
22_M	316_F	0.867	0.87
185_A	188_A	0.865	0.87
323_A	369_S	0.864	0.87
13_I	249_H	0.863	0.87
156_L	233_F	0.861	0.87
58_A	352_A	0.861	0.87
120_F	205_I	0.857	0.87
75_I	289_A	0.857	0.87
123_W	331_S	0.857	0.87
134_L	236_F	0.854	0.86
118_H	126_D	0.853	0.86
108_L	112_L	0.852	0.86
271_G	275_L	0.852	0.86
120_F	208_R	0.849	0.86
80_F	235_M	0.847	0.86
12_R	17_D	0.845	0.86
132_A	240_A	0.843	0.86
35_F	338_F	0.842	0.86
371_L	376_F	0.842	0.86
69_F	296_Y	0.840	0.85
32_L	361_V	0.837	0.85
190_H	194_S	0.837	0.85
295_F	299_T	0.835	0.85
28_L	32_L	0.833	0.85
257_G	265_G	0.833	0.85
109_M	113_L	0.832	0.85
75_I	79_S	0.828	0.85
192_Y	195_G	0.828	0.85
376_F	383_W	0.828	0.85
362_C	366_M	0.825	0.84
114_F	328_L	0.822	0.84
26_G	31_N	0.817	0.84
13_I	301_V	0.816	0.84
75_I	231_P	0.815	0.84
306_K	309_V	0.814	0.84
309_V	313_L	0.814	0.84
152_W	155_S	0.813	0.84
302_Y	305_H	0.808	0.83
106_R	386_R	0.806	0.83
92_R	123_W	0.802	0.83
335_T	339_Y	0.799	0.83
189_I	192_Y	0.797	0.82
111_L	376_F	0.795	0.82
240_A	243_A	0.786	0.81
31_N	131_Y	0.785	0.81
333_V	365_Q	0.781	0.81
149_L	244_K	0.779	0.81
266_L	296_Y	0.775	0.81
122_I	125_G	0.773	0.80
258_L	298_T	0.772	0.80
269_G	273_Q	0.770	0.80
138_L	236_F	0.769	0.80
63_A	351_P	0.765	0.80
92_R	96_K	0.763	0.80
21_G	25_F	0.761	0.79
103_L	390_Y	0.758	0.79
155_S	159_L	0.756	0.79
105_V	140_L	0.756	0.79
106_R	390_Y	0.753	0.79
200_I	339_Y	0.748	0.78
152_W	156_L	0.748	0.78
187_Q	190_H	0.748	0.78
58_A	62_A	0.747	0.78
85_G	103_L	0.745	0.78
259_K	263_M	0.744	0.78
152_W	271_G	0.740	0.77
367_V	370_H	0.739	0.77
73_K	76_L	0.739	0.77
82_F	135_G	0.737	0.77
81_L	84_F	0.736	0.77
311_T	315_S	0.735	0.77
161_S	287_I	0.733	0.77
85_G	285_L	0.732	0.77
138_L	233_F	0.732	0.77
200_I	204_R	0.731	0.77
31_N	85_G	0.731	0.77
32_L	36_S	0.731	0.77
354_G	358_T	0.724	0.76
330_Q	339_Y	0.723	0.76
28_L	361_V	0.723	0.76
74_C	296_Y	0.722	0.76
191_V	195_G	0.722	0.76
29_F	70_I	0.718	0.75
13_I	16_L	0.717	0.75
28_L	339_Y	0.716	0.75
28_L	323_A	0.716	0.75
85_G	89_M	0.715	0.75
322_M	325_T	0.714	0.75
186_K	189_I	0.712	0.75
73_K	288_G	0.712	0.75
149_L	241_A	0.709	0.74
123_W	323_A	0.708	0.74
325_T	381_F	0.707	0.74
78_F	81_L	0.703	0.74
85_G	240_A	0.703	0.74
88_V	372_W	0.703	0.74
75_I	232_Y	0.702	0.74
128_L	328_L	0.702	0.74
100_F	132_A	0.702	0.74
114_F	129_T	0.701	0.74
150_L	153_A	0.698	0.73
276_Y	284_C	0.696	0.73
118_H	123_W	0.693	0.73
82_F	330_Q	0.692	0.73
81_L	131_Y	0.690	0.72
187_Q	191_V	0.690	0.72
228_A	232_Y	0.689	0.72
192_Y	339_Y	0.689	0.72
247_Y	252_E	0.688	0.72
62_A	350_Y	0.688	0.72
292_L	295_F	0.685	0.72
84_F	362_C	0.685	0.72
118_H	328_L	0.685	0.72
16_L	85_G	0.684	0.72
11_E	390_Y	0.681	0.71
28_L	358_T	0.681	0.71
360_A	367_V	0.678	0.71
197_L	200_I	0.677	0.71
103_L	389_T	0.676	0.71
31_N	358_T	0.675	0.71
25_F	365_Q	0.674	0.71
322_M	365_Q	0.673	0.70
159_L	209_L	0.672	0.70
17_D	21_G	0.672	0.70
86_M	108_L	0.671	0.70
15_V	19_L	0.671	0.70
323_A	373_L	0.669	0.70
12_R	20_R	0.669	0.70
139_L	142_R	0.668	0.70
86_M	240_A	0.667	0.70
36_S	338_F	0.666	0.70
340_H	343_L	0.666	0.70
310_R	314_Q	0.666	0.70
118_H	122_I	0.665	0.70
230_I	234_S	0.664	0.69
200_I	341_Y	0.664	0.69
125_G	386_R	0.661	0.69
82_F	131_Y	0.661	0.69
91_E	95_N	0.660	0.69
329_M	365_Q	0.658	0.69
54_K	158_L	0.658	0.69
368_F	372_W	0.651	0.68
72_T	76_L	0.651	0.68
37_Y	41_Y	0.650	0.68
361_V	365_Q	0.648	0.68
256_K	263_M	0.646	0.67
91_E	243_A	0.645	0.67
253_K	305_H	0.644	0.67
388_A	391_L	0.644	0.67
20_R	107_R	0.643	0.67
12_R	16_L	0.642	0.67
84_F	297_V	0.641	0.67
256_K	265_G	0.641	0.67
386_R	389_T	0.641	0.67
75_I	330_Q	0.641	0.67
18_V	309_V	0.640	0.67
158_L	287_I	0.639	0.67
78_F	107_R	0.638	0.66
111_L	128_L	0.638	0.66
339_Y	342_G	0.638	0.66
188_A	203_Q	0.637	0.66
323_A	385_W	0.634	0.66
31_N	123_W	0.633	0.66
157_Y	161_S	0.631	0.66
89_M	100_F	0.630	0.65
311_T	314_Q	0.629	0.65
73_K	104_Y	0.628	0.65
164_F	168_S	0.628	0.65
85_G	386_R	0.627	0.65
15_V	293_M	0.625	0.65
196_S	297_V	0.624	0.65
198_K	202_E	0.623	0.65
276_Y	297_V	0.623	0.65
25_F	290_P	0.622	0.64
19_L	23_A	0.620	0.64
27_I	78_F	0.619	0.64
310_R	313_L	0.618	0.64
129_T	224_N	0.616	0.64
19_L	297_V	0.616	0.64
111_L	385_W	0.612	0.63
148_T	162_I	0.609	0.63
197_L	335_T	0.609	0.63
159_L	166_L	0.608	0.63
29_F	316_F	0.606	0.62
305_H	309_V	0.605	0.62
11_E	92_R	0.602	0.62
106_R	391_L	0.601	0.62
264_A	360_A	0.600	0.62
377_R	387_S	0.600	0.62
29_F	355_V	0.598	0.61
31_N	36_S	0.597	0.61
91_E	97_G	0.594	0.61
36_S	354_G	0.593	0.61
89_M	142_R	0.592	0.61
358_T	362_C	0.591	0.61
269_G	288_G	0.590	0.60
57_E	297_V	0.589	0.60
300_V	304_Y	0.589	0.60
31_N	106_R	0.589	0.60
75_I	124_D	0.589	0.60
131_Y	325_T	0.587	0.60
26_G	322_M	0.587	0.60
56_S	256_K	0.584	0.60
24_I	319_V	0.584	0.60
134_L	232_Y	0.582	0.59
329_M	332_I	0.578	0.59
108_L	385_W	0.576	0.59
335_T	340_H	0.575	0.58
164_F	366_M	0.575	0.58
226_F	230_I	0.573	0.58
111_L	328_L	0.573	0.58
171_Q	263_M	0.572	0.58
75_I	243_A	0.572	0.58
35_F	123_W	0.571	0.58
108_L	365_Q	0.571	0.58
146_P	149_L	0.570	0.58
82_F	338_F	0.569	0.58
21_G	319_V	0.569	0.58
258_L	262_W	0.568	0.58
82_F	118_H	0.567	0.57
387_S	391_L	0.565	0.57
24_I	78_F	0.565	0.57
144_A	241_A	0.565	0.57
295_F	302_Y	0.565	0.57
93_A	103_L	0.564	0.57
158_L	371_L	0.564	0.57
108_L	139_L	0.564	0.57
324_F	385_W	0.563	0.57
275_L	312_V	0.561	0.57
18_V	22_M	0.561	0.57
255_R	302_Y	0.559	0.56
322_M	369_S	0.559	0.56
27_I	289_A	0.559	0.56
231_P	235_M	0.559	0.56
342_G	345_L	0.558	0.56
64_D	277_S	0.557	0.56
27_I	82_F	0.557	0.56
91_E	94_E	0.557	0.56
69_F	271_G	0.557	0.56
379_G	382_E	0.556	0.56
80_F	85_G	0.554	0.56
259_K	302_Y	0.554	0.56
84_F	231_P	0.554	0.56
105_V	108_L	0.551	0.55
118_H	296_Y	0.551	0.55
268_I	271_G	0.551	0.55
263_M	302_Y	0.551	0.55
19_L	22_M	0.550	0.55
167_T	170_D	0.548	0.55
124_D	341_Y	0.547	0.55
38_P	346_Y	0.547	0.55
332_I	381_F	0.547	0.55
257_G	261_L	0.546	0.55
31_N	386_R	0.542	0.54
294_F	297_V	0.541	0.54
52_M	55_W	0.541	0.54
56_S	59_D	0.541	0.54
292_L	296_Y	0.540	0.54
153_A	332_I	0.540	0.54
23_A	323_A	0.539	0.54
9_T	274_V	0.539	0.54
118_H	125_G	0.539	0.54
74_C	289_A	0.536	0.53
16_L	244_K	0.533	0.53
58_A	61_A	0.533	0.53
93_A	100_F	0.533	0.53
27_I	118_H	0.533	0.53
31_N	354_G	0.532	0.53
256_K	259_K	0.532	0.53
142_R	240_A	0.531	0.53
299_T	302_Y	0.531	0.53
19_L	89_M	0.530	0.52
34_H	124_D	0.530	0.52
227_F	230_I	0.530	0.52
30_V	289_A	0.530	0.52
385_W	388_A	0.529	0.52
251_P	255_R	0.529	0.52
274_V	277_S	0.529	0.52
72_T	276_Y	0.528	0.52
125_G	385_W	0.528	0.52
279_T	332_I	0.527	0.52
232_Y	235_M	0.527	0.52
23_A	372_W	0.527	0.52
104_Y	142_R	0.527	0.52
72_T	75_I	0.527	0.52
112_L	136_F	0.525	0.52
242_A	247_Y	0.524	0.52
145_K	150_L	0.523	0.51
123_W	197_L	0.522	0.51
155_S	263_M	0.522	0.51
364_V	371_L	0.521	0.51
78_F	331_S	0.520	0.51
385_W	389_T	0.518	0.51
23_A	111_L	0.518	0.51
133_L	137_V	0.518	0.51
158_L	263_M	0.517	0.51
235_M	294_F	0.515	0.50
155_S	269_G	0.514	0.50
186_K	325_T	0.514	0.50
75_I	296_Y	0.513	0.50
261_L	294_F	0.512	0.50
349_V	354_G	0.512	0.50
62_A	66_L	0.512	0.50
117_I	145_K	0.512	0.50
187_Q	195_G	0.509	0.50
99_R	133_L	0.508	0.49
120_F	201_A	0.507	0.49
93_A	321_R	0.506	0.49
21_G	365_Q	0.505	0.49
276_Y	316_F	0.505	0.49
312_V	315_S	0.505	0.49
118_H	386_R	0.505	0.49
100_F	361_V	0.504	0.49
199_D	202_E	0.503	0.49
126_D	330_Q	0.502	0.49
75_I	82_F	0.501	0.49
262_W	265_G	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o5gB	1	0.0473	2.8	0.979	Contact Map
2gfpA	2	0.49	2.3	0.979	Contact Map
3mi9A	1	0.1318	1.8	0.981	Contact Map
3j7y3	1	0.0373	1.7	0.981	Contact Map
2m3eA	1	0.1244	1.7	0.981	Contact Map
2k1aA	1	0.1045	1.7	0.981	Contact Map
4p02A	1	0.296	1.7	0.981	Contact Map
1wazA	1	0.1144	1.6	0.981	Contact Map
4i5sA	2	0.0871	1.5	0.981	Contact Map
2eq8C	1	0.0572	1.3	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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