GREMLIN Database
YXAF - Uncharacterized HTH-type transcriptional regulator YxaF
UniProt: P42105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (176)
Sequences: 44296 (34840)
Seq/√Len: 2626.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_N40_K4.0611.00
22_Q31_Q3.9771.00
17_R35_E3.5601.00
48_P53_E2.6851.00
19_F27_T2.4171.00
49_N53_E2.1591.00
33_V43_L2.0961.00
7_S10_K2.0761.00
14_T35_E2.0581.00
9_E61_Y2.0451.00
18_L35_E1.9971.00
10_K14_T1.9861.00
18_L31_Q1.9711.00
21_L35_E1.9711.00
132_E150_N1.9661.00
8_R57_E1.9031.00
18_L27_T1.8961.00
79_D82_E1.8741.00
30_N34_K1.7881.00
18_L22_Q1.7671.00
136_A140_M1.7541.00
132_E136_A1.7381.00
16_S61_Y1.7301.00
39_P42_S1.7201.00
14_T17_R1.7041.00
83_A137_R1.6791.00
9_E13_H1.6641.00
136_A149_A1.6611.00
12_L57_E1.6571.00
15_A19_F1.6161.00
29_L44_Y1.5681.00
29_L40_K1.5501.00
60_T123_V1.5151.00
15_A54_L1.4981.00
61_Y65_I1.4971.00
17_R21_L1.4841.00
31_Q34_K1.4771.00
31_Q35_E1.4751.00
137_R141_E1.4671.00
136_A139_L1.4581.00
57_E60_T1.4501.00
13_H61_Y1.4381.00
139_L146_E1.4311.00
16_S58_A1.4151.00
108_L112_E1.4141.00
155_L159_M1.4131.00
16_S62_T1.4021.00
56_I60_T1.4011.00
89_K180_A1.3891.00
23_G27_T1.3821.00
42_S45_H1.3821.00
47_F57_E1.3481.00
134_V138_K1.3161.00
6_D10_K1.3081.00
28_G31_Q1.3051.00
29_L43_L1.2771.00
27_T32_I1.2721.00
14_T18_L1.2701.00
53_E57_E1.2511.00
6_D9_E1.2511.00
128_F132_E1.2501.00
38_A42_S1.2191.00
23_G26_A1.2061.00
41_G45_H1.2011.00
42_S46_F1.2001.00
24_Y55_A1.1971.00
19_F24_Y1.1921.00
139_L147_E1.1831.00
138_K144_F1.1791.00
69_L90_K1.1751.00
22_Q26_A1.1711.00
85_Q89_K1.1521.00
138_K143_G1.1481.00
104_I108_L1.1351.00
52_E56_I1.1311.00
82_E86_L1.1211.00
12_L47_F1.1111.00
148_E151_Q1.1091.00
40_K44_Y1.0911.00
81_V85_Q1.0891.00
44_Y49_N1.0851.00
14_T36_S1.0821.00
175_P178_L1.0701.00
53_E56_I1.0661.00
43_L54_L1.0631.00
86_L89_K1.0581.00
12_L58_A1.0551.00
56_I119_P1.0501.00
39_P45_H1.0421.00
79_D143_G1.0411.00
49_N52_E1.0391.00
139_L149_A1.0341.00
32_I54_L1.0321.00
8_R46_F1.0311.00
60_T64_K1.0171.00
7_S46_F1.0011.00
151_Q178_L1.0011.00
13_H17_R0.9941.00
139_L142_N0.9911.00
22_Q35_E0.9771.00
158_S162_G0.9761.00
73_S86_L0.9731.00
16_S20_Q0.9691.00
78_S86_L0.9661.00
62_T65_I0.9641.00
89_K177_L0.9551.00
71_Q130_S0.9501.00
7_S38_A0.9391.00
151_Q182_Q0.9351.00
61_Y64_K0.9311.00
82_E85_Q0.9311.00
94_Q98_T0.9291.00
137_R140_M0.9241.00
150_N154_T0.9211.00
69_L72_Q0.9191.00
33_V40_K0.9151.00
73_S90_K0.8981.00
133_A137_R0.8971.00
133_A136_A0.8961.00
85_Q181_E0.8951.00
57_E61_Y0.8831.00
5_G9_E0.8691.00
134_V137_R0.8671.00
128_F154_T0.8661.00
40_K45_H0.8651.00
86_L90_K0.8641.00
90_K93_S0.8621.00
17_R100_S0.8611.00
71_Q75_D0.8601.00
15_A58_A0.8591.00
130_S133_A0.8591.00
129_K133_A0.8481.00
68_H72_Q0.8471.00
77_S83_A0.8441.00
174_T178_L0.8291.00
129_K132_E0.8221.00
64_K68_H0.8121.00
12_L61_Y0.7991.00
10_K13_H0.7951.00
119_P123_V0.7911.00
167_S170_N0.7881.00
139_L144_F0.7861.00
89_K93_S0.7861.00
10_K36_S0.7841.00
78_S82_E0.7831.00
119_P122_T0.7831.00
118_E122_T0.7801.00
67_E71_Q0.7771.00
24_Y51_K0.7771.00
125_M129_K0.7651.00
30_N44_Y0.7631.00
34_K40_K0.7571.00
88_I156_I0.7561.00
149_A153_G0.7561.00
108_L111_S0.7521.00
123_V126_K0.7501.00
113_T117_S0.7501.00
80_P138_K0.7491.00
136_A150_N0.7401.00
112_E116_I0.7371.00
52_E117_S0.7351.00
67_E130_S0.7351.00
77_S86_L0.7291.00
80_P141_E0.7281.00
13_H16_S0.7271.00
18_L21_L0.7251.00
25_H112_E0.7191.00
151_Q155_L0.7191.00
76_E86_L0.7191.00
52_E119_P0.7191.00
151_Q181_E0.7111.00
29_L33_V0.7061.00
126_K130_S0.7011.00
65_I68_H0.6951.00
107_G111_S0.6951.00
179_I182_Q0.6931.00
19_F55_A0.6911.00
11_I43_L0.6831.00
93_S176_L0.6801.00
56_I123_V0.6761.00
22_Q27_T0.6761.00
132_E153_G0.6741.00
132_E149_A0.6721.00
178_L182_Q0.6721.00
92_A177_L0.6711.00
103_G108_L0.6691.00
11_I36_S0.6681.00
21_L31_Q0.6671.00
93_S97_N0.6671.00
107_G110_A0.6621.00
177_L181_E0.6591.00
83_A138_K0.6531.00
11_I46_F0.6531.00
105_P108_L0.6441.00
116_I120_L0.6431.00
103_G107_G0.6431.00
7_S39_P0.6431.00
151_Q154_T0.6411.00
72_Q90_K0.6391.00
135_F139_L0.6381.00
107_G112_E0.6371.00
122_T126_K0.6361.00
118_E121_R0.6341.00
104_I107_G0.6321.00
36_S39_P0.6311.00
176_L179_I0.6291.00
24_Y52_E0.6291.00
114_A117_S0.6271.00
180_A183_I0.6251.00
121_R124_C0.6251.00
178_L181_E0.6221.00
68_H71_Q0.6211.00
85_Q88_I0.6201.00
176_L180_A0.6171.00
155_L158_S0.6171.00
12_L16_S0.6151.00
166_L170_N0.6121.00
148_E152_L0.6071.00
166_L169_T0.6051.00
175_P180_A0.6041.00
80_P143_G0.5991.00
138_K141_E0.5961.00
172_D175_P0.5921.00
91_T95_F0.5891.00
81_V143_G0.5871.00
109_L113_T0.5851.00
16_S65_I0.5851.00
79_D83_A0.5771.00
7_S42_S0.5751.00
33_V39_P0.5741.00
138_K142_N0.5731.00
159_M162_G0.5721.00
83_A134_V0.5701.00
121_R125_M0.5701.00
173_K177_L0.5591.00
72_Q76_E0.5571.00
109_L112_E0.5521.00
90_K94_Q0.5511.00
33_V38_A0.5501.00
161_E166_L0.5491.00
158_S161_E0.5471.00
128_F150_N0.5451.00
174_T177_L0.5441.00
127_V131_W0.5431.00
67_E126_K0.5411.00
36_S40_K0.5401.00
110_A114_A0.5391.00
69_L94_Q0.5361.00
88_I91_T0.5311.00
15_A32_I0.5301.00
117_S121_R0.5291.00
94_Q97_N0.5271.00
33_V36_S0.5241.00
89_K181_E0.5221.00
158_S166_L0.5211.00
154_T166_L0.5181.00
65_I69_L0.5121.00
140_M149_A0.5111.00
73_S77_S0.5081.00
73_S76_E0.5061.00
5_G8_R0.5051.00
113_T116_I0.5031.00
135_F156_I0.5011.00
24_Y27_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sgmA 2 0.9581 100 0.208 Contact Map
2g7sA 2 0.9686 100 0.229 Contact Map
2ibdA 2 0.9738 100 0.245 Contact Map
1vi0A 2 0.9634 100 0.246 Contact Map
3qbmA 2 0.9948 100 0.246 Contact Map
3kz9A 2 0.9948 100 0.246 Contact Map
2genA 2 0.9581 100 0.25 Contact Map
3f0cA 2 0.9476 100 0.25 Contact Map
4udsA 2 0.9424 100 0.25 Contact Map
3bruA 2 0.9686 100 0.251 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.