GREMLIN Database
YXAC - Uncharacterized protein YxaC
UniProt: P42102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 230 (221)
Sequences: 1921 (1327)
Seq/√Len: 89.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_V214_A5.6241.00
135_A153_V4.9951.00
137_Q140_A4.0931.00
139_A149_T3.6081.00
14_T57_Y3.3921.00
127_P139_A3.2831.00
176_S199_G3.1331.00
183_L195_A3.0341.00
164_G183_L3.0231.00
160_G187_S2.7031.00
17_A42_L2.6531.00
192_T206_S2.5231.00
130_I138_I2.4111.00
169_K179_Q2.3891.00
194_K197_E2.2671.00
112_A117_I2.2081.00
164_G168_L2.1951.00
112_A122_L2.0701.00
17_A39_T2.0111.00
168_L183_L1.9881.00
21_M38_T1.9441.00
38_T42_L1.8811.00
199_G202_A1.8661.00
23_K27_R1.8291.00
179_Q202_A1.8221.00
58_M65_N1.7881.00
123_L142_L1.7821.00
21_M39_T1.7431.00
124_S145_V1.7231.00
124_S144_G1.7071.00
101_L213_C1.6821.00
45_A49_M1.6821.00
99_V103_M1.6781.00
84_H88_K1.6661.00
45_A48_M1.6601.00
208_V214_A1.6441.00
10_I52_V1.6261.00
17_A43_I1.5951.00
112_A125_I1.5861.00
20_A24_L1.5821.00
89_H92_P1.5771.00
181_I185_S1.5741.00
17_A46_A1.5661.00
108_G156_A1.5051.00
129_S156_A1.5011.00
17_A21_M1.4781.00
109_L126_L1.4700.99
119_H123_L1.4640.99
166_L170_W1.4440.99
131_T134_V1.4320.99
58_M62_K1.4190.99
110_I114_A1.4020.99
98_L216_L1.3860.99
130_I134_V1.3670.99
20_A42_L1.3640.99
26_K29_P1.3610.99
41_I45_A1.3580.99
46_A50_F1.3540.99
181_I209_S1.3420.99
16_A20_A1.3320.99
90_C94_L1.3240.99
133_P137_Q1.3180.99
127_P149_T1.2960.99
101_L105_M1.2880.99
23_K28_F1.2850.99
187_S206_S1.2840.99
72_V77_Y1.2600.98
58_M61_G1.2550.98
106_I110_I1.2550.98
181_I205_M1.2480.98
83_W87_V1.2430.98
146_P150_V1.2340.98
105_M221_G1.2310.98
89_H205_M1.2300.98
138_I217_G1.2280.98
176_S202_A1.2100.98
110_I113_E1.2050.98
69_G133_P1.2000.98
128_K156_A1.1870.98
47_L54_Y1.1830.98
136_I150_V1.1660.97
118_D121_L1.1610.97
20_A23_K1.1570.97
148_M152_F1.1560.97
59_I62_K1.1370.97
13_L43_I1.1310.97
219_F223_L1.1080.96
10_I60_G1.1050.96
132_T154_M1.0970.96
154_M158_F1.0880.96
168_L173_I1.0730.96
25_Y33_L1.0710.96
78_P207_S1.0690.96
72_V156_A1.0680.96
68_L189_A1.0640.96
23_K26_K1.0600.95
56_G61_G1.0600.95
156_A187_S1.0260.95
81_K200_E1.0250.95
44_V48_M1.0250.95
196_L204_S1.0180.94
22_V26_K1.0130.94
195_A203_V1.0130.94
136_I139_A1.0070.94
195_A199_G1.0030.94
30_L33_L1.0030.94
24_L38_T1.0020.94
105_M126_L1.0000.94
28_F33_L1.0000.94
84_H87_V0.9930.94
121_L124_S0.9820.93
207_S211_T0.9680.93
105_M220_F0.9660.93
161_V190_L0.9650.93
101_L217_G0.9580.92
136_I146_P0.9500.92
80_Y83_W0.9390.92
19_L23_K0.9370.91
179_Q198_Y0.9340.91
185_S213_C0.9330.91
149_T153_V0.9310.91
91_V94_L0.9250.91
68_L133_P0.9250.91
100_G185_S0.9200.91
109_L122_L0.9180.91
97_V213_C0.9180.91
34_I38_T0.9180.91
188_H191_G0.9160.90
33_L38_T0.8960.89
192_T203_V0.8930.89
50_F53_S0.8850.89
160_G206_S0.8820.89
163_L166_L0.8800.89
158_F190_L0.8790.89
175_S178_G0.8770.88
124_S149_T0.8710.88
108_G128_K0.8680.88
189_A207_S0.8650.88
54_Y73_V0.8590.87
196_L203_V0.8570.87
113_E122_L0.8560.87
33_L164_G0.8450.87
90_C154_M0.8360.86
36_V190_L0.8350.86
95_G99_V0.8350.86
156_A159_S0.8310.86
53_S56_G0.8300.86
54_Y151_V0.8270.85
10_I61_G0.8250.85
34_I37_L0.8250.85
157_G160_G0.8250.85
121_L145_V0.8240.85
31_P34_I0.8190.85
48_M51_H0.8120.84
177_L205_M0.8100.84
79_L222_P0.8070.84
150_V153_V0.8040.84
123_L225_V0.8040.84
223_L227_L0.8030.84
18_Y22_V0.8000.83
139_A144_G0.7990.83
39_T42_L0.7960.83
93_I181_I0.7940.83
201_L215_V0.7920.83
160_G188_H0.7900.83
56_G59_I0.7880.82
142_L221_G0.7880.82
206_S209_S0.7880.82
137_Q141_G0.7870.82
126_L225_V0.7850.82
74_A150_V0.7840.82
205_M210_M0.7800.82
199_G205_M0.7760.82
96_G205_M0.7760.82
75_L128_K0.7750.81
138_I221_G0.7750.81
89_H177_L0.7730.81
7_A10_I0.7720.81
42_L45_A0.7650.81
182_A186_A0.7640.81
97_V185_S0.7610.80
185_S207_S0.7610.80
131_T214_A0.7600.80
25_Y133_P0.7540.80
115_F215_V0.7530.80
113_E227_L0.7440.79
39_T43_I0.7430.79
163_L167_F0.7400.78
104_G107_S0.7390.78
124_S139_A0.7380.78
58_M63_W0.7330.78
101_L216_L0.7320.78
128_K218_S0.7310.78
34_I205_M0.7290.77
125_I152_F0.7270.77
84_H99_V0.7260.77
25_Y28_F0.7250.77
133_P146_P0.7150.76
111_F115_F0.7150.76
28_F31_P0.7130.76
188_H192_T0.7100.75
108_G111_F0.7090.75
60_G127_P0.7050.75
96_G104_G0.7040.75
25_Y30_L0.7010.75
123_L144_G0.7000.74
130_I217_G0.7000.74
119_H227_L0.6980.74
132_T153_V0.6970.74
105_M210_M0.6960.74
126_L221_G0.6890.73
13_L46_A0.6830.73
77_Y104_G0.6820.72
214_A218_S0.6740.72
72_V217_G0.6680.71
7_A66_S0.6670.71
37_L162_I0.6660.71
73_V148_M0.6640.70
159_S163_L0.6640.70
165_P169_K0.6630.70
165_P194_K0.6620.70
86_I204_S0.6620.70
85_I177_L0.6610.70
85_I205_M0.6610.70
76_A130_I0.6570.70
132_T136_I0.6550.69
16_A51_H0.6540.69
82_Q201_L0.6540.69
223_L226_W0.6530.69
156_A188_H0.6480.69
51_H169_K0.6460.68
102_C170_W0.6450.68
218_S221_G0.6450.68
85_I201_L0.6420.68
51_H55_E0.6400.68
73_V78_P0.6390.68
157_G188_H0.6370.67
102_C106_I0.6360.67
77_Y208_V0.6360.67
99_V110_I0.6320.67
141_G211_T0.6230.66
64_I67_L0.6230.66
107_S111_F0.6190.65
102_C111_F0.6160.65
48_M120_D0.6150.65
98_L212_L0.6150.65
34_I40_T0.6140.64
82_Q136_I0.6110.64
95_G225_V0.6070.64
98_L220_F0.6070.64
56_G170_W0.6050.63
131_T165_P0.6030.63
97_V209_S0.6010.63
22_V128_K0.6000.63
160_G192_T0.5990.63
15_V19_L0.5990.63
40_T132_T0.5980.62
187_S191_G0.5970.62
165_P214_A0.5960.62
96_G143_G0.5930.62
7_A60_G0.5890.61
194_K200_E0.5890.61
177_L209_S0.5880.61
106_I109_L0.5870.61
189_A197_E0.5860.61
23_K29_P0.5850.61
14_T189_A0.5850.61
47_L53_S0.5810.60
134_V138_I0.5780.60
110_I227_L0.5780.60
75_L196_L0.5770.60
189_A192_T0.5760.60
190_L193_S0.5760.60
210_M214_A0.5750.59
24_L33_L0.5740.59
97_V124_S0.5740.59
33_L93_I0.5730.59
194_K198_Y0.5700.59
104_G182_A0.5680.59
69_G128_K0.5680.59
10_I96_G0.5660.58
103_M107_S0.5660.58
168_L172_R0.5640.58
121_L222_P0.5630.58
196_L207_S0.5630.58
94_L167_F0.5630.58
86_I205_M0.5630.58
23_K163_L0.5630.58
63_W102_C0.5600.57
84_H174_R0.5570.57
112_A148_M0.5560.57
168_L182_A0.5540.57
138_I225_V0.5510.56
206_S213_C0.5490.56
42_L143_G0.5490.56
9_I50_F0.5470.56
75_L192_T0.5460.56
132_T211_T0.5450.55
30_L104_G0.5420.55
25_Y197_E0.5390.55
79_L112_A0.5390.55
109_L225_V0.5360.54
138_I218_S0.5360.54
18_Y175_S0.5340.54
51_H155_I0.5340.54
75_L92_P0.5320.54
187_S220_F0.5300.53
135_A150_V0.5290.53
111_F117_I0.5250.53
209_S218_S0.5240.53
132_T149_T0.5230.52
125_I193_S0.5230.52
101_L186_A0.5210.52
59_I95_G0.5210.52
104_G133_P0.5190.52
34_I187_S0.5190.52
179_Q212_L0.5180.52
15_V24_L0.5160.51
68_L104_G0.5160.51
154_M190_L0.5120.51
204_S208_V0.5120.51
100_G107_S0.5110.51
130_I153_V0.5100.51
20_A46_A0.5080.50
28_F190_L0.5060.50
163_L226_W0.5050.50
161_V193_S0.5050.50
86_I95_G0.5040.50
13_L16_A0.5040.50
57_Y67_L0.5030.50
108_G207_S0.5020.50
110_I120_D0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7391 94.3 0.917 Contact Map
4n7wA 2 0.7304 93 0.921 Contact Map
4czbA 2 0.9696 52.8 0.947 Contact Map
4bwzA 2 0.8304 44.8 0.95 Contact Map
2a65A 2 0.387 41.9 0.951 Contact Map
4cz8A 2 0.9087 41 0.951 Contact Map
2zy9A 2 0.787 22.1 0.957 Contact Map
3qe7A 2 0.9 18.3 0.959 Contact Map
4u9nA 2 0.6174 14.1 0.961 Contact Map
4r0cA 3 0.7565 10.2 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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