GREMLIN Database
GS30 - General stress protein 30
UniProt: P42101 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (291)
Sequences: 400 (354)
Seq/√Len: 20.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_Y92_T7.7241.00
50_A180_V4.4871.00
96_N108_R4.3381.00
33_L51_E4.0761.00
158_E291_S4.0241.00
268_M296_L4.0071.00
268_M278_C3.5861.00
194_G258_K3.5831.00
105_E109_R3.1721.00
282_G289_K3.0940.99
156_A165_V3.0730.99
47_I93_G3.0080.99
47_I265_L2.9970.99
127_V165_V2.9360.99
51_E92_T2.9360.99
123_L179_M2.7380.99
177_P295_W2.7060.99
153_T174_I2.5820.98
155_A176_T2.5260.98
147_H171_S2.4700.97
91_F111_V2.4230.97
93_G265_L2.3430.96
120_S149_N2.3100.96
37_P98_G2.3030.96
127_V161_T2.2670.96
196_L257_S2.2120.95
278_C296_L2.2020.95
54_F179_M2.0950.93
47_I95_G1.8990.89
264_R287_K1.7880.86
158_E285_Y1.7570.85
41_N44_D1.7160.84
159_T163_D1.6980.83
41_N287_K1.6850.83
313_L317_I1.6810.82
105_E108_R1.6800.82
33_L123_L1.6780.82
35_G92_T1.6550.81
163_D167_E1.6330.81
113_S148_Q1.5950.79
109_R138_E1.5800.78
154_I165_V1.5790.78
99_N105_E1.5730.78
210_D261_I1.5680.78
40_T158_E1.5320.76
79_V89_V1.4910.74
96_N101_Y1.4760.73
46_A180_V1.4750.73
31_V48_A1.4650.73
37_P51_E1.4550.72
41_N200_R1.4520.72
41_N264_R1.4240.70
116_K149_N1.4110.70
181_L272_I1.4030.69
99_N130_E1.3790.68
97_L105_E1.3670.67
95_G101_Y1.3670.67
51_E179_M1.3650.67
88_I118_Y1.3560.67
303_E319_R1.3520.66
38_S123_L1.3520.66
98_G108_R1.3450.66
124_P204_E1.3380.66
50_A183_L1.3180.64
280_V288_A1.3130.64
95_G126_S1.3090.64
155_A174_I1.3090.64
92_T96_N1.3080.64
127_V154_I1.3070.64
156_A169_F1.2920.63
48_A250_M1.2910.63
250_M253_R1.2850.62
113_S256_S1.2840.62
125_Q177_P1.2810.62
105_E146_Y1.2720.62
247_F251_L1.2650.61
278_C302_I1.2560.61
198_I254_I1.2560.61
36_S66_E1.2440.60
54_F93_G1.2430.60
55_I90_C1.2380.59
35_G282_G1.2270.59
34_F91_F1.2260.59
95_G98_G1.2210.58
98_G129_F1.2020.57
117_D144_D1.1940.57
280_V292_Y1.1930.56
54_F283_N1.1840.56
217_Q221_K1.1700.55
31_V59_F1.1700.55
181_L291_S1.1670.55
108_R291_S1.1650.55
259_L279_L1.1620.54
37_P48_A1.1390.53
148_Q271_S1.1390.53
37_P45_Q1.1270.52
188_R255_G1.1250.52
47_I101_Y1.1200.52
200_R287_K1.1190.52
94_G287_K1.1120.51
37_P124_P1.1100.51
158_E272_I1.0980.50
282_G286_G1.0940.50
48_A126_S1.0900.50
157_R266_H1.0760.49
31_V90_C1.0690.48
36_S45_Q1.0660.48
30_K87_D1.0570.48
205_K219_A1.0570.48
129_F274_T1.0550.47
198_I263_D1.0540.47
119_K151_N1.0540.47
239_D243_R1.0400.46
309_D314_E1.0390.46
51_E123_L1.0370.46
175_F294_D1.0280.46
39_Y140_K1.0280.46
41_N94_G1.0260.45
99_N109_R1.0260.45
44_D94_G1.0260.45
189_E260_V1.0170.45
305_T313_L1.0170.45
276_T301_F1.0160.45
47_I54_F1.0140.45
46_A280_V1.0120.45
163_D166_K1.0110.45
177_P267_A1.0090.44
305_T312_E1.0010.44
29_R87_D0.9980.44
126_S198_I0.9980.44
300_N311_E0.9970.44
123_L165_V0.9970.44
280_V285_Y0.9970.44
101_Y291_S0.9870.43
50_A182_S0.9850.43
260_V271_S0.9830.43
202_D262_T0.9820.43
90_C123_L0.9820.43
81_E220_E0.9780.42
33_L90_C0.9730.42
98_G105_E0.9710.42
212_I216_K0.9660.42
45_Q101_Y0.9640.41
311_E316_M0.9600.41
123_L281_F0.9600.41
138_E146_Y0.9570.41
309_D320_L0.9530.41
44_D287_K0.9510.41
166_K281_F0.9490.41
175_F295_W0.9440.40
170_N173_V0.9440.40
174_I193_D0.9430.40
56_K159_T0.9400.40
54_F95_G0.9380.40
140_K144_D0.9380.40
285_Y291_S0.9360.40
62_Y243_R0.9290.39
95_G283_N0.9270.39
164_V168_T0.9250.39
201_A209_E0.9250.39
131_D189_E0.9250.39
288_A292_Y0.9250.39
99_N132_T0.9220.39
101_Y108_R0.9200.39
289_K304_Y0.9170.38
202_D295_W0.9160.38
156_A265_L0.9130.38
195_V258_K0.9120.38
79_V279_L0.9100.38
290_H294_D0.9050.38
48_A105_E0.8990.37
70_Y302_I0.8990.37
55_I112_F0.8980.37
44_D95_G0.8950.37
314_E317_I0.8900.37
139_K143_Q0.8880.37
271_S300_N0.8850.37
166_K248_M0.8840.36
98_G101_Y0.8840.36
31_V174_I0.8790.36
238_I242_D0.8780.36
196_L285_Y0.8750.36
47_I50_A0.8750.36
139_K164_V0.8730.36
194_G257_S0.8670.35
212_I219_A0.8650.35
109_R142_T0.8630.35
268_M276_T0.8630.35
35_G96_N0.8600.35
243_R268_M0.8570.35
43_G157_R0.8560.35
43_G266_H0.8560.35
195_V300_N0.8560.35
42_I247_F0.8540.35
260_V275_K0.8540.35
50_A176_T0.8520.35
117_D173_V0.8510.34
99_N149_N0.8490.34
37_P179_M0.8460.34
50_A274_T0.8420.34
31_V51_E0.8400.34
36_S142_T0.8390.34
62_Y65_I0.8330.33
179_M286_G0.8330.33
94_G264_R0.8300.33
245_K275_K0.8300.33
100_L284_S0.8260.33
45_Q246_H0.8230.33
61_Y79_V0.8200.33
33_L254_I0.8160.32
261_I302_I0.8160.32
97_L230_T0.8140.32
129_F169_F0.8130.32
30_K63_E0.8120.32
40_T269_I0.8060.32
99_N269_I0.8060.32
268_M291_S0.8040.32
24_L31_V0.8030.32
102_L109_R0.8010.32
126_S233_D0.7970.31
101_Y267_A0.7960.31
95_G204_E0.7930.31
265_L288_A0.7890.31
200_R264_R0.7880.31
142_T146_Y0.7870.31
50_A95_G0.7840.31
33_L64_Y0.7790.30
111_V160_Q0.7780.30
93_G283_N0.7740.30
35_G108_R0.7710.30
108_R146_Y0.7710.30
78_L269_I0.7700.30
117_D166_K0.7680.30
180_V296_L0.7680.30
91_F108_R0.7640.29
124_P202_D0.7630.29
313_L318_D0.7610.29
163_D225_T0.7610.29
47_I177_P0.7600.29
262_T280_V0.7570.29
226_E229_D0.7560.29
47_I202_D0.7560.29
51_E285_Y0.7540.29
28_K280_V0.7530.29
34_F89_V0.7500.29
154_I167_E0.7500.29
197_F288_A0.7480.29
267_A295_W0.7470.29
119_K145_A0.7470.29
205_K288_A0.7460.28
162_L292_Y0.7460.28
129_F142_T0.7370.28
38_S283_N0.7370.28
84_R87_D0.7360.28
47_I179_M0.7340.28
46_A276_T0.7330.28
124_P262_T0.7320.28
237_T271_S0.7320.28
178_D265_L0.7300.28
131_D279_L0.7270.27
131_D228_T0.7260.27
267_A301_F0.7220.27
203_K275_K0.7210.27
94_G266_H0.7200.27
94_G157_R0.7200.27
296_L302_I0.7190.27
37_P129_F0.7190.27
44_D200_R0.7180.27
264_R271_S0.7180.27
45_Q278_C0.7160.27
53_K279_L0.7120.27
67_I268_M0.7110.27
89_V115_F0.7100.27
266_H287_K0.7070.26
157_R287_K0.7070.26
197_F297_E0.7060.26
96_N291_S0.7060.26
126_S262_T0.7020.26
112_F142_T0.7000.26
113_S117_D0.7000.26
69_D103_D0.6990.26
156_A161_T0.6990.26
37_P92_T0.6980.26
47_I283_N0.6980.26
72_T75_G0.6970.26
205_K263_D0.6970.26
36_S55_I0.6960.26
165_V268_M0.6960.26
106_E109_R0.6940.26
271_S320_L0.6910.26
54_F58_H0.6890.26
243_R296_L0.6880.25
151_N183_L0.6860.25
265_L291_S0.6830.25
180_V270_F0.6830.25
95_G108_R0.6830.25
144_D218_W0.6820.25
195_V201_A0.6820.25
124_P178_D0.6760.25
44_D47_I0.6750.25
32_F83_I0.6740.25
56_K97_L0.6730.25
95_G200_R0.6710.25
85_E195_V0.6690.25
93_G101_Y0.6680.24
72_T76_I0.6670.24
239_D242_D0.6670.24
35_G50_A0.6640.24
98_G118_Y0.6640.24
188_R252_D0.6640.24
128_Y158_E0.6610.24
44_D264_R0.6600.24
127_V147_H0.6540.24
62_Y145_A0.6530.24
199_L317_I0.6500.24
314_E318_D0.6490.24
138_E142_T0.6480.24
64_Y121_I0.6480.24
257_S281_F0.6470.23
83_I126_S0.6440.23
191_E259_L0.6390.23
314_E319_R0.6380.23
157_R178_D0.6370.23
178_D266_H0.6370.23
98_G124_P0.6360.23
50_A291_S0.6350.23
165_V173_V0.6330.23
125_Q282_G0.6330.23
35_G176_T0.6320.23
112_F166_K0.6310.23
47_I200_R0.6280.23
146_Y288_A0.6270.23
204_E295_W0.6260.22
99_N158_E0.6260.22
50_A93_G0.6230.22
127_V269_I0.6210.22
66_E243_R0.6200.22
122_S154_I0.6190.22
88_I313_L0.6190.22
260_V279_L0.6190.22
248_M269_I0.6180.22
48_A90_C0.6160.22
122_S247_F0.6130.22
112_F149_N0.6120.22
126_S254_I0.6080.22
204_E262_T0.6070.22
126_S290_H0.6070.22
282_G285_Y0.6050.22
89_V123_L0.6020.21
200_R204_E0.6020.21
45_Q254_I0.6020.21
97_L282_G0.6020.21
117_D225_T0.6020.21
47_I204_E0.6010.21
57_N114_A0.5970.21
196_L260_V0.5940.21
315_R320_L0.5940.21
67_I296_L0.5930.21
108_R295_W0.5930.21
173_V281_F0.5920.21
255_G271_S0.5910.21
278_C291_S0.5900.21
268_M274_T0.5880.21
271_S278_C0.5870.21
193_D255_G0.5820.21
152_L298_S0.5820.21
225_T258_K0.5790.20
39_Y177_P0.5770.20
46_A251_L0.5770.20
179_M285_Y0.5760.20
167_E260_V0.5740.20
105_E251_L0.5730.20
156_A229_D0.5710.20
42_I250_M0.5710.20
125_Q270_F0.5670.20
90_C116_K0.5670.20
94_G200_R0.5660.20
50_A90_C0.5640.20
49_Y273_I0.5620.20
155_A254_I0.5600.20
30_K79_V0.5600.20
98_G295_W0.5600.20
172_N222_T0.5580.20
119_K288_A0.5570.19
215_M228_T0.5560.19
286_G289_K0.5550.19
45_Q243_R0.5530.19
269_I291_S0.5530.19
123_L279_L0.5520.19
161_T266_H0.5520.19
157_R161_T0.5520.19
101_Y204_E0.5510.19
64_Y73_D0.5500.19
195_V259_L0.5500.19
160_Q271_S0.5490.19
183_L273_I0.5490.19
157_R264_R0.5450.19
53_K56_K0.5410.19
253_R269_I0.5400.19
124_P263_D0.5370.19
95_G282_G0.5360.19
283_N286_G0.5360.19
269_I288_A0.5350.19
272_I301_F0.5340.19
202_D287_K0.5330.18
51_E283_N0.5330.18
226_E232_L0.5260.18
177_P202_D0.5250.18
76_I156_A0.5240.18
31_V155_A0.5240.18
126_S149_N0.5230.18
35_G283_N0.5230.18
68_M160_Q0.5220.18
47_I178_D0.5210.18
92_T108_R0.5180.18
48_A101_Y0.5170.18
161_T264_R0.5170.18
45_Q48_A0.5170.18
95_G202_D0.5150.18
105_E196_L0.5140.18
120_S145_A0.5140.18
205_K227_R0.5140.18
311_E315_R0.5140.18
105_E295_W0.5140.18
41_N157_R0.5100.18
41_N266_H0.5100.18
71_A278_C0.5080.18
229_D254_I0.5070.17
178_D204_E0.5060.17
112_F118_Y0.5060.17
173_V224_Y0.5050.17
59_F243_R0.5030.17
52_E66_E0.5030.17
48_A55_I0.5020.17
177_P204_E0.5000.17
163_D253_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gt1A 1 0.8163 96.3 0.926 Contact Map
3l7iA 4 0.9329 95.5 0.931 Contact Map
3tovA 1 0.8105 94.9 0.933 Contact Map
3rhzA 4 0.8484 91 0.942 Contact Map
4nesA 2 0.8251 81.5 0.95 Contact Map
3oy2A 2 0.8513 80.3 0.95 Contact Map
2iw1A 1 0.8601 78.8 0.951 Contact Map
1pswA 1 0.8076 73.9 0.953 Contact Map
2x6qA 1 0.9125 73.4 0.953 Contact Map
4w6qA 4 0.8426 72.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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