GREMLIN Database
GLXK - Glycerate kinase
UniProt: P42100 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (372)
Sequences: 2548 (1928)
Seq/√Len: 100.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_S114_T3.5721.00
67_G71_E3.2751.00
269_I307_G2.8451.00
128_R187_K2.7171.00
29_S367_R2.6141.00
139_N205_T2.6101.00
25_R363_E2.6031.00
66_T116_E2.5671.00
273_L278_F2.4981.00
143_A153_L2.4751.00
77_F120_A2.4731.00
234_E240_T2.4351.00
295_I321_G2.4251.00
128_R189_E2.3661.00
5_I23_I2.3381.00
79_M126_A2.3361.00
279_E314_S2.3331.00
294_R325_S2.3271.00
279_E311_A2.2901.00
151_G176_V2.2481.00
27_F370_A2.2001.00
141_G229_F2.1961.00
71_E103_K2.1861.00
277_D280_S2.1611.00
24_E38_K2.1451.00
22_A26_G2.1351.00
241_F255_W2.1021.00
199_T223_D2.0991.00
64_V74_R2.0941.00
29_S363_E2.0861.00
62_E74_R2.0701.00
215_T218_M2.0381.00
4_I285_A2.0281.00
23_I366_A1.9851.00
37_R281_I1.9681.00
367_R371_A1.9591.00
53_V78_G1.9551.00
84_R127_E1.9281.00
100_P103_K1.9241.00
2_K35_D1.9171.00
20_A38_K1.9141.00
161_I167_A1.8901.00
24_E28_K1.8861.00
214_A222_L1.8761.00
123_D182_R1.8351.00
61_I124_A1.8341.00
131_I257_L1.8271.00
233_A260_Y1.8261.00
151_G179_L1.8131.00
42_A48_T1.8031.00
90_M253_L1.8001.00
191_A271_I1.7991.00
21_E38_K1.7641.00
155_D159_S1.7621.00
76_F92_A1.7571.00
65_V116_E1.7521.00
210_P219_L1.7361.00
192_C265_L1.7321.00
64_V72_P1.7281.00
18_E359_A1.7211.00
50_Q60_I1.7111.00
129_L186_V1.7101.00
295_I323_A1.7081.00
299_T306_I1.7071.00
66_T110_T1.6771.00
147_Q163_P1.6711.00
5_I36_Y1.6671.00
90_M133_I1.6631.00
127_E185_N1.6611.00
129_L188_L1.6521.00
133_I190_V1.6441.00
14_L358_A1.6411.00
205_T219_L1.6091.00
99_V103_K1.5991.00
105_N108_I1.5961.00
155_D170_Q1.5931.00
68_P98_L1.5831.00
60_I76_F1.5671.00
67_G73_V1.5601.00
77_F124_A1.5591.00
161_I171_L1.5581.00
123_D180_D1.5581.00
153_L171_L1.5531.00
2_K284_D1.5381.00
231_D242_R1.5371.00
321_G338_I1.5331.00
56_T81_G1.5321.00
278_F311_A1.5291.00
146_I256_S1.5201.00
41_V304_T1.5191.00
3_I287_L1.5181.00
147_Q153_L1.5101.00
187_K264_D1.5041.00
162_G167_A1.4931.00
39_L281_I1.4861.00
19_A362_M1.4721.00
23_I289_I1.4711.00
166_G225_N1.4651.00
120_A124_A1.4591.00
282_V317_V1.4561.00
269_I273_L1.4521.00
93_A114_T1.4501.00
15_S18_E1.4471.00
322_I366_A1.4411.00
279_E315_Y1.4211.00
14_L359_A1.4041.00
350_P353_D1.3991.00
313_K339_D1.3981.00
357_H360_E1.3901.00
152_R160_E1.3820.99
146_I151_G1.3820.99
198_L255_W1.3810.99
152_R175_D1.3720.99
199_T242_R1.3700.99
66_T70_G1.3510.99
7_P23_I1.3460.99
189_E266_K1.3370.99
288_V308_V1.3340.99
127_E186_V1.3300.99
195_D202_K1.3190.99
111_T138_T1.3160.99
65_V93_A1.3150.99
107_L221_V1.3130.99
63_Q77_F1.3080.99
2_K37_R1.3070.99
122_L180_D1.3060.99
247_A258_L1.3030.99
165_G225_N1.2910.99
349_V354_A1.2900.99
146_I260_Y1.2900.99
274_E311_A1.2890.99
111_T253_L1.2890.99
122_L182_R1.2850.99
7_P20_A1.2700.99
80_M87_V1.2700.99
7_P16_A1.2660.99
31_F34_A1.2520.99
284_D317_V1.2480.99
41_V273_L1.2460.99
165_G222_L1.2390.99
12_E97_H1.2360.99
164_G167_A1.2320.99
233_A255_W1.2300.99
122_L186_V1.2250.99
27_F34_A1.2230.99
342_F369_I1.2190.99
143_A161_I1.2180.99
63_Q117_L1.2180.99
205_T214_A1.2180.99
72_P116_E1.2070.99
282_V288_V1.1940.98
190_V265_L1.1820.98
108_I166_G1.1710.98
280_S283_Q1.1700.98
169_S221_V1.1630.98
349_V361_Y1.1620.98
202_K301_H1.1610.98
282_V311_A1.1610.98
366_A370_A1.1600.98
9_S46_E1.1560.98
49_V92_A1.1550.98
206_A220_D1.1500.98
27_F36_Y1.1440.98
199_T227_S1.1410.98
107_L218_M1.1410.98
93_A117_L1.1340.98
257_L263_A1.1300.98
119_G180_D1.1280.98
112_R163_P1.1250.98
25_R359_A1.1160.98
75_A117_L1.1120.98
147_Q160_E1.1110.98
244_T258_L1.0930.97
49_V89_E1.0780.97
143_A229_F1.0760.97
309_A338_I1.0750.97
214_A219_L1.0750.97
118_I188_L1.0740.97
323_A326_I1.0670.97
325_S348_A1.0600.97
52_L275_A1.0590.97
130_I271_I1.0590.97
342_F372_S1.0520.97
346_P361_Y1.0460.96
353_D357_H1.0410.96
50_Q54_D1.0390.96
14_L19_A1.0350.96
227_S231_D1.0240.96
273_L311_A1.0230.96
61_I77_F1.0190.96
133_I250_A1.0180.96
4_I317_V1.0160.96
266_K274_E1.0110.96
183_L188_L1.0100.96
145_M253_L1.0050.96
342_F365_T1.0040.96
5_I20_A1.0040.96
53_V60_I1.0030.96
112_R148_A1.0020.95
56_T80_M1.0020.95
153_L229_F0.9980.95
119_G123_D0.9940.95
118_I145_M0.9870.95
23_I322_I0.9850.95
154_L173_S0.9830.95
112_R116_E0.9820.95
342_F368_D0.9800.95
306_I310_K0.9750.95
143_A147_Q0.9740.95
24_E36_Y0.9700.95
206_A219_L0.9690.95
88_I117_L0.9550.94
85_T128_R0.9550.94
345_V354_A0.9530.94
58_G78_G0.9500.94
143_A171_L0.9470.94
49_V132_G0.9450.94
190_V257_L0.9430.94
90_M111_T0.9410.94
147_Q164_G0.9330.93
65_V75_A0.9320.93
12_E104_R0.9320.93
75_A93_A0.9270.93
305_P338_I0.9270.93
169_S225_N0.9250.93
205_T223_D0.9230.93
39_L276_V0.9230.93
17_L21_E0.9230.93
156_N172_A0.9170.93
167_A170_Q0.9160.93
218_M221_V0.9150.93
197_P247_A0.9140.93
90_M94_S0.9110.93
233_A259_T0.9100.93
205_T225_N0.9080.92
322_I369_I0.9070.92
75_A92_A0.9040.92
195_D301_H0.8970.92
207_V297_S0.8970.92
26_G30_V0.8940.92
239_S262_Q0.8940.92
255_W259_T0.8930.92
111_T256_S0.8920.92
4_I284_D0.8910.92
326_I341_L0.8910.92
232_M235_K0.8900.92
130_I191_A0.8850.91
62_E76_F0.8700.91
205_T226_V0.8700.91
227_S242_R0.8670.91
27_F289_I0.8650.91
30_V367_R0.8630.90
28_K36_Y0.8630.90
63_Q120_A0.8620.90
23_I370_A0.8620.90
106_P109_T0.8570.90
69_L99_V0.8560.90
3_I31_F0.8540.90
299_T323_A0.8540.90
8_D46_E0.8500.90
230_A242_R0.8480.90
219_L226_V0.8480.90
196_N207_V0.8450.89
295_I341_L0.8440.89
105_N218_M0.8430.89
163_P167_A0.8420.89
58_G80_M0.8420.89
67_G99_V0.8410.89
105_N109_T0.8380.89
257_L261_L0.8380.89
283_Q315_Y0.8360.89
287_L318_P0.8320.89
90_M145_M0.8310.89
85_T130_I0.8310.89
234_E242_R0.8260.88
31_F370_A0.8230.88
306_I333_V0.8100.87
13_S358_A0.8100.87
232_M236_A0.8090.87
49_V76_F0.8090.87
361_Y368_D0.8080.87
359_A363_E0.8070.87
330_S341_L0.8070.87
51_S54_D0.8070.87
51_S87_V0.8050.87
7_P19_A0.8030.87
5_I289_I0.8020.87
107_L166_G0.8020.87
15_S50_Q0.8020.87
30_V370_A0.7980.87
294_R327_S0.7950.86
17_L54_D0.7920.86
188_L260_Y0.7880.86
306_I338_I0.7870.86
332_A335_Q0.7840.86
229_F233_A0.7820.86
295_I299_T0.7810.85
312_A319_V0.7780.85
110_T163_P0.7770.85
152_R178_G0.7760.85
4_I282_V0.7750.85
135_G193_D0.7750.85
209_G214_A0.7740.85
326_I330_S0.7740.85
12_E355_F0.7730.85
288_V312_A0.7650.84
361_Y364_R0.7650.84
133_I254_G0.7620.84
71_E99_V0.7600.84
209_G223_D0.7600.84
176_V179_L0.7590.84
35_D284_D0.7590.84
311_A315_Y0.7580.84
167_A171_L0.7530.83
347_G357_H0.7500.83
155_D161_I0.7490.83
49_V53_V0.7490.83
269_I304_T0.7450.83
297_S332_A0.7430.83
277_D281_I0.7430.83
143_A164_G0.7420.82
346_P349_V0.7400.82
71_E100_P0.7400.82
112_R147_Q0.7400.82
118_I129_L0.7390.82
223_D226_V0.7370.82
9_S97_H0.7350.82
211_Q303_K0.7350.82
27_F366_A0.7340.82
69_L109_T0.7330.82
121_A126_A0.7330.82
165_G214_A0.7310.81
363_E367_R0.7310.81
219_L223_D0.7300.81
158_G173_S0.7300.81
90_M136_S0.7270.81
104_R109_T0.7270.81
67_G103_K0.7240.81
68_P73_V0.7240.81
190_V263_A0.7230.81
141_G226_V0.7220.81
247_A255_W0.7210.81
136_S250_A0.7200.80
329_D332_A0.7180.80
22_A359_A0.7130.80
4_I39_L0.7120.80
4_I308_V0.7110.80
228_H232_M0.7100.80
300_V336_H0.7070.79
343_S346_P0.7060.79
101_V352_E0.7050.79
300_V333_V0.7050.79
153_L174_I0.7040.79
266_K271_I0.7030.79
357_H361_Y0.7020.79
79_M83_G0.7010.79
173_S236_A0.6990.79
161_I225_N0.6980.78
287_L373_I0.6980.78
101_V104_R0.6960.78
154_L160_E0.6910.78
86_A121_A0.6890.78
305_P309_A0.6890.78
22_A363_E0.6850.77
73_V98_L0.6840.77
306_I336_H0.6840.77
171_L229_F0.6830.77
322_I362_M0.6800.77
48_T132_G0.6790.76
156_N170_Q0.6780.76
365_T369_I0.6740.76
120_A123_D0.6730.76
327_S331_N0.6720.76
53_V58_G0.6720.76
20_A23_I0.6710.76
90_M114_T0.6690.75
68_P94_S0.6680.75
344_I361_Y0.6660.75
16_A20_A0.6660.75
164_G171_L0.6650.75
223_D227_S0.6650.75
348_A361_Y0.6650.75
297_S327_S0.6620.75
109_T165_G0.6600.74
145_M257_L0.6600.74
66_T72_P0.6590.74
225_N228_H0.6580.74
86_A126_A0.6560.74
351_L355_F0.6560.74
135_G194_V0.6550.74
106_P139_N0.6540.74
230_A233_A0.6540.74
166_G169_S0.6480.73
81_G84_R0.6430.73
179_L183_L0.6420.72
176_V237_L0.6410.72
118_I183_L0.6410.72
208_F301_H0.6410.72
129_L257_L0.6380.72
48_T272_V0.6380.72
366_A369_I0.6380.72
138_T253_L0.6350.72
29_S364_R0.6350.72
59_R124_A0.6330.71
171_L225_N0.6320.71
15_S19_A0.6310.71
106_P218_M0.6300.71
334_Y368_D0.6290.71
247_A254_G0.6270.71
23_I362_M0.6250.70
206_A223_D0.6250.70
126_A186_V0.6230.70
176_V236_A0.6220.70
141_G233_A0.6210.70
333_V341_L0.6190.70
94_S111_T0.6170.69
241_F259_T0.6170.69
146_I261_L0.6160.69
37_R284_D0.6150.69
16_A40_P0.6120.69
67_G110_T0.6100.69
250_A268_G0.6090.68
61_I120_A0.6070.68
94_S137_A0.6060.68
135_G268_G0.6050.68
212_K303_K0.6040.68
80_M85_T0.6040.68
199_T205_T0.6030.68
198_L252_G0.6000.67
59_R79_M0.5990.67
200_G203_G0.5990.67
300_V306_I0.5990.67
346_P364_R0.5990.67
295_I338_I0.5990.67
193_D250_A0.5990.67
5_I27_F0.5990.67
188_L257_L0.5980.67
193_D268_G0.5960.67
338_I341_L0.5930.66
114_T145_M0.5880.66
348_A351_L0.5870.66
330_S334_Y0.5860.65
233_A241_F0.5840.65
321_G326_I0.5840.65
14_L362_M0.5830.65
36_Y370_A0.5830.65
4_I37_R0.5820.65
205_T222_L0.5810.65
282_V315_Y0.5810.65
201_P206_A0.5780.64
348_A354_A0.5780.64
211_Q298_Q0.5770.64
143_A225_N0.5750.64
169_S228_H0.5750.64
110_T138_T0.5750.64
114_T117_L0.5750.64
63_Q67_G0.5740.64
360_E364_R0.5730.64
287_L320_I0.5720.64
216_A219_L0.5720.64
116_E148_A0.5720.64
27_F31_F0.5700.63
349_V353_D0.5700.63
145_M254_G0.5700.63
278_F308_V0.5690.63
327_S334_Y0.5690.63
131_I263_A0.5690.63
109_T214_A0.5680.63
67_G116_E0.5680.63
10_F291_G0.5670.63
220_D224_Q0.5650.63
21_E24_E0.5650.63
3_I27_F0.5640.63
289_I370_A0.5630.62
340_A372_S0.5610.62
365_T368_D0.5570.62
11_K46_E0.5570.62
325_S345_V0.5570.62
12_E361_Y0.5570.62
13_S351_L0.5550.61
221_V224_Q0.5540.61
208_F211_Q0.5530.61
228_H231_D0.5530.61
21_E25_R0.5520.61
143_A168_L0.5520.61
189_E264_D0.5520.61
225_N229_F0.5510.61
39_L278_F0.5500.61
344_I362_M0.5480.60
317_V339_D0.5470.60
99_V109_T0.5460.60
292_E303_K0.5440.60
194_V303_K0.5430.60
193_D204_A0.5420.60
133_I208_F0.5420.60
122_L181_S0.5410.59
114_T137_A0.5410.59
348_A372_S0.5390.59
116_E119_G0.5390.59
5_I38_K0.5380.59
145_M256_S0.5360.59
171_L228_H0.5360.59
49_V88_I0.5350.59
320_I369_I0.5350.59
208_F303_K0.5340.58
88_I131_I0.5340.58
327_S330_S0.5330.58
207_V210_P0.5330.58
146_I153_L0.5330.58
194_V268_G0.5310.58
344_I365_T0.5310.58
99_V104_R0.5310.58
127_E182_R0.5290.58
8_D193_D0.5280.58
135_G250_A0.5270.57
133_I265_L0.5270.57
205_T209_G0.5250.57
26_G366_A0.5250.57
256_S260_Y0.5240.57
147_Q162_G0.5220.57
66_T163_P0.5220.57
244_T255_W0.5210.57
109_T139_N0.5210.57
255_W258_L0.5190.56
66_T73_V0.5190.56
154_L161_I0.5190.56
322_I365_T0.5190.56
167_A225_N0.5190.56
284_D315_Y0.5170.56
278_F281_I0.5170.56
206_A210_P0.5160.56
65_V117_L0.5140.56
49_V60_I0.5140.56
135_G204_A0.5140.56
297_S300_V0.5130.55
345_V349_V0.5130.55
224_Q227_S0.5130.55
345_V348_A0.5120.55
370_A373_I0.5110.55
48_T87_V0.5100.55
143_A163_P0.5100.55
355_F361_Y0.5100.55
161_I172_A0.5090.55
141_G168_L0.5080.55
254_G265_L0.5070.55
8_D291_G0.5070.55
165_G168_L0.5040.54
299_T333_V0.5040.54
133_I192_C0.5030.54
86_A129_L0.5030.54
151_G175_D0.5030.54
114_T131_I0.5030.54
181_S185_N0.5020.54
274_E279_E0.5020.54
9_S298_Q0.5010.54
320_I372_S0.5000.54
31_F36_Y0.5000.54
18_E21_E0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwcA 2 0.9764 100 0.005 Contact Map
1to6A 4 0.9712 100 0.032 Contact Map
2r751 1 0.466 83.6 0.962 Contact Map
3jx9A 2 0.4084 61.6 0.968 Contact Map
1vimA 4 0.445 60 0.969 Contact Map
2xz9A 2 0.7042 58.5 0.969 Contact Map
4oxxA 1 0.3403 52.5 0.97 Contact Map
4h2dA 1 0.3743 52.3 0.97 Contact Map
3f6rA 1 0.3351 50.8 0.97 Contact Map
2hnaA 1 0.3534 50 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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