GREMLIN Database
RECO - DNA repair protein RecO
UniProt: P42095 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (235)
Sequences: 2998 (2340)
Seq/√Len: 152.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_G24_L3.6011.00
155_C173_C3.5431.00
31_K99_D3.4701.00
190_T217_E3.4121.00
24_L34_V3.3471.00
94_V118_S3.3041.00
24_L58_F3.0711.00
155_C176_C2.9531.00
6_E27_R2.8781.00
173_C176_C2.7581.00
27_R113_E2.6131.00
7_G58_F2.4741.00
93_Y136_Q2.4271.00
152_C155_C2.4091.00
34_V69_L2.3751.00
98_V135_V2.3221.00
5_C28_E2.1941.00
8_I116_L2.1801.00
187_K217_E2.1171.00
34_V60_M2.1031.00
118_S131_I2.0721.00
127_D215_K2.0511.00
35_M66_L2.0301.00
98_V115_I1.9861.00
55_Y112_F1.9811.00
94_V115_I1.9731.00
7_G26_T1.9681.00
187_K190_T1.9591.00
21_I33_G1.9081.00
97_L136_Q1.8451.00
14_D40_K1.8311.00
76_L120_K1.7951.00
49_V72_G1.7171.00
137_M222_I1.7021.00
8_I115_I1.6911.00
23_T31_K1.6901.00
22_V50_S1.6551.00
20_K39_A1.6141.00
25_L98_V1.6141.00
157_S175_R1.5781.00
80_G123_N1.5691.00
5_C29_H1.5591.00
84_D87_L1.5241.00
4_K57_S1.5161.00
152_C173_C1.5071.00
171_F191_A1.4981.00
59_L71_Q1.4961.00
33_G66_L1.4901.00
37_R68_T1.4861.00
14_D20_K1.4551.00
10_L52_P1.4501.00
21_I66_L1.4391.00
25_L108_N1.4221.00
148_E151_H1.4181.00
15_Y21_I1.4151.00
108_N142_V1.3811.00
55_Y78_M1.3721.00
54_L74_M1.3611.00
133_F136_Q1.3581.00
74_M77_S1.3541.00
62_K67_G1.3471.00
212_E216_A1.3291.00
12_T20_K1.3211.00
129_D219_K1.3191.00
6_E55_Y1.3111.00
53_F91_A1.3101.00
4_K59_L1.3091.00
101_G143_M1.2981.00
186_I190_T1.2891.00
155_C158_Q1.2701.00
223_D237_K1.2691.00
87_L125_G1.2671.00
55_Y116_L1.2671.00
164_F225_Y1.2651.00
91_A95_A1.2591.00
13_N21_I1.2471.00
85_L89_A1.2451.00
78_M116_L1.2341.00
78_M119_L1.2311.00
227_E233_Y1.2171.00
152_C176_C1.2071.00
6_E57_S1.1991.00
165_S168_D1.1961.00
23_T33_G1.1911.00
233_Y238_R1.1891.00
165_S170_G1.1851.00
16_G19_N1.1831.00
188_P192_R1.1741.00
152_C158_Q1.1641.00
116_L120_K1.1591.00
163_H170_G1.1431.00
31_K102_T1.1421.00
13_N23_T1.1371.00
15_Y35_M1.1271.00
136_Q219_K1.1231.00
57_S73_E1.1191.00
21_I35_M1.1060.99
55_Y76_L1.1030.99
60_M67_G1.1000.99
12_T22_V1.1000.99
6_E75_I1.0970.99
49_V52_P1.0940.99
188_P191_A1.0840.99
137_M197_F1.0810.99
166_V169_N1.0720.99
96_E236_S1.0660.99
141_G146_Y1.0660.99
164_F169_N1.0640.99
223_D241_D1.0560.99
94_V132_T1.0490.99
90_Y132_T1.0480.99
87_L128_P1.0360.99
167_R170_G1.0300.99
18_T40_K1.0290.99
16_G35_M1.0250.99
93_Y133_F1.0250.99
22_V36_A1.0160.99
9_V24_L1.0140.99
129_D215_K1.0120.99
10_L31_K1.0070.99
36_A69_L1.0050.99
111_L135_V1.0050.99
63_T67_G0.9900.99
56_G72_G0.9880.99
110_Y142_V0.9760.99
22_V34_V0.9760.99
193_L210_L0.9720.99
6_E116_L0.9650.99
61_Q70_Q0.9640.98
197_F218_L0.9630.98
98_V102_T0.9610.98
5_C27_R0.9540.98
100_R232_L0.9520.98
130_V215_K0.9500.98
26_T30_G0.9490.98
133_F226_Y0.9170.98
26_T32_I0.9120.98
54_L78_M0.9110.98
186_I221_V0.9090.98
180_D183_R0.9090.98
111_L139_M0.9070.98
136_Q140_L0.8980.98
10_L99_D0.8960.98
160_G163_H0.8920.98
93_Y132_T0.8870.97
32_I36_A0.8860.97
38_G41_K0.8810.97
235_K238_R0.8800.97
91_A122_L0.8790.97
9_V22_V0.8770.97
238_R242_Q0.8760.97
76_L123_N0.8750.97
228_E231_G0.8750.97
25_L102_T0.8740.97
90_Y240_L0.8730.97
86_F128_P0.8710.97
134_I138_K0.8620.97
222_I226_Y0.8610.97
100_R234_L0.8600.97
102_T111_L0.8590.97
136_Q223_D0.8580.97
29_H60_M0.8570.97
19_N41_K0.8550.97
114_F138_K0.8540.97
61_Q68_T0.8510.97
26_T29_H0.8500.97
153_V170_G0.8470.97
162_F169_N0.8450.97
93_Y223_D0.8430.97
159_D162_F0.8420.96
189_Q214_T0.8410.96
46_L69_L0.8360.96
15_Y33_G0.8280.96
36_A50_S0.8240.96
36_A46_L0.8240.96
154_H176_C0.8220.96
79_R83_E0.8190.96
110_Y113_E0.8190.96
216_A220_Q0.8170.96
28_E109_P0.8160.96
93_Y97_L0.8140.96
132_T136_Q0.8130.96
78_M120_K0.8090.96
42_P46_L0.8060.95
192_R196_L0.7960.95
19_N38_G0.7940.95
95_A115_I0.7850.95
190_T218_L0.7800.95
11_R23_T0.7790.95
214_T217_E0.7780.95
95_A119_L0.7770.95
137_M194_L0.7730.94
165_S169_N0.7730.94
49_V74_M0.7700.94
121_Q131_I0.7650.94
25_L111_L0.7610.94
24_L60_M0.7590.94
114_F142_V0.7570.94
36_A72_G0.7540.94
39_A44_S0.7490.93
166_V224_L0.7490.93
137_M147_P0.7480.93
166_V228_E0.7450.93
22_V52_P0.7440.93
106_K145_L0.7410.93
192_R195_R0.7410.93
136_Q237_K0.7390.93
201_D204_R0.7350.93
27_R109_P0.7320.93
14_D21_I0.7300.92
115_I236_S0.7230.92
217_E224_L0.7100.91
53_F92_A0.7100.91
18_T38_G0.7070.91
93_Y240_L0.7050.91
36_A48_A0.7040.91
46_L72_G0.7030.91
177_F183_R0.7020.91
19_N35_M0.7010.91
163_H183_R0.6960.91
24_L56_G0.6950.91
15_Y66_L0.6920.90
227_E237_K0.6870.90
186_I217_E0.6860.90
78_M123_N0.6840.90
211_K214_T0.6840.90
76_L116_L0.6830.90
23_T99_D0.6810.90
152_C156_K0.6810.90
162_F172_I0.6800.90
148_E153_V0.6800.90
31_K104_E0.6790.89
49_V56_G0.6770.89
164_F221_V0.6760.89
32_I67_G0.6760.89
18_T41_K0.6760.89
119_L161_T0.6700.89
19_N37_R0.6700.89
159_D163_H0.6690.89
16_G37_R0.6680.89
81_I88_T0.6680.89
120_K207_N0.6670.89
19_N40_K0.6650.89
65_G104_E0.6630.88
152_C157_S0.6600.88
43_N121_Q0.6600.88
51_Q82_R0.6590.88
94_V111_L0.6570.88
117_E121_Q0.6550.88
25_L115_I0.6460.87
33_G104_E0.6450.87
97_L234_L0.6420.87
194_L218_L0.6410.87
189_Q204_R0.6370.86
37_R137_M0.6350.86
189_Q192_R0.6300.86
42_P45_R0.6280.86
163_H169_N0.6270.85
81_I92_A0.6250.85
17_E105_K0.6250.85
200_F204_R0.6240.85
38_G42_P0.6220.85
10_L95_A0.6220.85
130_V210_L0.6210.85
5_C26_T0.6210.85
133_F219_K0.6190.85
167_R228_E0.6190.85
98_V139_M0.6170.85
200_F205_L0.6120.84
115_I135_V0.6080.84
85_L239_F0.6070.84
218_L221_V0.6050.83
162_F170_G0.6010.83
64_S67_G0.6000.83
164_F168_D0.5990.83
210_L214_T0.5970.83
150_N195_R0.5950.82
46_L49_V0.5940.82
29_H62_K0.5940.82
154_H178_E0.5920.82
84_D89_A0.5900.82
160_G174_H0.5900.82
147_P222_I0.5900.82
82_R88_T0.5880.82
52_P92_A0.5870.82
108_N111_L0.5870.82
141_G198_Y0.5870.82
44_S48_A0.5830.81
94_V122_L0.5780.81
130_V222_I0.5760.80
157_S160_G0.5760.80
105_K108_N0.5740.80
102_T108_N0.5730.80
10_L25_L0.5710.80
189_Q193_L0.5700.80
145_L231_G0.5690.79
69_L72_G0.5660.79
25_L107_P0.5660.79
191_A195_R0.5650.79
138_K200_F0.5630.79
81_I91_A0.5540.78
151_H171_F0.5530.78
8_I55_Y0.5520.77
164_F171_F0.5520.77
8_I112_F0.5510.77
139_M143_M0.5500.77
164_F170_G0.5490.77
220_Q224_L0.5480.77
12_T52_P0.5480.77
103_E106_K0.5450.77
37_R40_K0.5430.76
93_Y96_E0.5420.76
175_R178_E0.5420.76
114_F117_E0.5420.76
50_S58_F0.5370.75
163_H166_V0.5370.75
234_L238_R0.5370.75
210_L218_L0.5350.75
51_Q54_L0.5350.75
36_A194_L0.5350.75
40_K61_Q0.5340.75
26_T82_R0.5340.75
107_P110_Y0.5340.75
39_A50_S0.5280.74
39_A88_T0.5270.74
17_E38_G0.5230.74
117_E120_K0.5220.73
187_K214_T0.5200.73
81_I122_L0.5180.73
52_P95_A0.5180.73
224_L228_E0.5170.73
147_P225_Y0.5170.73
93_Y237_K0.5170.73
20_K44_S0.5160.73
81_I85_L0.5150.72
80_G83_E0.5140.72
162_F165_S0.5120.72
13_N33_G0.5110.72
44_S47_S0.5110.72
141_G147_P0.5110.72
78_M81_I0.5100.72
24_L104_E0.5070.71
238_R241_D0.5070.71
226_Y230_S0.5070.71
44_S49_V0.5070.71
11_R99_D0.5070.71
118_S121_Q0.5060.71
162_F196_L0.5060.71
71_Q90_Y0.5050.71
177_F185_P0.5020.71
48_A235_K0.5010.70
150_N199_Y0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u5kA 2 0.9373 100 0.194 Contact Map
3q8dA 1 0.8902 100 0.231 Contact Map
3lvqE 1 0.4431 72.1 0.928 Contact Map
2owaA 1 0.4667 64.8 0.932 Contact Map
1d4uA 1 0.4196 63 0.933 Contact Map
1dcqA 1 0.3922 61.9 0.933 Contact Map
3subA 1 0.4314 50.2 0.938 Contact Map
4bbrM 1 0.3725 47.4 0.939 Contact Map
2b0oE 3 0.4706 47.4 0.939 Contact Map
2olmA 2 0.4588 45.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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