GREMLIN Database
PHYT - 3-phytase
UniProt: P42094 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (329)
Sequences: 598 (441)
Seq/√Len: 24.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_R216_D4.3801.00
230_I275_A4.3041.00
70_L351_I4.1101.00
170_A186_E3.8281.00
165_S236_E3.4751.00
41_T326_Y3.4021.00
271_G288_R3.2171.00
354_W358_A3.1371.00
83_D87_K3.1191.00
201_R235_A3.0811.00
229_A258_I3.0131.00
261_L273_L2.8861.00
165_S172_Y2.6730.99
162_L173_A2.6600.99
176_T209_T2.5120.99
161_S212_L2.4840.99
247_D286_Y2.4370.98
331_F357_I2.4240.98
40_H356_Q2.3970.98
80_V88_Q2.3500.98
264_Y319_G2.3440.98
312_T315_I2.3290.98
315_I331_F2.2790.97
224_A258_I2.2470.97
230_I273_L2.2460.97
230_I261_L2.2450.97
117_A128_I2.2260.97
261_L275_A2.1910.97
160_F173_A2.1030.96
324_P327_P2.0750.96
184_Q201_R2.0580.95
234_N240_G1.9870.94
217_E265_Y1.9410.94
233_F243_G1.8900.93
330_I351_I1.8900.93
309_T333_A1.8780.92
184_Q237_P1.8690.92
172_Y184_Q1.8510.92
222_Y292_N1.8190.91
61_H67_K1.7540.89
130_V187_I1.7450.89
264_Y354_W1.7370.89
116_A133_I1.7320.89
104_Y114_D1.7080.88
176_T224_A1.6990.88
283_Y309_T1.6490.86
120_N129_E1.6480.86
217_E288_R1.6410.86
235_A239_G1.6400.86
210_E313_D1.6320.86
64_H67_K1.6090.85
109_N355_E1.6060.85
168_T186_E1.6010.85
172_Y200_V1.5930.84
318_L322_L1.5880.84
165_S168_T1.5790.84
105_D135_G1.5760.84
71_I116_A1.5640.83
75_K313_D1.5610.83
176_T212_L1.5500.83
287_E293_R1.5370.82
172_Y235_A1.5250.82
259_E313_D1.5050.81
287_E295_V1.5020.81
39_A303_G1.4540.78
201_R237_P1.4510.78
79_L100_V1.4480.78
106_F113_I1.4410.78
262_T315_I1.4400.78
184_Q235_A1.4330.77
163_Y235_A1.4290.77
162_L171_F1.4280.77
328_Y355_E1.4190.77
300_I352_V1.4130.76
46_V74_N1.4100.76
72_T349_F1.4090.76
243_G286_Y1.3970.75
54_D278_Q1.3920.75
75_K210_E1.3840.75
108_L113_I1.3780.74
74_N80_V1.3740.74
75_K121_R1.3680.74
75_K259_E1.3510.73
99_N276_S1.3390.72
229_A245_V1.3380.72
259_E278_Q1.3250.71
117_A130_V1.3240.71
327_P353_S1.3220.71
210_E278_Q1.3190.71
98_N313_D1.3150.71
120_N157_V1.3140.71
106_F115_I1.3090.70
282_S299_E1.3090.70
213_V263_I1.3080.70
278_Q313_D1.3020.70
83_D351_I1.2870.69
106_F195_V1.2870.69
174_L182_F1.2760.68
210_E259_E1.2690.68
257_D276_S1.2520.67
205_L243_G1.2470.67
99_N257_D1.2330.66
159_G210_E1.2260.65
75_K278_Q1.2250.65
126_N156_E1.2230.65
75_K98_N1.2230.65
98_N210_E1.2150.65
296_A361_L1.2070.64
66_E324_P1.2050.64
99_N313_D1.2030.64
55_D99_N1.2020.64
114_D133_I1.1910.63
115_I168_T1.1870.63
274_M285_M1.1810.62
309_T331_F1.1780.62
128_I173_A1.1690.61
52_A347_Q1.1630.61
44_D87_K1.1620.61
264_Y317_V1.1590.61
277_S282_S1.1570.61
53_A82_Y1.1530.60
184_Q200_V1.1500.60
210_E276_S1.1430.60
98_N259_E1.1380.59
94_F131_Y1.1350.59
46_V52_A1.1320.59
71_I102_L1.1250.58
75_K99_N1.1240.58
257_D313_D1.1240.58
159_G226_E1.1220.58
213_V261_L1.1130.58
35_F102_L1.1110.57
213_V273_L1.1110.57
59_W73_T1.1010.57
68_S322_L1.1000.57
234_N239_G1.0940.56
273_L286_Y1.0860.56
75_K159_G1.0850.56
55_D101_D1.0830.55
103_R171_F1.0790.55
85_D325_K1.0770.55
73_T98_N1.0770.55
62_E65_P1.0760.55
163_Y172_Y1.0750.55
353_S358_A1.0730.55
263_I317_V1.0710.55
226_E313_D1.0680.54
99_N210_E1.0590.54
98_N278_Q1.0580.54
163_Y236_E1.0530.53
134_D360_H1.0500.53
119_S173_A1.0490.53
161_S225_E1.0490.53
210_E226_E1.0490.53
54_D257_D1.0470.53
121_R313_D1.0460.53
274_M317_V1.0390.52
296_A360_H1.0340.52
158_Y208_Q1.0320.52
284_A294_Y1.0290.52
51_D347_Q1.0260.51
46_V347_Q1.0220.51
159_G313_D1.0220.51
117_A160_F1.0180.51
58_I332_V1.0170.51
229_A256_A1.0120.50
117_A187_I1.0120.50
99_N278_Q1.0110.50
353_S356_Q1.0090.50
274_M312_T1.0060.50
275_A300_I1.0020.50
283_Y315_I0.9970.49
294_Y297_N0.9910.49
54_D313_D0.9910.49
277_S280_N0.9890.49
182_F233_F0.9810.48
220_N232_K0.9780.48
117_A162_L0.9770.48
327_P355_E0.9770.48
84_L330_I0.9750.48
54_D75_K0.9720.48
78_G95_G0.9700.47
335_D350_K0.9670.47
99_N259_E0.9660.47
212_L225_E0.9640.47
181_E202_E0.9630.47
158_Y313_D0.9630.47
209_T224_A0.9620.47
276_S313_D0.9600.47
75_K158_Y0.9570.47
54_D314_G0.9530.46
226_E259_E0.9510.46
262_T317_V0.9510.46
69_K138_G0.9450.46
317_V321_G0.9440.46
204_K207_S0.9440.46
85_D89_L0.9420.45
164_H171_F0.9410.45
158_Y210_E0.9380.45
328_Y358_A0.9370.45
284_A297_N0.9360.45
69_K89_L0.9300.45
185_Y199_K0.9300.45
321_G327_P0.9270.44
184_Q214_A0.9260.44
58_I330_I0.9260.44
159_G259_E0.9220.44
75_K257_D0.9200.44
110_G290_G0.9170.44
54_D210_E0.9160.44
200_V235_A0.9110.43
61_H68_S0.9110.43
278_Q312_T0.9100.43
274_M315_I0.9080.43
21_A24_V0.9080.43
60_V318_L0.9050.43
107_P110_G0.9050.43
56_P99_N0.8990.42
119_S160_F0.8930.42
287_E360_H0.8910.42
121_R210_E0.8880.42
52_A74_N0.8860.42
181_E204_K0.8840.41
106_F171_F0.8830.41
48_S77_S0.8750.41
309_T312_T0.8740.41
98_N158_Y0.8740.41
42_E338_N0.8690.40
274_M354_W0.8680.40
55_D257_D0.8620.40
310_S336_G0.8610.40
40_H131_Y0.8600.40
103_R162_L0.8600.40
77_S129_E0.8600.40
55_D276_S0.8590.40
98_N121_R0.8570.40
180_G209_T0.8500.39
24_V27_H0.8490.39
217_E269_G0.8480.39
121_R158_Y0.8450.39
121_R159_G0.8430.39
25_S33_H0.8420.38
226_E278_Q0.8330.38
56_P259_E0.8320.38
257_D278_Q0.8230.37
75_K276_S0.8170.37
121_R259_E0.8170.37
54_D259_E0.8150.37
89_L116_A0.8150.37
54_D98_N0.8140.37
102_L361_L0.8030.36
229_A349_F0.7990.36
311_D336_G0.7980.36
74_N77_S0.7970.35
102_L164_H0.7950.35
108_L189_D0.7920.35
44_D88_Q0.7900.35
159_G278_Q0.7870.35
241_S357_I0.7870.35
158_Y278_Q0.7860.35
30_N66_E0.7830.35
40_H230_I0.7820.35
56_P278_Q0.7790.34
182_F203_F0.7790.34
272_Y285_M0.7760.34
87_K362_G0.7730.34
219_G326_Y0.7710.34
159_G276_S0.7650.33
226_E276_S0.7630.33
134_D137_K0.7630.33
157_V336_G0.7620.33
75_K226_E0.7580.33
61_H64_H0.7500.32
163_Y214_A0.7490.32
186_E198_K0.7480.32
278_Q314_G0.7430.32
56_P210_E0.7420.32
221_L320_F0.7400.32
83_D113_I0.7390.32
315_I333_A0.7390.32
39_A73_T0.7390.32
216_D265_Y0.7360.32
56_P98_N0.7340.31
72_T129_E0.7330.31
210_E312_T0.7310.31
75_K312_T0.7230.31
180_G347_Q0.7210.31
70_L333_A0.7190.31
158_Y334_Q0.7180.30
53_A334_Q0.7170.30
338_N350_K0.7160.30
99_N121_R0.7150.30
182_F185_Y0.7110.30
262_T316_D0.7100.30
52_A76_K0.7070.30
250_T283_Y0.7060.30
222_Y240_G0.7040.30
318_L330_I0.7030.30
355_E358_A0.7030.30
157_V353_S0.7030.30
99_N159_G0.7010.29
150_I197_G0.7010.29
61_H84_L0.7010.29
103_R164_H0.7010.29
220_N288_R0.7000.29
281_N334_Q0.6980.29
271_G289_Q0.6980.29
188_V196_T0.6980.29
111_E230_I0.6940.29
54_D99_N0.6910.29
106_F189_D0.6870.29
259_E312_T0.6870.29
264_Y358_A0.6850.29
102_L114_D0.6850.29
68_S84_L0.6810.28
262_T346_N0.6790.28
210_E257_D0.6790.28
157_V176_T0.6780.28
120_N127_T0.6770.28
158_Y259_E0.6740.28
226_E312_T0.6730.28
28_Y92_Y0.6720.28
134_D143_I0.6710.28
83_D89_L0.6700.28
42_E350_K0.6680.28
135_G230_I0.6670.27
102_L130_V0.6650.27
159_G314_G0.6650.27
253_H294_Y0.6630.27
55_D313_D0.6630.27
51_D76_K0.6620.27
246_V321_G0.6620.27
39_A300_I0.6600.27
86_G348_N0.6590.27
28_Y31_E0.6580.27
88_Q91_S0.6580.27
81_V140_L0.6580.27
222_Y291_K0.6580.27
259_E314_G0.6560.27
280_N297_N0.6560.27
219_G235_A0.6560.27
178_K225_E0.6550.27
75_K314_G0.6540.27
287_E291_K0.6530.27
42_E211_G0.6520.27
70_L330_I0.6500.27
80_V91_S0.6490.26
237_P240_G0.6470.26
304_E361_L0.6460.26
80_V214_A0.6450.26
153_N179_Q0.6450.26
178_K250_T0.6430.26
46_V53_A0.6430.26
217_E270_K0.6420.26
36_K301_T0.6420.26
58_I318_L0.6400.26
163_Y237_P0.6390.26
33_H70_L0.6380.26
131_Y179_Q0.6370.26
54_D226_E0.6360.26
165_S235_A0.6350.26
128_I263_I0.6340.26
63_K357_I0.6340.26
222_Y273_L0.6320.26
72_T84_L0.6320.26
56_P313_D0.6310.25
121_R278_Q0.6310.25
130_V331_F0.6310.25
298_F335_D0.6300.25
225_E347_Q0.6280.25
54_D158_Y0.6270.25
172_Y203_F0.6270.25
55_D210_E0.6250.25
312_T334_Q0.6240.25
165_S171_F0.6240.25
49_G77_S0.6220.25
321_G324_P0.6200.25
26_A66_E0.6140.25
126_N197_G0.6120.24
201_R240_G0.6110.24
33_H357_I0.6110.24
27_H30_N0.6100.24
115_I130_V0.6100.24
65_P291_K0.6090.24
177_G181_E0.6040.24
56_P276_S0.6030.24
43_T82_Y0.6010.24
187_I197_G0.6000.24
163_Y184_Q0.6000.24
272_Y354_W0.6000.24
105_D111_E0.5980.24
98_N226_E0.5980.24
22_T360_H0.5970.24
59_W313_D0.5970.24
280_N336_G0.5960.24
119_S334_Q0.5930.23
208_Q224_A0.5920.23
262_T270_K0.5920.23
73_T259_E0.5890.23
236_E240_G0.5890.23
35_F70_L0.5890.23
105_D321_G0.5890.23
281_N312_T0.5830.23
264_Y272_Y0.5830.23
59_W312_T0.5820.23
159_G312_T0.5800.23
59_W259_E0.5800.23
201_R214_A0.5780.23
107_P112_K0.5770.23
240_G243_G0.5770.23
56_P75_K0.5760.23
244_Q258_I0.5750.23
169_G186_E0.5740.23
127_T157_V0.5740.23
46_V51_D0.5730.22
98_N276_S0.5710.22
302_D308_G0.5700.22
249_A254_L0.5690.22
98_N159_G0.5680.22
267_P270_K0.5680.22
51_D225_E0.5680.22
262_T274_M0.5660.22
198_K293_R0.5660.22
257_D260_G0.5650.22
99_N158_Y0.5630.22
84_L322_L0.5630.22
37_V356_Q0.5620.22
259_E276_S0.5620.22
73_T99_N0.5620.22
105_D110_G0.5600.22
182_F223_I0.5600.22
96_K122_S0.5600.22
210_E314_G0.5590.22
37_V285_M0.5590.22
58_I257_D0.5590.22
243_G246_V0.5570.22
120_N185_Y0.5570.22
318_L323_G0.5520.21
143_I186_E0.5490.21
70_L302_D0.5490.21
62_E66_E0.5460.21
41_T70_L0.5440.21
184_Q240_G0.5420.21
257_D314_G0.5410.21
97_L129_E0.5400.21
322_L327_P0.5400.21
42_E71_I0.5390.21
165_S200_V0.5350.21
254_L258_I0.5330.21
230_I300_I0.5330.21
108_L187_I0.5310.20
155_S283_Y0.5300.20
203_F349_F0.5300.20
106_F198_K0.5300.20
115_I187_I0.5290.20
52_A177_G0.5290.20
99_N226_E0.5290.20
100_V315_I0.5270.20
209_T223_I0.5260.20
118_A131_Y0.5260.20
117_A173_A0.5260.20
52_A82_Y0.5250.20
333_A352_V0.5250.20
261_L331_F0.5250.20
203_F233_F0.5220.20
223_I349_F0.5210.20
246_V273_L0.5190.20
34_H282_S0.5190.20
99_N312_T0.5180.20
54_D159_G0.5170.20
168_T172_Y0.5160.20
23_S27_H0.5150.20
73_T278_Q0.5150.20
132_A194_Y0.5150.20
194_Y256_A0.5140.20
43_T219_G0.5140.20
184_Q236_E0.5140.20
55_D98_N0.5120.20
130_V194_Y0.5120.20
54_D260_G0.5120.20
84_L349_F0.5090.19
21_A27_H0.5090.19
53_A279_G0.5090.19
21_A29_V0.5090.19
252_D268_N0.5060.19
208_Q336_G0.5050.19
179_Q252_D0.5040.19
260_G278_Q0.5040.19
324_P330_I0.5040.19
60_V104_Y0.5030.19
97_L347_Q0.5020.19
77_S119_S0.5010.19
182_F209_T0.5000.19
261_L315_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3amrA 1 0.9215 100 0.103 Contact Map
3qqzA 1 0.5864 98.8 0.908 Contact Map
3sreA 1 0.7513 98.6 0.912 Contact Map
1npeA 1 0.6675 98.6 0.913 Contact Map
3vgzA 1 0.7225 98.6 0.914 Contact Map
4a0pA 1 0.6623 98.5 0.915 Contact Map
1ri6A 1 0.7199 98.4 0.92 Contact Map
1ijqA 1 0.6702 98.3 0.921 Contact Map
1q7fA 1 0.7173 98.3 0.922 Contact Map
3fvzA 1 0.7408 98.3 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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