GREMLIN Database
CGEE - Uncharacterized N-acetyltransferase CgeE
UniProt: P42093 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (227)
Sequences: 104 (95)
Seq/√Len: 6.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_V244_F4.8190.98
210_V242_L3.6650.91
21_S45_H3.3260.86
26_S45_H3.1320.83
44_L56_F2.9490.79
209_L213_M2.6470.70
24_H91_G2.5530.67
124_L191_I2.1740.54
79_F130_I2.1570.54
22_F25_Y2.0980.51
21_S225_A2.0820.51
120_T203_K2.0390.49
79_F94_V2.0210.49
194_V206_G2.0030.48
30_D33_L1.9980.48
64_L100_Y1.9530.46
233_D241_K1.9390.46
95_E193_E1.8910.44
36_I39_H1.8680.43
48_F192_E1.8650.43
53_L98_L1.8640.43
104_L107_W1.8610.43
78_V249_R1.8460.42
48_F190_K1.8200.41
73_A210_V1.8130.41
104_L214_L1.8030.41
21_S26_S1.7950.41
167_S203_K1.7920.40
113_H116_T1.7880.40
115_L124_L1.7820.40
30_D143_I1.7500.39
100_Y233_D1.7490.39
38_S72_K1.7450.39
164_V171_Q1.7420.39
41_F209_L1.7010.37
190_K226_Y1.6950.37
49_P87_L1.6730.36
135_D194_V1.5960.34
27_V60_V1.5860.33
230_A233_D1.5550.32
70_H188_T1.5520.32
248_E255_H1.5490.32
165_C192_E1.5370.32
126_D166_Y1.5340.32
50_L106_D1.5290.32
107_W214_L1.5210.31
64_L231_S1.5130.31
70_H119_G1.4970.31
192_E226_Y1.4890.30
57_L92_F1.4460.29
192_E205_Y1.4360.29
36_I143_I1.4220.28
201_Q224_A1.4110.28
48_F73_A1.4080.28
127_G192_E1.3940.28
73_A244_F1.3810.27
71_L189_A1.3800.27
210_V226_Y1.3730.27
87_L124_L1.3700.27
140_G210_V1.3500.26
131_M193_E1.3410.26
214_L225_A1.3370.26
236_T254_F1.3340.26
126_D236_T1.3340.26
201_Q206_G1.3160.25
229_A233_D1.3090.25
190_K205_Y1.2890.25
127_G190_K1.2880.25
153_P225_A1.2760.24
105_S116_T1.2740.24
20_A25_Y1.2670.24
117_A207_S1.2660.24
116_T136_S1.2660.24
132_K136_S1.2640.24
130_I174_P1.2330.23
131_M177_C1.2290.23
70_H174_P1.2290.23
226_Y244_F1.2220.23
163_V202_R1.2200.23
102_M174_P1.2170.23
25_Y53_L1.2110.23
45_H207_S1.2000.22
194_V238_F1.1920.22
85_Q171_Q1.1880.22
29_R68_Y1.1850.22
98_L119_G1.1840.22
194_V209_L1.1790.22
80_P112_G1.1780.22
34_P146_Q1.1740.22
79_F127_G1.1660.21
60_V217_A1.1610.21
102_M181_F1.1500.21
83_L94_V1.1490.21
194_V235_A1.1470.21
140_G236_T1.1470.21
110_Q146_Q1.1430.21
198_D202_R1.1410.21
124_L130_I1.1130.20
19_S114_P1.1120.20
44_L107_W1.1110.20
25_Y124_L1.1070.20
126_D199_Q1.0950.20
27_V198_D1.0930.20
51_E170_A1.0850.20
200_F219_S1.0780.19
39_H248_E1.0780.19
190_K244_F1.0760.19
51_E168_D1.0750.19
49_P237_Q1.0690.19
44_L244_F1.0650.19
202_R241_K1.0560.19
234_G237_Q1.0490.19
227_L239_Y1.0400.19
142_A153_P1.0390.18
101_D157_A1.0290.18
34_P188_T1.0290.18
190_K210_V1.0280.18
131_M147_K1.0260.18
48_F205_Y1.0190.18
40_N238_F1.0130.18
134_Y195_A1.0030.18
192_E244_F0.9980.18
165_C190_K0.9810.17
126_D157_A0.9770.17
38_S53_L0.9760.17
177_C193_E0.9710.17
83_L158_D0.9650.17
125_S152_Y0.9610.17
192_E213_M0.9570.17
140_G196_I0.9570.17
100_Y241_K0.9570.17
140_G244_F0.9540.17
41_F57_L0.9470.17
70_H102_M0.9460.17
105_S175_I0.9420.16
43_Q209_L0.9380.16
28_Y42_V0.9360.16
72_K127_G0.9320.16
140_G242_L0.9310.16
26_S37_F0.9280.16
64_L70_H0.9280.16
197_L215_S0.9270.16
75_P127_G0.9210.16
176_G189_A0.9130.16
174_P187_K0.9080.16
67_N193_E0.9050.16
111_M200_F0.9050.16
117_A178_G0.9020.16
179_E231_S0.9020.16
54_L143_I0.8990.16
50_L86_S0.8920.15
89_K161_I0.8900.15
162_L235_A0.8810.15
161_I198_D0.8790.15
192_E229_A0.8770.15
246_K249_R0.8750.15
68_Y252_T0.8710.15
55_N158_D0.8680.15
28_Y255_H0.8670.15
171_Q203_K0.8660.15
40_N239_Y0.8630.15
91_G203_K0.8610.15
143_I254_F0.8610.15
23_D168_D0.8590.15
174_P201_Q0.8570.15
44_L210_V0.8550.15
64_L251_H0.8470.15
42_V245_K0.8440.15
82_G105_S0.8430.15
100_Y246_K0.8410.15
134_Y177_C0.8400.15
21_S49_P0.8360.14
116_T165_C0.8360.14
163_V231_S0.8350.14
44_L214_L0.8320.14
52_R245_K0.8280.14
234_G238_F0.8280.14
61_P139_I0.8270.14
38_S70_H0.8210.14
42_V60_V0.8180.14
41_F70_H0.8120.14
234_G250_V0.8080.14
151_K206_G0.8080.14
147_K252_T0.8080.14
48_F165_C0.8060.14
189_A203_K0.8060.14
161_I170_A0.8010.14
227_L238_F0.8010.14
63_L235_A0.7970.14
63_L99_L0.7910.14
21_S234_G0.7900.14
85_Q89_K0.7890.14
50_L68_Y0.7880.14
149_K168_D0.7810.13
32_Q248_E0.7800.13
127_G196_I0.7770.13
23_D197_L0.7740.13
29_R162_L0.7740.13
84_K202_R0.7700.13
27_V147_K0.7690.13
126_D164_V0.7690.13
41_F44_L0.7660.13
209_L236_T0.7660.13
243_T254_F0.7640.13
79_F129_S0.7630.13
48_F127_G0.7570.13
135_D170_A0.7570.13
36_I126_D0.7570.13
120_T189_A0.7530.13
57_L248_E0.7490.13
119_G242_L0.7460.13
170_A245_K0.7440.13
73_A178_G0.7440.13
165_C205_Y0.7400.13
80_P209_L0.7400.13
176_G239_Y0.7380.13
178_G209_L0.7340.13
193_E235_A0.7330.13
44_L68_Y0.7310.13
54_L129_S0.7290.13
92_F135_D0.7290.13
159_I200_F0.7280.13
80_P245_K0.7250.13
46_D49_P0.7220.13
60_V114_P0.7210.12
133_I186_E0.7200.12
75_P132_K0.7190.12
128_S140_G0.7120.12
71_L171_Q0.7090.12
98_L244_F0.7080.12
82_G114_P0.7030.12
181_F190_K0.7010.12
67_N233_D0.6980.12
149_K171_Q0.6940.12
230_A234_G0.6930.12
91_G108_K0.6910.12
93_V171_Q0.6910.12
39_H144_A0.6910.12
48_F210_V0.6740.12
93_V232_T0.6720.12
44_L92_F0.6690.12
232_T253_V0.6680.12
171_Q254_F0.6670.12
124_L201_Q0.6670.12
74_S254_F0.6590.12
65_D89_K0.6570.12
65_D191_I0.6560.11
132_K144_A0.6550.11
163_V219_S0.6510.11
26_S197_L0.6460.11
123_S228_V0.6450.11
59_S209_L0.6450.11
190_K213_M0.6440.11
116_T203_K0.6430.11
47_T143_I0.6380.11
210_V238_F0.6340.11
60_V64_L0.6330.11
44_L139_I0.6320.11
176_G204_G0.6310.11
99_L230_A0.6270.11
89_K160_I0.6260.11
194_V204_G0.6260.11
153_P240_E0.6260.11
127_G226_Y0.6250.11
64_L73_A0.6240.11
90_S121_A0.6240.11
92_F107_W0.6240.11
98_L191_I0.6190.11
198_D225_A0.6160.11
114_P237_Q0.6120.11
98_L210_V0.6120.11
54_L171_Q0.6080.11
109_G158_D0.6000.11
45_H92_F0.5990.11
53_L60_V0.5990.11
73_A190_K0.5990.11
160_I179_E0.5980.11
70_H231_S0.5980.11
25_Y147_K0.5930.11
38_S54_L0.5920.11
165_C229_A0.5920.11
26_S236_T0.5900.11
72_K228_V0.5900.11
139_I168_D0.5860.10
56_F243_T0.5850.10
158_D163_V0.5850.10
198_D201_Q0.5830.10
207_S218_K0.5810.10
58_P136_S0.5800.10
86_S127_G0.5800.10
35_Q193_E0.5770.10
56_F139_I0.5750.10
192_E210_V0.5750.10
83_L109_G0.5740.10
190_K238_F0.5700.10
56_F92_F0.5680.10
93_V109_G0.5680.10
91_G228_V0.5660.10
114_P244_F0.5660.10
25_Y228_V0.5650.10
25_Y191_I0.5650.10
19_S79_F0.5640.10
104_L211_K0.5630.10
21_S107_W0.5600.10
201_Q219_S0.5600.10
206_G228_V0.5590.10
167_S187_K0.5590.10
145_E203_K0.5580.10
100_Y249_R0.5580.10
41_F194_V0.5550.10
28_Y211_K0.5540.10
64_L98_L0.5530.10
163_V212_E0.5520.10
47_T254_F0.5480.10
127_G194_V0.5460.10
201_Q205_Y0.5410.10
65_D120_T0.5410.10
56_F107_W0.5400.10
116_T201_Q0.5390.10
44_L242_L0.5370.10
81_L219_S0.5370.10
62_K168_D0.5330.10
34_P217_A0.5270.10
49_P164_V0.5240.10
55_N247_Y0.5230.10
91_G111_M0.5220.10
204_G238_F0.5210.10
76_Q200_F0.5210.10
82_G149_K0.5200.10
192_E242_L0.5200.10
166_Y217_A0.5110.10
55_N89_K0.5110.10
67_N100_Y0.5090.09
26_S126_D0.5080.09
99_L192_E0.5070.09
44_L60_V0.5060.09
141_E203_K0.5040.09
52_R211_K0.5040.09
99_L190_K0.5020.09
19_S208_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3frmA 3 0.9498 100 0.682 Contact Map
1sqhA 1 0.9112 99.6 0.811 Contact Map
1s3zA 2 0.5405 99.6 0.813 Contact Map
1z4rA 1 0.5521 99.6 0.814 Contact Map
1n71A 4 0.5444 99.5 0.818 Contact Map
1qsmA 3 0.5444 99.5 0.818 Contact Map
1vkcA 2 0.5405 99.5 0.819 Contact Map
1yghA 1 0.5483 99.5 0.822 Contact Map
3pp9A 2 0.5598 99.5 0.822 Contact Map
3gy9A 3 0.5367 99.5 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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