GREMLIN Database
CGED - Protein CgeD
UniProt: P42092 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (357)
Sequences: 745 (706)
Seq/√Len: 37.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_S46_T4.8991.00
166_R170_N4.6311.00
39_D63_N4.3141.00
81_I97_T4.2241.00
20_K215_Y4.1821.00
81_I95_Y3.9051.00
6_S34_E3.5631.00
29_T108_S3.3871.00
34_E90_G3.3341.00
71_R80_L3.3161.00
13_N42_S2.9911.00
18_L46_T2.9081.00
40_D76_R2.8181.00
6_S90_G2.7931.00
193_I197_R2.7931.00
14_K98_D2.7331.00
91_D115_S2.7151.00
9_L21_A2.5501.00
62_H87_F2.4751.00
30_H111_V2.4641.00
172_I178_G2.4601.00
19_Q52_K2.4541.00
85_L93_I2.3971.00
39_D42_S2.3931.00
169_L194_F2.3911.00
34_E60_Q2.3741.00
40_D74_T2.3241.00
38_M80_L2.3231.00
15_P49_V2.3091.00
5_V163_M2.2550.99
72_L75_A2.2150.99
102_Y106_R2.1830.99
85_L169_L2.1200.99
108_S112_Q2.1120.99
15_P45_E2.1010.99
9_L35_L2.0910.99
28_Q100_T2.0770.99
121_Q165_R2.0450.99
50_I61_Y2.0340.99
125_S211_L2.0150.99
25_V96_L1.9560.98
7_I25_V1.9440.98
47_T61_Y1.9370.98
5_V111_V1.9290.98
77_Y97_T1.9220.98
106_R110_M1.9130.98
77_Y81_I1.9000.98
12_Y74_T1.8930.98
19_Q23_E1.8890.98
172_I177_G1.8830.98
113_E205_L1.8740.98
8_I88_A1.8710.98
75_A79_T1.8570.98
110_M114_F1.8560.98
54_L61_Y1.8510.98
120_A205_L1.8420.98
88_A166_R1.8420.98
9_L25_V1.8070.97
14_K217_T1.7890.97
12_Y40_D1.7830.97
51_H63_N1.7240.96
109_R209_E1.7210.96
47_T63_N1.6830.96
34_E88_A1.6770.96
38_M84_A1.6710.96
106_R125_S1.6590.95
39_D47_T1.6400.95
6_S88_A1.6390.95
94_S107_L1.6040.95
13_N39_D1.5800.94
22_I53_Y1.5740.94
83_S87_F1.5670.94
21_A102_Y1.5470.93
9_L96_L1.5430.93
113_E117_K1.5270.93
23_E53_Y1.5090.92
45_E48_A1.5080.92
100_T215_Y1.5030.92
12_Y76_R1.5020.92
13_N43_N1.4970.92
40_D80_L1.4940.92
110_M163_M1.4880.92
100_T214_T1.4860.92
41_H72_L1.4790.92
30_H33_W1.4710.91
30_H37_I1.4690.91
75_A80_L1.4610.91
17_Y215_Y1.4460.91
22_I35_L1.4310.90
76_R190_G1.4280.90
71_R75_A1.4210.90
93_I169_L1.4210.90
11_S14_K1.4140.90
95_Y190_G1.4080.90
22_I26_I1.4050.89
105_E109_R1.4050.89
6_S36_F1.4030.89
8_I84_A1.3980.89
110_M123_V1.3940.89
102_Y110_M1.3820.89
106_R212_D1.3670.88
81_I190_G1.3650.88
5_V107_L1.3600.88
97_T190_G1.3560.88
11_S37_I1.3310.87
77_Y190_G1.3000.85
92_Y115_S1.2920.85
46_T49_V1.2820.85
47_T51_H1.2720.84
82_N191_D1.2700.84
47_T50_I1.2500.83
4_K91_D1.2420.83
31_D56_D1.2360.82
26_I59_I1.2330.82
194_F198_L1.2330.82
164_H195_W1.2320.82
164_H194_F1.2290.82
41_H80_L1.2270.82
72_L79_T1.2270.82
121_Q178_G1.2260.82
20_K101_V1.2250.82
42_S46_T1.2180.81
82_N85_L1.2010.80
88_A93_I1.2000.80
78_A82_N1.1910.80
49_V53_Y1.1790.79
21_A189_H1.1730.79
121_Q202_T1.1700.79
77_Y95_Y1.1560.78
40_D81_I1.1490.77
261_G265_L1.1420.77
71_R83_S1.1330.76
77_Y188_N1.1300.76
130_V215_Y1.1290.76
62_H83_S1.1250.76
114_F163_M1.1240.76
37_I50_I1.1130.75
35_L59_I1.1120.75
361_L368_P1.0770.73
365_E375_V1.0770.73
11_S18_L1.0700.72
25_V33_W1.0660.72
33_W107_L1.0650.72
10_T81_I1.0560.71
103_H211_L1.0480.71
10_T84_A1.0480.71
92_Y163_M1.0380.70
22_I61_Y1.0350.70
44_A74_T1.0310.69
319_Q322_Q1.0240.69
358_G361_L1.0240.69
48_A51_H1.0130.68
368_P374_G1.0110.68
86_P179_Y1.0100.68
14_K212_D1.0080.68
169_L178_G1.0040.67
5_V30_H1.0020.67
102_Y212_D1.0010.67
181_D193_I0.9960.67
46_T74_T0.9950.67
94_S102_Y0.9920.66
177_G181_D0.9850.66
100_T159_H0.9830.66
110_M211_L0.9820.65
190_G214_T0.9810.65
97_T100_T0.9810.65
94_S106_R0.9800.65
106_R161_S0.9790.65
167_S171_L0.9790.65
96_L102_Y0.9670.64
172_I179_Y0.9640.64
100_T212_D0.9600.64
106_R214_T0.9550.63
81_I217_T0.9540.63
28_Q108_S0.9500.63
110_M125_S0.9470.63
365_E371_F0.9440.62
81_I84_A0.9430.62
34_E89_D0.9410.62
78_A190_G0.9400.62
7_I107_L0.9390.62
80_L97_T0.9380.62
26_I53_Y0.9340.62
82_N178_G0.9340.62
106_R159_H0.9310.61
8_I38_M0.9290.61
85_L178_G0.9250.61
17_Y21_A0.9200.60
10_T40_D0.9190.60
358_G362_F0.9180.60
99_D191_D0.9110.60
13_N44_A0.9080.59
92_Y111_V0.9040.59
94_S163_M0.9040.59
103_H106_R0.9030.59
7_I94_S0.9030.59
321_Y332_G0.9000.59
159_H195_W0.8980.58
111_V114_F0.8930.58
72_L83_S0.8930.58
16_D49_V0.8930.58
141_H144_R0.8840.57
192_A195_W0.8800.57
81_I159_H0.8710.56
13_N46_T0.8680.56
11_S98_D0.8670.56
81_I162_V0.8570.55
21_A96_L0.8520.54
100_T199_N0.8520.54
77_Y160_C0.8510.54
72_L80_L0.8510.54
106_R160_C0.8510.54
234_D237_F0.8470.54
76_R97_T0.8460.54
11_S39_D0.8450.54
14_K21_A0.8430.54
115_S165_R0.8420.54
352_L356_P0.8410.54
206_P216_K0.8410.54
368_P375_V0.8400.53
77_Y193_I0.8390.53
25_V203_P0.8380.53
21_A98_D0.8360.53
94_S110_M0.8350.53
373_N376_F0.8350.53
114_F120_A0.8340.53
362_F376_F0.8340.53
107_L163_M0.8320.53
78_A189_H0.8310.53
156_Q192_A0.8260.52
158_D161_S0.8230.52
366_R376_F0.8200.52
5_V92_Y0.8200.52
20_K130_V0.8190.52
81_I194_F0.8130.51
28_Q58_R0.8110.51
101_V213_T0.8070.50
181_D197_R0.8020.50
39_D74_T0.8010.50
92_Y100_T0.8000.50
160_C214_T0.7980.50
252_V258_E0.7970.50
11_S49_V0.7960.50
79_T182_D0.7950.49
192_A211_L0.7920.49
14_K77_Y0.7860.49
162_V202_T0.7820.48
110_M161_S0.7810.48
88_A119_E0.7790.48
56_D59_I0.7790.48
234_D239_K0.7770.48
92_Y114_F0.7760.48
161_S188_N0.7750.48
77_Y80_L0.7750.48
81_I184_M0.7740.48
358_G372_L0.7730.47
338_T348_K0.7720.47
40_D97_T0.7720.47
134_E137_E0.7720.47
237_F241_S0.7710.47
366_R370_L0.7710.47
222_Q225_Y0.7700.47
7_I96_L0.7630.47
78_A191_D0.7570.46
86_P89_D0.7560.46
77_Y159_H0.7540.46
28_Q214_T0.7540.46
325_R335_E0.7520.46
168_L198_L0.7500.45
24_S96_L0.7490.45
23_E52_K0.7470.45
45_E115_S0.7450.45
265_L286_N0.7440.45
39_D191_D0.7360.44
234_D241_S0.7360.44
98_D139_I0.7350.44
12_Y42_S0.7350.44
124_Y206_P0.7350.44
371_F376_F0.7340.44
363_F375_V0.7330.44
100_T106_R0.7330.44
253_R263_L0.7330.44
228_L231_D0.7320.44
28_Q33_W0.7310.44
32_L37_I0.7300.44
372_L375_V0.7300.44
21_A106_R0.7290.44
15_P214_T0.7280.44
81_I106_R0.7260.43
347_W356_P0.7240.43
14_K18_L0.7210.43
46_T98_D0.7200.43
58_R211_L0.7200.43
146_A149_V0.7180.43
156_Q195_W0.7180.43
21_A157_V0.7170.43
33_W58_R0.7160.42
97_T122_A0.7120.42
168_L202_T0.7110.42
165_R199_N0.7100.42
265_L268_T0.7090.42
369_F375_V0.7080.42
232_L237_F0.7080.42
81_I100_T0.7040.41
120_A162_V0.7040.41
14_K214_T0.7040.41
77_Y221_F0.7010.41
145_N256_V0.7010.41
28_Q32_L0.7000.41
53_Y56_D0.6980.41
80_L83_S0.6970.41
106_R192_A0.6960.41
28_Q97_T0.6960.41
289_N292_L0.6960.41
98_D124_Y0.6940.41
8_I89_D0.6930.41
30_H105_E0.6930.41
371_F374_G0.6920.40
367_E371_F0.6890.40
14_K37_I0.6890.40
37_I58_R0.6880.40
107_L161_S0.6880.40
361_L375_V0.6860.40
41_H71_R0.6850.40
358_G363_F0.6840.40
362_F365_E0.6800.39
80_L84_A0.6760.39
368_P373_N0.6750.39
82_N99_D0.6750.39
162_V195_W0.6750.39
125_S210_V0.6730.39
93_I203_P0.6720.39
91_D210_V0.6720.39
164_H198_L0.6700.39
367_E370_L0.6700.39
15_P46_T0.6670.38
101_V215_Y0.6670.38
6_S376_F0.6660.38
78_A97_T0.6660.38
124_Y162_V0.6660.38
210_V214_T0.6620.38
30_H41_H0.6620.38
15_P97_T0.6620.38
139_I166_R0.6600.38
125_S189_H0.6590.38
262_F266_N0.6590.38
359_R362_F0.6580.38
363_F371_F0.6560.37
155_F199_N0.6540.37
28_Q191_D0.6530.37
21_A110_M0.6530.37
295_E301_I0.6520.37
293_V333_K0.6520.37
97_T106_R0.6510.37
29_T102_Y0.6500.37
110_M113_E0.6480.37
39_D51_H0.6480.37
124_Y129_V0.6460.37
10_T98_D0.6460.37
103_H213_T0.6450.36
43_N74_T0.6450.36
101_V130_V0.6440.36
14_K74_T0.6410.36
363_F376_F0.6410.36
97_T215_Y0.6410.36
363_F366_R0.6410.36
350_S355_N0.6400.36
7_I87_F0.6390.36
306_A313_V0.6380.36
92_Y99_D0.6380.36
42_S74_T0.6350.36
372_L376_F0.6320.35
17_Y100_T0.6320.35
189_H193_I0.6300.35
45_E49_V0.6290.35
4_K32_L0.6280.35
96_L212_D0.6270.35
95_Y110_M0.6270.35
56_D102_Y0.6260.35
84_A110_M0.6240.35
40_D98_D0.6230.35
155_F195_W0.6210.35
122_A162_V0.6210.35
335_E344_P0.6200.34
60_Q89_D0.6200.34
272_P277_F0.6200.34
12_Y46_T0.6190.34
169_L195_W0.6190.34
24_S53_Y0.6170.34
30_H114_F0.6160.34
155_F189_H0.6160.34
22_I39_D0.6140.34
21_A136_G0.6140.34
15_P100_T0.6140.34
192_A214_T0.6130.34
11_S212_D0.6130.34
366_R371_F0.6130.34
31_D58_R0.6120.34
368_P376_F0.6100.34
28_Q81_I0.6090.34
191_D195_W0.6090.34
320_F327_D0.6090.34
48_A247_F0.6080.34
238_V242_D0.6070.33
91_D167_S0.6060.33
166_R309_K0.6050.33
164_H212_D0.6040.33
159_H162_V0.6030.33
213_T216_K0.6020.33
81_I212_D0.6010.33
98_D217_T0.6000.33
32_L35_L0.5990.33
263_L268_T0.5980.33
92_Y107_L0.5980.33
100_T191_D0.5980.33
36_F42_S0.5970.33
364_I367_E0.5970.33
14_K96_L0.5960.33
193_I211_L0.5950.32
100_T177_G0.5950.32
97_T217_T0.5940.32
164_H169_L0.5930.32
300_A319_Q0.5920.32
261_G264_Y0.5910.32
36_F352_L0.5900.32
358_G364_I0.5900.32
7_I33_W0.5890.32
289_N302_F0.5880.32
365_E376_F0.5850.32
264_Y270_A0.5840.32
325_R330_T0.5840.32
97_T161_S0.5840.32
121_Q162_V0.5840.32
183_D339_L0.5840.32
159_H217_T0.5830.32
279_Y282_G0.5820.31
24_S28_Q0.5820.31
320_F329_V0.5820.31
80_L158_D0.5780.31
139_I142_F0.5770.31
41_H75_A0.5760.31
325_R339_L0.5760.31
124_Y159_H0.5750.31
10_T14_K0.5750.31
28_Q99_D0.5750.31
195_W216_K0.5750.31
5_V110_M0.5730.31
330_T333_K0.5720.31
97_T164_H0.5720.31
18_L80_L0.5710.31
25_V32_L0.5700.31
247_F250_Q0.5700.31
74_T99_D0.5670.30
160_C188_N0.5670.30
124_Y204_F0.5660.30
233_I237_F0.5650.30
106_R163_M0.5650.30
192_A196_A0.5630.30
7_I178_G0.5620.30
84_A125_S0.5620.30
348_K351_E0.5610.30
33_W106_R0.5600.30
7_I316_Y0.5600.30
22_I351_E0.5600.30
78_A81_I0.5590.30
138_E142_F0.5590.30
24_S102_Y0.5590.30
319_Q323_F0.5580.30
96_L101_V0.5540.29
82_N194_F0.5540.29
21_A25_V0.5540.29
34_E166_R0.5500.29
85_L88_A0.5500.29
268_T346_T0.5470.29
41_H78_A0.5470.29
93_I287_I0.5460.29
155_F158_D0.5460.29
48_A352_L0.5440.29
346_T352_L0.5420.29
327_D330_T0.5420.29
34_E92_Y0.5420.29
77_Y214_T0.5410.28
84_A190_G0.5400.28
28_Q92_Y0.5390.28
97_T212_D0.5390.28
291_I301_I0.5390.28
181_D184_M0.5380.28
111_V115_S0.5350.28
39_D107_L0.5340.28
365_E368_P0.5330.28
246_Y351_E0.5330.28
38_M204_F0.5310.28
14_K159_H0.5300.28
75_A83_S0.5290.28
199_N204_F0.5280.28
92_Y165_R0.5280.28
304_I318_F0.5280.28
14_K127_Q0.5270.27
117_K313_V0.5270.27
166_R203_P0.5260.27
17_Y23_E0.5260.27
359_R368_P0.5240.27
14_K22_I0.5230.27
361_L365_E0.5220.27
312_I316_Y0.5210.27
114_F162_V0.5210.27
194_F318_F0.5210.27
8_I332_G0.5210.27
35_L60_Q0.5200.27
10_T58_R0.5180.27
314_D318_F0.5180.27
313_V320_F0.5180.27
247_F252_V0.5170.27
304_I313_V0.5160.27
363_F372_L0.5150.27
18_L100_T0.5140.27
11_S50_I0.5130.26
354_K357_P0.5130.26
363_F368_P0.5120.26
95_Y106_R0.5120.26
369_F374_G0.5120.26
47_T54_L0.5100.26
269_V272_P0.5100.26
347_W350_S0.5090.26
160_C195_W0.5080.26
157_V204_F0.5080.26
148_A152_Q0.5070.26
202_T212_D0.5070.26
143_Y146_A0.5040.26
125_S155_F0.5040.26
78_A181_D0.5030.26
22_I95_Y0.5030.26
33_W99_D0.5020.26
94_S161_S0.5010.26
358_G367_E0.5000.26
333_K350_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qg8A 1 0.5282 100 0.469 Contact Map
3bcvA 2 0.4202 100 0.482 Contact Map
2z86A 2 0.5915 100 0.506 Contact Map
3l7iA 4 0.2559 100 0.508 Contact Map
1xhbA 1 0.8779 100 0.584 Contact Map
5ajoA 1 0.838 100 0.588 Contact Map
2d7iA 1 0.8709 100 0.59 Contact Map
4fixA 3 0.8592 100 0.595 Contact Map
2nxvA 4 0.5164 100 0.607 Contact Map
3ckjA 2 0.5939 100 0.607 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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