CGED - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CGED - Protein CgeD

UniProt:	P42092	Sequences: MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNAETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVYHPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHCSVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTPDSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYLFQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKEEMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQKPISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	426 (357)
Sequences:	745 (706)
Seq/√Len:	37.4

ECOLI - YIBD WCAA
BACSU - CGED GGAA GGAB YFNE EPSJ EPSH EPSE SPSA
HALSA - Q9HQP4 Q9HQP8
SULSO - Q7LXF7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_S	46_T	4.899	1.00
166_R	170_N	4.631	1.00
39_D	63_N	4.314	1.00
81_I	97_T	4.224	1.00
20_K	215_Y	4.182	1.00
81_I	95_Y	3.905	1.00
6_S	34_E	3.563	1.00
29_T	108_S	3.387	1.00
34_E	90_G	3.334	1.00
71_R	80_L	3.316	1.00
13_N	42_S	2.991	1.00
18_L	46_T	2.908	1.00
40_D	76_R	2.818	1.00
6_S	90_G	2.793	1.00
193_I	197_R	2.793	1.00
14_K	98_D	2.733	1.00
91_D	115_S	2.715	1.00
9_L	21_A	2.550	1.00
62_H	87_F	2.475	1.00
30_H	111_V	2.464	1.00
172_I	178_G	2.460	1.00
19_Q	52_K	2.454	1.00
85_L	93_I	2.397	1.00
39_D	42_S	2.393	1.00
169_L	194_F	2.391	1.00
34_E	60_Q	2.374	1.00
40_D	74_T	2.324	1.00
38_M	80_L	2.323	1.00
15_P	49_V	2.309	1.00
5_V	163_M	2.255	0.99
72_L	75_A	2.215	0.99
102_Y	106_R	2.183	0.99
85_L	169_L	2.120	0.99
108_S	112_Q	2.112	0.99
15_P	45_E	2.101	0.99
9_L	35_L	2.091	0.99
28_Q	100_T	2.077	0.99
121_Q	165_R	2.045	0.99
50_I	61_Y	2.034	0.99
125_S	211_L	2.015	0.99
25_V	96_L	1.956	0.98
7_I	25_V	1.944	0.98
47_T	61_Y	1.937	0.98
5_V	111_V	1.929	0.98
77_Y	97_T	1.922	0.98
106_R	110_M	1.913	0.98
77_Y	81_I	1.900	0.98
12_Y	74_T	1.893	0.98
19_Q	23_E	1.889	0.98
172_I	177_G	1.883	0.98
113_E	205_L	1.874	0.98
8_I	88_A	1.871	0.98
75_A	79_T	1.857	0.98
110_M	114_F	1.856	0.98
54_L	61_Y	1.851	0.98
120_A	205_L	1.842	0.98
88_A	166_R	1.842	0.98
9_L	25_V	1.807	0.97
14_K	217_T	1.789	0.97
12_Y	40_D	1.783	0.97
51_H	63_N	1.724	0.96
109_R	209_E	1.721	0.96
47_T	63_N	1.683	0.96
34_E	88_A	1.677	0.96
38_M	84_A	1.671	0.96
106_R	125_S	1.659	0.95
39_D	47_T	1.640	0.95
6_S	88_A	1.639	0.95
94_S	107_L	1.604	0.95
13_N	39_D	1.580	0.94
22_I	53_Y	1.574	0.94
83_S	87_F	1.567	0.94
21_A	102_Y	1.547	0.93
9_L	96_L	1.543	0.93
113_E	117_K	1.527	0.93
23_E	53_Y	1.509	0.92
45_E	48_A	1.508	0.92
100_T	215_Y	1.503	0.92
12_Y	76_R	1.502	0.92
13_N	43_N	1.497	0.92
40_D	80_L	1.494	0.92
110_M	163_M	1.488	0.92
100_T	214_T	1.486	0.92
41_H	72_L	1.479	0.92
30_H	33_W	1.471	0.91
30_H	37_I	1.469	0.91
75_A	80_L	1.461	0.91
17_Y	215_Y	1.446	0.91
22_I	35_L	1.431	0.90
76_R	190_G	1.428	0.90
71_R	75_A	1.421	0.90
93_I	169_L	1.421	0.90
11_S	14_K	1.414	0.90
95_Y	190_G	1.408	0.90
22_I	26_I	1.405	0.89
105_E	109_R	1.405	0.89
6_S	36_F	1.403	0.89
8_I	84_A	1.398	0.89
110_M	123_V	1.394	0.89
102_Y	110_M	1.382	0.89
106_R	212_D	1.367	0.88
81_I	190_G	1.365	0.88
5_V	107_L	1.360	0.88
97_T	190_G	1.356	0.88
11_S	37_I	1.331	0.87
77_Y	190_G	1.300	0.85
92_Y	115_S	1.292	0.85
46_T	49_V	1.282	0.85
47_T	51_H	1.272	0.84
82_N	191_D	1.270	0.84
47_T	50_I	1.250	0.83
4_K	91_D	1.242	0.83
31_D	56_D	1.236	0.82
26_I	59_I	1.233	0.82
194_F	198_L	1.233	0.82
164_H	195_W	1.232	0.82
164_H	194_F	1.229	0.82
41_H	80_L	1.227	0.82
72_L	79_T	1.227	0.82
121_Q	178_G	1.226	0.82
20_K	101_V	1.225	0.82
42_S	46_T	1.218	0.81
82_N	85_L	1.201	0.80
88_A	93_I	1.200	0.80
78_A	82_N	1.191	0.80
49_V	53_Y	1.179	0.79
21_A	189_H	1.173	0.79
121_Q	202_T	1.170	0.79
77_Y	95_Y	1.156	0.78
40_D	81_I	1.149	0.77
261_G	265_L	1.142	0.77
71_R	83_S	1.133	0.76
77_Y	188_N	1.130	0.76
130_V	215_Y	1.129	0.76
62_H	83_S	1.125	0.76
114_F	163_M	1.124	0.76
37_I	50_I	1.113	0.75
35_L	59_I	1.112	0.75
361_L	368_P	1.077	0.73
365_E	375_V	1.077	0.73
11_S	18_L	1.070	0.72
25_V	33_W	1.066	0.72
33_W	107_L	1.065	0.72
10_T	81_I	1.056	0.71
103_H	211_L	1.048	0.71
10_T	84_A	1.048	0.71
92_Y	163_M	1.038	0.70
22_I	61_Y	1.035	0.70
44_A	74_T	1.031	0.69
319_Q	322_Q	1.024	0.69
358_G	361_L	1.024	0.69
48_A	51_H	1.013	0.68
368_P	374_G	1.011	0.68
86_P	179_Y	1.010	0.68
14_K	212_D	1.008	0.68
169_L	178_G	1.004	0.67
5_V	30_H	1.002	0.67
102_Y	212_D	1.001	0.67
181_D	193_I	0.996	0.67
46_T	74_T	0.995	0.67
94_S	102_Y	0.992	0.66
177_G	181_D	0.985	0.66
100_T	159_H	0.983	0.66
110_M	211_L	0.982	0.65
190_G	214_T	0.981	0.65
97_T	100_T	0.981	0.65
94_S	106_R	0.980	0.65
106_R	161_S	0.979	0.65
167_S	171_L	0.979	0.65
96_L	102_Y	0.967	0.64
172_I	179_Y	0.964	0.64
100_T	212_D	0.960	0.64
106_R	214_T	0.955	0.63
81_I	217_T	0.954	0.63
28_Q	108_S	0.950	0.63
110_M	125_S	0.947	0.63
365_E	371_F	0.944	0.62
81_I	84_A	0.943	0.62
34_E	89_D	0.941	0.62
78_A	190_G	0.940	0.62
7_I	107_L	0.939	0.62
80_L	97_T	0.938	0.62
26_I	53_Y	0.934	0.62
82_N	178_G	0.934	0.62
106_R	159_H	0.931	0.61
8_I	38_M	0.929	0.61
85_L	178_G	0.925	0.61
17_Y	21_A	0.920	0.60
10_T	40_D	0.919	0.60
358_G	362_F	0.918	0.60
99_D	191_D	0.911	0.60
13_N	44_A	0.908	0.59
92_Y	111_V	0.904	0.59
94_S	163_M	0.904	0.59
103_H	106_R	0.903	0.59
7_I	94_S	0.903	0.59
321_Y	332_G	0.900	0.59
159_H	195_W	0.898	0.58
111_V	114_F	0.893	0.58
72_L	83_S	0.893	0.58
16_D	49_V	0.893	0.58
141_H	144_R	0.884	0.57
192_A	195_W	0.880	0.57
81_I	159_H	0.871	0.56
13_N	46_T	0.868	0.56
11_S	98_D	0.867	0.56
81_I	162_V	0.857	0.55
21_A	96_L	0.852	0.54
100_T	199_N	0.852	0.54
77_Y	160_C	0.851	0.54
72_L	80_L	0.851	0.54
106_R	160_C	0.851	0.54
234_D	237_F	0.847	0.54
76_R	97_T	0.846	0.54
11_S	39_D	0.845	0.54
14_K	21_A	0.843	0.54
115_S	165_R	0.842	0.54
352_L	356_P	0.841	0.54
206_P	216_K	0.841	0.54
368_P	375_V	0.840	0.53
77_Y	193_I	0.839	0.53
25_V	203_P	0.838	0.53
21_A	98_D	0.836	0.53
94_S	110_M	0.835	0.53
373_N	376_F	0.835	0.53
114_F	120_A	0.834	0.53
362_F	376_F	0.834	0.53
107_L	163_M	0.832	0.53
78_A	189_H	0.831	0.53
156_Q	192_A	0.826	0.52
158_D	161_S	0.823	0.52
366_R	376_F	0.820	0.52
5_V	92_Y	0.820	0.52
20_K	130_V	0.819	0.52
81_I	194_F	0.813	0.51
28_Q	58_R	0.811	0.51
101_V	213_T	0.807	0.50
181_D	197_R	0.802	0.50
39_D	74_T	0.801	0.50
92_Y	100_T	0.800	0.50
160_C	214_T	0.798	0.50
252_V	258_E	0.797	0.50
11_S	49_V	0.796	0.50
79_T	182_D	0.795	0.49
192_A	211_L	0.792	0.49
14_K	77_Y	0.786	0.49
162_V	202_T	0.782	0.48
110_M	161_S	0.781	0.48
88_A	119_E	0.779	0.48
56_D	59_I	0.779	0.48
234_D	239_K	0.777	0.48
92_Y	114_F	0.776	0.48
161_S	188_N	0.775	0.48
77_Y	80_L	0.775	0.48
81_I	184_M	0.774	0.48
358_G	372_L	0.773	0.47
338_T	348_K	0.772	0.47
40_D	97_T	0.772	0.47
134_E	137_E	0.772	0.47
237_F	241_S	0.771	0.47
366_R	370_L	0.771	0.47
222_Q	225_Y	0.770	0.47
7_I	96_L	0.763	0.47
78_A	191_D	0.757	0.46
86_P	89_D	0.756	0.46
77_Y	159_H	0.754	0.46
28_Q	214_T	0.754	0.46
325_R	335_E	0.752	0.46
168_L	198_L	0.750	0.45
24_S	96_L	0.749	0.45
23_E	52_K	0.747	0.45
45_E	115_S	0.745	0.45
265_L	286_N	0.744	0.45
39_D	191_D	0.736	0.44
234_D	241_S	0.736	0.44
98_D	139_I	0.735	0.44
12_Y	42_S	0.735	0.44
124_Y	206_P	0.735	0.44
371_F	376_F	0.734	0.44
363_F	375_V	0.733	0.44
100_T	106_R	0.733	0.44
253_R	263_L	0.733	0.44
228_L	231_D	0.732	0.44
28_Q	33_W	0.731	0.44
32_L	37_I	0.730	0.44
372_L	375_V	0.730	0.44
21_A	106_R	0.729	0.44
15_P	214_T	0.728	0.44
81_I	106_R	0.726	0.43
347_W	356_P	0.724	0.43
14_K	18_L	0.721	0.43
46_T	98_D	0.720	0.43
58_R	211_L	0.720	0.43
146_A	149_V	0.718	0.43
156_Q	195_W	0.718	0.43
21_A	157_V	0.717	0.43
33_W	58_R	0.716	0.42
97_T	122_A	0.712	0.42
168_L	202_T	0.711	0.42
165_R	199_N	0.710	0.42
265_L	268_T	0.709	0.42
369_F	375_V	0.708	0.42
232_L	237_F	0.708	0.42
81_I	100_T	0.704	0.41
120_A	162_V	0.704	0.41
14_K	214_T	0.704	0.41
77_Y	221_F	0.701	0.41
145_N	256_V	0.701	0.41
28_Q	32_L	0.700	0.41
53_Y	56_D	0.698	0.41
80_L	83_S	0.697	0.41
106_R	192_A	0.696	0.41
28_Q	97_T	0.696	0.41
289_N	292_L	0.696	0.41
98_D	124_Y	0.694	0.41
8_I	89_D	0.693	0.41
30_H	105_E	0.693	0.41
371_F	374_G	0.692	0.40
367_E	371_F	0.689	0.40
14_K	37_I	0.689	0.40
37_I	58_R	0.688	0.40
107_L	161_S	0.688	0.40
361_L	375_V	0.686	0.40
41_H	71_R	0.685	0.40
358_G	363_F	0.684	0.40
362_F	365_E	0.680	0.39
80_L	84_A	0.676	0.39
368_P	373_N	0.675	0.39
82_N	99_D	0.675	0.39
162_V	195_W	0.675	0.39
125_S	210_V	0.673	0.39
93_I	203_P	0.672	0.39
91_D	210_V	0.672	0.39
164_H	198_L	0.670	0.39
367_E	370_L	0.670	0.39
15_P	46_T	0.667	0.38
101_V	215_Y	0.667	0.38
6_S	376_F	0.666	0.38
78_A	97_T	0.666	0.38
124_Y	162_V	0.666	0.38
210_V	214_T	0.662	0.38
30_H	41_H	0.662	0.38
15_P	97_T	0.662	0.38
139_I	166_R	0.660	0.38
125_S	189_H	0.659	0.38
262_F	266_N	0.659	0.38
359_R	362_F	0.658	0.38
363_F	371_F	0.656	0.37
155_F	199_N	0.654	0.37
28_Q	191_D	0.653	0.37
21_A	110_M	0.653	0.37
295_E	301_I	0.652	0.37
293_V	333_K	0.652	0.37
97_T	106_R	0.651	0.37
29_T	102_Y	0.650	0.37
110_M	113_E	0.648	0.37
39_D	51_H	0.648	0.37
124_Y	129_V	0.646	0.37
10_T	98_D	0.646	0.37
103_H	213_T	0.645	0.36
43_N	74_T	0.645	0.36
101_V	130_V	0.644	0.36
14_K	74_T	0.641	0.36
363_F	376_F	0.641	0.36
97_T	215_Y	0.641	0.36
363_F	366_R	0.641	0.36
350_S	355_N	0.640	0.36
7_I	87_F	0.639	0.36
306_A	313_V	0.638	0.36
92_Y	99_D	0.638	0.36
42_S	74_T	0.635	0.36
372_L	376_F	0.632	0.35
17_Y	100_T	0.632	0.35
189_H	193_I	0.630	0.35
45_E	49_V	0.629	0.35
4_K	32_L	0.628	0.35
96_L	212_D	0.627	0.35
95_Y	110_M	0.627	0.35
56_D	102_Y	0.626	0.35
84_A	110_M	0.624	0.35
40_D	98_D	0.623	0.35
155_F	195_W	0.621	0.35
122_A	162_V	0.621	0.35
335_E	344_P	0.620	0.34
60_Q	89_D	0.620	0.34
272_P	277_F	0.620	0.34
12_Y	46_T	0.619	0.34
169_L	195_W	0.619	0.34
24_S	53_Y	0.617	0.34
30_H	114_F	0.616	0.34
155_F	189_H	0.616	0.34
22_I	39_D	0.614	0.34
21_A	136_G	0.614	0.34
15_P	100_T	0.614	0.34
192_A	214_T	0.613	0.34
11_S	212_D	0.613	0.34
366_R	371_F	0.613	0.34
31_D	58_R	0.612	0.34
368_P	376_F	0.610	0.34
28_Q	81_I	0.609	0.34
191_D	195_W	0.609	0.34
320_F	327_D	0.609	0.34
48_A	247_F	0.608	0.34
238_V	242_D	0.607	0.33
91_D	167_S	0.606	0.33
166_R	309_K	0.605	0.33
164_H	212_D	0.604	0.33
159_H	162_V	0.603	0.33
213_T	216_K	0.602	0.33
81_I	212_D	0.601	0.33
98_D	217_T	0.600	0.33
32_L	35_L	0.599	0.33
263_L	268_T	0.598	0.33
92_Y	107_L	0.598	0.33
100_T	191_D	0.598	0.33
36_F	42_S	0.597	0.33
364_I	367_E	0.597	0.33
14_K	96_L	0.596	0.33
193_I	211_L	0.595	0.32
100_T	177_G	0.595	0.32
97_T	217_T	0.594	0.32
164_H	169_L	0.593	0.32
300_A	319_Q	0.592	0.32
261_G	264_Y	0.591	0.32
36_F	352_L	0.590	0.32
358_G	364_I	0.590	0.32
7_I	33_W	0.589	0.32
289_N	302_F	0.588	0.32
365_E	376_F	0.585	0.32
264_Y	270_A	0.584	0.32
325_R	330_T	0.584	0.32
97_T	161_S	0.584	0.32
121_Q	162_V	0.584	0.32
183_D	339_L	0.584	0.32
159_H	217_T	0.583	0.32
279_Y	282_G	0.582	0.31
24_S	28_Q	0.582	0.31
320_F	329_V	0.582	0.31
80_L	158_D	0.578	0.31
139_I	142_F	0.577	0.31
41_H	75_A	0.576	0.31
325_R	339_L	0.576	0.31
124_Y	159_H	0.575	0.31
10_T	14_K	0.575	0.31
28_Q	99_D	0.575	0.31
195_W	216_K	0.575	0.31
5_V	110_M	0.573	0.31
330_T	333_K	0.572	0.31
97_T	164_H	0.572	0.31
18_L	80_L	0.571	0.31
25_V	32_L	0.570	0.31
247_F	250_Q	0.570	0.31
74_T	99_D	0.567	0.30
160_C	188_N	0.567	0.30
124_Y	204_F	0.566	0.30
233_I	237_F	0.565	0.30
106_R	163_M	0.565	0.30
192_A	196_A	0.563	0.30
7_I	178_G	0.562	0.30
84_A	125_S	0.562	0.30
348_K	351_E	0.561	0.30
33_W	106_R	0.560	0.30
7_I	316_Y	0.560	0.30
22_I	351_E	0.560	0.30
78_A	81_I	0.559	0.30
138_E	142_F	0.559	0.30
24_S	102_Y	0.559	0.30
319_Q	323_F	0.558	0.30
96_L	101_V	0.554	0.29
82_N	194_F	0.554	0.29
21_A	25_V	0.554	0.29
34_E	166_R	0.550	0.29
85_L	88_A	0.550	0.29
268_T	346_T	0.547	0.29
41_H	78_A	0.547	0.29
93_I	287_I	0.546	0.29
155_F	158_D	0.546	0.29
48_A	352_L	0.544	0.29
346_T	352_L	0.542	0.29
327_D	330_T	0.542	0.29
34_E	92_Y	0.542	0.29
77_Y	214_T	0.541	0.28
84_A	190_G	0.540	0.28
28_Q	92_Y	0.539	0.28
97_T	212_D	0.539	0.28
291_I	301_I	0.539	0.28
181_D	184_M	0.538	0.28
111_V	115_S	0.535	0.28
39_D	107_L	0.534	0.28
365_E	368_P	0.533	0.28
246_Y	351_E	0.533	0.28
38_M	204_F	0.531	0.28
14_K	159_H	0.530	0.28
75_A	83_S	0.529	0.28
199_N	204_F	0.528	0.28
92_Y	165_R	0.528	0.28
304_I	318_F	0.528	0.28
14_K	127_Q	0.527	0.27
117_K	313_V	0.527	0.27
166_R	203_P	0.526	0.27
17_Y	23_E	0.526	0.27
359_R	368_P	0.524	0.27
14_K	22_I	0.523	0.27
361_L	365_E	0.522	0.27
312_I	316_Y	0.521	0.27
114_F	162_V	0.521	0.27
194_F	318_F	0.521	0.27
8_I	332_G	0.521	0.27
35_L	60_Q	0.520	0.27
10_T	58_R	0.518	0.27
314_D	318_F	0.518	0.27
313_V	320_F	0.518	0.27
247_F	252_V	0.517	0.27
304_I	313_V	0.516	0.27
363_F	372_L	0.515	0.27
18_L	100_T	0.514	0.27
11_S	50_I	0.513	0.26
354_K	357_P	0.513	0.26
363_F	368_P	0.512	0.26
95_Y	106_R	0.512	0.26
369_F	374_G	0.512	0.26
47_T	54_L	0.510	0.26
269_V	272_P	0.510	0.26
347_W	350_S	0.509	0.26
160_C	195_W	0.508	0.26
157_V	204_F	0.508	0.26
148_A	152_Q	0.507	0.26
202_T	212_D	0.507	0.26
143_Y	146_A	0.504	0.26
125_S	155_F	0.504	0.26
78_A	181_D	0.503	0.26
22_I	95_Y	0.503	0.26
33_W	99_D	0.502	0.26
94_S	161_S	0.501	0.26
358_G	367_E	0.500	0.26
333_K	350_S	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qg8A	1	0.5282	100	0.469	Contact Map
3bcvA	2	0.4202	100	0.482	Contact Map
2z86A	2	0.5915	100	0.506	Contact Map
3l7iA	4	0.2559	100	0.508	Contact Map
1xhbA	1	0.8779	100	0.584	Contact Map
5ajoA	1	0.838	100	0.588	Contact Map
2d7iA	1	0.8709	100	0.59	Contact Map
4fixA	3	0.8592	100	0.595	Contact Map
2nxvA	4	0.5164	100	0.607	Contact Map
3ckjA	2	0.5939	100	0.607	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.